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Progesterone administration

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https://www.readbyqxmd.com/read/29353143/contractile-effect-of-rifaximin-on-bovine-uterus-in-the-presence-of-steroid-hormone-antagonists
#1
R L Sciorsci, M Piccinno, A Rizzo
This in vitro study investigated the modulatory effect of rifaximin on bovine uterus contractility, in both phases of the oestrous cycle, with and without the steroid hormones that are predominant in the respective phases: oestrogen in the follicular phase and progesterone in the luteal phase. The procedures were conducted in an isolated organ bath by using rifaximin alone (10-4 M) and in association with the steroid hormone antagonists (10-5 M) tamoxifen (oestrogen antagonist) in the follicular phase and mifepristone (progesterone antagonist) in the luteal phase...
January 10, 2018: Theriogenology
https://www.readbyqxmd.com/read/29346046/ultrasonographic-characteristics-of-the-reproductive-tract-and-serum-progesterone-and-estradiol-concentrations-in-captive-female-red-wolves-canis-rufus-with-and-without-reproductive-tract-disease
#2
Kadie M Anderson, Mandi W Schook, Karen L Goodrowe, William T Waddell, Karen N Wolf
OBJECTIVE To describe ultrasonographic characteristics of the reproductive tract and serum progesterone and estradiol concentrations in captive female red wolves (Canis rufus) with and without reproductive tract disease. DESIGN Prospective study. ANIMALS 13 adult female red wolves. PROCEDURES Wolves with varying parity and history of contraceptive treatment were anesthetized to facilitate ultrasonographic examination and measurement of the reproductive tract and blood collection for determination of serum progesterone and estradiol concentrations in December 2011 and June 2012...
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29345445/the-impact-of-high-progesterone-levels-on-the-day-of-hcg-administration-in-assisted-human-reproduction-treatments
#3
Michelli S Tanada, Ivan H Yoshida, Monise Santos, Caroline Z Berton, Elen Souto, Waldemar P de Carvalho, Emerson B Cordts, Caio P Barbosa
OBJECTIVE: Progesterone is a steroid hormone that acts on the endometrium. It is known for producing physical and mood-related side effects. Few studies have looked into how progesterone levels affect embryo development and quality. This study aimed to find a cutoff level for serum progesterone on the day of HCG administration from which embryo quality is impaired. METHODS: The study included 145 cycles, from which 885 oocytes and 613 embryos were obtained. All patients had their serum progesterone levels measured on the day of HCG administration...
January 18, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29336491/effect-of-sex-steroid-hormone-fluctuations-in-the-pathophysiology-of-male-retinal-pigment-epithelial-cells
#4
Carlo Astarita, Barbara D'Angelo-Maansson, Mina Massaro-Giordano, Maria Pia Alba, Silvia Boffo, Ilaria Macchi, Antonio Giordano, Marcella Macaluso
Gender-based differences may influence the occurrence of several ocular conditions suggesting the possibility that fluctuations in sex steroid homeostasis may have direct effects on the eye physiology. Here, we evaluated the effect of sex steroid hormone fluctuations in male retinal pigment epithelial cells, RPEs (ARPE-19). To mimic hormonal fluctuations occurring during aging, we exposed ARPE-19 to acute, prolonged or chronic estradiol and progesterone challenges. We found that chronic estradiol treatment promotes a remarkable necrosis of RPE cells, and does not affect pRb2/p130 or PAI-2 sub-cellular localization...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29335465/the-high-concentration-of-progesterone-is-harmful-for-endometrial-receptivity-and-decidualization
#5
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-Huan Liang, Yong-Sheng Fu, Xiao-Wei Gu, Zeng-Ming Yang
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334661/altered-expression-of-il-1%C3%AE-il-1ri-il-1rii-il-1ra-and-il-4-could-contribute-to-anovulation-and-follicular-persistence-in-cattle
#6
A F Stassi, M E Baravalle, E M Belotti, A N Amweg, E Angeli, M M L Velázquez, F Rey, N R Salvetti, H H Ortega
Cystic ovarian disease (COD) is an important cause of infertility in dairy cattle. The main signs of this infertility are ovulation failure and follicular persistence. The aim of this study was to examine the expression of the cytokines IL-1β, IL-1RI, IL-1RII, IL-1RA and IL-4 in ovarian follicular structures at different times of persistence in a model of follicular persistence induced by prolonged administration of progesterone in dairy cows. Protein expression of IL-1β, IL-1RI, IL-1RII, IL-1RA and IL-4 was evaluated by immunohistochemistry...
January 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29331723/progesterone-arrested-cell-cycle-progression-through-progesterone-receptor-isoform-a-in-pancreatic-neuroendocrine-neoplasm
#7
Samaneh Yazdani, Atsuko Kasajima, Yoshiaki Onodera, Keely May McNamara, Kazue Ise, Yasuhiro Nakamura, Tomoyoshi Tachibana, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano
In pancreatic neuroendocrine neoplasms (Pan-NEN) progesterone signaling has been shown to have both inhibitory and stimulatory effects on cell proliferation. The ability of progesterone to inhibit tumor proliferation is of particular interest and is suggested to be mediated through the less abundantly expressed progesterone receptor (PR) isoform A (PRA). To date the mechanistic processes underlying this inhibition of proliferation remain unclear. To examine the mechanism of PRA actions, the human Pan-NEN cell line QGP-1, that endogenously expresses PR isoform B (PRB) without PRA, was transfected with PRA...
January 10, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29330782/characterization-of-the-pharmacokinetics-of-vilaprisan-bioavailability-excretion-biotransformation-and-drug-drug-interaction-potential
#8
Marcus-Hillert Schultze-Mosgau, Joachim Höchel, Olaf Prien, Torsten Zimmermann, Ashley Brooks, Jim Bush, Antje Rottmann
BACKGROUND AND OBJECTIVES: In-vitro data suggest that clearance of vilaprisan is mediated by cytochrome P450 3A4 (oxidation) and aldoketoreductases (reduction). To fully understand the elimination and biotransformation pathways of vilaprisan, a selective progesterone receptor modulator, and to quantify the impact of cytochrome P450 3A4 inhibition on the pharmacokinetics of vilaprisan, two clinical studies in healthy postmenopausal women were conducted. METHODS: In study 1, pharmacokinetics, mass balance, and metabolite patterns were determined after single oral administration of 5 mg of [14C]-labeled vilaprisan in six subjects...
January 12, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29313260/preparation-and-evaluation-of-progesterone-nanocrystals-to-decrease-muscle-irritation-and-improve-bioavailability
#9
Li Li, Wanqing Li, Jianxu Sun, Hui Zhang, Jing Gao, Fei Guo, Xi Yang, Xun Zhang, Ying Li, Aiping Zheng
Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection was developed to decrease muscle toxicity. PG/NCs injection containing 10% (w/v) PG was first prepared using a wet grinding method. Then, particle size, zeta potential, morphology powder, X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) studies were carried out to evaluate the characteristics of dosage form...
January 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29305844/progesterone-rise-on-hcg-day-is-negatively-correlated-with-ivf-et-outcomes-in-natural-cycles
#10
Xiadi Wu, Yundong Mao, Yan Gao, Xiaoqiao Qian, Wei Wang, Wei Ding, Shi-Wen Jiang, Jiayin Liu
OBJECTIVE: To investigate the effect of progesterone rise on hCG day on the laboratory and clinical outcomes in natural cycles and to explore the possible factors related to the occurrence of progesterone elevation. PATIENTS AND STUDY METHODS: Retrospective analysis was performed in 1157 infertile women with decreased ovarian reserve. Eligible infertile women undergoing IVF in natural cycles were assigned to four groups according to serum progesterone levels on the day of hCG administration: group 1, P<2nmol/L; group 2, 2<P<2...
January 3, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29300975/new-application-of-dydrogesterone-as-a-part-of-a-progestin-primed-ovarian-stimulation-protocol-for-ivf-a-randomized-controlled-trial-including-516-first-ivf-icsi-cycles
#11
Sha Yu, Hui Long, Hannah Ya-Ning Chang, Yali Liu, Hongyuan Gao, Jing Zhu, Xinxin Quan, Qifeng Lyu, Yanping Kuang, Ai Ai
STUDY QUESTION: Can dydrogesterone (DYG) be used as an alternative progestin in a progesterone primed ovarian stimulation (PPOS) protocol? SUMMARY ANSWER: DYG can be used as an appropriate alternative progestin in a PPOS protocol. WHAT IS KNOWN ALREADY: PPOS is a new ovarian stimulation regimen based on a freeze-all strategy that uses progestin as an alternative to a GnRH analog for suppressing a premature LH surge during the follicular phase...
December 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29300901/aromatase-inhibitor-use-during-ovarian-stimulation-suppresses-growth-of-uterine-endometrial-cancer-in-xenograft-mouse-model
#12
Tai Kawahara, Naoki Okamoto, Seido Takae, Megumi Kashiwagi, Mariko Nakajima, Atsushi Uekawa, Junya Ito, Naomi Kashiwazaki, Yodo Sugishita, Nao Suzuki
STUDY QUESTION: Could aromatase inhibitors (AI) be used to reduce risks of uterine endometrial cancer growth or recurrence during ovarian stimulation? SUMMARY ANSWER: In a xenograft mouse model of endometrial cancer, concomitant AI administration suppressed the growth of endometrial cancer during ovarian stimulation. WHAT IS KNOWN ALREADY: Recurrence and mortality rates of estrogen receptor-positive early breast cancer are reduced by long-term AI administration...
December 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29275865/a-european-observational-study-of-endocrine-therapy-administration-in-patients-with-an-initial-diagnosis-of-hormone-receptor-positive-advanced-breast-cancer
#13
Esther Bastiaannet, Jackie Charman, Tom Børge Johannesen, Simone Schrodi, Sabine Siesling, Liesbet van Eycken, Paul M Walsh, Riccardo A Audisio, Petra G Boelens, Isabel T Rubio, Nick Jones, Jan Lewis, Cornelis J H van de Velde
BACKGROUND: Despite guideline recommendations, reports suggest that a proportion of patients with hormone receptor (HR)-positive locally advanced or metastatic breast cancer (LA/MBC) might not receive endocrine therapy. The aims of this study were to estimate the proportion of postmenopausal patients with an initial (primary) diagnosis of HR-positive LA/MBC in Europe, and to assess the administration of endocrine treatment in these patients. MATERIALS AND METHODS: Fourteen national and regional cancer registries across Europe were invited to participate in this observational study...
November 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29249775/effects-of-gonadotropin-releasing-hormone-agonist-on-human-chorionic-gonadotropin-activity-in-granulosa-cells-of-immature-female-rats
#14
Tungmahasuk Doungrut, Numfa Fungbun, Titaree Laoharatchatathanin, Ryota Terashima, Shiro Kurusu, Mitsumori Kawaminami
Although the expression of gonadotropin-releasing hormone (GnRH) in the ovaries is well established, its physiological role remains unknown. The aim of this study was to determine whether ovarian GnRH mediates the actions of human chorionic gonadotropin (hCG) in the granulosa cells of immature female rats. Follicular growth was induced by administration of pregnant mare serum gonadotropin (PMSG, 15 IU/0.15 ml) on day 25 after birth, and hCG (20 IU/0.2 ml) was administered on day 27 to increase the plasma levels of progesterone...
December 15, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29249328/monitoring-and-controlling-follicular-activity-in-camelids
#15
Ahmed Tibary
This paper reviews that state of our knowledge concerning follicular wave dynamics, monitoring and manipulation. All camelids have overlapping follicular waves in absence of ovulation which is induced by a seminal plasma factor (βNGF). The interval between follicular waves varies. The size of the ovulatory follicle varies between 11 and 25 mm in camels and between in 6 and 13 mm in South American Camelids. The interval between induction of ovulation and next ovulatory follicle is 15 ± 1 day for all camelids...
December 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29231589/-effects-of-moxibustion-at-shenshu-bl-23-on-level-of-sex-hormones-and-amh-in-sub-health-peri-menopausal-women
#16
Jie Shen, Meihong Shen, Zhongren Li, Rongli Zhang, Xia Li, Bingwei Ai
OBJECTIVE: To compare the effects between moxibustion at Shenshu (BL 23) and oral administration of Vitamin E on quality of life and mechanism in sub-health perimenopausal women, aiming to provide clinical evidence of moxibustion for health care of sub-health female. METHODS: Sixty participants were randomly divided into a moxibustion group and a medication group, 30 cases in each one. The volunteers in the moxibustion group were treated with mild moxibustion at bilateral Shenshu (BL 23) for 15 min, once a day; five treatments were considered as a course of treatment, and totally 4 courses were given with an interval of 2 days between courses...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231342/-the-effect-of-warm-needling-pretreatment-for-endometrial-receptivity-of-frozen-embryo-transfer
#17
Guoqun Luo, Wenwu Su, Wenmin Ma, Yanqiu Situ, Chongju Xie, Meiqiong Yang
OBJECTIVE: To explore the effect of warming needling pretreatment for endometrial receptivity before frozen-thawed embryo transfer (FET). METHODS: Fifty-six repeatedly embryo transfer (ET) failure patients with ultrasound showing follicular phase endometrium of C type, hysteroscopy examination presenting endometritis were randomly assigned into an observation group (25 cases) and a control group (31 cases). The patients in the observation group three months before ET were treated with antibiotics in the menstrual period, warming needle (once a day) at Zhongwan (CV 12), Tianshu (ST 25), Guanyuan (CV 4), Zhongji (CV 3), Zigong (EX-CA 1), Liangqiu (ST 34), Zusanli (ST 36), Shangjuxu (ST 37), Xiajuxu (ST 39) after menstruation until the ovulation stopped, and oral administration of progesterone was applied after ovulation...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29223656/endometrial-expression-of-estrogen-and-progesterone-receptors-in-non-cyclic-mares-treated-only-with-long-acting-progesterone
#18
L F S Maciel, E S M Silva, J P Oliveira-Filho, S C Fritsch, R S Rossi, J A C Lourenção, C Meira
Administration of progesterone (P4) after estradiol is usually performed to prepare non-cyclic mares as embryo recipients. However, there are successful pregnancy reports after embryo transfer in non-cyclic mares treated only with progestins. The objective of this study was to evaluate endometrial gene expression and immunostaining for estrogen receptor alpha (ERα), beta (ERβ) and progesterone receptor (PR) in seasonal anestrous mares treated with long acting P4 (LA P4). Endometrial tissue from eight seasonal anestrous mares was collected immediately before administration of 1...
December 2, 2017: Theriogenology
https://www.readbyqxmd.com/read/29217167/potential-protective-effect-of-pistacia-lentiscus-oil-against-chlorpyrifos-induced-hormonal-changes-and-oxidative-damage-in-ovaries-and-thyroid-of-female-rats
#19
Samira Chebab, Fatiha Mekircha, Essaid Leghouchi
The purpose of this study was to evaluate the protective effect of Pistacia lentiscus oil (PLO), known for its antioxidant properties, on chlorpyrifos (CPF)-induced alterations in the thyroid, reproductive hormone levels, and oxidative damage in the ovaries and thyroid of adult Wistar rats. The animals were treated with orally administered PLO (2 mL/kg), CPF (6.75 mg/kg), and a combination of CPF and PLO for 30 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (Pg), estradiol (E2), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were assessed using chemiluminescence assay...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#20
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
December 1, 2017: Human Reproduction
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