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Cervical shortening

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https://www.readbyqxmd.com/read/27922187/tomentosin-induces-telomere-shortening-and-caspase-dependant-apoptosis-in-cervical-cancer-cells
#1
Nawel Merghoub, Hassan El Btaouri, Laila Benbacer, Saïd Gmouh, Chantal Trentesaux, Bertrand Brassart, Mohammed Attaleb, Claudie Madoulet, Thomas Wenner, Saaid Amzazi, Hamid Morjani, Mohamed El Mzibri
Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti-proliferative, telomere shortening and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit the growth of SiHa and HeLa cell lines in dose and time-dependent manner (IC50 values of 7.10 ± 0.78µM and 5.87 ± 0.36µM, respectively after 96h of treatment). As evidenced by TTAGGG telomere length assay, tomentosin target specifically the telomeric overhang lengthening...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27904309/robot-assisted-abdominal-cerclage-during-pregnancy
#2
Burak Zeybek, Amanda Hill, Gulden Menderes, Mostafa A Borahay, Masoud Azodi, Gokhan Sami Kilic
BACKGROUND AND OBJECTIVES: Cervical insufficiency is a difficult condition to diagnose and can lead to preterm birth, miscarriage, or perinatal infant morbidity and mortality. We conducted this retrospective case study and literature review to evaluate the safety and efficacy of robot-assisted abdominal cerclage during pregnancy. METHODS: We conducted a case series and a systematic review that included patients who underwent robot-assisted abdominal cerclage during pregnancy from January 2010 through March 2016...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27903087/two-cervical-preparation-regimens-prior-to-surgical-abortion-at-10-14-weeks-of-gestation-a-randomized-clinical-trial
#3
Qingyun Guo, Zhida Qian, Lili Huang
BACKGROUND: The aim of the study was to determine whether same-day cervical preparation with an osmotic dilator and misoprostol was as effective and safe as overnight cervical preparation for surgical abortions at 10-14 weeks. METHODS: Seventy women seeking surgical abortion at 10-14 weeks were allocated to receive one osmotic dilator 16-17 h or 6-7 h prior to an abortion. All women received misoprostol 400 μg orally 2 h before the abortion. RESULTS: The abortion time of the same-day group was 7...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27844147/acute-ivabradine-treatment-reduces-heart-rate-without-increasing-atrial-fibrillation-inducibility-irrespective-of-underlying-vagal-activity-in-dogs
#4
Kazunori Uemura, Masashi Inagaki, Can Zheng, Toru Kawada, Meihua Li, Masafumi Fukumitsu, Masaru Sugimachi
Ivabradine, a bradycardic agent, has been shown to stably reduce patient's heart rate (HR) in the setting of acute cardiac care. However, an association between atrial fibrillation (AF) risk and acute ivabradine treatment remains a controversial clinical issue, and has not been thoroughly investigated. Bradycardia and abnormal atrial refractoriness induced by ivabradine treatment may enhance vulnerability to AF induction, especially when vagal nerve is concurrently activated. We aimed to experimentally investigate the effects of acute ivabradine treatment with/without concurrent vagal activation on AF inducibility...
November 14, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27806772/-endoscopic-thyroid-surgery-the-past-the-present-and-the-future
#5
P Wang, Q Z Zhao
Thyroid diseases are much more common in women than in men. The traditional open thyroidectomy brings almost patients significant visible scars in the anterior neck. The demand for cosmesis after surgery promotes the occurrence and development of endoscopic techniques. Various endoscopic techniques were designed to minimize the visible scar and promote the rehabilitation after surgery. In order to achieve these, two distinct ideas have developed. One is committed to shorten the length of surgical incision as much as possible...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27746413/characterization-of-inflammatory-responses-by-cervical-cytology-cytokine-expression-and-ultrastructure-changes-in-a-goat-subclinical-endometritis-model
#6
Chunyan Shao, Heng Wang, Xiaodu Wang, Sheng Jiang, Jing Sun, Houhui Song, Jianji Li
Endometritis is a common puerperal disease in livestock. Thus, a practical clinical test for the establishment of diagnosis is needed. We developed a goat model for subclinical endometritis diagnosis by examining cytological, ultrastructural features and molecular expression in cervical discharge collected by cervical cytobrush method. A suspension of E. coli was infused into the uterine horn of goats, and cervical discharge, peripheral blood and endomertrial biopsy samples were collected before inoculation and at 3, 6, 12, 24, 72, 120 and 168 hr post-inoculation (pi)...
October 16, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27741189/prenatally-diagnosed-vasa-previa-a-single-institution-series-of-96-cases
#7
Val Catanzarite, Larry Cousins, Sean Daneshmand, Wade Schwendemann, Holly Casele, Joanna Adamczak, Tevy Tith, Ami Patel
OBJECTIVE: To describe outcomes for a large cohort of women with prenatally diagnosed vasa previa, determine the percentage in patients without risk factors, and compare delivery timing and indications for singletons and twins. METHODS: This was a retrospective case series of women with prenatally diagnosed vasa previa delivered at a single tertiary center over 12 years. Potential participants were identified using hospital records and perinatal databases. Patients were included if vasa previa was confirmed at delivery and by pathologic examination...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27725298/scarcity-of-implants-has-partially-replaced-cervical-spondylotic-myelopathy-decompression-and-instrumented-fusion-with-implant-less-expansile-cervical-laminopalsty-paupertas-artis-omnis-perdocet
#8
Marin Stančić, Ivana Stančić, Petra Barl, Ivan Pašalić
OBJECTIVE: Scarcity of implants during the economic crisis has partially replaced cervical spondylotic myelopathy decompression and instrumented fusion with implant-less expansile cervical laminopalsty. The aim of the study was comparison of the results obtained with instrumented anterior cervical corpectomy and fusion (ACCF) with implant-less expansile cervical laminoplasty (ECL). METHODS: Patients suffering from cervical spondylotic myelopathy (CSM) Nurick 3-5, with preoperative tethering and postoperative untethering were included...
October 7, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27718765/vaginal-alpha-lipoic-acid-shows-an-anti-inflammatory-effect-on-the-cervix-preventing-its-shortening-after-primary-tocolysis-a-pilot-randomized-placebo-controlled-study
#9
Giovanni Grandi, Lucrezia Pignatti, Francesca Ferrari, Giulia Dante, Isabella Neri, Fabio Facchinetti
INTRODUCTION: Inflammation might be an important underlying cause of preterm birth. Our aim is to explore whether vaginal administration α-lipoic acid reduces cervical inflammation and shortening after primary tocolysis. Matherials and Methods: Singleton pregnancies between 24-30 weeks remaining undelivered after hospitalization for preterm labor were randomly allocated to placebo (20 women, 15 analyzed) or vaginal ALA 400 mg daily (20 women, 17 analyzed) for 30 days. A cervical swab to quantify pro-inflammatory (IL1, IL2, IL6, IL8, TNFα) and anti-inflammatory (IL4, IL10) cytokines as well as transvaginal ultrasound cervical length measurement (CL) were performed before and after treatment...
October 9, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27669366/prenatal-diagnosis-and-early-postnatal-management-of-pyriform-sinus-cyst-experience-at-a-single-medical-center-in-mainland-china
#10
Wei Zhong, Zhe Wang, Qiu-Ming He, Ting-Ting Shi, Jia-Kang Yu, Guang-Lan Zhang, Dong-Zhi Li
OBJECTIVE: The aim of this study was to determine whether prenatal diagnosis of pyriform sinus cyst can improve the prognosis of this disorder. METHODS: A retrospective review was performed in 15 neonates with a pyriform sinus cyst seen at a single center between 2010 and 2014. Among the 15 cases, the diagnosis was made prenatally in eight cases (PreD), while the diagnosis was made postnatally in seven cases (PostD). Neonatal outcome was compared in the two subgroups...
November 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27648846/rubber-dam-isolation-for-restorative-treatment-in-dental-patients
#11
Yan Wang, Chunjie Li, He Yuan, May Cm Wong, Jing Zou, Zongdao Shi, Xuedong Zhou
BACKGROUND: Successful restorations in dental patients depend largely on the effective control of moisture and microbes during the procedure. The rubber dam technique has been one of the most widely used isolation methods in dental restorative treatments. The evidence on the effects of rubber dam usage on the longevity of dental restorations is conflicting. Therefore, it is important to summarise the available evidence to determine the effects of this method. OBJECTIVES: To assess the effects of rubber dam isolation compared with other types of isolation used for direct and indirect restorative treatments in dental patients...
September 20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27600865/the-prevalence-of-short-cervix-between-20-and-24-weeks-of-gestation-and-vaginal-progesterone-for-prolonging-of-gestation
#12
Malipati Maerdan, Chunyan Shi, Xiaoxiao Zhang, Lixin Fan
OBJECTIVE: The objective of this study is to understand the prevalence of short cervical length between 20 and 24 weeks gestation in China and to evaluate the efficacy of micronized progesterone for prolonging gestation in nulliparous patients with a short cervix. METHODS: From May 2010 to May 2015, a total of 25 328 asymptomatic women with singleton pregnancies at Peking University First Hospital had their cervical length routinely measured between 20 and 24 weeks of gestation...
September 7, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27527716/short-and-long-term-outcomes-of-larynx-preserving-surgery-for-cervical-esophageal-cancer-analysis-of-100-consecutive-cases
#13
Tomoki Makino, Makoto Yamasaki, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
BACKGROUND: Surgical interventions for cervical esophageal cancer (CEC), particularly larynx-preserving procedures, have not yet been standardized in terms of short- and long-term outcome. METHODS: We retrospectively analyzed 100 consecutive surgeries for CEC in our department. We compared clinicopathological parameters and long-term outcomes between larynx-preserving esophagectomies (LP group) and nonpreserving procedures (NP group). We also evaluated preoperative predictive parameters for larynx-preservation...
August 15, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27491941/obstetrical-outcomes-of-emergency-compared-with-elective-cervical-cerclage
#14
Ohad Gluck, Yossi Mizrachi, Shimon Ginath, Jacob Bar, Ron Sagiv
OBJECTIVE: To study obstetric outcomes of emergency cerclage compared with elective cerclage. STUDY DESIGN: Retrospective cohort study of pregnancy outcomes of patients who underwent cervical cerclage, performed according to ACOG guidelines, between January 2006 and December 2014. Patients who underwent emergency cerclage, due to cervical shortening or cervical dilation (emergency cerclage group) were compared with patients who underwent history-indicated cerclage (elective cerclage group)...
August 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27465872/-comparison-of-the-clinical-efficacy-of-different-treatments-based-on-radical-surgery-in-stage-%C3%A2-b2-and-%C3%A2-a2-cervical-cancer-a-prospective-randomized-control-study
#15
X Li, W M Kong, C Han, Z Yan, H Zhao, W Y Zhang, J D Wang
OBJECTIVE: To compare the clinical efficacy of different treatments based on radical surgery in stage Ⅰ b2 and Ⅱ a2 cervical cancer through prospective randomized controlled study. METHODS: A total of 133 patients with stage Ⅰ b2 and Ⅱ a2 cervical cancer treated at Beijing Obstetrics and Gynecology Hospital of Capital Medical University during January 2009 to December 2012 were enrolled and randomly assigned to receive one of the following three treatments: preoperative intracavitary irradiation(PII)group, radical hysterectomy(RH)group, and neoadjuvant chemotherapy(NACT)group...
July 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27446569/clinical-investigation-of-the-safety-and-efficacy-of-a-cervical-intraepithelial-neoplasia-treatment-using-a-hyperthermia-device-that-uses-heat-induced-by-alternating-magnetic-fields
#16
Koji Koizumi, Toru Fujioka, Toshiaki Yasuoka, Aya Inoue, Yuka Uchikura, Hiroki Tanaka, Katsuko Takagi, Miki Mori, Masae Koizumi, Hisashi Hashimoto, Takashi Matsumoto, Yuko Matsubara, Keiichi Matsubara, Akihiro Nawa
Multiple techniques have been used for the conservative treatment of high-grade cervical intraepithelial neoplasia (HG-CIN) in women of fertile age. Conization has been associated with stenosis of the cervix and a decrease in cervical mucus secretion, in addition to the increase in the risk of cervical canal shortening and problems during the perinatal period, including premature birth and premature rupture of membranes. Although the laser transpiration technique does not cause shortening of the cervical canal, it is associated with the recurrent risk of deep residual disease...
August 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27367357/complex-spine-pathology-simulator-an-innovative-tool-for-advanced-spine-surgery-training
#17
Cristian Gragnaniello, Amal Abou-Hamden, Pietro Mortini, Elena V Colombo, Michele Bailo, Kevin A Seex, Zachary Litvack, Anthony J Caputy, Filippo Gagliardi
Background Technical advancements in spine surgery have made possible the treatment of increasingly complex pathologies with less morbidity. Time constraints in surgeons' training have made it necessary to develop new training models for spine pathology. Objective To describe the application of a novel compound, Stratathane resin ST-504 derived polymer (SRSDP), that can be injected at different spinal target locations to mimic spinal epidural, subdural extra-axial, and intra-axial pathologies for the use in advanced surgical training...
July 1, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27365289/fetal-and-neonatal-outcomes-after-term-and-preterm-delivery-following-betamethasone-administration-in-twin-pregnancies
#18
Thorsten Braun, Alexander Weichert, Hannah C Gil, Deborah M Sloboda, Boris Tutschek, Thomas Harder, Joachim W Dudenhausen, Andreas Plagemann, Wolfgang Henrich
OBJECTIVE: To investigate effects of betamethasone on fetal growth and neonatal outcomes in twins. METHODS: A retrospective cohort study was conducted of twins delivered at one center in Berlin, Germany, between 1993 and 2011. The betamethasone group included twin pregnancies with preterm labor, cervical shortening, preterm premature rupture of membranes, or vaginal bleeding, and exposure to betamethasone between 23(+5) and 33(+6) weeks. The control group included twin pregnancies with no betamethasone exposure matched for length at delivery...
September 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27365003/do-serial-measurements-of-cervical-length-improve-the-prediction-of-preterm-birth-in-asymptomatic-women-with-twin-gestations
#19
Nir Melamed, Alex Pittini, Liran Hiersch, Yariv Yogev, Steven J Korzeniewski, Roberto Romero, Jon Barrett
BACKGROUND: Cervical length at midtrimester is a powerful predictor of preterm birth in twin gestations. However, given the fact that, in some cases, cervical shortening may become evident only later during the second trimester, it seems reasonable that serial monitoring of cervical length may improve the detection of preterm birth in women with twins. However, data in support of such a practice are limited and conflicting. The contradictory results may be related to the fact that in most of these studies, the analysis of the predictive value of serial measurements of cervical length was limited to data derived from only two sequential measurements of cervical length, while data on the predictive value of multiple (>2) measurements are scarce...
November 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27299072/are-two-surgeries-necessary-for-correction-of-1-deformity-cervical-kyphosis-in-neurofibromatosis-a-rare-case-report
#20
Kevin R Choksey, Jayprakash V Modi
INTRODUCTION: Dystrophic neurofibromatosis type I, involving upper cervical spines, is rare, which can cause serious complications. Myelopathy develops due to compression of the cord posteriorly. Surgical correction has its inherent risks and difficulties because of poor bone quality, difficult anterior approach because of bizarre deformities, and the necessary manipulation, which might cause more cord damage and ischemia. Anterior decompression with alignment correction was an early popular choice...
July 2015: Journal of Orthopaedic Case Reports
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