keyword
https://read.qxmd.com/read/38535848/beyond-birth-pioneering-insights-into-colostrum-quality-variation-among-bitches-with-different-types-of-parturition
#1
JOURNAL ARTICLE
Maja Zakošek Pipan, Meta Sterniša, Tanja Plavec
This study deals with the immunological quality of canine colostrum in relation to the different parturition modes in bitches. It included four groups of bitches, who underwent vaginal parturition (VP), emergency cesarean section (EM-CS), elective cesarean section (EL-CS), or elective cesarean section with aglepristone injection 24 h prior to surgery (EL-A). Colostrum samples from 40 bitches of 18 breeds were taken immediately after the birth of the first puppy or directly after surgery, and four hours later...
March 3, 2024: Veterinary Sciences
https://read.qxmd.com/read/38528444/adjuvant-chemotherapy-and-survival-in-males-aged-70-years-or-older-with-breast-cancer-a-population-based-retrospective-study
#2
JOURNAL ARTICLE
Yushuai Yu, Kaiyan Huang, Yushan Liu, Ruiliang Chen, Xin Yu, Chuangui Song
BACKGROUND: Male breast cancer constitutes a minority of breast cancer diagnoses, yet its incidence has been on the rise in recent decades. However, elderly male breast cancer patients have been inadequately represented in clinical trials, posing challenges in treatment decisions. This study seeks to clarify the efficacy of chemotherapy in this demographic and identify the population most likely to benefit from such intervention. METHODS: We conducted a retrospective analysis using the Surveillance, Epidemiology, and End Results (SEER) database, encompassing a total of 1900 male breast cancer patients aged 70 years or older...
March 25, 2024: BMC Geriatrics
https://read.qxmd.com/read/38526937/progesterone-induces-neuroprotection-associated-with-immune-inflammatory-modulation-in-experimental-traumatic-brain-injury
#3
JOURNAL ARTICLE
Ziwei Zhou, Yadan Li, Ruilong Peng, Mingming Shi, Weiwei Gao, Ping Lei, Jianning Zhang
An imbalance of immune/inflammatory reactions aggravates secondary brain injury after traumatic brain injury (TBI) and can deteriorate clinical prognosis. So far, not enough therapeutic avenues have been found to prevent such an imbalance in the clinical setting. Progesterone has been shown to regulate immune/inflammatory reactions in many diseases and conveys a potential protective role in TBI. This study was designed to investigate the neuroprotective effects of progesterone associated with immune/inflammatory modulation in experimental TBI...
March 1, 2024: Neuroreport
https://read.qxmd.com/read/38524211/the-efficacy-of-medical-management-of-leiomyoma-associated-heavy-menstrual-bleeding-a-mini-review
#4
JOURNAL ARTICLE
Mariam Barseghyan, Jennifer Chae-Kim, William H Catherino
Leiomyomas, or fibroids, are benign uterine tumors that are commonly associated with abnormal uterine bleeding-L particularly heavy menstrual bleeding (HMB). Treatment options include expectant, medical, image-guided, and surgical. Medical management of HMB is the preferred first-line treatment and includes nonsteroidal anti-inflammatory drugs, contraceptive hormones, tranexamic acid, levonorgestrel intrauterine system, gonadotropin-releasing hormone (GnRH) antagonists and antagonists, selective progesterone receptor modulators, selective estrogen receptor modulators, and aromatase inhibitors...
March 2024: F&S reports
https://read.qxmd.com/read/38512151/aptamer-as-a-targeted-approach-towards-treatment-of-breast-cancer
#5
REVIEW
Anjali Bisht, Shuvadip Bhowmik, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
Aptamers, a novel type of targeted ligand used in drug delivery, have quickly gained popularity due to their high target specificity and affinity. Different aptamer-mediated drug delivery systems, such as aptamer-drug conjugate (ApDC), aptamer-siRNA, and aptamer-functionalized nanoparticle systems, are currently being developed for the successful treatment of cancer based on the excellent properties of aptamers. These systems can decrease potential toxicity and enhance therapeutic efficacy by targeting the drug moiety...
March 21, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38510564/does-gnrh-treatment-at-tai-regardless-of-estrus-occurrence-increase-pregnancy-rate-in-crossbred-bos-taurus-suckled-cows
#6
JOURNAL ARTICLE
Vanessa Silva Fernandes, Gabriella Dos Santos Velho, Mateus Felipe Osório Dos Santos, Kelly Alves Evangelista, Bernardo Garziera Gasperin, Luiz Francisco Machado Pfeifer, Rogério Ferreira, Paulo Bayard Dias Gonçalves, Gustavo Desire Antunes Gastal, André Gustavo Cabrera Dalto, Monique Tomazele Rovani
The impact of GnRH treatment on the day of TAI in beef cows has received limited investigation, especially concerning its association with estrus expression. Consequently, two experiments were conducted to assess the potential of GnRH treatment on the day of TAI to enhance fertility according to the expression or not of estrus in beef cows. Experiment 1 aimed to determine ovulation rate and luteal function, while Experiment 2 aimed to determine the effect of the two GnRH treatment approaches on pregnancy rate...
2024: Animal Reproduction
https://read.qxmd.com/read/38505459/combination-therapy-with-platelet-rich-plasma-prp-and-granulocyte-colony-stimulating-factor-g-csf-for-thin-endometrium-a-case-report
#7
Sudhanshu M Dakre, Akash More, Shilpa Dutta, Shradha M Ulhe, Namrata Choudhary
This case study highlights the challenges faced by a couple with a history of two failed in-vitro fertilization (IVF) attempts, including miscarriage and ectopic pregnancy. After treating the female partner for pelvic inflammatory disease (PID) with ceftriaxone and doxycycline, the decision was made to proceed with intra-cytoplasmic sperm injection (ICSI) and fresh embryo transfer. Despite the transfer of two good-quality (4AB and 3AA) day five embryos, the human chorionic gonadotropin (β-hCG) test yielded a negative result...
February 2024: Curēus
https://read.qxmd.com/read/38502838/magnitude-and-persistence-of-higher-estrus-associated-temperatures-in-beef-heifers-and-suckled-cows
#8
JOURNAL ARTICLE
Megan D Mills, Abigayle B Pollock, Ian E Batey, Michael A O'Neil, F Neal Schrick, Rebecca R Payton, Sarah E Moorey, Pablo Fioravanti, Will Hipsher, Saulo M Zoca, J Lannett Edwards
Higher estrus associated temperatures (HEAT) are a hallmark feature in sexually active females. The overarching aim of this study was to characterize the variability, magnitude, and persistence of HEAT in heifers and suckled beef cows as well as identify associated factors when occurring during thermoneutral conditions at the onset of the spring breeding season. In both heifers and cows, estrus was induced using a seven-day controlled internal drug release (CIDR)-PGF2α protocol. Vaginal temperature after prostaglandin F2α administration was recorded every 5 min using a Thermochron iButton affixed to a blank CIDR (containing no progesterone)...
March 19, 2024: Journal of Animal Science
https://read.qxmd.com/read/38501644/the-effectiveness-of-low-dose-of-ecg-in-timed-ai-nelore-bos-indicus-heifers
#9
JOURNAL ARTICLE
A R Felisbino Neto, D F C Souza, R A Campos, S Albertini, M R Bastos, B G Freitas, M H A Colli, F M Elliff, J N S Sales, P S Baruselli
This study evaluated the efficacy of the administration of different doses of equine chorionic gonadotropin (eCG; 0 IU, 200 IU, or 300 IU) at the time of the progesterone device removal in 2-year-old Nelore (Bos indicus) heifers synchronized for fixed-timed artificial insemination (FTAI). On day 0 (D0), a total of 398 heifers received 2 mg of oestradiol benzoate i.m., 0.53 mg of cloprostenol i.m., and an eight-day previously used (second use) intravaginal device containing 1 g of progesterone (P4)...
March 2024: Reproduction in Domestic Animals
https://read.qxmd.com/read/38498835/ovarian-response-and-embryo-ploidy-following-oral-micronized-progesterone-primed-ovarian-stimulation-versus-gnrh-antagonist-protocol-a-prospective-study-with-repeated-ovarian-stimulation-cycles
#10
JOURNAL ARTICLE
M Del Mar Vidal, Francisca Martínez, Ignacio Rodríguez, Nikolaos P Polyzos
STUDY QUESTION: Is there any difference in ovarian response and embryo ploidy following progesterone-primed ovarian stimulation (PPOS) using micronized progesterone or GnRH antagonist protocol? SUMMARY ANSWER: Pituitary downregulation with micronized progesterone as PPOS results in higher number of oocytes retrieved and a comparable number of euploid blastocysts to a GnRH antagonist protocol. WHAT IS KNOWN ALREADY: Although the GnRH antagonist is considered by most the gold standard protocol for controlling the LH surge during ovarian stimulation (OS) for IVF/ICSI, PPOS protocols are being increasingly used in freeze-all protocols...
March 18, 2024: Human Reproduction
https://read.qxmd.com/read/38495866/the-effect-of-estrogen-containing-birth-control-pills-on-the-constituents-of-bradykinin-expression-in-plasma
#11
JOURNAL ARTICLE
Janette M Birmingham, Juan Wisnivesky, Paula J Busse
BACKGROUND: Hereditary angioedema with C1-inhibitor deficiency (HAE-C1INH) is a rare autosomal disorder presenting with recurrent angioedema. Estrogen-containing medications trigger angioedema in some patients, and conversely, progesterone may decrease attack frequency. The mechanism by which estrogen may exacerbate angioedema in HAE-C1INH is not well characterized. OBJECTIVE: Our aim was to investigate the link between estrogen and bradykinin constituents to better understand the specific underlying triggers that may exacerbate angioedema in patients with HAE-C1INH...
May 2024: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/38493224/local-effect-of-allopregnanolone-in-rat-ovarian-steroidogenesis-follicular-and-corpora-lutea-development
#12
JOURNAL ARTICLE
Antonella Rosario Ramona Cáceres, Daniela Alejandra Cardone, María de Los Ángeles Sanhueza, Ignacio Manuel Bosch, Fernando Darío Cuello-Carrión, Graciela Beatriz Rodriguez, Leopoldina Scotti, Fernanda Parborell, Julia Halperin, Myriam Raquel Laconi
Allopregnanolone (ALLO) is a known neurosteroid and a progesterone metabolite synthesized in the ovary, CNS, PNS, adrenals and placenta. Its role in the neuroendocrine control of ovarian physiology has been studied, but its in situ ovarian effects are still largely unknown. The aims of this work were to characterize the effects of intrabursal ALLO administration on different ovarian parameters, and the probable mechanism of action. ALLO administration increased serum progesterone concentration and ovarian 3β-HSD2 while decreasing 20α-HSD mRNA expression...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38487340/multi-omic-analysis-of-precocious-puberty-girls-pathway-changes-and-metabolite-validation
#13
JOURNAL ARTICLE
Fang Zhou, Jianhong Mao, Zhenzhen Jin, Li Zhu, Xiaofang Li
OBJECTIVE: Precocious puberty (PP) is a prevalent endocrine disorder affecting the physical and mental wellbeing of children. Identifying the triggering factors of PP has become a central issue. This study seeks to investigate the metabolomic and transcriptomic alterations in PP. MATERIAL AND METHODS: First, 37 school-aged girls diagnosed with PP and 25 age-matched prepubertal control girls were recruited, and the fecal samples were collected for non-targeted metabolomic analysis to screen for differentially expressed metabolites (DEMs)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38484946/apilarnil-ameliorates-bisphenol-a-induced-testicular-toxicity-in-adult-male-rats-via-improving-antioxidant-potency-and-pcna-expression
#14
JOURNAL ARTICLE
Mohamed H Elashal, Aida A Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A M Khalifa, Badr Aldahmash, Hesham R El-Seedi, Bishoy El-Aarag
Apilarnil, a bee-derived product originating from drone larvae, offers a range of advantageous properties for both humans and animals. It functions as an antioxidant, provides neuroprotection, boosts fertility, and has antiviral capabilities. Additionally, it is a provider of androgenic hormones. These beneficial functions are supported by its chemical composition, which comprises mineral salts, vitamins, carbs, lipids, hormones, and amino acids. The current study aimed to evaluate the ameliorative effect of apilarnil against Bisphenol A (BPA)-induced testicular toxicity in male adult rats...
March 12, 2024: Reproductive Toxicology
https://read.qxmd.com/read/38465078/clinical-outcomes-in-hormone-replacement-therapy-hrt-frozen-embryo-transfer-fet-protocol-increased-by-administering-gonadotropin-releasing-hormone-agonist-gnrh-in-the-initial-stage-of-the-luteal-phase-a-retrospective-analysis
#15
JOURNAL ARTICLE
Aamir Mahmood, Li Tan
OBJECTIVE: The objective of this study was to determine if gonadotropin-releasing hormone agonist (GnRH) administration supporting the luteal phase in frozen embryo transfer (FET) improves clinical outcomes Methods and materials This is a retrospective cohort study and we analyzed 3515 cycles of FET at the Department of Reproductive Medicine in our hospital from February 2018 through December 2021. Patients were divided into the GnRH (triptorelin+progesterone and human chorionic gonadotropin (hCG)) group and the non-GnRHa (existing treatment without triptorelin) group...
February 2024: Curēus
https://read.qxmd.com/read/38448000/-ovarian-hyperstimulation-syndrome-with-controlled-ovarian-stimulation-after-induction-therapy-for-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
#16
JOURNAL ARTICLE
Kai Osone, Seiichiro Katagiri, Yuya Arai, Akiko Yamada, Tamiko Suguro, Daigo Akahane, Nahoko Furuya, Hiroaki Fujimoto, Masanori Ono, Akihiko Gotoh
A 27-year-old woman with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia received induction therapy with dasatinib and prednisolone. From the time of diagnosis, oocyte storage was planned in accordance with the patient's wishes. After progesterone administration for suppression of menstruation, and blood cell recovery, ovarian stimulation was performed and a sufficient number of eggs was collected. The patient was considered at high risk for ovarian stimulation syndrome (OHSS) and received cabergoline and letrozole...
2024: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/38445292/dynamic-changes-in-ai-based-analysis-of-endometrial-cellular-composition-analysis-of-pcos-and-rif-endometrium
#17
JOURNAL ARTICLE
Seungbaek Lee, Riikka K Arffman, Elina K Komsi, Outi Lindgren, Janette Kemppainen, Keiu Kask, Merli Saare, Andres Salumets, Terhi T Piltonen
BACKGROUND: The human endometrium undergoes a monthly cycle of tissue growth and degeneration. During the mid-secretory phase, the endometrium establishes an optimal niche for embryo implantation by regulating cellular composition (e.g., epithelial and stromal cells) and differentiation. Impaired endometrial development observed in conditions such as polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF) contributes to infertility. Surprisingly, despite the importance of the endometrial lining properly developing prior to pregnancy, precise measures of endometrial cellular composition in these two infertility-associated conditions are entirely lacking...
December 2024: Journal of Pathology Informatics
https://read.qxmd.com/read/38437955/mechanisms-of-adverse-mammary-effect-induced-by-olanzapine-and-therapeutic-interventions-in-rat-model
#18
JOURNAL ARTICLE
Yingyue Dong, Xiaozhe Sun, Hanxiao Li, Chunmiao Han, Yue Zhang, Huiru Ding, Lisha Xia, Huamin Wang, Shaomin Yang, Lingzi Xu, Guoheng Xu
BACKGROUND: Olanzapine antagonizes dopamine receptors and is prescribed to treat multiple psychiatric conditions. The main side effect of concern for olanzapine is weight gain and metabolic syndrome. Olanzapine induces hyperprolactinemia, however its effect on the mammary gland is poorly documented. METHODS: Rats received olanzapine by gavage or in drinking water at 1, 3, and 6 mg/kg/day for 5-40 days or 100 days, with and without coadministration of bromocriptine or aripiprazole and using once daily or continuous administration strategies...
March 2, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38435758/oral-gnrh-antagonists-in-combination-with-estradiol-and-norethindrone-acetate-for-pain-relief-associated-with-endometriosis-a-review-of-evidence-of-a-novel-class-of-hormonal-agents
#19
REVIEW
Essam R Othman, Ayman Al-Hendy, Radwa Mostafa, Cornelis B Lambalk, Velja Mijatovic
Current medical treatment options for endometriosis associated pains are inadequate. Evidence on effects of nonsteroidal anti-inflammatory drugs is scarce. Around one third of patients are not responsive to oral contraceptives or progestins due to progesterone resistance. Gonadotropin-releasing hormone (GnRH) agonists can only be used for a short duration because of associated side effects. Oral GnRH antagonists, including elagolix, relugolix, and linzagolix allow oral administration, induce dose dependent reduction of estradiol levels, do not cause initial flare up of endometriosis symptoms, and allow the fast return of ovarian function and menstruation after discontinuation...
2024: International Journal of Women's Health
https://read.qxmd.com/read/38403412/effects-of-repeated-embryo-flushing-without-pgf-2%C3%AE-administration-on-luteal-function-percentage-of-unwanted-pregnancy-and-subsequent-fertility-in-mares
#20
JOURNAL ARTICLE
Rebeca Martínez-Boví, Laura Sala-Ayala, Aurora Querol-Paajanen, María Plaza-Dávila, Juan Cuervo-Arango
BACKGROUND: PGF2α is commonly given at the end of embryo flushing (EF) to shorten the interval to the next oestrus and ovulation. OBJECTIVES: To determine the effect of repeated EF on plasma progesterone concentration, percentage of mares with endometritis, unwanted pregnancy and subsequent fertility in mares flushed without the use of PGF2α . STUDY DESIGN: Controlled experiments. METHODS: Nine mares were inseminated in seven consecutive cycles (n = 63), to either perform an EF (n = 54) 7-9 days after ovulation or left pregnant (n = 9)...
February 25, 2024: Equine Veterinary Journal
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