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https://www.readbyqxmd.com/read/27903798/lubac-modulates-lmp1-activation-of-nf%C3%AE%C2%BAb-and-irf7
#1
Ling Wang, Yujia Wang, Juan Zhao, Junping Ren, Kenton H Hall, Jonathan P Moorman, Zhi Q Yao, Shunbin Ning
: Recently, Linear Ubiquitin Assembly Complex (LUBAC)-mediated linear ubiquitination has come into focus due to its emerging role in activation of NFκB in different biological contexts. However, the role of LUBAC in LMP1 signaling leading to NFκB and IRF7 activation has not been investigated. We have shown here that RNF31, the key component of LUBAC complex, interacts with LMP1 and IRF7 in EBV-transformed cells, and that LUBAC stimualtes linear ubiquitination of NEMO and IRF7. Consequently, LUBAC is required for LMP1 signaling to full activation of NFκB, but inhibits LMP1-stimulated IRF7 transcriptional activity...
November 30, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27894709/external-validation-in-an-intermediate-unit-of-a-respiratory-decompensation-model-trained-in-an-intensive-care-unit
#2
Holly N Blackburn, Matthew T Clark, Travis J Moss, Jeffrey S Young, J Randall Moorman, Douglas E Lake, J Forrest Calland
BACKGROUND: Preventing urgent intubation and upgrade in level of care in patients with subclinical deterioration could be of great utility in hospitalized patients. Early detection should result in decreased mortality, duration of stay, and/or resource use. The goal of this study was to externally validate a previously developed, vital sign-based, intensive care unit, respiratory instability model on a separate population, intermediate care patients. METHODS: From May 2014 to May 2016, the model calculated relative risk of adverse events every 15 minutes (n = 373,271 observations) for 2,050 patients in a surgical intermediate care unit...
November 25, 2016: Surgery
https://www.readbyqxmd.com/read/27888529/long-term-progression-of-viral-load-and-serum-markers-of-fibrosis-among-treated-and-untreated-patients-with-chronic-hepatitis-b
#3
Jia Li, Stuart C Gordon, Loralee B Rupp, Talan Zhang, Sheri Trudeau, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu H Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Mei Lu
BACKGROUND AND AIMS: Antiviral therapy for patients with hepatitis B (HBV) infection is generally deferred for "immune inactive" patients, although longitudinal changes in viral load and liver fibrosis remain understudied in this population. Likewise, in treated patients, the temporal relationship between changes in viral load and liver fibrosis is not well-characterized. Using data from the Chronic Hepatitis Cohort Study, we investigated viral load and the Fibrosis-4 index (FIB4, a serum-based marker of liver fibrosis) trajectories in both untreated and treated HBV patients...
November 26, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27884980/an-interactive-three-dimensional-digital-atlas-and-quantitative-database-of-human-development
#4
Bernadette S de Bakker, Kees H de Jong, Jaco Hagoort, Karel de Bree, Clara T Besselink, Froukje E C de Kanter, Tyas Veldhuis, Babette Bais, Reggie Schildmeijer, Jan M Ruijter, Roelof-Jan Oostra, Vincent M Christoffels, Antoon F M Moorman
Current knowledge about human development is based on the description of a limited number of embryonic specimens published in original articles and textbooks, often more than 100 years ago. It is exceedingly difficult to verify this knowledge, given the restricted availability of human embryos. We created a three-dimensional digital atlas and database spanning the first 2 months of human development, based on analysis of nearly 15,000 histological sections of the renowned Carnegie Collection of human embryonic specimens...
November 25, 2016: Science
https://www.readbyqxmd.com/read/27871663/surgical-management-and-treatment-of-the-anterior-cruciate-ligament-medial-collateral-ligament-injured-knee
#5
REVIEW
Kevin M Dale, James R Bailey, Claude T Moorman
The medial collateral ligament (MCL) is the most commonly injured ligament of the knee. The anterior cruciate ligament (ACL) is the most commonly injured ligament in conjunction with the MCL. Most MCL injuries can be treated nonoperatively, whereas the ACL often requires reconstruction. A good physical examination is essential for diagnosis, whereas radiographs and MRI of the knee confirm diagnosis and help guide treatment planning. Preoperative physical therapy should be completed before surgical management to allow for return of knee range of motion and an attempt at MCL healing...
January 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27824051/genomic-analyses-identify-recurrent-mef2d-fusions-in-acute-lymphoblastic-leukaemia
#6
Zhaohui Gu, Michelle Churchman, Kathryn Roberts, Yongjin Li, Yu Liu, Richard C Harvey, Kelly McCastlain, Shalini C Reshmi, Debbie Payne-Turner, Ilaria Iacobucci, Ying Shao, I-Ming Chen, Marcus Valentine, Deqing Pei, Karen L Mungall, Andrew J Mungall, Yussanne Ma, Richard Moore, Marco Marra, Eileen Stonerock, Julie M Gastier-Foster, Meenakshi Devidas, Yunfeng Dai, Brent Wood, Michael Borowitz, Eric E Larsen, Kelly Maloney, Leonard A Mattano, Anne Angiolillo, Wanda L Salzer, Michael J Burke, Francesca Gianni, Orietta Spinelli, Jerald P Radich, Mark D Minden, Anthony V Moorman, Bella Patel, Adele K Fielding, Jacob M Rowe, Selina M Luger, Ravi Bhatia, Ibrahim Aldoss, Stephen J Forman, Jessica Kohlschmidt, Krzysztof Mrózek, Guido Marcucci, Clara D Bloomfield, Wendy Stock, Steven Kornblau, Hagop M Kantarjian, Marina Konopleva, Elisabeth Paietta, Cheryl L Willman, Mignon L Loh, Stephen P Hunger, Charles G Mullighan
Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL9, CSF1R, DAZAP1, HNRNPUL1 and SS18) in 22 B progenitor ALL (B-ALL) cases with a distinct gene expression profile, the most common of which is MEF2D-BCL9. Examination of an extended cohort of 1,164 B-ALL cases identified 30 cases with MEF2D rearrangements, which include an additional fusion partner, FOXJ2; thus, MEF2D-rearranged cases comprise 5...
November 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27819673/lmp1-signaling-pathway-activates-irf4-in-latent-ebv-infection-and-a-positive-circuit-between-pi3k-and-src-is-required
#7
L Wang, J Ren, G Li, J P Moorman, Z Q Yao, S Ning
Interferon (IFN) regulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis. We have recently shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells. However, the intracellular signaling pathway triggering Src activation of IRF4 remains unknown. In this study, we provide evidence that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphorylation and markedly stimulates IRF4 transcriptional activity, and that Src mediates LMP1 activation of IRF4...
November 7, 2016: Oncogene
https://www.readbyqxmd.com/read/27813662/matrix-metalloproteinase-activity-and-prostaglandin-e2-are-elevated-in-the-synovial-fluid-of-meniscus-tear-patients
#8
Betty Liu, Adam P Goode, Teralyn E Carter, Gangadhar M Utturkar, Janet L Huebner, Dean C Taylor, Claude T Moorman Iii, William E Garrett, Virginia B Kraus, Farshid Guilak, Louis E DeFrate, Amy L McNulty
PURPOSE: Meniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study was to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compared to those in the synovial fluid of radiographic non-OA control knees. MATERIALS AND METHODS: Sixteen subjects with an isolated unilateral meniscus injury and six subjects who served as reference controls (knee Kellgren-Lawrence grade 0-1) were recruited...
November 4, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27809352/t-bet-mediated-tim-3-expression-dampens-monocyte-function-during-chronic-hepatitis-c-virus-infection
#9
Wenjing Yi, Peixin Zhang, Yan Liang, Yun Zhou, Huanjun Shen, Chao Fan, Jonathan P Moorman, Zhi Q Yao, Zhansheng Jia, Ying Zhang
Hepatitis C virus (HCV) induces a high rate of chronic infection via dysregulation of host immunity. We have previously shown that T-cell immunoglobulin and mucin domain protein-3 (Tim-3) is up-regulated on monocyte/macrophages (M/MФ ) during chronic HCV infection; little is known, however, about the transcription factor that controls its expression in these cells. In this study, we investigated the transcription factor, T-box expressed in T cells (T-bet), on Tim-3 expression in M/MФ in the setting of HCV infection...
November 3, 2016: Immunology
https://www.readbyqxmd.com/read/27780221/breeding-early-successional-bird-response-to-forest-harvests-for-bioenergy
#10
Steven M Grodsky, Christopher E Moorman, Sarah R Fritts, Steven B Castleberry, T Bently Wigley
Forest regeneration following timber harvest is a principal source of habitat for early-successional birds and characterized by influxes of early-successional vegetation and residual downed woody material. Early-successional birds may use harvest residues for communication, cover, foraging, and nesting. Yet, increased market viability of woody biomass as bioenergy feedstock may intensify harvest residue removal. Our objectives were to: 1) evaluate effects of varying intensities of woody biomass harvest on the early-successional bird community; and (2) document early-successional bird use of harvest residues in regenerating stands...
2016: PloS One
https://www.readbyqxmd.com/read/27771284/orexin-hypocretin-1-receptor-antagonism-reduces-ethanol-self-administration-and-reinstatement-selectively-in-highly-motivated-rats
#11
David E Moorman, Morgan H James, Elisabeth A Kilroy, Gary Aston-Jones
The orexin/hypocretin (ORX) system regulates motivation for natural rewards and drugs of abuse such as alcohol. ORX receptor antagonists, most commonly OX1R antagonists including SB-334867 (SB), decrease alcohol drinking, self-administration and reinstatement in both genetically-bred alcohol-preferring and outbred strains of rats. Importantly, levels of alcohol seeking and drinking in outbred rats are variable, as they are in humans. We have shown that OX1R antagonism selectively decreases homecage alcohol drinking in high-, but not low-alcohol-preferring rats...
January 1, 2017: Brain Research
https://www.readbyqxmd.com/read/27761785/physical-and-psychological-health-in-rare-cancer-survivors
#12
Nora K Horick, Adoma Manful, Jan Lowery, Susan Domchek, Patricia Moorman, Constance Griffin, Kala Visvanathan, Claudine Isaacs, Anita Y Kinney, Dianne M Finkelstein
PURPOSE: Registries provide a unique tool for tracking quality of life in rare cancer survivors, whose survivorship experience is less known than for common cancers. This paper reports on these outcomes in 321 patients enrolled in the Rare Cancer Genetics Registry diagnosed with rare gastrointestinal, genitourinary, gynecologic, sarcoma, head/neck, or hematologic cancers. METHODS: Four outcomes were assessed, reflecting registrants' self-reported physical and mental health, psychological distress, and loneliness...
October 19, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27761576/evaluation-of-inertial-measurement-units-as-a-novel-method-for-kinematic-gait-evaluation-in-dogs
#13
Felix M Duerr, Alexandra Pauls, Chris Kawcak, Kevin Haussler, Gina Bertocci, Valerie Moorman, Melissa King
OBJECTIVE: To evaluate the use of inertial measurement units (IMU) for quantification of canine limb kinematics. METHODS: Sixteen clinically healthy, medium-sized dogs were enrolled. Baseline kinematic data were acquired using an optical motion capture system. Following this baseline data acquisition, a harness system was used for attachment of IMU to the animals. Optical kinematic data of dogs with and without the harness were compared to evaluate the influence of the harness on gait parameters...
October 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27754985/martin-black-award-for-the-best-paper-published-in-2015
#14
Randall Moorman, Maggie Simmons
No abstract text is available yet for this article.
October 18, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27753084/decline-of-mir-124-in-myeloid-cells-promotes-regulatory-t-cell-development-in-hepatitis-c-virus-infection
#15
Jun P Ren, Lin Wang, Juan Zhao, Ling Wang, Shun B Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao
Myeloid-derived suppressor cells (MDSCs) and microRNAs (miRNAs) contribute to attenuating immune responses during chronic viral infection; however, the precise mechanisms underlying their suppressive activities remain incompletely understood. We have recently shown marked expansion of MDSCs that promote regulatory T (Treg) cell development in patients with chronic hepatitis C virus (HCV) infection. Here we further investigated whether the HCV-induced expansion of MDSCs and Treg cells is regulated by an miRNA-mediated mechanism...
October 18, 2016: Immunology
https://www.readbyqxmd.com/read/27727481/dietary-inflammatory-index-and-risk-of-epithelial-ovarian-cancer-in-african-american-women
#16
Lauren C Peres, Elisa V Bandera, Bo Qin, Kristin A Guertin, Nitin Shivappa, James R Hebert, Sarah E Abbott, Anthony J Alberg, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Ann G Schwartz, Paul D Terry, Fabian Camacho, Frances Wang, Joellen M Schildkraut
Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory index (DII), a novel literature-derived tool to assess the inflammatory potential of one's diet, and EOC risk in African American (AA) women in the African American Cancer Epidemiology Study, the largest population-based case-control study of EOC in AA women to date...
October 11, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27708750/classification-and-substrate-head-group-specificity-of-membrane-fatty-acid-desaturases
#17
Dongdi Li, Ruth Moorman, Thomas Vanhercke, James Petrie, Surinder Singh, Colin J Jackson
Membrane fatty acid desaturases are a diverse superfamily of enzymes that catalyze the introduction of double bonds into fatty acids. They are essential in a range of metabolic processes, such as the production of omega-3 fatty acids. However, our structure-function understanding of this superfamily is still developing and their range of activities and substrate specificities are broad, and often overlapping, which has made their systematic characterization challenging. A central issue with characterizing these proteins has been the lack of a structural model, which has been overcome with the recent publication of the crystal structures of two mammalian fatty acid desaturases...
2016: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/27694927/a-genome-wide-association-study-identifies-risk-loci-for-childhood-acute-lymphoblastic-leukemia-at-10q26-13-and-12q23-1
#18
J Vijayakrishnan, R Kumar, M Y R Henrion, A V Moorman, P S Rachakonda, I Hosen, M I da Silva Filho, A Holroyd, S E Dobbins, R Koehler, H Thomsen, J A Irving, J M Allan, T Lightfoot, E Roman, S E Kinsey, E Sheridan, P D Thompson, P Hoffmann, M M Nöthen, S Heilmann-Heimbach, J Karl-Heinz, M Greaves, C J Harrison, C R Bartram, M Schrappe, M Stanulla, K Hemminki, R S Houlston
Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWAS with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases and 7224 controls). After genotyping an additional 2525 cases and 3575 controls we identify new susceptibility loci for BCP-ALL mapping to 10q26...
October 3, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27640985/distribution-of-disease-phase-treatment-prescription-and-severe-liver-disease-among-1598-patients-with-chronic-hepatitis-b-in-the-chronic-hepatitis-cohort-study-2006-2013
#19
P R Spradling, J Xing, L B Rupp, A C Moorman, S C Gordon, E T Teshale, M Lu, J A Boscarino, M A Schmidt, C M Trinacty, S D Holmberg
BACKGROUND: Limited information exists regarding the distribution of disease phases, treatment prescription and severe liver disease among patients with chronic hepatitis B (CHB) in US general healthcare settings. AIM: To determine the distribution of disease phases, treatment prescription and severe liver disease among patients with CHB in general US healthcare settings. METHODS: We analysed demographic and clinical data collected during 2006-2013 from patients with confirmed CHB in the Chronic Hepatitis Cohort Study, an observational cohort study involving patients from healthcare organisations in Michigan, Pennsylvania, Oregon and Hawaii...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27632371/dairy-calcium-vitamin-d-and-ovarian-cancer-risk-in-african-american-women
#20
Bo Qin, Patricia G Moorman, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Paul Terry, Joellen M Schildkraut, Elisa V Bandera
BACKGROUND: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. METHODS: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US...
September 15, 2016: British Journal of Cancer
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