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M-M Gellrich
BACKGROUND: Today's slit lamps have been optimized to realise the principle of focal illumination. When doing clinical work the result is that the slit lamp can be operated simply by using intuition; however, other applications are excluded due to the rigid construction principle. These other applications are summarized in the accompanying film (available online). METHODS: First, the slit lamp's classical fields of application are shown. Thereafter, a description follows of how modern methods of image processing and also simple alterations in the slit lamp illumination and observation optics open up exciting new perspectives for diagnostics and documentation...
July 13, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Hildegard Kehrer-Sawatzki, Lan Kluwe, Reinhard E Friedrich, Anna Summerer, Eleonora Schäfer, Ute Wahlländer, Cordula Matthies, Isabel Gugel, Said Farschtschi, Christian Hagel, David N Cooper, Victor-Felix Mautner
Schwannomatosis and neurofibromatosis type 2 (NF2) are both characterized by the development of multiple schwannomas but represent different genetic entities. Whereas NF2 is caused by mutations of the NF2 gene, schwannomatosis is associated with germline mutations of SMARCB1 or LZTR1. Here, we studied 15 sporadic patients with multiple non-intradermal schwannomas, but lacking vestibular schwannomas and ophthalmological abnormalities, who fulfilled the clinical diagnostic criteria for schwannomatosis. None of them harboured germline NF2 or SMARCB1 mutations as determined by the analysis of blood samples but seven had germline LZTR1 variants predicted to be pathogenic...
July 13, 2018: Human Genetics
Yoon Pyo Lee, Young-Su Ju, Dong Gyu Choi
The purpose of this study was to identify the normative values of ganglion cell-inner plexiform layer (GCIPL) thickness in healthy Korean children using swept-source optical coherence tomography (SS-OCT) and to investigate the correlations of age, refractive error, axial length (AL), retinal nerve fiber layer (RNFL) thickness and cup-to-disc (C/D) ratio with GCIPL thickness. Children aged between 3 and 17 who had visited our pediatric ophthalmology clinic were enrolled. Each subject underwent full ophthalmic examinations including RNFL thickness, C/D ratio and GCIPL thickness measurement by SS-OCT as well as AL measurement by partial-coherence interferometry...
July 13, 2018: Scientific Reports
Tan Duong, Shahin Shahbazi, Sung Lee
INTRODUCTION: Endogenous endophthalmitis is a rare condition that is caused by hematogenous spread of bacteria or fungi and is usually seen in patients with predisposed medical conditions. We are reporting an unusual case of group A streptococcal infection causing endogenous endophthalmitis and septic arthritis in a healthy 42-year-old man. CASE PRESENTATION: A previously healthy 42-year-old man presented to the Emergency Department with chills, fever, left wrist pain, left eye pain, and vision loss...
June 26, 2018: Permanente Journal
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2018: JAMA Ophthalmology
Caleb Busch, Noriyasu Hashida, Kohji Nishida
Purpose: To report a case of corneal infiltration and xanthoma formation in mycosis fungoides (cutaneous T-cell lymphoma). Observations: A middle aged Japanese man with mycosis fungoides (MF) involving the face was referred to Ophthalmology for evaluation of unilateral, painless conjunctival injection. Biopsy of the conjunctiva revealed a malignant T cell population consistent with MF tumor invasion. Years later, he returned following several episodes of infectious keratitis with a painless, yellow, rapidly forming mass in the left eye over two weeks...
September 2018: American Journal of Ophthalmology Case Reports
Alessandro Arrigo, Adriano Carnevali, Riccardo Sacconi, Lea Querques, Giuseppe Querques, Francesco Bandello
Purpose: To report a case of a patient affected by branch retinal vein occlusion (BRVO) showing a possible spontaneous retinal-choroidal anastomosis (RCA) at the level of the fovea. Observations: A 72 years old male patient with diagnosis of BRVO of left eye (LE) one year before came to our observation for a follow-up visit.The patient underwent a complete ophthalmologic examination, including fluorescein angiography, structural optical coherence tomography (OCT), OCT-Angiography (OCT-A)...
September 2018: American Journal of Ophthalmology Case Reports
Jung-Ho Noh, Ji-Seong Jeong, Sang-Jin Park, Eun-Young Yun, Jae Sam Hwang, Ji-Young Kim, Kyung-Jin Jung, Hee Jin Park, Hwa-Young Son, Kyoung-Sik Moon
White-spotted flower chafer ( Protaetia brevitarsis ) is an edible insect and its larva was used as a traditional Asian medicine. It's a promising material as a novel food source because of its nutritional components. In this study, as part of the preclinical toxicity program, we evaluated the toxicity of freeze-dried P. brevitarsis larva powder to develop a novel food material. In a single-dose oral toxicity study in rats, there were no changes in mortality, clinical observations, and body weight in rats administered 5000 mg/kg P...
2018: Toxicology Reports
Marilita M Moschos, Nikolaos S Gouliopoulos, Chris Kalogeropoulos, Sofia Androudi, George Kitsos, Dimitrios Ladas, Michael Tsatsos, Irini Chatziralli
Purpose: To assess the psychological status of keratoconus sufferers and to determine the relationship between depression and visual impairment in this group of patients. Methods: Fifty-six patients with keratoconus and forty-seven age- and gender-matched healthy control subjects were retroprospectively analyzed. Every participant underwent a complete ophthalmological examination. Keratoconus diagnosis was confirmed with corneal topography and tomography. Zung Depression Inventory Questionnaire and Patient Health Questionnaire-9 (PHQ-9) were completed by everyone...
2018: Journal of Ophthalmology
Su Ann Tee, Earn Hui Gan, Mohamad Zaher Kanaan, David Ashley Price, Tim Hoare, Simon H S Pearce
Primary adrenal insufficiency secondary to syphilis is extremely rare, with only five cases being reported in the literature. We report a case of adrenal insufficiency as a manifestation of Treponema pallidum infection (tertiary syphilis). A 69-year-old, previously fit and well Caucasian male was found to have adrenal insufficiency after being admitted with weight loss, anorexia and postural dizziness resulting in a fall. Biochemical testing showed hyponatraemia, hyperkalaemia, and an inadequate response to Synacthen testing, with a peak cortisol level of 302 nmol/L after administration of 250 µg Synacthen...
2018: Endocrinology, Diabetes & Metabolism Case Reports
Matthew Yu Heng Wong, Nicholas Y Q Tan, Charumathi Sabanayagam
We analysed the 100 top cited articles in ophthalmology to identify and characterise the most influential articles of the past four decades. Two independent investigators searched the Scopus database to determine the 100 most frequently cited articles in ophthalmology (T100-Eye) and general non-ophthalmology journals (T100-Gen) published from 1975 to December 2017. The T100-Eye list consisted of 83 original articles and 17 reviews, and the number of citations ranged from 582 to 2833. Seventy-eight of these articles were published in three journals alone (impact factor (IF): 5...
July 12, 2018: British Journal of Ophthalmology
Emmanuelle A Kuntz, Srinivas Kammanadiminti
BACKGROUND: Lotilaner is a new member of the isoxazoline class for treatment of flea and tick infestations in cats. This laboratory study with lotilaner vanilla-yeast flavoured chewable tablets (CredelioTM , Elanco) investigated the safety in healthy kittens starting at 8 weeks of age in a randomized, blinded, parallel-group design. Lotilaner tablets were given orally once a month over eight months at one, three and five times the upper level of the maximum recommended dose range (26 mg/kg)...
July 13, 2018: Parasites & Vectors
Eveline Teresa Hidalgo, Michelle W McQuinn, Jeffrey H Wisoff
Optic pathway gliomas (OPGs) are relatively common and benign lesions in children; however, in adults these lesions are nearly always malignant and hold a very poor prognosis. In this report the authors present the case of an adult patient with a benign OPG who underwent subtotal resection without adjuvant therapy and has had no tumor progression for more than 20 years. A 50-year-old woman presented with a 2-year history of personality changes, weight gain, and a few months of visual disturbances. Ophthalmological evaluation showed incomplete right homonymous hemianopsia...
June 1, 2018: Journal of Neurosurgery
Yi Zhang, Yu Fan, Jinlu Fan, Yanhui Cui
PURPOSE: To evaluate the surgical intervention and its effect on congenital dacryocystocele. METHODS: A total of 531 children with congenital dacryocystocele admitted to the Department of Ophthalmology of Beijing Children's Hospital, Shanghai Aier Eye Hospital, Nanjing Aier Eye Hospital, and the First Affiliated Hospital of Jinzhou Medical University between January 2007 and January 2017 were retrospectively analyzed. RESULTS: A total of 531 patients were followed up for 3-24 months, with an average of 13...
July 1, 2018: European Journal of Ophthalmology
Helen Khan, Sarah E Coupland, Mariya Moosajee
No abstract text is available yet for this article.
January 2018: Therapeutic advances in ophthalmology
D Joshua Cameron
No abstract text is available yet for this article.
January 2018: Therapeutic advances in ophthalmology
Valentina Favoni, Giulia Pierangeli, Francesco Toni, Luigi Cirillo, Chiara La Morgia, Samir Abu-Rumeileh, Monica Messia, Raffaele Agati, Pietro Cortelli, Sabina Cevoli
Background: To determine the prevalence of Idiopathic intracranial hypertension without papilledema (IIHWOP) testing revised diagnostic criteria by Friedman in refractory chronic headache (CH) patients. Methods: This is a prospective observational study. Each patient underwent ophthalmologic evaluation and Optical Coherence Tomography; brain magnetic resonance venography (MRV) and a lumbar puncture (LP) with opening pressure (OP) measurement. CSF withdrawal was performed in patients with CSF OP > 200 mmH20...
2018: Frontiers in Neurology
Eleni Papageorgiou, Anastasia Pilat, Frank Proudlock, Helena Lee, Ravi Purohit, Viral Sheth, Pradeep Vasudevan, Irene Gottlob
OBJECTIVE: To investigate the morphology of the retina and optic nerve (ON) in microcephaly. METHODS: This was a prospective case-control study including 27 patients with microcephaly and 27 healthy controls. All participants underwent ophthalmologic examination and handheld optical coherence tomography (OCT) of the macula and ON head. The thickness of individual retinal layers was quantified at the foveal center and the parafovea (1,000 μm nasal and temporal to the fovea)...
July 11, 2018: Neurology
Qian Xu, Ying Li, Ying Cheng, Yi Qu
BACKGROUND: To determine the effect of age on the thickness of individual retinal and choroidal vascular layers in the macula in an ophthalmologically healthy Chinese cohort by using spectral-domain optical coherence tomography (SD-OCT). METHODS: In all, 525 health eyes of 525 subjects were examined with SD-OCT. The instrument automatically obtained the regional retinal thickness of 8 layers. Subfoveal choroidal vascular layers' thickness was measured using enhanced depth imaging mode...
July 11, 2018: BMC Ophthalmology
Olivier Senese, Edward Boutremans, Caroline Gossiaux, Isabelle Loeb, Didier Dequanter
BACKGROUND: The aim of our retrospective study is to evaluate the management of isolated orbital floor fractures considering the clinical, functional and aesthetic results according to the surgical approach and the type of materials used. METHODS: Retrospectively, clinical, radiological, surgical, and ophthalmological data from 79 patients were collected from January 2010 to December 2016. Furthermore, included patients were interrogated on functional and aesthetic satisfaction...
June 2018: Archives of Craniofacial Surgery
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