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https://www.readbyqxmd.com/read/29767628/heart-rate-differences-between-symptomatic-and-asymptomatic-brugada-syndrome-patients-at-night
#1
Mireia Calvo, Virginie Le Rolle, Daniel Romero, Nathalie Behar, Pedro Gomis, Philippe Mabo, Alfredo Hernandez
Ventricular arrhythmias in Brugada syndrome (BS) mainly occur at rest, especially during nighttime, suggesting that parasympathetic activity at night may play an important role in the arrhythmogenesis of the disease. This study examined and compared the autonomic function of symptomatic and asymptomatic BS patients overnight.
 Approach: We analyzed different heart rate variability (HRV) and heart rate complexity (HRC) markers in a clinical series including 87 BS patients, where 23 were symptomatic.
 Main results: Statistically significant differences were found in MIRR, SDNN, SDANN, δSDANN and SampEn, suggesting that symptomatic patients may be related to lower heart rate variability and complexity values, as well as to greater circadian fluctuations overnight...
May 16, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29751567/the-gender-impact-on-morphogenetic-variability-in-coronary-artery-disease-a-preliminary-study
#2
Radmila Karan, Biljana Obrenovic-Kircanski, Suzana Cvjeticanin, Natasa Kovacevic-Kostic, Milos Velinovic, Vladimir Milicevic, Milica Vranes-Stoimirov, Dejan Nikolic
We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2...
May 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29703576/neonatal-intensive-care-unit-length-of-stay-reduction-by-heart-rate-characteristics-monitoring
#3
Jonathan R Swanson, William E King, Robert A Sinkin, Douglas E Lake, Waldemar A Carlo, Robert L Schelonka, Peter J Porcelli, Christina T Navarrete, Eduardo Bancalari, Judy L Aschner, Jose A Perez, T Michael O'Shea, M Whit Walker
OBJECTIVE: To examine the effect of heart rate characteristics (HRC) monitoring on length of stay among very low birth weight (VLBW; <1500 g birth weight) neonates in the HeRO randomized controlled trial (RCT). STUDY DESIGN: We performed a retrospective analysis of length of stay metrics among 3 subpopulations (all patients, all survivors, and survivors with positive blood or urine cultures) enrolled in a multicenter, RCT of HRC monitoring. RESULTS: Among all patients in the RCT, infants randomized to receive HRC monitoring were more likely than controls to be discharged alive and prior to day 120 (83...
April 24, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29605703/variability-in-the-time-to-initiation-of-cpr-in-continuously-monitored-pediatric-icus
#4
M Olson, E Helfenbein, L Su, M Berg, L Knight, L Troy, L Sacks, D Sakai, F Su
AIM: To study the influence of patient characteristics and unit ergonomics and human factors on the time to initiation of CPR. METHODS: A single center study of children, 0 to 21 years old, admitted to an ICU who experienced cardiopulmonary arrest (CPA) requiring >1 minute of chest compressions. Time of CPA was determined by analysis of continuous ECG, plethysmography, arterial blood pressure, and end-tidal CO2 (EtCO2 ) waveforms. Initiation of CPR was identified by the onset of cyclic artifact in the ECG waveform...
March 29, 2018: Resuscitation
https://www.readbyqxmd.com/read/29581887/improving-imputation-in-disease-relevant-regions-lessons-from-cystic-fibrosis
#5
Naim Panjwani, Bowei Xiao, Lizhen Xu, Jiafen Gong, Katherine Keenan, Fan Lin, Gengming He, Zeynep Baskurt, Sangook Kim, Lin Zhang, Mohsen Esmaeili, Scott Blackman, Stephen W Scherer, Harriet Corvol, Mitchell Drumm, Michael Knowles, Garry Cutting, Johanna M Rommens, Lei Sun, Lisa J Strug
Does genotype imputation with public reference panels identify variants contributing to disease? Genotype imputation using the 1000 Genomes Project (1KG; 2504 individuals) displayed poor coverage at the causal cystic fibrosis (CF) transmembrane conductance regulator ( CFTR ) locus for the International CF Gene Modifier Consortium. Imputation with the larger Haplotype Reference Consortium (HRC; 32,470 individuals) displayed improved coverage but low sensitivity of variants clinically relevant for CF. A hybrid reference that combined whole genome sequencing (WGS) from 101 CF individuals with the 1KG imputed a greater number of single-nucleotide variants (SNVs) that would be analyzed in a genetic association study ( r 2  ≥ 0...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29460790/protein-and-micronutrient-deficiencies-in-patients-with-radiation-cystitis-and-outcome-after-hyperbaric-oxygen-therapy
#6
Valérie Platzer, Guillaume Perez, Anne Galinier, Michèle Genestal, Béatrice Riu-Poulenc, Leslie Gonzalez, Eric Huyghe, Sylvie Caspar-Bauguil
BACKGROUND & AIMS: Haemorrhagic radiation cystitis (HRC) is a late complication of pelvic radiotherapy. Severe cases are difficult to treat due to persistent or recurrent bleeding, despite urological and hyperbaric oxygen therapy (HBOT). However, wound healing requires a good nutritional status. In this respect, we aimed at analysing the nutritional status of patients with HRC prior to the onset of HBOT and at highlighting predictive nutritional factors of outcome. METHODS: Data were retrospectively collected from a cohort of 179 patients with HRC (between 2011 and 2015)...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29459627/understanding-the-functional-role-of-genistein-in-the-bone-differentiation-in-mouse-osteoblastic-cell-line-mc3t3-e1-by-rna-seq-analysis
#7
Myungsuk Kim, Jisun Lim, Jung-Hee Lee, Kyung-Mi Lee, Suji Kim, Kye Won Park, Chu Won Nho, Yoon Shin Cho
Genistein, a phyto-estrogen, can potentially replace endogenous estrogens in postmenopausal women, but the underlying molecular mechanisms remain incompletely understood. To obtain insight into the effect of genistein on bone differentiation, RNA sequencing (RNA-seq) analysis was used to detect differentially expressed genes (DEGs) in genistein-treated vs. untreated MC3T3-E1 mouse osteoblastic cells. Osteoblastic cell differentiation was monitored by measuring osteoblast differentiation factors (ALP production, bone mineralization, and expression of osteoblast differentiation markers)...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420036/light-induced-electron-spin-polarized-esp-epr-signal-of-the-p800-menaquinone-radical-pair-state-in-oriented-membranes-of-heliobacterium-modesticaldum-role-location-of-menaquinone-in-the-homodimeric-type-i-reaction-center
#8
Toru Kondo, Masahiro Matsuoka, Chihiro Azai, Masami Kobayashi, Shigeru Itoh, Hirozo Oh-Oka
Function/location of menaquinone (MQ) was studied in the photosynthetic reaction center of Heliobacterium (Hbt.) modesticaldum (hRC), which is one of the most primitive homodimeric type I RCs. The spin-polarized electron paramagnetic resonance signals of light-induced radical pair species, which are made of oxidized electron donor bacteriochlorophyll g (P800+ ) and reduced menaquinone (MQ- ) or iron-sulfur cluster (FX - ), were measured in the oriented membranes of Hbt. modesticaldum at cryogenic temperature...
March 8, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29362236/a-phosphorylation-switch-on-lon-protease-regulates-bacterial-type-iii-secretion-system-in-host
#9
Xiaofeng Zhou, Doron Teper, Maxuel O Andrade, Tong Zhang, Sixue Chen, Wen-Yuan Song, Nian Wang
Most pathogenic bacteria deliver virulence factors into host cytosol through type III secretion systems (T3SS) to perturb host immune responses. The expression of T3SS is often repressed in rich medium but is specifically induced in the host environment. The molecular mechanisms underlying host-specific induction of T3SS expression is not completely understood. Here we demonstrate in Xanthomonas citri that host-induced phosphorylation of the ATP-dependent protease Lon stabilizes HrpG, the master regulator of T3SS, conferring bacterial virulence...
January 23, 2018: MBio
https://www.readbyqxmd.com/read/29353790/remediation-of-chlorinated-ethenes-in-fractured-sandstone-by-natural-and-enhanced-biotic-and-abiotic-processes-a-crushed-rock-microcosm-study
#10
Rong Yu, Richard G Andrachek, Leo G Lehmicke, David L Freedman
Biostimulation was identified as a potential technology to treat a fractured sandstone aquifer contaminated with trichloroethene (TCE) and cis-1,2-dichloroethene (cis-DCE). Most of the mass of TCE and cis-DCE resides within the rock matrix and strategies to restore groundwater to pre-existing conditions are severely limited by back diffusion. A microcosm study using crushed rock and groundwater from the site was performed to assess biostimulation and natural attenuation. Lactate, hydrogen release compound® (HRC), and emulsified vegetable oil (EVO) significantly increased the rate of TCE reduction to cis-DCE...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29286932/dexamethasone-effect-on-heart-rate-variability-in-preterm-infants-on-mechanical-ventilation
#11
Corrie J Alonzo, Karen D Fairchild
BACKGROUND: Dexamethasone is administered to some preterm infants with chronic lung disease to facilitate weaning from mechanical ventilation. Heart rate characteristics (HRC), including heart rate variability (HRV), may be impacted by glucocorticoids and may predict extubation readiness. A commercially available monitor developed for sepsis detection continuously calculates HRV and an HRC index, which are inversely related. OBJECTIVES: Determine the impact of dexamethasone on HRV and the HRC index, in relation to extubation success...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29223338/molecular-cloning-and-expression-analysis-of-aquaporin-genes-in-pearl-millet-pennisetum-glaucum-l-r-br-genotypes-contrasting-in-their-transpiration-response-to-high-vapour-pressure-deficits
#12
Palakolanu Sudhakar Reddy, Murugesan Tharanya, Kaliamoorthy Sivasakthi, Mallayee Srikanth, C Tom Hash, Jana Kholova, Kiran K Sharma, Vincent Vadez
Pearl millet is a crop of the semi-arid tropics having high degree of genetic diversity and variable tolerance to drought stress. To investigate drought tolerance mechanism that possibly accounts for differences in drought tolerance, four recombinant inbred lines from a high resolution cross (HRC) were selected for variability in their transpiration rate (Tr) response to vapour pressure deficit (VPD) conditions. The differential Tr response of the genotypes to increased VPD conditions was used to classify the genotypes as sensitive or insensitive to high VPD...
December 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29212939/the-heptad-repeat-c-domain-of-the-respiratory-syncytial-virus-fusion-protein-plays-a-key-role-in-membrane-fusion
#13
Imogen M Bermingham, Keith J Chappell, Daniel Watterson, Paul R Young
Respiratory syncytial virus (RSV) mediates host cell entry through the fusion (F) protein, which undergoes a conformational change to facilitate the merger of viral and host lipid membrane envelopes. The RSV F protein comprises a trimer of disulfide-bonded F1 and F2 subunits that is present on the virion surface in a metastable prefusion state. This prefusion form is readily triggered to undergo refolding to bring two heptad repeats (heptad repeat A [HRA] and HRB) into close proximity to form a six-helix bundle that stabilizes the postfusion form and provides the free energy required for membrane fusion...
February 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29190776/large-scale-identification-of-human-cerebrovascular-proteins-inter-tissue-and-intracerebral-vascular-protein-diversity
#14
Soo Jung Lee, Soonhyung Kwon, John R Gatti, Ejona Korcari, Ty E Gresser, Princess C Felix, Simon G Keep, Kevin C Pasquale, Tongxu Bai, Sabrina A Blanchett-Anderson, Nancy W Wu, Charissa Obeng-Nyarko, Kossi M Senagbe, Kathy C Young, Snehaa Maripudi, Bharath C Yalavarthi, Dajana Korcari, Andre Y Liu, Benjamin C Schaffler, Richard F Keep, Michael M Wang
The human cerebrovascular system is responsible for regulating demand-dependent perfusion and maintaining the blood-brain barrier (BBB). In addition, defects in the human cerebrovasculature lead to stroke, intracerebral hemorrhage, vascular malformations, and vascular cognitive impairment. The objective of this study was to discover new proteins of the human cerebrovascular system using expression data from the Human Protein Atlas, a large-scale project which allows public access to immunohistochemical analysis of human tissues...
2017: PloS One
https://www.readbyqxmd.com/read/29126132/cost-effective-and-accurate-method-of-measuring-fetal-fraction-using-snp-imputation
#15
Minjeong Kim, Jai-Hoon Kim, Kangseok Kim, Sunshin Kim
Motivation: With the discovery of cell-free fetal DNA in maternal blood, the demand for non-invasive prenatal testing (NIPT) has been increasing. To obtain reliable NIPT results, it is important to accurately estimate the fetal fraction. In this study, we propose an accurate and cost-effective method for measuring fetal fractions using single-nucleotide polymorphisms (SNPs). Results: A total of 84 samples were sequenced via semiconductor sequencing using a 0.3× sequencing coverage...
April 1, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29116318/land-use-land-cover-and-prevalence-of-canine-visceral-leishmaniasis-in-teresina-piau%C3%A3-state-brazil-an-approach-using-orbital-remote-sensing
#16
Anna Barreto Fernandes Figueiredo, Guilherme Loureiro Werneck, Maria do Socorro Pires E Cruz, João Pereira da Silva, Andréa Sobral de Almeida
This study examines the association between land use and land cover and the occurrence of canine visceral leishmaniasis (VL). This is a case-control study in which cases were households with seropositive dogs for canine VL and controls were households with seronegative dogs. We used remote sensing images (CBERS: 2/CCD and 2B/HRC) to describe land use and cover in squares of 625m2 in the study area. Odds of canine VL were twice as high in households located in squares with an area ≤ 25m2 covered by residential structures with little vegetation in comparison to those where the cover reached ≥ 600m2...
November 6, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29102817/low-frequency-fluctuation-of-brain-spontaneous-activity-and-obsessive-compulsive-symptoms-in-a-large-school-age-sample
#17
Marcelo Q Hoexter, Claudinei E Biazoli, Pedro G Alvarenga, Marcelo C Batistuzzo, Giovanni A Salum, Ary Gadelha, Pedro M Pan, Mauricio Anés, Leticia Mancini-Martins, Luciana M Moura, Carles Soriano-Mas, Marco A G Del' Aquilla, Edson Amaro, Luis A Rohde, Andrea P Jackowski, Rodrigo A Bressan, Euripedes C Miguel, Maria C do Rosario, João R Sato
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'...
October 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29098590/identification-and-characterization-of-key-circadian-clock-genes-of-tobacco-hairy-roots-putative-regulatory-role-in-xenobiotic-metabolism
#18
Lucas G Sosa Alderete, Mario E Guido, Elizabeth Agostini, Paloma Mas
The circadian clock is an endogenous system that allows organisms to daily adapt and optimize their physiology and metabolism. We studied the key circadian clock gene (CCG) orthologs in Nicotiana tabacum seedlings and in hairy root cultures (HRC). Putative genes involved in the metabolism of xenobiotic compounds (MXC) were selected and their expression profiles were also analyzed. Seedlings and HRC displayed similar diurnal variations in the expression profiles for the CCG examined under control conditions (CC)...
January 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29029869/determination-of-the-hip-rotation-centre-from-landmarks-in-pelvic-radiograph
#19
Hasan Bombaci, Bestami Simsek, Mehmet Soyarslan, Mustafa Murat Yildirim
OBJECTIVE: The hip rotation centre (HRC) is an important reference point in cases of total hip arthroplasty (THA). The aim of this study is to investigate the reference points in the Turkish population that enable the identification of the HRC in standard pelvic radiographs. METHODS: The pelvic radiographs of 50 women and 50 men were examined. The mean age was 46.2 (range; 18-91). Patients with deformity of the hip joint and non-standard pelvic radiograph due to hip flexion contracture were excluded from the study...
December 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28967577/progressive-surgical-autonomy-observed-in-a-hand-surgery-resident-clinic-model
#20
Kristopher M Day, Evon S Zoog, Chase T Kluemper, Jillian K Scott, Caleb M Steffen, James Woodfin Kennedy, David Marshall Jemison, Jason P Rehm, Mark A Brzezienski
OBJECTIVE: Resident clinics (RCs) are intended to catalyze the achievement of educational milestones through progressively autonomous patient care. However, few studies quantify their effect on competency-based surgical education, and no previous publications focus on hand surgery RCs (HRCs). We demonstrate the achievement of progressive surgical autonomy in an HRC model. DESIGN: A retrospective review of all patients seen in a weekly half-day HRC from October 2010 to October 2015 was conducted...
September 26, 2017: Journal of Surgical Education
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