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https://www.readbyqxmd.com/read/28214980/sil2r-ratio-as-early-marker-for-response-in-hairy-cell-leukemia-and-the-prognostic-relevance-of-il28b-genotype-to-interferon-%C3%AE-therapy
#1
Stéphanie Jud, Jeroen S Goede, Oliver Senn, Katharina Spanaus, Markus G Manz, Rudolf Benz
Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where a single nucleotide polymorphism of interleukin-28B gene (IL28B) correlates with therapy response. The role of this polymorphism in therapy response of IFNα-treated patients with HCL is unknown...
February 18, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28214948/reduced-anticoagulation-variability-in-patients-on-warfarin-monitored-with-fiix-prothrombin-time-associates-with-reduced-thromboembolism-the-fiix-trial
#2
Alma Rut Oskarsdóttir, Brynja R Gudmundsdottir, Olafur S Indridason, Sigrun H Lund, David O Arnar, Einar S Bjornsson, Magnus K Magnusson, Hulda M Jensdottir, Brynjar Vidarsson, Charles W Francis, Pall T Onundarson
Fiix-prothrombin time (Fiix-PT) differs from traditional PT in being affected by reduced factor (F) II or FX only. In the randomized controlled Fiix-trial, patients on warfarin monitored with Fiix-PT (Fiix-warfarin patients) had fewer thromboembolisms (TE), similar major bleeding (MB) and more stable anticoagulation than patients monitored with PT (PT-warfarin patients). In the current Fiix-trial report we analyzed how reduced anticoagulation variability during Fiix-PT monitoring was reflected in patients with TE or bleeding...
February 18, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28214941/monitoring-water-pollution-levels-in-wadi-hanifa-riyadh-saudi-arabia-and-its-public-health-implications
#3
Bushra Ahmed Al-Hammad, Magda Magdy Abd El-Salam
This study was performed to evaluate the levels of metals in the fish caught from Wadi Hanifa's main basin over four seasons, determine the potential fitness of the fish for human consumption, and evaluate the overall water quality after enforcement of local standards. The physical and chemical parameters from a total of 192 water samples were tested using standard methods. Additionally, a total of 48 fish samples were analyzed for heavy metal concentrations. Mean values for basic water quality parameters of COD, PO4(-3), NH3(-)-N, and NO3(-)-N exceeded Saudi standards in all seasons...
February 18, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28214674/development-of-a-quick-serum-il-6-measuring-system-in-rheumatoid-arthritis
#4
Kensuke Koyama, Tetsuro Ohba, Kentaro Ishii, Giman Jung, Hirotaka Haro, Kenichi Matsuda
OBJECTIVE: Interleukin-6 (IL-6) plays a crucial role in the pathogenesis of rheumatoid arthritis (RA). Both fulfillment of remission criteria and assessment of other methods of evaluation of RA are important for preventing joint damage progression. Measurement of serum IL-6 concentrations has been reported to be useful for monitoring RA disease activity. However, it takes at least 4-5h to measure serum IL-6 concentrations using traditional methods, which limits its utility during routine assessment in daily clinical practice settings...
February 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28214607/real-time-liver-uptake-and-biodistribution-of-magnetic-nanoparticles-determined-by-ac-biosusceptometry
#5
Caio C Quini, André G Próspero, Marcos F F Calabresi, Gustavo M Moretto, Nicholas Zufelato, Sunil Krishnan, Diana R Pina, Ricardo B Oliveira, Oswaldo Baffa, Andris F Bakuzis, Jose R A Miranda
We describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR)...
February 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28214581/oxadiargyl-induced-conformational-transition-of-cystatin-isolated-from-yellow-mustard-seeds-biophysical-and-biochemical-approach
#6
Azaj Ahmed, Anas Shamsi, Bilqees Bano
Phytocystatins are thiol proteinase inhibitors crucial due to their inhibitory activity in plants. These play important roles in improving crop yield, protection against insects and pathogens and modulation of apoptosis. In this chemical era, various pesticides are being used globally to increase the crop biomass. These pesticides accumulate in plant body and produce harmful effects on plants itself by interacting with essential proteins. In this present study, we have monitored the interaction of a herbicide; oxadiargyl, with phytocystatin isolated from yellow mustard seeds (YMP) by employing spectroscopic techniques viz...
February 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28214114/effects-of-salvage-logging-on-soil-properties-and-vegetation-recovery-in-a-fire-affected-mediterranean-forest-a-two-year-monitoring-research
#7
F García-Orenes, V Arcenegui, K Chrenková, J Mataix-Solera, J Moltó, A B Jara-Navarro, M P Torres
Post-fire management can have an additional impact on the ecosystem; in some cases, even more severe than the fire. Salvage logging (SL) is a common practice in most fire-affected areas. The management of burnt wood can determine microclimatic conditions and seriously affect soil properties. In some cases, the way of doing it, using heavy machinery, and the vulnerability of soils to erosion and degradation can make this management potentially aggressive to soil. Research was done in "Sierra de Mariola Natural Park" (E Spain)...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28213832/dynamic-fluorescence-microscopy-of-cellular-uptake-of-intercalating-model-drugs-by-ultrasound-activated-microbubbles
#8
B H A Lammertink, R Deckers, M Derieppe, I De Cock, I Lentacker, G Storm, C T W Moonen, C Bos
PURPOSE: The combination of ultrasound and microbubbles can facilitate cellular uptake of (model) drugs via transient permeabilization of the cell membrane. By using fluorescent molecules, this process can be studied conveniently with confocal fluorescence microscopy. This study aimed to investigate the relation between cellular uptake and fluorescence intensity increase of intercalating model drugs. PROCEDURES: SYTOX Green, an intercalating fluorescent dye that displays >500-fold fluorescence enhancement upon binding to nucleic acids, was used as a model drug for ultrasound-induced cellular uptake...
February 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28213743/development-of-cer-001-preclinical-dose-selection-through-to-phase-i-clinical-findings
#9
Constance H Keyserling, Ronald Barbaras, Renee Benghozi, Jean-Louis Dasseux
BACKGROUND: CER-001 comprises recombinant human apolipoprotein A-I complexed with phospholipids that mimics natural, nascent, pre-β high-density lipoprotein (HDL). We present animal model data showing dose-dependent increases in cholesterol efflux with CER-001 and its subsequent elimination by reverse lipid transport, together with inhibition of atherosclerotic plaque progression. We report the first phase I study results with CER-001 in humans, starting at 0.25 mg/kg, which is 1/80th of the safe dose (20 mg/kg) established in 4-week multiple-dose animal studies dosed every second day...
February 17, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28213360/circulating-endothelial-microparticles-and-mir-92a-in-acute-myocardial-infarction
#10
Yuchen Zhang, Junjun Cheng, Fang Chen, Changyan Wu, Junmeng Zhang, Xuejun Ren, Yu Pan, Bin Nie, Quan Li, Yu Li
Background : Microparticles (MPs) and microRNAs (miRNAs) have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. This study aims to investigate the diagnostic value of endothelial microparticles (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocardial infarction (AMI) from those with CAD. Methods : Plasma samples from 37 patients with AMI, 42 patients with stable coronary artery disease (SCAD) and 35 healthy adults were collected for investigation in this study...
February 17, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28213231/stable-isotope-labeling-assisted-liquid-chromatography-tandem-mass-spectrometry-for-the-analysis-of-perfluorinated-carboxylic-acids-in-serum-samples
#11
Shijuan Zhang, Zhongyin Ji, Zhiwei Sun, Mingshuang Li, Cuncun Sheng, Mingbo Yue, Yanxin Yu, Guang Chen, Jinmao You
A new stable isotope labeling (SIL) reagent pair, 10-methyl-acridone-2-sulfonohydrazide (MASH) and its deuterated counterpart d3-MASH was synthesized and successfully applied to the analysis of perfluorinated carboxylic acids (PFCAs) in serum samples. The limits of detection (LODs) were in the range of 0.07-0.42μg/L, and the limits of quantitation (LOQs) were in the range of 0.25-1.38μg/L. Besides ionization enhancing effect, MASH also showed excellent fluorescence property. Therefore, the mass spectrometer operation cost was greatly lowered by carrying out parameter optimization experiments on HPLC which is easier to operate and maintain...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213228/smartphone-based-immunosensor-for-ca125-detection
#12
Oana Hosu, Andrea Ravalli, Giuseppe Mattia Lo Piccolo, Cecilia Cristea, Robert Sandulescu, Giovanna Marrazza
In this work, we report the design, the development and the characterization of the analytical performances of a colorimetric smartphone-based immunosensor for the detection of cancer antigen 125 (CA125). The immunosensor was based on a sandwich strategy in which the primary antibody was immobilized by spotting onto the 3D nitrocellulose membrane. The immunospots were subsequently incubated with CA125 solutions, followed by the affinity reaction with a secondary antibody labeled with gold nanoparticles (AuNPs)...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212587/prevalence-of-urinary-incontinence-in-females-performing-high-impact-exercises
#13
Magdaléna Hagovska, Ján Švihra, Alena Buková, Agáta Hrobacz, Dana Dračková, Viera Švihrová, Lenka Kraus
The aim of this cross-sectional study was to monitor the prevalence of symptoms of stress (SUI) and mixed urinary incontinence (MUI) in sportswomen performing high-impact exercises. A further objective was to compare the symptoms of urinary incontinence (UI) and quality of life in sportswomen. We used the International Consultation on Incontinence Questionnaire (ICIQ-SF), the Overactive Bladder Questionnaire (OAB-q), the Urinary Incontinence Quality of Life Scale (I-QOL) and the International Physical Activity Questionnaire (IPAQ), short version...
February 17, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28212432/genetically-encoded-ratiometric-fluorescent-thermometer-with-wide-range-and-rapid-response
#14
Masahiro Nakano, Yoshiyuki Arai, Ippei Kotera, Kohki Okabe, Yasuhiro Kamei, Takeharu Nagai
Temperature is a fundamental physical parameter that plays an important role in biological reactions and events. Although thermometers developed previously have been used to investigate several important phenomena, such as heterogeneous temperature distribution in a single living cell and heat generation in mitochondria, the development of a thermometer with a sensitivity over a wide temperature range and rapid response is still desired to quantify temperature change in not only homeotherms but also poikilotherms from the cellular level to in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28211643/postural-analysis-in-a-pediatric-cohort-of-patients-with-ehlers-danlos-syndrome-a-pilot-study
#15
Claudio Lisi, Serena Monteleone, Carmine Tinelli, Berardo Rinaldi, Giuseppe Di Natali, Salvatore Savasta
BACKGROUND: The Ehlers-Danlos Syndrome (EDS) is a rare disorder affecting the connective tissue. EDS patients may suffer of proprioception and balance impairment but all the studies dealing with such symptoms have been addressed to adult subjects. The Study of such impairment in younger patients may lead to a better awareness of own motor abilities and to a focused rehabilitative intervention. Therefore, our work aims to assess the occurrence of these alterations in a pediatric cohort of EDS patients...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28211558/anxiety-associated-with-parachute-jumping-as-the-cause-of-blood-red-ox-balance-impairment
#16
Mateusz Kowalczyk, Katarzyna Kozak, Julita Ciećwierz, Monika Sienkiewicz, Marcin Kura, Łukasz Jasiak, Edward Kowalczyk
OBJECTIVES: The aim of the study was to assess the effect of anxiety associated with parachute jumps on selected redox balance parameters in regular soldiers from airborne forces. The study allows estimating whether the paratroopers exposed to high level of mental stress are simultaneously under severe oxidative stress. METHODS: The investigations were carried out on 46 professional soldiers from airborne forces divided into groups depending on the number of performed parachute jumps...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28210891/aquatic-monitoring-programs-conducted-during-environmental-impact-assessments-in-canada-preliminary-assessment-before-and-after-weakened-environmental-regulation
#17
Brynn Roach, Tony R Walker
Aquatic monitoring programs are imperative for the functioning of the environmental impact assessment (EIA) process and a cornerstone for industrial compliance in Canada. However, in 2012, several leading pieces of federal environmental legislation (e.g., Canadian Environmental Assessment Act c.19, s. 52, 2012) were drastically altered, effectively weakening levels of environmental protection for aquatic ecosystems during project developments. This paper assesses the impact of CEAA 2012 on aquatic monitoring programs (and subsequent monitoring data reporting) across Canada for ten projects (five completed pre-CEAA 2012 and five completed post-CEAA 2012)...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28210448/assessing-the-need-for-a-protocol-in-monitoring-weight-loss-and-nutritional-status-in-orthognathic-surgery-based-on-patients-experiences
#18
Muhammad Ruslin, Hannah Dekker, Dirk B Tuinzing, Tymour Forouzanfar
BACKGROUND: To investigate retrospectively the orthognathic surgery (OGS) patients experience in weight loss and the influence of gender, age, duration of the surgical procedure, length of hospital stay, location of surgery and use of intermaxillary fixation (IMF) or without IMF on postoperative weight loss. MATERIAL AND METHODS: A total of 4487 patients treated by OGS where all patients visited the outpatient clinic one, three and six weeks after the surgical procedure...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210440/analytical-parameters-and-vital-signs-in-patients-subjected-to-dental-extraction
#19
Enric Jané-Pallí, Carlos Arranz-Obispo, Beatriz González-Navarro, Jesús Murat, Raúl Ayuso-Montero, Santiago Rojas, Amparo Santamaría, Enric Jané-Salas, José López-López
BACKGROUND: Dental consultation may provoke stress to the patient, especially when a dental surgery is going to be performed, stressful situations can cause a reaction in the sympathetic nervous system that could lead to cardiovascular alterations. Blood pressure and cardiac frequency are used often as an indirect measurement and this parameters combined can serve as good indicators of stress. Objective: Analyze the changes in vital signs and analytical parameters induced by a dental extraction...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209944/impact-of-contact-force-technology-on-reducing-the-recurrence-and-major-complications-of-atrial-fibrillation-ablation-a-systematic-review-and-meta-analysis
#20
Xianhui Zhou, Wenkui Lv, Wenhui Zhang, Yuanzheng Ye, Yaodong Li, Qina Zhou, Qiang Xing, Jianghua Zhang, Yanmei Lu, Ling Zhang, Hongli Wang, Wen Qin, Baopeng Tang
Contact force (CF) monitoring can be useful in accomplishing circumferential pulmonary vein (PV) isolation for atrial fibrillation (AF). This meta-analysis aimed to assess the efficacy and safety of a CF-sensing catheter in treating AF. Randomized controlled trials or non-randomized observational studies comparing AF ablation using CF-sensing or standard non-CF (NCF)-sensing catheters were identified from PubMed, EMBASE, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure (January 1, 1998-2016)...
February 2017: Anatolian Journal of Cardiology
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