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https://www.readbyqxmd.com/read/28535290/dietary-quality-and-ovarian-cancer-risk-in-african-american-women
#1
Bo Qin, Patricia G Moorman, Linda E Kelemen, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Paul Terry, Joellen M Schildkraut, Elisa V Bandera
This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28510291/associations-between-rna-splicing-regulatory-variants-of-stemness-related-genes-and-racial-disparities-in-susceptibility-to-prostate-cancer
#2
Yanru Wang, Jennifer A Freedman, Hongliang Liu, Patricia G Moorman, Terry Hyslop, Daniel J George, Norman H Lee, Steven R Patierno, Qingyi Wei
Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiethnic/Minority Cohort Study of Diet and Cancer (MEC) and the Ghana Prostate Study, as well as two GWAS datasets of non-Hispanic whites, from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Breast and Prostate Cancer Cohort Consortium (BPC3), to analyze the associations between genetic variants of stemness-related genes and racial disparities in susceptibility to prostate cancer...
May 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28503217/assessment-and-use-of-drug-information-references-in-utah-pharmacies
#3
Krystal L Moorman, Elyse A Macdonald, Anthony Trovato, Casey R Tak
OBJECTIVE: To determine which drug references Utah pharmacists use most frequently. To determine which types of drug information questions are most commonly asked, and whether Utah pharmacists have access to adequate references to respond to these questions. METHODS: A 19-question survey was created using Qualtrics, LLC (Provo, Utah) software. An electronic survey link was sent to 1,431 pharmacists with a valid e-mail address listed in the Department of Professional Licensing database...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28466107/cigarette-smoking-and-the-association-with-serous-ovarian-cancer-in-african-american-women-african-american-cancer-epidemiology-study-aaces
#4
Linda E Kelemen, Sarah Abbott, Bo Qin, Lauren Cole Peres, Patricia G Moorman, Kristin Wallace, Elisa V Bandera, Jill S Barnholtz-Sloan, Melissa Bondy, Kathleen Cartmell, Michele L Cote, Ellen Funkhouser, Lisa E Paddock, Edward S Peters, Ann G Schwartz, Paul Terry, Anthony J Alberg, Joellen M Schildkraut
BACKGROUND: Smoking is a risk factor for mucinous ovarian cancer (OvCa) in Caucasians. Whether a similar association exists in African Americans (AA) is unknown. METHODS: We conducted a population-based case-control study of incident OvCa in AA women across 11 geographic locations in the US. A structured telephone interview asked about smoking, demographic, health, and lifestyle factors. Odds ratios and 95% confidence intervals (OR, 95% CI) were estimated from 613 cases and 752 controls using unconditional logistic regression in multivariable adjusted models...
May 2, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28444120/premenopausal-hysterectomy-and-risk-of-ovarian-cancer-in-african-american-women
#5
Lauren C Peres, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Ann G Schwartz, Paul D Terry, Sarah E Abbott, Fabian Camacho, Frances Wang, Joellen M Schildkraut
Although the inverse association between hysterectomy and epithelial ovarian cancer (EOC) was considered well established, investigators in recent studies including women diagnosed after 2000 have observed modest increases in risk. Most studies have been conducted in white women with little representation of African-American women. We examined the relationship between premenopausal hysterectomy and EOC in African-American women and explored whether hormone therapy (HT) modified this association in 614 cases and 743 controls enrolled in the African American Cancer Epidemiology Study (2010-2015)...
April 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28422699/hemorrhage-prediction-models-in-surgical-intensive-care-bedside-monitoring-data-adds-information-to-lab-values
#6
Marco De Pasquale, Travis Moss, Sergio Cerutti, James Calland, Douglas Lake, Randall Moorman, Manuela Ferrario
Hemorrhage is a frequent complication in surgery patients; its identification and management have received increasing attention as a target for quality improvement in patient care in the Intensive Care Unit (ICU). The purposes of this work were i) to find an early detection model for hemorrhage by exploring the range of data mining methods that are currently available, and ii) to compare prediction models utilizing continuously measured physiological data from bedside monitors to those using commonly obtained laboratory tests...
April 12, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28385580/food-brand-recognition-and-bmi-in-preschoolers
#7
Kristen Harrison, Jessica Moorman, Mericarmen Peralta, Kally Fayhee
Children's food brand recognition predicts health-related outcomes such as preference for obesogenic foods and increased risk for overweight. However, it is uncertain to what degree food brand recognition acts as a proxy for other factors such as parental education and income, child vocabulary, child age, child race/ethnicity, parent healthy eating guidance, child commercial TV viewing, and child dietary intake, all of which may influence or be influenced by food brand recognition. U.S. preschoolers (N = 247, average age 56 months) were measured for BMI and completed the Peabody Picture Vocabulary Test plus recognition and recall measures for a selection of U...
April 4, 2017: Appetite
https://www.readbyqxmd.com/read/28369591/how-social-network-size-and-quality-affect-end-of-life-surrogate-preferences
#8
Sara M Moorman, Kathrin Boerner
Objective: Older adults typically choose their next-of-kin to serve as surrogate on their behalf should they become decisionally incapacitated at the end of life. However, some older adults do not choose their closest relative, even if they are married or parents. We compared the social networks of these latter persons to their peers who prefer a next-of-kin surrogate, anticipating differences in relationship quality and network size. Methods: We used multinomial logistic regressions to investigate the quality and size of the social networks of 1,245 persons whose next of kin was a spouse and 723 persons whose next-of-kin was an adult child, and who participated in the 2005 National Social Life, Health and Aging Project...
March 29, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28329821/extracurricular-involvement-in-high-school-and-later-life-participation-in-voluntary-associations
#9
Emily A Greenfield, Sara M Moorman
Objectives: Scholars have identified participation in voluntary associations as a central component of civic engagement for younger and older people alike. However, there has been little longitudinal examination of how such participation potentially fluctuates across multiple periods of the life course, as well as the extent to which involvement in youth is associated with participation in later life. Method: We used data from the Wisconsin Longitudinal Study-which is among the oldest and most comprehensive cohort studies in the United States to date...
January 19, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28322704/transmission-of-hepatitis-a-virus-through-combined-liver-small-intestine-pancreas-transplantation
#10
Monique A Foster, Lauren M Weil, Sherry Jin, Thomas Johnson, Tonya R Hayden-Mixson, Yury Khudyakov, Pallavi D Annambhotla, Sridhar V Basavaraju, Saleem Kamili, Jana M Ritter, Noele Nelson, George Mazariegos, Michael Green, Ryan W Himes, David T Kuhar, Matthew J Kuehnert, Jeffrey A Miller, Rachel Wiseman, Anne C Moorman
Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi-visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28296811/new-onset-atrial-fibrillation-in-the-critically-ill
#11
Travis J Moss, James Forrest Calland, Kyle B Enfield, Diana C Gomez-Manjarres, Caroline Ruminski, John P DiMarco, Douglas E Lake, J Randall Moorman
OBJECTIVE: To determine the association of new-onset atrial fibrillation with outcomes, including ICU length of stay and survival. DESIGN: Retrospective cohort of ICU admissions. We found atrial fibrillation using automated detection (≥ 90 s in 30 min) and classed as new-onset if there was no prior diagnosis of atrial fibrillation. We identified determinants of new-onset atrial fibrillation and, using propensity matching, characterized its impact on outcomes...
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28282352/partial-pectoralis-tear-treated-with-orthobiologics-a-case-report
#12
Blake Boggess, Claude Moorman
No abstract text is available yet for this article.
March 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28278142/notes-from-the-field-hepatitis-c-transmission-from-inappropriate-reuse-of-saline-flush-syringes-for-multiple-patients-in-an-acute-care-general-hospital-texas-2015
#13
Sandi Arnold, Sharon K Melville, Bonnie Morehead, Gilberto Vaughan, Anne Moorman, Matthew B Crist
No abstract text is available yet for this article.
March 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28265482/evaluating-the-effects-of-diffused-lavender-in-an-adult-day-care-center-for-patients-with-dementia-in-an-effort-to-decrease-behavioral-issues-a-pilot-study
#14
Robin Moorman Li, Brian Gilbert, Anna Orman, Petra Aldridge, Sue Leger-Krall, Clare Anderson, Juan Hincapie Castillo
Objectives: To evaluate the effects of diffused lavender on the frequency of behavioral issues [BIs], defined as a composite of restlessness/wandering [RW], agitation [AGT], anger [ANG], and anxiety [ANX] in an adult day care center. Secondary objectives evaluate systematic differences on the frequency of BIs between age cohorts, gender, and individual behaviors. Design: Pre-post quasi-experimental study. Setting: Private nonprofit adult day care center for patients with dementia. Participants: Elderly patients older than 65 years of age with a clinical diagnosis of dementia, who require daytime monitoring...
2017: Journal of drug assessment
https://www.readbyqxmd.com/read/28255018/acute-lymphoblastic-leukemia-with-aleukemic-prodrome-preleukemic-dynamics-and-possible-mechanisms-of-immunosurveillance
#15
Olga Zimmermannova, Marketa Zaliova, Anthony V Moorman, Halima Al-Shehhi, Eva Fronkova, Zuzana Zemanova, Tomas Kalina, Ajay Vora, Jan Stary, Jan Trka, Ondrej Hrusak, Jan Zuna
No abstract text is available yet for this article.
March 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28251458/lifetime-number-of-ovulatory-cycles-and-epithelial-ovarian-cancer-risk-in-african-american-women
#16
Lauren C Peres, Patricia G Moorman, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Paul D Terry, Sarah E Abbott, Fabian Camacho, Frances Wang, Joellen M Schildkraut
PURPOSE: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of predominantly white women. In the present study, we examined the association between lifetime number of ovulatory cycles (LOCs) and EOC risk among African American (AA) women. METHODS: We used data from 534 cases and 722 controls enrolled in the African American Cancer Epidemiology Study...
May 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28237943/kinome-profiling-identifies-druggable-targets-for-novel-human-cytomegalovirus-hcmv-antivirals
#17
Kyle C Arend, Erik M Lenarcic, Heather A Vincent, Naim Rashid, Eric Lazear, Ian M McDonald, Thomas S K Gilbert, Michael P East, Laura E Herring, Gary L Johnson, Lee M Graves, Nathaniel J Moorman
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and intensity of their use. There is thus an urgent need for new strategies to treat HCMV infection. Repurposing existing drugs as antivirals is an attractive approach to limit the time and cost of new antiviral drug development. Virus-induced changes in infected cells are often driven by changes in cellular kinase activity, which led us to hypothesize that defining the complement of kinases (the kinome), whose abundance or expression is altered during infection would identify existing kinase inhibitors that could be repurposed as new antivirals...
April 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28223408/inducing-circular-rna-formation-using-the-crispr-endoribonuclease-csy4
#18
Erin K Borchardt, Rita M Meganck, Heather A Vincent, Christopher B Ball, Silvia B V Ramos, Nathaniel J Moorman, William F Marzluff, Aravind Asokan
Circular RNAs (circRNAs) are highly stable, covalently closed RNAs that are regulated in a spatiotemporal manner and whose functions are largely unknown. These molecules have the potential to be incorporated into engineered systems with broad technological implications. Here we describe a switch for inducing back-splicing of an engineered circRNA that relies on the CRISPR endoribonuclease, Csy4, as an activator of circularization. The endoribonuclease activity and 3' end-stabilizing properties of Csy4 are particularly suited for this task...
May 2017: RNA
https://www.readbyqxmd.com/read/28215751/rewriting-age-to-overcome-misaligned-age-and-gender-norms-in-later-life
#19
Jeremiah C Morelock, Jeffrey E Stokes, Sara M Moorman
In this paper we suggest that older adults undergo a misalignment between societal age norms and personal lived experience, and attempt reconciliation through discursive strategies: They rewrite how they frame chronological age as well as their subjective relations to it. Using a sample of 4041 midlife and older adults from the 2004-2006 wave of the National Survey of Midlife Development in the United States (MIDUS II), we explore associations of age and gender with subjective age and at what age respondents felt people enter later life...
January 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28207317/effects-of-sensor-position-on-kinematic-data-obtained-with-an-inertial-sensor-system-during-gait-analysis-of-trotting-horses
#20
Valerie J Moorman, David D Frisbie, Christopher E Kawcak, C Wayne McIlwraith
OBJECTIVE To determine the effects of altering location of right forelimb and pelvic sensors on kinematic data obtained with a commonly used inertial sensor system during gait analysis of trotting horses. DESIGN Experimental study. ANIMALS 12 horses with mild to moderate lameness of at least 1 hind limb, with or without lameness of the forelimbs. PROCEDURES All horses were examined while trotting on a high-speed treadmill. The right forelimb sensor was tested at 3 anatomic locations in random order: dorsal midline and 2 cm medial and lateral to that midline...
March 1, 2017: Journal of the American Veterinary Medical Association
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