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https://www.readbyqxmd.com/read/28198457/identification-of-a-novel-type-iii-secretion-associated-outer-membrane-bound-protein-from-xanthomonas-campestris-pv-campestris
#1
Lei Li, Rui-Fang Li, Zhen-Hua Ming, Guang-Tao Lu, Ji-Liang Tang
Many bacterial pathogens employ the type III secretion system (T3SS) to translocate effector proteins into eukaryotic cells to overcome host defenses. To date, most of our knowledge about the T3SS molecular architecture comes from the studies on animal pathogens. In plant pathogens, nine Hrc proteins are believed to be structural components of the T3SS, of which HrcC and HrcJ form the outer and inner rings of the T3SS, respectively. Here, we demonstrated that a novel outer membrane-bound protein (HpaM) of Xanthomonas campestris pv...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28134132/heart-rate-complexity-analysis-in-brugada-syndrome-during-physical-stress-testing
#2
M Calvo, P Gomis, D Romero, V Le Rolle, N Béhar, P Mabo, A Hernández
Symptoms such as ventricular arrhythmias in Brugada syndrome (BS) typically occur at rest, especially during sleep, suggesting that the autonomic nervous system (ANS) function may be relevant in the arrhythmogenesis of the disease. The aim of this work was to assess the ANS response captured by nonlinear heart rate variability (HRV) measures in 69 patients diagnosed with BS, who underwent a standardized physical stress test. Heart rate complexity (HRC) was evaluated by the power-law scaling analysis (β slope) during rest, exercise, recovery and rest post-recovery, in order to discriminate between symptomatic and asymptomatic BS patients...
February 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28108841/increased-incidence-of-post-term-delivery-and-cesarean-section-after-frozen-thawed-embryo-transfer-during-a-hormone-replacement-cycle
#3
Kazuki Saito, Kenji Miyado, Kenji Yamatoya, Akira Kuwahara, Eisuke Inoue, Mami Miyado, Maki Fukami, Tomonori Ishikawa, Takakazu Saito, Toshiro Kubota, Hidekazu Saito
PURPOSE: This study aimed to clarify the risks of adverse pregnancy outcomes in patients who conceive singletons after frozen embryo transfer (FET) during a hormone replacement cycle and their offspring. METHODS: A retrospective cohort study was conducted in patients who conceived after FET, based on the Japanese-assisted reproductive technology registry for 2013. The perinatal outcomes in cases with live-born singletons achieved through natural ovulatory cycle FET (NC-FET) (n = 6287) or hormone replacement cycle FET (HRC-FET) (n = 10,235) were compared...
January 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28051295/long-term-immobilization-of-technetium-via-bioremediation-with-slow-release-substrates
#4
Laura Newsome, Adrian Cleary, Katherine Morris, Jonathan R Lloyd
Radionuclides are present in groundwater at contaminated nuclear facilities with technetium-99, one of the most mobile radionuclides encountered. In situ bioremediation via the generation of microbially reducing conditions has the potential to remove aqueous and mobile Tc(VII) from groundwater as insoluble Tc(IV). However, questions remain regarding the optimal methods of biostimulation and the stability of reduced Tc(IV) phases under oxic conditions. Here, we selected a range of slow-release electron donor/chemical reduction based substrates available for contaminated land treatment, and assessed their potential to stimulate the formation of recalcitrant Tc(IV) biominerals under conditions relevant to radioactively contaminated land...
January 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27991471/cigarette-and-snus-modified-association-between-unprotected-exposure-to-noise-from-hunting-rifle-caliber-weapons-and-high-frequency-hearing-loss-a-cross-sectional-study-among-swedish-hunters
#5
Louise Honeth, Peter Ström, Alexander Ploner, Dan Bagger-Sjöbäck, Ulf Rosenhall, Olof Nyrén
AIM: To investigate in this cross-sectional study among Swedish hunters if tobacco use modifies the previously observed association, expressed as prevalence ratio (PR), between unprotected exposure to impulse noise from hunting rifle caliber (HRC) weapons and high-frequency hearing impairment (HFHI). SETTINGS AND DESIGN: A nationwide cross-sectional epidemiologic study was conducted among Swedish sport hunters in 2012. MATERIALS AND METHODS: The study was Internet-based and consisted of a questionnaire and an Internet-based audiometry test...
November 2016: Noise & Health
https://www.readbyqxmd.com/read/27881436/knockdown-of-histidine-rich-calcium-binding-protein-hrc-suppresses-liver-fibrosis-by-inhibiting-the-activation-of-hepatic-stellate-cells
#6
Jingmei Liu, Mengke Li, Jin Gong, Ping Han, Yunwu Wang, Dongxiao Li, Dean Tian, Jiazhi Liao
The histidine-rich calcium-binding protein (HRC) is a regulator of Ca(2+) homeostasis and it plays a significant role in hepatocellular carcinoma (HCC) progression. However, the relationship between HRC and liver fibrogenesis is still unknown. Our data demonstrates that HRC was upregulated in fibrotic liver and activated hepatic stellate cells (HSCs). TGF-β treatment increased α-SMA and HRC expression dose-dependently in HSCs. Repression of HRC reduced α-SMA, CTGF and collagen expression, and inhibited HSC proliferation and migration...
January 15, 2017: Biology Open
https://www.readbyqxmd.com/read/27864825/individual-hippocampal-subfield-assessment-indicates-that-matrix-macromolecules-and-gliosis-are-key-elements-for-the-increased-t2-relaxation-time-seen-in-temporal-lobe-epilepsy
#7
Jose Eduardo Peixoto-Santos, Ludmyla Kandratavicius, Tonicarlo Rodrigues Velasco, Joao Alberto Assirati, Carlos Gilberto Carlotti, Renata Caldo Scandiuzzi, Carlos Ernesto Garrido Salmon, Antonio Carlos Dos Santos, Joao Pereira Leite
OBJECTIVE: Increased T2 relaxation time is often seen in temporal lobe epilepsy (TLE) with hippocampal sclerosis. Water content directly affects the effective T2 in a voxel. Our aim was to evaluate the relation between T2 values and two molecules associated with brain water homeostasis aquaporin 4 (AQP4) and chondroitin sulfate proteoglycan (CSPG), as well as cellular populations in the hippocampal region of patients with TLE. METHODS: Hippocampal T2 imaging and diffusion tensor imaging (DTI) were obtained from 42 drug-resistant patients with TLE and 20 healthy volunteers (radiologic controls, RCs)...
January 2017: Epilepsia
https://www.readbyqxmd.com/read/27843793/evaluation-of-performance-of-the-medical-research-department-in-research-naive-non-academic-hospital-an-audit
#8
Mukta Sunil Kuyare, Parag Vijayrao Sarve, Komal S Dalal, Raakhi K Tripathi
INTRODUCTION: Conducting medical research is not limited to academia and pharmaceutical industry but even multispeciality hospitals need to venture in this area along with patient care. To develop research culture among well-established non-acedemic hospital is always difficult and challenging task. This article attempts to evaluate the performance of the department in 'Research naïve' hospital in the last two years and review the strengths and challenges it faced at each step. METHODS: This was a retrospective document analysis study evaluating the steps towards setting and sustaining of Medical Research Department of Bhaktivedanta Hospital during the period of January 2013 to June 2015 (30 Months)...
October 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27793461/-clinical-processes-in-a-high-resolution-clinic-of-specialist-outpatient-clinics
#9
J L Zambrana-García, M Torres-Jiménez, J M Rubio-Sánchez, A Montijano-Cabrera, J A Peña-Ojeda, M J Velasco-Malagón
OBJECTIVES: The high resolution clinic (HRC) is an outpatient care process by which treatment and diagnosis are established, recorded, and completed in a single day. The aim of this study was to assess the extent to which patients with medical conditions may benefit from a single consultation system. MATERIAL AND METHODS: A descriptive study of 795 first visit events, randomly selected as high-resolution consultations in cardiology, gastroenterology, internal medicine, and chest diseases...
October 25, 2016: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/27772772/cortical-and-spinal-excitability-in-patients-with-multiple-sclerosis-and-spasticity-after-oromucosal-cannabinoid-spray
#10
Giovanna Squintani, Francesco Donato, Mara Turri, Luciano Deotto, Francesco Teatini, Giuseppe Moretto, Roberto Erro
BACKGROUND: Delta-9-tetrahydrocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex®) has been recently approved for the management of treatment-resistant multiple sclerosis (MS) spasticity. Although the symptomatic relief of Sativex® on MS-spasticity has been consistently demonstrated, the pathogenetic implications remain unclear and the few electrophysiological studies performed to address this topic yielded controversial results. We therefore aimed to investigate the mechanisms underpinning the modulation of spastic hypertonia by Sativex®, at both central and spinal levels, through an extensive neurophysiological battery in patients with MS...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27707895/streptococcal-group-b-integrative-and-mobilizable-element-imesag-rpsi-encodes-a-functional-relaxase-involved-in-its-transfer
#11
Fabian Lorenzo-Diaz, Cris Fernández-Lopez, Pierre-Emmanuel Douarre, Adrian Baez-Ortega, Carlos Flores, Philippe Glaser, Manuel Espinosa
Streptococcus agalactiae or Group B Streptococcus (GBS) are opportunistic bacteria that can cause lethal sepsis in children and immuno-compromised patients. Their genome is a reservoir of mobile genetic elements that can be horizontally transferred. Among them, integrative and conjugative elements (ICEs) and the smaller integrative and mobilizable elements (IMEs) primarily reside in the bacterial chromosome, yet have the ability to be transferred between cells by conjugation. ICEs and IMEs are therefore a source of genetic variability that participates in the spread of antibiotic resistance...
October 2016: Open Biology
https://www.readbyqxmd.com/read/27702817/ovarian-cancers-harbour-defects-in-non-homologous-end-joining-resulting-in-resistance-to-rucaparib
#12
Aiste McCormick, Peter Donoghue, Michelle Dixon, Richard O'Sullivan, Rachel Louise O'Donnell, James Murray, Angelika Kaufmann, Nicola J Curtin, Richard J Edmondson
PURPOSE: DNA damage defects are common in ovarian cancer and can be used to stratify treatment. Although most work has focussed on Homologous Recombination (HR), DNA double strand breaks are repaired primarily by non-homologous end joining (NHEJ). Defects in NHEJ have been shown to contribute to genomic instability and have been associated with the development of chemoresistance. EXPERIMENTAL DESIGN: NHEJ was assessed in a panel of ovarian cancer cell lines and 47 primary ascitic derived ovarian cancer cultures, by measuring the ability of cell extracts to end-join linearized plasmid monomers into multimers...
October 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27694958/reference-based-phasing-using-the-haplotype-reference-consortium-panel
#13
Po-Ru Loh, Petr Danecek, Pier Francesco Palamara, Christian Fuchsberger, Yakir A Reshef, Hilary K Finucane, Sebastian Schoenherr, Lukas Forer, Shane McCarthy, Goncalo R Abecasis, Richard Durbin, Alkes L Price
Haplotype phasing is a fundamental problem in medical and population genetics. Phasing is generally performed via statistical phasing in a genotyped cohort, an approach that can yield high accuracy in very large cohorts but attains lower accuracy in smaller cohorts. Here we instead explore the paradigm of reference-based phasing. We introduce a new phasing algorithm, Eagle2, that attains high accuracy across a broad range of cohort sizes by efficiently leveraging information from large external reference panels (such as the Haplotype Reference Consortium; HRC) using a new data structure based on the positional Burrows-Wheeler transform...
November 2016: Nature Genetics
https://www.readbyqxmd.com/read/27534120/influence-of-different-carbohydrates-on-flavonoid-accumulation-in-hairy-root-cultures-of-scutellaria-baicalensis
#14
COMPARATIVE STUDY
Chang Ha Park, Young Seon Kim, Xiaohua Li, Haeng Hoon Kim, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Sook Young Lee, Sang Un Park
Carbohydrate sources play important roles in energy and growth of plants. Therefore, in this study, we investigated the optimal carbohydrate source in hairy root cultures (HRCs) of Scutellaria baicalensis infected with Agrobacterium rhizogenes strain R1000. The hairy roots were cultured in half-strength B5 liquid medium supplemented with seven different carbohydrates sources (sucrose, fructose, glucose, galactose, sorbitol, mannitol and maltose), each at a concentration of 100 mM, in order to identify the best carbon sources for the production of major flavones, such as wogonin, baicalin and baicalein...
June 2016: Natural Product Communications
https://www.readbyqxmd.com/read/27465634/acute-physiological-and-performance-responses-to-high-intensity-resistance-circuit-training-in-hypoxic-and-normoxic-conditions
#15
Domingo J Ramos-Campo, Jacobo A Rubio-Arias, Tomás Freitas, Arturo Camacho, José Fernando Jiménez-Diaz, Pedro E Alcaraz
The aim of this study was to analyze physical performance and physiological variables during High-Intensity Resistance Circuit Training (HRC) with the addition of two levels (moderate and high) of systemic hypoxia. Twelve resistance-trained young male subjects participated in the study. After a 6RM testing session, participants performed three randomized trials of HRC: normoxia (NORM: FiO2=0.21; ∼0 m altitude), moderate hypoxia (MH: FiO2=0.16; ∼2.100 m altitude) or high hypoxia (HH: FiO2=0.13; ∼3.800 m altitude), as controlled by a hypoxic generator...
July 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27459614/-late-myelotoxicity-of-high-dose-chemotherapy-according-to-the-modified-nhl-bfm-90-program-in-adult-patients-with-diffuse-large-b-cell-lymphoma
#16
E I Dorokhina, A U Magomedova, V N Dvirnyk, I V Gal'tseva, S A Glinkina, S M Kulikov, T N Obukhova, S K Kravchenko
AIM: to evaluate late myelotoxicity (MT) relate to high-dose chemotherapy (CT) according to the modified NHL-BFM-90 (mNHL-BFM-90) program in adult patients with diffuse large B-cell lymphoma (DLBCL). SUBJECTS AND METHODS: The results of a complex clinical, laboratory, and instrumental examination, including cytologic, histologic, and routine cytogenetic studies of the bone marrow (BM), were analyzed in 40 DLBCL patients treated according to the mNHL-BFM-90 program in the National Research Center for Hematology (NRCH), Ministry of Health of the Russian Federation (MHRF), in 2002 to 2009; among them, there were 20 men and 20 women (median age, 57 years)...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27113378/early-heart-rate-characteristics-predict-death-and-morbidities-in%C3%A2-preterm%C3%A2-infants
#17
Brynne A Sullivan, Christina McClure, Jamie Hicks, Douglas E Lake, J Randall Moorman, Karen D Fairchild
OBJECTIVES: To determine whether an early heart rate characteristics (HRC) index (HeRO score), measured in the first day and week after birth predicts death and morbidities compared with established illness severity scores. STUDY DESIGN: For all very low birth weight infants in a single neonatal intensive care unit from 2004-2014, the average first day HRC index was calculated within 24 hours of birth (aHRC-24h) and the average first week HRC index within 7 days of birth (aHRC-7d)...
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27101081/orientations-of-iron-sulfur-clusters-fa-and-fb-in-the-homodimeric-type-i-photosynthetic-reaction-center-of-heliobacterium-modesticaldum
#18
Toru Kondo, Masahiro Matsuoka, Chihiro Azai, Shigeru Itoh, Hirozo Oh-Oka
Orientations of the FA and FB iron-sulfur (FeS) clusters in a structure-unknown type-I homodimeric heriobacterial reaction center (hRC) were studied in oriented membranes of the thermophilic anaerobic photosynthetic bacterium Heliobacterium modesticaldum by electron paramagnetic resonance (EPR), and compared with those in heterodimeric photosystem I (PS I). The Rieske-type FeS center in the cytochrome b/c complex showed a well-oriented EPR signal. Illumination at 14 K induced an FB(-) signal with g-axes of gz = 2...
May 12, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27096933/hematopoietic-stem-cell-activity-is-regulated-by-pten-phosphorylation-through-a-niche-dependent-mechanism
#19
Jing Li, Jun Zhang, Minghui Tang, Junping Xin, Yan Xu, Andrew Volk, Caiqin Hao, Chenglong Hu, Jiewen Sun, Wei Wei, Quichan Cao, Peter Breslin, Jiwang Zhang
The phosphorylated form of Pten (p-Pten) is highly expressed in >70% of acute myeloid leukemia samples. However, the role of p-Pten in normal and abnormal hematopoiesis has not been studied. We found that Pten protein levels are comparable among long-term (LT) hematopoietic stem cells (HSCs), short-term (ST) HSCs, and multipotent progenitors (MPPs); however, the levels of p-Pten are elevated during the HSC-to-MPP transition. To study whether p-Pten is involved in regulating self-renewal and differentiation in HSCs, we compared the effects of overexpression of p-Pten and nonphosphorylated Pten (non-p-Pten) on the hematopoietic reconstitutive capacity (HRC) of HSCs...
August 2016: Stem Cells
https://www.readbyqxmd.com/read/26982550/differences-in-false-recollection-according-to-the-cognitive-reserve-of-healthy-older-people
#20
Alfonso Pitarque, Juan Meléndez, Alicia Sales, Teresa Mayordomo, Joaquín Escudero, Salvador Algarabel
We present an associative recognition experiment comparing three samples of healthy people (young people, older people with high cognitive reserve [HCR], and older people with low cognitive reserve [LCR], with each sample consisting of 40 people), manipulating stimuli repetition during the study phase. The results show significant differences among the three samples in their overall performance. However, these differences are not due to a different use of familiarity, but rather due to a different way of using recollection: although there are no differences in the hit rates between the HRC and LRC samples, the LCR group makes significantly more recollective false alarms than the HCR group...
September 2016: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
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