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https://www.readbyqxmd.com/read/28548467/outcomes-of-trastuzumab-therapy-for-6-and-12-months-in-indonesian-national-health-insurance-system-clients-with-operable-her2-positive-breast-cancer
#1
Wirsma Arif Harahap, Ramadhan, Daan Khambri, Samuel Haryono, Ricvan Dana Nindrea
Objective: The aim of this study is to determine the outcome of trastuzumab therapy for 6 or 12 months in patients with HER2 positive operable breast cancer who followed the national health insurance system in Indonesia. Methods: Data were extracted from medical records of Dr. M Djamil General Hospital Padang and Dharmais Cancer Hospital/ National Cancer Center Jakarta for post-operative breast HER-2 positive cancer patients treated with trastuzumab for 6 or 12 months who had been followed up for at least 5 years (January 1st in 2010 until December 31st in 2015)...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28458498/the-appropriate-rainfall-to-development-of-zika-virus-an-indonesian-case
#2
Ramadhan Tosepu
No abstract text is available yet for this article.
January 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28441790/eradicating-breast-cancer-longevity-impact-on-kuwaiti-women
#3
Muhammad Ali Al Ramadhan
Objective: To explore salient trends in incidence and mortality from breast cancer among Kuwaiti females and to quantify the number of years that could be saved if breast cancer deaths were eliminated. Methods: Appling life table technique, the paper constructs a bridged, multiple decrement and cancer-elimination life tables for Kuwaiti females. Data sources include Kuwait Cancer Control Center Registry along with vital statistics on mortality by age groups, nationality, and causes of death according to ICD-10 revision...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28418620/fast-and-highly-sensitive-ionic-polymer-gated-ws2-graphene-photodetectors
#4
Jake D Mehew, Selim Unal, Elias Torres Alonso, Gareth F Jones, Saad Fadhil Ramadhan, Monica F Craciun, Saverio Russo
The combination of graphene with semiconductor materials in heterostructure photodetectors enables amplified detection of femtowatt light signals using micrometer-scale electronic devices. Presently, long-lived charge traps limit the speed of such detectors, and impractical strategies, e.g., the use of large gate-voltage pulses, have been employed to achieve bandwidths suitable for applications such as video-frame-rate imaging. Here, atomically thin graphene-WS2 heterostructure photodetectors encapsulated in an ionic polymer are reported, which are uniquely able to operate at bandwidths up to 1...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28193198/prevalence-of-intimate-partner-violence-and-abuse-and-associated-factors-among-women-enrolled-into-a-cluster-randomised-trial-in-northwestern-tanzania
#5
Saidi Kapiga, Sheila Harvey, Abdul Khalie Muhammad, Heidi Stöckl, Gerry Mshana, Ramadhan Hashim, Christian Hansen, Shelley Lees, Charlotte Watts
BACKGROUND: Intimate partner violence (IPV) is recognised as an important public health and social problem, with far reaching consequences for women's physical and emotional health and social well-being. Furthermore, controlling behaviour by a partner has a similar impact on women's well-being, yet little is known about the prevalence of this type of behaviour and other related abuses in Tanzania and in other sub-Saharan African countries. METHODS: We conducted a cross-sectional study to determine the lifetime and past 12-month prevalence of physical and sexual IPV, economic abuse, emotional abuse and controlling behaviour among ever-partnered women in Mwanza, Tanzania...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28173818/the-predictive-value-of-methylene-blue-dye-as-a-single-technique-in-breast-cancer-sentinel-node-biopsy-a-study-from-dharmais-cancer-hospital
#6
Bayu Brahma, Rizky Ifandriani Putri, Ramadhan Karsono, Bob Andinata, Walta Gautama, Lenny Sari, Samuel J Haryono
BACKGROUND: Axillary lymph node dissection (ALND) has been the standard treatment of breast cancer axillary staging in Indonesia. The limited facilities of radioisotope tracer and isosulfan or patent blue dye (PBD) have been the major obstacles to perform sentinel node biopsy (SNB) in our country. We studied the application of 1% methylene blue dye (MBD) alone for SNB to overcome the problem. METHODS: This prospective study enrolled 108 patients with suspicious malignant lesions or breast cancer stages I-III...
February 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28144147/neuroleptic-malignant-syndrome-an-easily-overlooked-neurologic-emergency
#7
REVIEW
Ramadhan Oruch, Ian F Pryme, Bernt A Engelsen, Anders Lund
Neuroleptic malignant syndrome is an unpredictable iatrogenic neurologic emergency condition, mainly arising as an idiosyncratic reaction to antipsychotic agent use. It is characterized by distinctive clinical features including a change in mental status, generalized rigidity, hyperpyrexia, and dysautonomia. It can be lethal if not diagnosed and treated properly. Mortality and morbidity attributed to this syndrome have recently declined markedly due to greater awareness, earlier diagnosis, and intensive care intervention...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28024230/in-silico-study-of-porphyrin-anthraquinone-hybrids-as-cdk2-inhibitor
#8
Muhammad Arba, Sunandar Ihsan, La Ode Ahmad Nur Ramadhan, Daryono Hadi Tjahjono
Cyclin-Dependent Kinases (CDKs) are known to play crucial roles in controlling cell cycle progression of eukaryotic cell and inhibition of their activity has long been considered as potential strategy in anti-cancer drug research. In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituents, i.e. either pyridine or pyrazole rings were designed and computationally evaluated for their Cyclin Dependent Kinase-2 (CDK2) inhibitory activity using molecular docking, molecular dynamics simulation, and binding free energy calculation...
December 19, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/27887607/erratum-to-the-effectiveness-of-non-pyrethroid-insecticide-treated-durable-wall-lining-to-control-malaria-in-rural-tanzania-study-protocol-for-a-two-armed-cluster-randomized-trial
#9
George Mtove, Joseph P Mugasa, Louisa A Messenger, Robert C Malima, Peter Mangesho, Franklin Magogo, Mateusz Plucinski, Ramadhan Hashimu, Johnson Matowo, Donald Shepard, Bernard Batengana, Jackie Cook, Basiliana Emidi, Yara Halasa, Robert Kaaya, Aggrey Kihombo, Kimberly A Lindblade, Geofrey Makenga, Robert Mpangala, Abraham Mwambuli, Ruth Mzava, Abubakary Mziray, George Olang, Richard M Oxborough, Mohammed Seif, Edward Sambu, Aaron Samuels, Wema Sudi, John Thomas, Sophie Weston, Martin Alilio, Nancy Binkin, John Gimnig, Immo Kleinschmidt, Peter McElroy, Lawrence H Moulton, Laura Norris, Trenton Ruebush, Meera Venkatesan, Mark Rowland, Franklin W Mosha, William N Kisinza
No abstract text is available yet for this article.
November 25, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27753964/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#10
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27644681/increased-trend-of-haematological-malignancies-in-kurdistan-region-iraq
#11
Ramadhan T Othman, Nawfal R Hussein
No abstract text is available yet for this article.
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27643361/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#12
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27602187/evaluation-of-he4-ca-125-risk-of-ovarian-malignancy-algorithm-roma-and-risk-of-malignancy-index-rmi-in-the-preoperative-assessment-of-patients-with-adnexal-mass
#13
Khawla Al Musalhi, Manal Al Kindi, Faiza Al Aisary, Fatma Ramadhan, Thuraya Al Rawahi, Khalsa Al Hatali, Waad-Allah Mula-Abed
OBJECTIVES: To evaluate the validity and compare the performance of cancer antigen-125 (CA-125), human epididymis protein 4 (HE4), the risk of malignancy index (RMI), and the risk of ovarian malignancy algorithm (ROMA) in the diagnosis of ovarian cancer in patients with ovarian lesions discovered during their preoperative work-up investigations. METHODS: This prospective, cross-sectional study looked at patients who attended the gynecology department at the Royal Hospital, Muscat, from 1 March 2014 to 30 April 2015, for the evaluation of an ovarian lesion...
September 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27567200/a-review-of-stressors-uses-and-management-perspectives-for-the-larger-jakarta-bay-area-indonesia
#14
REVIEW
Annette Breckwoldt, Larissa Dsikowitzky, Gunilla Baum, Sebastian C A Ferse, Simon van der Wulp, Ima Kusumanti, Andrian Ramadhan, Luky Adrianto
No abstract text is available yet for this article.
September 30, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27474803/in-silico-binding-analysis-and-sar-elucidations-of-newly-designed-benzopyrazine-analogs-as-potent-inhibitors-of-thymidine-phosphorylase
#15
Muhammad Taha, Nor Hadiani Ismail, Syahrul Imran, Fazal Rahim, Abdul Wadood, Laode Muhammad Ramadhan Al Muqarrabun, Khalid Mohammed Khan, Mehreen Ghufran, Muhammad Ali
Thymidine phosphorylase (TP) is up regulated in wide variety of solid tumors and therefore presents a remarkable target for drug discovery in cancer. A novel class of extremely potent TPase inhibitors based on benzopyrazine (1-28) has been developed and evaluated against thymidine phosphorylase enzyme. Out of these twenty-eight analogs eleven (11) compounds 1, 4, 14, 15, 16, 17, 18, 19, 20, 24 and 28 showed potent thymidine phosphorylase inhibitory potentials with IC50 values ranged between 3.20±0.30 and 37...
October 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27456339/the-effectiveness-of-non-pyrethroid-insecticide-treated-durable-wall-lining-to-control-malaria-in-rural-tanzania-study-protocol-for-a-two-armed-cluster-randomized-trial
#16
George Mtove, Joseph P Mugasa, Louisa A Messenger, Robert C Malima, Peter Mangesho, Franklin Magogo, Mateusz Plucinski, Ramadhan Hashimu, Johnson Matowo, Donald Shepard, Bernard Batengana, Jackie Cook, Basiliana Emidi, Yara Halasa, Robert Kaaya, Aggrey Kihombo, Kimberly A Lindblade, Geofrey Makenga, Robert Mpangala, Abraham Mwambuli, Ruth Mzava, Abubakary Mziray, George Olang, Richard M Oxborough, Mohammed Seif, Edward Sambu, Aaron Samuels, Wema Sudi, John Thomas, Sophie Weston, Martin Alilio, Nancy Binkin, John Gimnig, Immo Kleinschmidt, Peter McElroy, Lawrence H Moulton, Laura Norris, Trenton Ruebush, Meera Venkatesan, Mark Rowland, Franklin W Mosha, William N Kisinza
BACKGROUND: Despite considerable reductions in malaria achieved by scaling-up long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), maintaining sustained community protection remains operationally challenging. Increasing insecticide resistance also threatens to jeopardize the future of both strategies. Non-pyrethroid insecticide-treated wall lining (ITWL) may represent an alternate or complementary control method and a potential tool to manage insecticide resistance...
July 25, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27454291/e2f8-mediates-tumor-suppression-in-postnatal-liver-development
#17
Lindsey N Kent, Jessica B Rakijas, Shusil K Pandit, Bart Westendorp, Hui-Zi Chen, Justin T Huntington, Xing Tang, Sooin Bae, Arunima Srivastava, Shantibhusan Senapati, Christopher Koivisto, Chelsea K Martin, Maria C Cuitino, Miguel Perez, Julian M Clouse, Veda Chokshi, Neelam Shinde, Raleigh Kladney, Daokun Sun, Antonio Perez-Castro, Ramadhan B Matondo, Sathidpak Nantasanti, Michal Mokry, Kun Huang, Raghu Machiraju, Soledad Fernandez, Thomas J Rosol, Vincenzo Coppola, Kamal S Pohar, James M Pipas, Carl R Schmidt, Alain de Bruin, Gustavo Leone
E2F-mediated transcriptional repression of cell cycle-dependent gene expression is critical for the control of cellular proliferation, survival, and development. E2F signaling also interacts with transcriptional programs that are downstream of genetic predictors for cancer development, including hepatocellular carcinoma (HCC). Here, we evaluated the function of the atypical repressor genes E2f7 and E2f8 in adult liver physiology. Using several loss-of-function alleles in mice, we determined that combined deletion of E2f7 and E2f8 in hepatocytes leads to HCC...
August 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27414468/synthesis-of-novel-disulfide-and-sulfone-hybrid-scaffolds-as-potent-%C3%AE-glucuronidase-inhibitor
#18
Muhammad Taha, Nor Hadiani Ismail, Syahrul Imran, Abdul Wadood, Fazal Rahim, Laode Muhammad Ramadhan Al Muqarrabin, Hamizah Mohd Zaki, Norizan Ahmat, Abdul Nasir, Fahad Khan
Novel series of disulfide and sulfone hybrid analogs (1-20) were synthesized and characterized through EI-MS and (1)H NMR and evaluated for β-glucuronidase inhibitory potential. All synthesized analogs except 13 and 15 showed excellent β-glucuronidase inhibitory potential with IC50 value ranging in between 2.20-88.16μM as compared to standard d-saccharic acid 1,4 lactone (48.4±1.25μM). Analogs 19, 16, 4, 1, 17, 6, 10, 3, 18, 2, 11, 14 and 5 showed many fold potent activity against β-glucuronidase inhibitor...
October 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27366347/antimicrobial-and-cytotoxicity-properties-of-the-organic-solvent-fractions-of-clerodendrum-myricoides-hochst-r-br-ex-vatke-kenyan-traditional-medicinal-plant
#19
Sospeter Ngoci Njeru, Meshack Obonyo, Samwel Nyambati, Silas Ngari, Ramadhan Mwakubambanya, Hawa Mavura
BACKGROUND/AIM: Clerodendrum myricoides is a Kenyan herbal plant used in the management of respiratory diseases. In the current study, we investigated in vitro antimicrobial activity, cytotoxicity, and phytochemical screening of C. myricoides. MATERIALS AND METHODS: Antimicrobial activities of C. myricoides organic fractions against array of microorganisms including: (i) Mycobacterium tuberculosis (MTB) H37Rv, (ii) Staphylococcus aureus, (iii) Klebsiella pneumoniae, (iv) Escherichia coli, (v) Candida albicans, (vi) Pseudomonas aeruginosa, (vii) Cryptococcus neoformans, (viii) Salmonella typhi, (ix) Shigella sonnei, and (x) Methicillin-resistant S...
June 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27356693/high-occurrence-of-non-clear-cell-renal-cell-carcinoma-in-oman
#20
Ajit Venniyoor, Abdul Monem Essam, Fatma Ramadhan, Heeranand Keswani, Itrat Mehdi, Bassim Al Bahrani
It is conventionally accepted that renal cell carcinoma (RCC) occurs in older patients and the clear cell type is the most common histology. However, ethnic variations exist and this study was carried out to determine the epidemiological pattern of RCC in Oman. Ninety RCC patients who presented to a tertiary care center in the Sultanate of Oman from 2010 to 2014 were studied. The main findings were that the median age of presentation was low, more patients presented with localized stage, and there was a higher incidence of non-clear (especially papillary) histology...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
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