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Progesterone administration

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https://www.readbyqxmd.com/read/28920796/successful-laparoscopic-oviductal-artificial-insemination-in-the-clouded-leopard-neofelis-nebulosa-in-thailand
#1
Wanlaya Tipkantha, Paweena Thuwanut, Umaporn Maikeaw, Ampika Thongphakdee, Saifon Yapila, Sumate Kamolnorranath, Boripat Siriaroonrat, Pierre Comizzoli, Kaywalee Chatdarong
Captive breeding of clouded leopards (Neofelis nebulosa) is challenging because of mating incompatibility, high incidence of teratospermia in males, and inconsistent ovulation patterns in females. Assisted reproductive techniques, therefore, are necessary to overcome these issues and maintain the genetic diversity in the captive population. The objective was to use laparoscopic oviductal artificial insemination (AI) to breed genetically valuable females (n = 4; aged 4.5-5 yr) that were unsuccessfully paired...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28917126/effects-of-a-single-administration-of-different-gonadotropins-on-day-7%C3%A2-post-insemination-on-pregnancy-outcomes-of-rabbit-does
#2
N M Hashem, Z R Aboul-Ezz
This study aimed to investigate the effects of a single administration of one of three different gonadotropins on Day 7 post-insemination on ovarian activity, progesterone (P4) concentration and pregnancy outcomes of rabbit does. Multiparous, non-lactating, V-line does were artificially inseminated after synchronization and ovulation induction with equine chorionic gonadotropin (eCG; 25 IU im) and gonadotropin releasing hormone (GnRH; 0.8  μg buserelin im) 48 h later. On Day 7 post-inseminarion, does were randomly allocated into four groups (n = 40/group)...
September 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/28915843/protective-effects-of-gaba-against-metabolic-and-reproductive-disturbances-in-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#3
Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf, Tayyaba Afsar
BACKGROUND: PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance. METHODS: PCOs in Adult female rat was induced by the daily gastric administration of letrozole (1 mg/kg/day) in CMC (0...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28913392/data-on-scaling-up-and-in-vivo-human-study-of-progesterone-lipid-nanoparticles
#4
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Rita Cortesi
Progesterone containing nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride were produced in a lab scale by ultrasound homogenization and in a pilot scale by high pressure homogenization. A study was conducted to select the pressure to be used in order to obtain homogenously sized nanoparticles. The Dialysis method was performed to mimic subcutaneous administration of lipid nanoparticles. Mathematical analyses of the results were conducted to understand and compare the drug release mechanisms...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28911882/aromatase-inhibitors-a-new-approach-for-controlling-ovarian-function-in-cattle
#5
M J Yapura, E M Zwiefelhofer, R A Pierson, G P Adams
Numerous treatments and protocols have been used to control the reproductive cycle in cattle, with varying effectiveness and many involving the administration of steroid hormones. Steroid hormones, such as estradiol, are perceived as having a negative impact on consumer health. This internationally shared opinion has led to a ban on the use of steroid hormones in food producing animals in many countries (i.e., European Union, New Zealand, and Australia). Letrozole, a non-steroidal aromatase inhibitor, inactivates the aromatase enzyme responsible for the synthesis of estrogens by reversibly binding to the "heme" group of the P450 subunit...
September 11, 2017: Theriogenology
https://www.readbyqxmd.com/read/28910675/equine-chorionic-gonadotropin-administration-after-insemination-affects-luteal-function-and-pregnancy-establishment-in-postpartum-anestrous-beef-cows
#6
R Núñez-Olivera, T de Castro, G A Bó, J Piaggio, A Menchaca
Two experiments were conducted with the aim of determining the effect of equine chorionic gonadotropin (eCG) administration on day 14 after insemination on ovarian response and pregnancy establishment in postpartum anestrous beef cows. In both experiments, cows were subjected to a progesterone- and estradiol-based treatment for fixed-time artificial insemination (FTAI) and were randomly allocated into 4 groups to receive or not receive eCG (400 IU) at the time of device removal and/or at 14 d after FTAI. In experiment 1, from day 14 to 22, daily ultrasonographic determinations were performed to monitor ovarian dynamics, and blood was collected to determine hormone concentrations in 60 cows...
August 31, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28905874/ovarian-hormones-and-transdermal-nicotine-administration-independently-and-synergistically-suppress-tobacco-withdrawal-symptoms-and-smoking-reinstatement-in-the-human-laboratory
#7
Raina D Pang, Madalyn M Liautaud, Matthew G Kirkpatrick, Jimi Huh, John Monterosso, Adam M Leventhal
Modeling intra-individual fluctuations in estradiol and progesterone may provide unique insight into the effects of ovarian hormones on the etiology and treatment of nicotine dependence. This randomized placebo-controlled laboratory study tested the independent and interactive effects of intra-individual ovarian hormone variation and nicotine on suppression of tobacco withdrawal symptoms and smoking behavior. Female smokers randomized to 21 mg. nicotine (TNP; n=37) or placebo (PBO; n=43) transdermal patch following overnight abstinence completed three sessions occurring during hormonally distinct menstrual cycle phases...
September 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28894396/a-validation-of-clinical-data-captured-from-a-novel-cancer-care-quality-program-directly-integrated-with-administrative-claims-data
#8
David M Kern, John J Barron, Bingcao Wu, Alex Ganetsky, Vincent J Willey, Ralph A Quimbo, Michael J Fisch, Joseph Singer, Ann Nguyen, Ronac Mamtani
BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the validity of the HIRE-Oncology data compared with medical records of breast, lung, and colorectal cancer patients. METHODS: Data elements included cancer type, stage, histology (lung only), and biomarkers...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28890427/blastocyst-transfer-does-not-improve-cycle-outcome-as-compared-to-d3-transfer-in-antagonist-cycles-with-an-elevated-progesterone-level-on-the-day-of-hcg
#9
Cem Demirel, Serkan Aydoğdu, Arzu İlknur Özdemir, Gülşah Keskin, Ercan Baştu, Faruk Buyru
OBJECTIVE: To evaluate the association between progesterone elevation on the day of human chorionic gonadotropin (hCG) administration and clinical pregnancy rates of gonadotropin-releasing hormone (GnRH) antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles with the transfer of embryos at different developmental stages (day-3 versus day-5 ETs). MATERIAL AND METHODS: This is a retrospective analysis of fresh IVF/ICSI; 194 cycles out of 2676 conducted in a single center...
September 1, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28890368/cyp17a1-independent-production-of-the-neurosteroid-derived-5%C3%AE-pregnan-3%C3%AE-6%C3%AE-diol-20-one-in-androgen-responsive-prostate-cancer-cell-lines-under-serum-starvation-and-inhibition-by-abiraterone
#10
Antonio G Gomes de Mello Martins, Giuseppe Allegretta, Gerhard Unteregger, Jörg Haupenthal, Jens Eberhard, Michael Hoffmann, Jill A van der Zee, Kerstin Junker, Michael Stöckle, Rolf Müller, Rolf W Hartmann, Carsten-H Ohlmann
CYP17A1-independent intratumoral steroid hormone synthesis is regarded as one possible explanation for resistance to treatment with the CYP17-inhibitor Abiraterone (Abi). The aim of our study was therefore to investigate the steroid metabolism of prostate cancer cells under serum starvation and the effects of Abi treatment. We assessed steroid metabolism in a panel of prostate cancer cells under serum starvation by radioactivity detector-coupled HPLC and HPLC-ESI-ToF-mass spectrometry after treatment with pregnenolone, progesterone and allopregnanolone...
September 7, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28877966/t-cell-mediation-of-pregnancy-analgesia-affecting-chronic-pain-in-mice
#11
Sarah F Rosen, Boram Ham, Shannon Drouin, Nadia Boachie, Anne-Julie Chabot-Dore, Jean-Sebastien Austin, Luda Diatchenko, Jeffrey S Mogil
It has been consistently reported that many female chronic pain sufferers have an attenuation of symptoms during pregnancy. Rats display increased pain tolerance during pregnancy, due to an increase in opioid receptors in the spinal cord. These past studies did not consider the role of non-neuronal cells, now appreciated to play an important role in chronic pain processing. Using an inflammatory (complete Freund's adjuvant) or neuropathic (spared nerve injury) model of persistent pain, we observe that young adult female mice in early pregnancy switch from a micgrolia-independent to a microglia-dependent pain hypersensitivity mechanism...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28868248/the-window-of-implantation-is-closed-by-estrogen-via-insulin-like-growth-factor-1-pathway
#12
Ryosuke Kobayashi, Jumpei Terakawa, Tsutomu Omatsu, Yupadee Hengjan, Tetsuya Mizutani, Yasushige Ohmori, Eiichi Hondo
BACKGROUND: The opening and closing of the implantation window is important for successful pregnancy in eutherians. The recent study demonstrated that the window of uterine receptivity was prepared by the sole action of progesterone in mice, but the mechanism to close the window remained to be elucidated. METHODS: The pregnant mice were ovariectomized on the evening on the third day of pregnancy with a single injection of medroxyprogesterone acetate to induce delayed implantation (DI)...
April 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28863997/micronized-progesterone-pretreatment-affects-the-inflammatory-response-of-human-gestational-tissues-and-the-cervix-to-lipopolysaccharide-stimulation
#13
Tai-Ho Hung, Szu-Fu Chen, Chung-Pu Wu, Meng-Jen Li, Yi-Lin Yeh, T'sang-T'ang Hsieh
INTRODUCTION: Vaginal administration of micronized progesterone (utrogestan capsule, UG) reduces the risk of preterm birth (PTB) in asymptomatic women with a sonographic short cervix at mid-trimester or with a prior history of spontaneous PTB; however, its exact mechanisms remain unclear. We hypothesized that UG limits the inflammatory processes within the gestational tissues and the cervix. METHODS: Fetal membranes and villous tissues were obtained from normal term placentas from women with cesarean delivery before labor onset...
September 2017: Placenta
https://www.readbyqxmd.com/read/28857251/hospital-admission-for-hyperemesis-gravidarum-in-women-at-increased-risk-of-spontaneous-preterm-birth
#14
Ira Kleine, Ana Da Silva, Wafaa Ahmed, Frida Forya, Sara M Whitten, Anna L David, Catherine P James
BACKGROUND: Progesterone administration prevents spontaneous preterm birth (sPTB) in women at increased risk. Progesterone concentration is lower in women with subsequent sPTB. Conversely, high concentrations of progesterone are implicated in the pathogenesis of hyperemesis gravidarum (HG). We hypothesized that women at increased risk of sPTB or spontaneous late miscarriage would be less likely to have a diagnosis of HG. To explore this hypothesis, we compared the incidence of HG in women at increased risk of sPTB and women with no identifiable risk factors...
August 30, 2017: Birth
https://www.readbyqxmd.com/read/28856795/development-of-medical-termination-of-pregnancy-a-review
#15
REVIEW
Pak Chung Ho
The synthesis of mifepristone, an antiprogestin blocking the action of progesterone at the receptor level, started the new era of medical termination of pregnancy (TOP). Initial results of medical TOP with mifepristone alone were disappointing. However, mifepristone can sensitise the myometrium to the action of prostaglandins. Clinical trials showed that the sequential administration of mifepristone followed 1-2 days later by a prostaglandin analogue is a safe, effective and acceptable method for medical TOP...
August 30, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28854414/chitosan-modified-cholesterol-free-liposomes-for-improving-the-oral-bioavailability-of-progesterone
#16
Mei Wang, Meng Liu, Tingting Xie, Bing-Feng Zhang, Xiao-Li Gao
Based on the structurally similar properties of progesterone and cholesterol, chitosan-coated cholesterol-free liposomes (CS-Lipo/Prog) were formulated. CS-Lipo/Prog are spherical and uniform in size (662.1±19.3nm) with positive potential (28.19±1.97mV). The average drug entrapment efficiency (EE) is approximately 80%. The in vitro release profile of CS-Lipo/Prog shows sustained release. The in vitro stability evaluation demonstrated that CS-Lipo/Prog can efficiently shield Prog from degradation in the gastrointestinal tract...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28852923/total-glycosides-of-paeony-shows-neuroprotective-effects-against-semen-strychni-induced-neurotoxicity-by-recovering-secretion-of-hormones-and-improving-brain-energy-metabolism
#17
Chenzhi Hou, Ruowen Zhang, Kexia Zhang, Xiaohui Chen
In this study, we investigated the protective effect of total glycosides of paeony against Semen Strychni-induced neurotoxicity and discussed some probably mechanisms. Levels of estrone, estradiol, estriol and growth hormone in male rats' serum were determined by ELISA, levels of ATP and substances associated with energy metabolism in rats' brain were determined by HPLC and levels of progesterone was determined by a UPLC-MS/MS method. The results showed that neurotoxicity induced by Semen Strychni could cause a significant decrease (p < 0...
August 29, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28851248/long-term-testosterone-treatment-during-pregnancy-does-not-alter-insulin-or-glucose-profile-in-a-sheep-model-of-polycystic-ovary-syndrome
#18
Monica Recabarren, Albert Carrasco, Daniel Sandoval, Felipe Diaz, Teresa Sir-Petermann, Sergio E Recabarren
The administration of testosterone to pregnant sheep to resemble fetal programming of the polycystic ovary syndrome could alter other hormones/factors of maternal origin with known effects on fetal growth. Hence, we studied the weekly profile of insulin, progesterone and glucose during a treatment with testosterone propionate given biweekly from weeks 5 to 17 of pregnancy (term at 21 weeks) and checked the outcome of their fetuses at 17 weeks of gestation after C-section. Control dams were only exposed to the vehicle of the hormone...
September 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28833805/carbon-isotope-ratios-of-endogenous-steroids-in-belgian-blue-and-holstein-cattle-method-development-reference-population-studies-and-application-to-steroid-misuse-control
#19
Thomas Piper, Marlen Putz, Phillipe Delahaut, Mario Thevis
RATIONALE: The misuse of growth promoters in livestock and breeding animals is prohibited according to the laws of the European Union. Among these growth promoters, the detection of endogenous steroids like testosterone, estradiol or progesterone remains especially challenging as concentration-based urinary thresholds may not provide conclusive results due to large inter-individual variations. In addition to the detection of intact steroid esters in blood or hair, carbon isotope ratio (CIR) determinations of urinary steroids has commonly been the method of choice...
August 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28833078/case-report-of-induced-medical-abortion-following-depot-administration-of-medroxyprogesterone-acetate
#20
Paige D Kendall, Melissa J Chen
No abstract text is available yet for this article.
August 21, 2017: International Journal of Gynaecology and Obstetrics
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