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https://www.readbyqxmd.com/read/29161235/influence-of-ductus-arteriosus-on-peripheral-muscle-oxygenation-and-perfusion-in-neonates
#1
Lukas Peter Mileder, Tessa Mueller, Nariae Baik-Schneditz, Jasmin Pansy, Bernhard Schwaberger, Corinna Binder-Heschl, Berndt Urlesberger, Gerhard Pichler
In neonates, a patent ductus arteriosus (DA) may be associated with severe complications. We used near-infrared spectroscopy (NIRS) with venous occlusion to investigate the influence of an open DA on peripheral muscle oxygenation/perfusion in preterm neonates. Approach: We analyzed secondary outcome parameters collected as part of prospective observational studies. NIRS measurements were performed between the first and third day of life. Arterial oxygen saturation (SaO2) and heart rate (HR) were monitored by pulse oximetry on the ipsilateral foot...
November 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29160043/influence-of-probe-pressure-on-diffuse-reflectance-spectra-of-human-skin-measured-in-vivo
#2
Alexey P Popov, Alexander V Bykov, Igor V Meglinski
Mechanical pressure superficially applied on the human skin surface by a fiber-optic probe influences the spatial distribution of blood within the cutaneous tissues. Upon gradual load of weight on the probe, a stepwise increase in the skin reflectance spectra is observed. The decrease in the load follows the similar inverse staircase-like tendency. The observed stepwise reflectance spectra changes are due to, respectively, sequential extrusion of blood from the topical cutaneous vascular beds and their filling afterward...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29159859/identifiability-in-n-mixture-models-a-large-scale-screening-test-with-bird-data
#3
Marc Kéry
Binomial N-mixture models have proven very useful in ecology, conservation and monitoring: they allow estimation and modeling of abundance separately from detection probability using simple counts. Recently, doubts about parameter identifiability have been voiced. I conducted a large-scale screening test with 137 bird data sets from 2,037 sites. I found virtually no identifiability problems for Poisson and zero-inflated Poisson (ZIP) binomial N-mixture models, but negative-binomial (NB) models had problems in 25% of all data sets...
November 21, 2017: Ecology
https://www.readbyqxmd.com/read/29159277/development-of-a-porcine-model-for-assessment-of-mucosal-repair-following-endoscopic-resection-of-the-lower-gastrointestinal-tract
#4
Nicolas Etchepare, Jérémy Bregeon, Lucille Quénéhervé, Sami Haddara, Yann Touchefeu, Michel Neunlist, Emmanuel Coron
Background and aims:  Endoscopic mucosal resection (EMR) is widely performed for the treatment of colorectal polyps. However, the pathophysiological mechanisms of mucosal repair, including in situations at high risk of post-polypectomy bleeding, remain largely unknown. The objective of our study was to develop a porcine model of EMR in the lower gastrointestinal tract to monitor mucosal wound healing over time. Methods:  Under general anesthesia, five large wounds were created in the lower gastrointestinal tract at different times, i...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29159200/analyzing-the-genotoxicity-of-retroviral-vectors-in-hematopoietic-cell-gene-therapy
#5
REVIEW
Luca Biasco, Michael Rothe, Hildegard Büning, Axel Schambach
Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found their way into the clinical arena and demonstrated remarkable efficacy for the treatment of immunodeficiencies, leukodystrophies, and globinopathies. Despite these successes, gene therapy unfortunately also has had to face severe adverse events in the form of leukemias and myelodysplastic syndromes, related to the semi-random vector integration into the host cell genome that caused deregulation of neighboring proto-oncogenes...
March 16, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29158568/arc-induced-long-period-gratings-in-standard-and-speciality-optical-fibers-under-mixed-neutron-gamma-irradiation
#6
Andrei Stancălie, Flavio Esposito, Rajeev Ranjan, Petrişor Bleotu, Stefania Campopiano, Agostino Iadicicco, Dan Sporea
In this paper, for the first time, the effects of mixed neutron and gamma flux on the spectral and sensing responses of Long Period Gratings (LPGs) are thoroughly analyzed. Six LPGs written by means of Electric Arc Discharge (EAD) technique in standard and speciality fibers, including radiation-hardened ones, were tested. The EAD technique was chosen because it enables the writing of gratings both in standard and not photosensitive fibers. The experiments have been carried out in a "TRIGA" pulsed nuclear reactor and the LPGs were irradiated by a gamma-ray dose-rate of 9 Gy/s and a mean 1...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158146/monitoring-and-predicting-disease-activity-in-autoimmune-pancreatitis-with-the-m-annheim-aip-activity-score
#7
Michael Hirth, Miroslav Vujasinovic, Markus Münch, Christel Weiss, Matthias Löhr, Matthias P Ebert, Alexander Schneider
BACKGROUND & OBJECTIVES: Autoimmune pancreatitis (AiP) is treated by immunosuppressive therapy. Exact description of disease activity of AiP is essential in clinical practice and research, but a score to describe the disease activity is missing. Thus, we aimed to establish an activity score of AiP. METHODS: We retrospectively studied long-term disease courses of 29 patients with AiP (Mannheim, Germany), receiving corticosteroid treatment (CST) by analyzing 613 treatment appointments...
October 25, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29157824/fraxetin-and-ethyl-acetate-extract-from-lawsonia-inermis-l-ameliorate-oxidative-stress-in-p-berghei-infected-mice-by-augmenting-antioxidant-defence-system
#8
Dhananjay Kumar Singh, Harveer Singh Cheema, Archana Saxena, Jyotshana, Shilpi Singh, Mahendra P Darokar, Dnyaneshwar U Bawankule, Karuna Shanker, Suaib Luqman
BACKGROUND: Lawsonia inermis L. is a well-documented plant for cosmetic as well as medicinal properties. It is used by local communities in India and Nigeria for the treatment of many parasitic diseases, including malaria. HYPOTHESIS/PURPOSE: Earlier studies on the plant's antiplasmodial activity were not assigned to any phytochemical with no quality assurance data. In this report, a recent chemically characterized extract and it's major constituent were investigated for in vitro antiplasmodial activity on chloroquine sensitive NF-54 strain...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157580/obstructive-sleep-apnea-and-diet-controlled-gestational-diabetes
#9
Ekasitt Wanitcharoenkul, Naricha Chirakalwasan, Somvang Amnakkittikul, Suranut Charoensri, Sunee Saetung, Suwannee Chanprasertyothin, La-Or Chailurkit, Panyu Panburana, Sommart Bumrungphuet, Boonsong Ongphiphadhanakul, Sirimon Reutrakul
BACKGROUND: Obstructive sleep apnea (OSA) was shown to be associated with gestational diabetes mellitus (GDM). However, prevalence of OSA in GDM women, its relationship to metabolic control, and predictive factors have not been studied. MATERIAL AND METHODS: Eighty-two obese pregnant women with diet-controlled GDM between 24 and 34 weeks of gestation participated. The Berlin questionnaire was used to assess OSA symptoms. OSA was diagnosed using an overnight monitor...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29157447/the-usefulness-and-actual-use-of-wearable-devices-among-the-elderly-population
#10
Shwetambara Kekade, Chung-Ho Hseieh, Md Mohaimenul Islam, Suleman Atique, Abdulwahed Mohammed Khalfan, Yu-Chuan Li, Shabbir Syed Abdul
BACKGROUND AND OBJECTIVE: Elderly populations are more prone to diseases and need continuous monitoring of parameters to ensure good health. Wearable devices (WDs) can be helpful in the early detection and management of medical conditions. However, less is known about the use of currently available WDs among elderly populations. The objectives of this study were to determine the usefulness and actual use of wearable devices among the elderly population. METHODS: Our methodology was based on a systematic review and a survey questionnaire...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157368/livestock-as-sentinels-for-an-infectious-disease-in-a-sympatric-or-adjacent-living-wildlife-reservoir-host
#11
D P Anderson, A M Gormley, M Bosson, P G Livingstone, G Nugent
A central question to address in managing wildlife diseases is how much effort and resources are required to reduce infection prevalence to below a requisite threshold? This requires surveillance for infection in at least one species involved in the infection cycle, a process that is often expensive and time-consuming but one which could be enhanced using additional sources of readily-obtainable surveillance data. We demonstrate how surveillance data from ruminant livestock monitored for bovine tuberculosis (bTB) in New Zealand can be employed in spatially-explicit modelling to help predict the probability of freedom from Mycobacterium bovis infection in a sympatric wildlife reservoir species, the brushtail possum (Trichosurus vulpecula)...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29157051/cerebral-nirs-patterns-in-late-preterm-and-very-preterm-infants-becoming-late-preterm
#12
Alice Grometto, Benedetta Pizzo, Maria Chiara Strozzi, Francesca Gazzolo, Diego Gazzolo
BACKGROUND: Near Infrared Spectroscopy (NIRS) has been proposed as a useful, noninvasive monitoring technique providing reliable information about central nervous system (CNS) oximetry and function. Recently, brain damage has been reconsidered as a dynamic process evolving over the weeks of gestation. We therefore investigated NIRS cerebral pattern differences between healthy late preterm infants (LPTo) and very preterm infants becoming late preterm (LPT). METHODS: We conducted an observational study in 40 healthy late preterm infants, matched for gestational age at monitoring, of whom 20 where LPTo and 20 LPT...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29156826/protective-effect-of-ginkgo-biloba-leaves-extract-egb761-on-myocardium-injury-in-ischemia-reperfusion-rats-via-regulation-of-tlr-4-nf-%C3%AE%C2%BAb-signaling-pathway
#13
Yuping Tang, Guisheng Zhou, Lijun Yao, Ping Xue, Danhong Yu, Renjie Xu, Wen Shi, Xin Yao, Zhaowei Yan, Jin-Ao Duan
Beneficial actions of EGb 761 against ischemia/reperfusion (I/R) injury in lung, brain and renal ischemia have been described. However, the relationship between EGb 761 and signal molecules in myocardial ischemia reperfusion has not been well elucidated. In this study, we investigated the effects and mechanism of EGb 761 preconditioning on anti-myocardial I/R injuries in vivo. Meanwhile, their potential anti-oxidative stress and anti-inflammation effect were assessed. Hemodynamic parameters were monitored as left ventricular systolic pressure, LV end-diastolic pressure and maximal rate of increase and decrease of left ventricular pressure (dP/dtmax)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156411/relationship-between-carotid-artery-sclerosis-and-blood-pressure-variability-in-essential-hypertension-patients
#14
Xianglin Chi, Min Li, Xia Zhan, Honghao Man, Shunliang Xu, Dingchang Zheng, Jianzhong Bi, Yingcui Wang, Chengyu Liu
OBJECTIVES: This study aimed to investigate the relationship between the presence of carotid arteriosclerosis (CAS) and blood pressure variability (BPV) in patients with essential hypertension. METHODS: One hundred and forty four essential hypertension patients underwent ambulatory BP monitoring for 24h after hospitalization. Common BPV metrics were calculated. General clinical parameters, including age, gender, height, weight, history of coronary heart disease, stroke, diabetes, hypertension, smoking and drink, were recorded...
March 18, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29156394/assessment-of-sampling-strategies-for-estimation-of-site-mean-concentrations-of-stormwater-pollutants
#15
David T McCarthy, Kefeng Zhang, Camilla Westerlund, Maria Viklander, Jean-Luc Bertrand-Krajewski, Tim D Fletcher, Ana Deletic
The estimation of stormwater pollutant concentrations is a primary requirement of integrated urban water management. In order to determine effective sampling strategies for estimating pollutant concentrations, data from extensive field measurements at seven different catchments was used. At all sites, 1-min resolution continuous flow measurements, as well as flow-weighted samples, were taken and analysed for total suspend solids (TSS), total nitrogen (TN) and Escherichia coli (E. coli). For each of these parameters, the data was used to calculate the Event Mean Concentrations (EMCs) for each event...
October 23, 2017: Water Research
https://www.readbyqxmd.com/read/29156269/autotrophic-denitrification-supported-by-biotite-dissolution-in-crystalline-aquifers-2-transient-mixing-and-denitrification-dynamic-during-long-term-pumping
#16
Clément Roques, Luc Aquilina, Alexandre Boisson, Virginie Vergnaud-Ayraud, Thierry Labasque, Laurent Longuevergne, Marc Laurencelle, Alexis Dufresne, Jean-Raynald de Dreuzy, Hélène Pauwels, Olivier Bour
We investigated the mixing and dynamic of denitrification processes induced by long-term pumping in the crystalline aquifer of Ploemeur (Brittany, France). Hydrological and geochemical parameters have been continuously recorded over 15 boreholes in 5km(2) on a 25-year period. This extensive spatial and temporal monitoring of conservative as well as reactive compounds is a key opportunity to identify aquifer-scale transport and reactive processes in crystalline aquifers. Time series analysis of the conservative elements recorded at the pumped well were used to determine mixing fractions from different compartments of the aquifer on the basis of a Principal Component Analysis approach coupled with an end-member mixing analysis...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155778/a-detailed-protocol-for-physiological-parameters-acquisition-and-analysis-in-neurosurgical-critical-patients
#17
Xiang Wu, Guoyi Gao, Junfeng Feng, Qing Mao, Jiyao Jiang
Intracranial pressure (ICP) monitoring is now widely used in neurosurgical critical patients. Besides mean ICP value, the ICP derived parameters such as ICP waveform, amplitude of pulse (AMP), the correlation of ICP amplitude and ICP mean (RAP), pressure reactivity index (PRx), ICP and arterial blood pressure (ABP) wave amplitude correlation (IAAC), and so on, can reflect intracranial status, predict prognosis, and can also be used as guidance of proper treatment. However, most of the clinicians focus only on the mean ICP value while ignoring these parameters because of the limitations of the current devices...
October 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155767/a-wireless-bidirectional-interface-for-in-vivo-recording-and-stimulation-of-neural-activity-in-freely-behaving-rats
#18
Liana Melo-Thomas, K-Alexander Engelhardt, Uwe Thomas, Dirk Hoehl, Sascha Thomas, Markus Wöhr, Bjoern Werner, Frank Bremmer, Rainer K W Schwarting
In vivo electrophysiology is a powerful technique to investigate the relationship between brain activity and behavior at a millisecond and micrometer scale. However, current methods mostly rely on tethered cable recordings or only use unidirectional systems, allowing either recording or stimulation of neural activity, but not at the same time or same target. Here, a new wireless, bidirectional device for simultaneous multichannel recording and stimulation of neural activity in freely behaving rats is described...
November 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155562/quantification-of-nanomaterial-nanomedicine-trafficking-in-vivo
#19
Liming Wang, Liang Yan, Jing Liu, Chunying Chen, Yuliang Zhao
Absorption, distribution, metabolism and excretion (ADME) of nanomaterials (NMs) or nanomedicines (NMs), are fundamental biological processes that dominate their nanomedical functions or nanotoxicities. Mostly, NMs exist in biological systems as a form of nanoparticles (NPs). However, to determine the composition, spatial distribution, and states of existence of NMs/NPs in vivo, upon entry into the body, as well as to monitor the dynamic changes of these information over time remain a challenge for the current analytical methodology due to their limited efficiently in characterizing interactions between these complex(nano)-complex(bio) systems...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29154875/optimization-of-pegylation-reaction-time-and-molar-ratio-of-rhg-csf-toward-increasing-bioactive-potency-of-monopegylated-protein
#20
Jamila Behi, RymHassiki, Nadia Ben Said, Balkiss Bouhaouala-Zahar, Mohamed Lamine Benkhoud
PEGylation is one of the strategies used for enhancing in vivo residence time of recombinant human Granulocyte Colony-Stimulating Factor (rhG-CSF) and therefore reducing in dose frequency to better fit with patient comfort treatment. In this study, three methoxy polyethylene glycol propionaldehydes (mPEG- ALD) of 10, 20 and 30kDa MW were utilized to produce biologically active monoPEGylated rhG-CSF with enhanced molecular weight. PEGylation reactions were carried out at room temperature and pH 5.0 in the presence of cyanoborohydride and two mPEG-ALD: protein molar ratios (3:1 and 5:1)...
November 14, 2017: International Journal of Biological Macromolecules
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