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https://www.readbyqxmd.com/read/29133042/synthesis-of-bis-indolylmethanes-as-new-potential-inhibitors-of-%C3%AE-glucuronidase-and-their-molecular-docking-studies
#1
Muhammad Taha, Hayat Ullah, Laode Muhammad Ramadhan Al Muqarrabun, Muhammad Naseem Khan, Fazal Rahim, Norizan Ahmat, Muhammad Ali, Shahnaz Perveen
Thirty-two (32) bis-indolylmethane-hydrazone hybrids 1-32 were synthesized and characterized by (1)HNMR, (13)CNNMR and HREI-MS. All compounds were evaluated in vitro for β-glucuronidase inhibitory potential. All analogs showed varying degree of β-glucuronidase inhibitory potential ranging from 0.10 ± 0.01 to 48.50 ± 1.10 μM when compared with the standard drug d-saccharic acid-1,4-lactone (IC50 value 48.30 ± 1.20 μM). Derivatives 1-32 showed the highest β-glucuronidase inhibitory potentials which is many folds better than the standard drug d-saccharic acid-1,4-lactone...
October 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29062360/humidity-is-an-ambient-parameter-to-development-of-zika-virus-an-indonesian-case
#2
Ramadhan Tosepu
No abstract text is available yet for this article.
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/28920455/a-new-4-arylflavan-from-the-pericarps-of-horsfieldia-motleyi-displaying-dual-inhibition-against-%C3%AE-glucosidase-and-free-radicals
#3
Rico Ramadhan, Irawan Wijaya Kusuma, Rudianto Amirta, Wisuttaya Worawalai, Preecha Phuwapraisirisan
In search for effective antidiabetic agents that simultaneously inhibit α-glucosidase and scavenge free radicals, Horsfieldia motleyi showed promising bioactivity according to the proposed criteria. Bioassay-guided isolation of pericarp extract yielded a new 4-arylflavan named myristinin G (6), whose gross structure and absolute configuration were verified by 2D NMR and electronic circular dichorism (ECD). Myristinin G (6) concomitantly inhibited α-glucosidases (IC50 107.0 and 126.9 μM) and free radicals (SC50 54...
September 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28839322/breast-cancer-in-a-patient-with-kindlers-syndrome
#4
Itrat Mehdi, Bassim Jaffar Al Bahrani, Taha Mohsin Al Lawati, Zahid Al Mandhari, Fatima Ramadhan Al Lawati
Breast Cancer (BC) has associated risk factors and genetic factors like BRCA1, and BRCA2. Many benign and malignant disease processes are found concurrently with BC and believed to be additional risk factors like gall bladder stones (cholelithiasis), hypertension, diabetes mellitus, cerebrovascular lesions, arthritis, spine and spinal cord degenerative lesions, infertility, depression, sleep disturbances, obesity, autoimmune diseases (SLE), and thyroid diseases. There are some malignant disease associations like synchronous or metachronous ovarian, colonic and endometrial tumours with Breast cancer...
August 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28748803/serial-mri-scan-of-posterior-fossa-tumours-predict-patients-at-risk-of-developing-neurocognitive-impairment
#5
Ramadhan Othman, Kurdistan Gh Abdullah
Background: Brain tumours are the most common solid tumours in children. More than 50% of these tumours develop in the posterior cranial fossa. Long term survivors of posterior fossa tumours (PFT) suffer from neurocognitive and memory issues. We hypothesized that serial MRI scanning of brain would show differences in hippocampal and ACC volume change in PFT patients treated with and without chemo-radiotherapy. Material and Methods: Twelve patients (8 females and 4 males) underwent 76 serial MR imaging examinations before and during treatment for posterior fossa tumours...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28548467/outcomes-of-trastuzumab-therapy-for-6-and-12-months-in-indonesian-national-health-insurance-system-clients-with-operable-her2-positive-breast-cancer
#6
Wirsma Arif Harahap, Ramadhan, Daan Khambri, Samuel Haryono, Ricvan Dana Nindrea
Objective: The aim of this study is to determine the outcome of trastuzumab therapy for 6 or 12 months in patients with HER2 positive operable breast cancer who followed the national health insurance system in Indonesia. Methods: Data were extracted from medical records of Dr. M Djamil General Hospital Padang and Dharmais Cancer Hospital/ National Cancer Center Jakarta for post-operative breast HER-2 positive cancer patients treated with trastuzumab for 6 or 12 months who had been followed up for at least 5 years (January 1st in 2010 until December 31st in 2015)...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28458498/the-appropriate-rainfall-to-development-of-zika-virus-an-indonesian-case
#7
Ramadhan Tosepu
No abstract text is available yet for this article.
January 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28441790/eradicating-breast-cancer-longevity-impact-on-kuwaiti-women
#8
Muhammad Ali Al Ramadhan
Objective: To explore salient trends in incidence and mortality from breast cancer among Kuwaiti females and to quantify the number of years that could be saved if breast cancer deaths were eliminated. Methods: Appling life table technique, the paper constructs a bridged, multiple decrement and cancer-elimination life tables for Kuwaiti females. Data sources include Kuwait Cancer Control Center Registry along with vital statistics on mortality by age groups, nationality, and causes of death according to ICD-10 revision...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28418620/fast-and-highly-sensitive-ionic-polymer-gated-ws2-graphene-photodetectors
#9
Jake D Mehew, Selim Unal, Elias Torres Alonso, Gareth F Jones, Saad Fadhil Ramadhan, Monica F Craciun, Saverio Russo
The combination of graphene with semiconductor materials in heterostructure photodetectors enables amplified detection of femtowatt light signals using micrometer-scale electronic devices. Presently, long-lived charge traps limit the speed of such detectors, and impractical strategies, e.g., the use of large gate-voltage pulses, have been employed to achieve bandwidths suitable for applications such as video-frame-rate imaging. Here, atomically thin graphene-WS2 heterostructure photodetectors encapsulated in an ionic polymer are reported, which are uniquely able to operate at bandwidths up to 1...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28193198/prevalence-of-intimate-partner-violence-and-abuse-and-associated-factors-among-women-enrolled-into-a-cluster-randomised-trial-in-northwestern-tanzania
#10
RANDOMIZED CONTROLLED TRIAL
Saidi Kapiga, Sheila Harvey, Abdul Khalie Muhammad, Heidi Stöckl, Gerry Mshana, Ramadhan Hashim, Christian Hansen, Shelley Lees, Charlotte Watts
BACKGROUND: Intimate partner violence (IPV) is recognised as an important public health and social problem, with far reaching consequences for women's physical and emotional health and social well-being. Furthermore, controlling behaviour by a partner has a similar impact on women's well-being, yet little is known about the prevalence of this type of behaviour and other related abuses in Tanzania and in other sub-Saharan African countries. METHODS: We conducted a cross-sectional study to determine the lifetime and past 12-month prevalence of physical and sexual IPV, economic abuse, emotional abuse and controlling behaviour among ever-partnered women in Mwanza, Tanzania...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28173818/the-predictive-value-of-methylene-blue-dye-as-a-single-technique-in-breast-cancer-sentinel-node-biopsy-a-study-from-dharmais-cancer-hospital
#11
Bayu Brahma, Rizky Ifandriani Putri, Ramadhan Karsono, Bob Andinata, Walta Gautama, Lenny Sari, Samuel J Haryono
BACKGROUND: Axillary lymph node dissection (ALND) has been the standard treatment of breast cancer axillary staging in Indonesia. The limited facilities of radioisotope tracer and isosulfan or patent blue dye (PBD) have been the major obstacles to perform sentinel node biopsy (SNB) in our country. We studied the application of 1% methylene blue dye (MBD) alone for SNB to overcome the problem. METHODS: This prospective study enrolled 108 patients with suspicious malignant lesions or breast cancer stages I-III...
February 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28144147/neuroleptic-malignant-syndrome-an-easily-overlooked-neurologic-emergency
#12
REVIEW
Ramadhan Oruch, Ian F Pryme, Bernt A Engelsen, Anders Lund
Neuroleptic malignant syndrome is an unpredictable iatrogenic neurologic emergency condition, mainly arising as an idiosyncratic reaction to antipsychotic agent use. It is characterized by distinctive clinical features including a change in mental status, generalized rigidity, hyperpyrexia, and dysautonomia. It can be lethal if not diagnosed and treated properly. Mortality and morbidity attributed to this syndrome have recently declined markedly due to greater awareness, earlier diagnosis, and intensive care intervention...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28024230/in-silico-study-of-porphyrin-anthraquinone-hybrids-as-cdk2-inhibitor
#13
Muhammad Arba, Sunandar Ihsan, La Ode Ahmad Nur Ramadhan, Daryono Hadi Tjahjono
Cyclin-Dependent Kinases (CDKs) are known to play crucial roles in controlling cell cycle progression of eukaryotic cell and inhibition of their activity has long been considered as potential strategy in anti-cancer drug research. In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituents, i.e. either pyridine or pyrazole rings were designed and computationally evaluated for their Cyclin Dependent Kinase-2 (CDK2) inhibitory activity using molecular docking, molecular dynamics simulation, and binding free energy calculation...
December 19, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/27887607/erratum-to-the-effectiveness-of-non-pyrethroid-insecticide-treated-durable-wall-lining-to-control-malaria-in-rural-tanzania-study-protocol-for-a-two-armed-cluster-randomized-trial
#14
George Mtove, Joseph P Mugasa, Louisa A Messenger, Robert C Malima, Peter Mangesho, Franklin Magogo, Mateusz Plucinski, Ramadhan Hashimu, Johnson Matowo, Donald Shepard, Bernard Batengana, Jackie Cook, Basiliana Emidi, Yara Halasa, Robert Kaaya, Aggrey Kihombo, Kimberly A Lindblade, Geofrey Makenga, Robert Mpangala, Abraham Mwambuli, Ruth Mzava, Abubakary Mziray, George Olang, Richard M Oxborough, Mohammed Seif, Edward Sambu, Aaron Samuels, Wema Sudi, John Thomas, Sophie Weston, Martin Alilio, Nancy Binkin, John Gimnig, Immo Kleinschmidt, Peter McElroy, Lawrence H Moulton, Laura Norris, Trenton Ruebush, Meera Venkatesan, Mark Rowland, Franklin W Mosha, William N Kisinza
No abstract text is available yet for this article.
November 25, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27753964/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#15
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27644681/increased-trend-of-haematological-malignancies-in-kurdistan-region-iraq
#16
Ramadhan T Othman, Nawfal R Hussein
No abstract text is available yet for this article.
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27643361/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#17
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27602187/evaluation-of-he4-ca-125-risk-of-ovarian-malignancy-algorithm-roma-and-risk-of-malignancy-index-rmi-in-the-preoperative-assessment-of-patients-with-adnexal-mass
#18
Khawla Al Musalhi, Manal Al Kindi, Faiza Al Aisary, Fatma Ramadhan, Thuraya Al Rawahi, Khalsa Al Hatali, Waad-Allah Mula-Abed
OBJECTIVES: To evaluate the validity and compare the performance of cancer antigen-125 (CA-125), human epididymis protein 4 (HE4), the risk of malignancy index (RMI), and the risk of ovarian malignancy algorithm (ROMA) in the diagnosis of ovarian cancer in patients with ovarian lesions discovered during their preoperative work-up investigations. METHODS: This prospective, cross-sectional study looked at patients who attended the gynecology department at the Royal Hospital, Muscat, from 1 March 2014 to 30 April 2015, for the evaluation of an ovarian lesion...
September 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27567200/a-review-of-stressors-uses-and-management-perspectives-for-the-larger-jakarta-bay-area-indonesia
#19
REVIEW
Annette Breckwoldt, Larissa Dsikowitzky, Gunilla Baum, Sebastian C A Ferse, Simon van der Wulp, Ima Kusumanti, Andrian Ramadhan, Luky Adrianto
No abstract text is available yet for this article.
September 30, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27474803/in-silico-binding-analysis-and-sar-elucidations-of-newly-designed-benzopyrazine-analogs-as-potent-inhibitors-of-thymidine-phosphorylase
#20
Muhammad Taha, Nor Hadiani Ismail, Syahrul Imran, Fazal Rahim, Abdul Wadood, Laode Muhammad Ramadhan Al Muqarrabun, Khalid Mohammed Khan, Mehreen Ghufran, Muhammad Ali
Thymidine phosphorylase (TP) is up regulated in wide variety of solid tumors and therefore presents a remarkable target for drug discovery in cancer. A novel class of extremely potent TPase inhibitors based on benzopyrazine (1-28) has been developed and evaluated against thymidine phosphorylase enzyme. Out of these twenty-eight analogs eleven (11) compounds 1, 4, 14, 15, 16, 17, 18, 19, 20, 24 and 28 showed potent thymidine phosphorylase inhibitory potentials with IC50 values ranged between 3.20±0.30 and 37...
October 2016: Bioorganic Chemistry
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