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https://www.readbyqxmd.com/read/27900529/effectiveness-of-pit-and-fissure-sealants-bonded-with-different-adhesive-systems-a-prospective-randomized-controlled-trial
#1
Gizem Erbas Unverdi, Stephan Atilla Atac, Zafer Cavit Cehreli
OBJECTIVES: To evaluate and compare the clinical retention of a resin-based fissure sealant placed with an intermediate layer of etch-and-rinse (ER) or self-etch (SE) adhesives. MATERIALS AND METHODS: Two hundred twenty-eight sealants were placed in 57 children with previously unsealed, caries-free permanent first molars, employing a split-mouth design. The teeth were randomized into four groups (n = 57 teeth/groups) according to the adhesive system placed under the tested sealant (Delton FS+; Dentsply)...
November 30, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27892844/identification-of-b-cell-epitope-of-leishmania-donovani-and-its-application-in-diagnosis-of-visceral-leishmaniasis
#2
Fauzia Jamal, Manas Ranjan Dikhit, Manish K Singh, Pushkar Shivam, Sarita Kumari, Pushpanjali, Amit K Dubey, Prakash Kumar, Shyam Narayan, Anil K Gupta, Krishna Pandey, V N R Das, Sanjiva Bimal, Pradeep Das, Shubhankar K Singh
Diagnosis of visceral leishmaniasis (VL) is often hindered by cross-reactions with antigens from other related parasite infections. This study aimed to develop an immunochromatographic test (ICT) which can detect the antigen present in circulating immune complexes (CICs) of VL patients using B cell epitope-specific antibodies. MS analysis of six immunoreactive 2DE spots revealed two epitopes i.e RFFVQGDGIGQHSLQEALERR (P1) and RRVAVLVLLDRL (P2) (From a hypothetical protein [Acc No: XP_003861458.1]). The epitope conservancy analysis suggested that the linear epitope (P1P2) is 97% to 100% conserved among Leishmania species and diverged from Homo sapiens (61% query coverage and 80% identity)...
November 28, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27892836/comparison-of-internal-adaptation-in-class-ii-bulk-fill-composite-restorations-using-micro-ct
#3
S H Han, S H Park
PURPOSE: This study compared the internal adaptation of bulk-fill composite restorations in class II cavities and explored the relationship between internal adaptation and polymerization shrinkage or stress. METHODS AND MATERIALS: Standardized mesio-occluso-distal cavities were prepared in 40 extracted human third molars and randomly divided into five groups (n=8). After having been applied by total-etch XP bond (Dentsply Caulk, Milford, DE, USA) and light curing, the teeth were restored with the following resin composites: group 1, Filtek Z350 (3M ESPE, St...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27871588/novel-resuscitation-devices-facilitate-complete-neurologic-recovery-after-prolonged-cardiac-arrest-in-postanesthesia-care-unit
#4
Elif C Cingi, Luke A McMahon, Richard C Prielipp
Cardiac arrest in the perioperative period is associated with significant morbidity and mortality. Novel resuscitation devices may afford patients improved survival and limit neurologic injury. We report a case of cardiac arrest in the postanesthesia care unit that required an extensive period of cardiopulmonary resuscitation assisted by the ResQPOD impedance threshold device to optimize coronary perfusion and a LUCAS chest compression system to maintain optimal cardiopulmonary resuscitation while transporting the patient to the cardiac catheterization laboratory...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27864007/six-generations-of-epidermolytic-palmoplantar-keratoderma-associated-with-a-krt9-r163w-mutation
#5
Peng Wang, Xiao-Jing Kang, Xiao-Hui Tang, Jian-Yong Liu, Wen-Zheng Li, Wei-Jia Wang, Sheng-Nan Liang, Yan-Yan Feng, Yuan Ding, Wen-Jing Chen
Epidermolytic palmoplantar keratoderma (EPPK) is a rare autosomal dominant skin disorder characterized by diffuse hyperkeratosis on the palms and soles. Whole-exome sequencing (WES) has become a powerful tool for the detection of rare causal variants of Mendelian disorders. However, no causal gene for EPPK in the Uygur population has been identified until now, and no treatment exists than can address the underlying pathology.WES analysis was undertaken on two individuals from a large Uygur EPPK pedigree whose disease locus mapped to 17q21...
November 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27863062/rehh-2-0-a-reimplementation-of-the-r-package-rehh-to-detect-positive-selection-from-haplotype-structure
#6
Mathieu Gautier, Alexander Klassmann, Renaud Vitalis
Identifying genomic regions with unusually high local haplotype homozygosity represents a powerful strategy to characterize candidate genes responding to natural or artificial positive selection. To that end, statistics measuring the extent of haplotype homozygosity within (e.g., EHH, iHS) and between (Rsb or XP-EHH) populations have been proposed in the literature. The REHH package for R was previously developed to facilitate genome-wide scans of selection, based on the analysis of long-range haplotypes. However, its performance was not sufficient to cope with the growing size of available data sets...
November 11, 2016: Molecular Ecology Resources
https://www.readbyqxmd.com/read/27862836/36-month-data-for-the-advance-xp-%C3%A2-male-sling-results-of-a-prospective-multicentre-study
#7
Ricarda M Bauer, Markus T Grabbert, Benedikt Klehr, Peter Gebhartl, Christian Gozzi, Roland Homberg, Florian May, Peter Rehder, Christian G Stief, Alexander Kretschmer
OBJECTIVES: To evaluate the efficacy and safety of the AdVance XP(®) sling (Boston Scientific, formerly American Medical Systems) in male stress urinary incontinence (SUI) after radical prostatectomy in a prospective multicentre study, as in recent years several studies have shown the effectiveness and safety of the AdVance sling for treating male SUI and in 2010 the second-generation AdVance XP was introduced with several changes in the sling design and a new needle shape. PATIENTS AND METHODS: In all, 115 patients were included...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27862702/efficacy-of-xp-endo-finisher-and-trushape-3d-conforming-file-compared-to-conventional-and-ultrasonic-irrigation-in-removing-calcium-hydroxide
#8
Ahmet Demirhan Uygun, Eyüp Candaş Gündoğdu, Hakan Arslan, İbrahim Ersoy
The aim of this study was to compare the efficacy of the XP-endo Finisher and TRUShape 3D Conforming File to conventional and ultrasonic irrigation techniques for removing calcium hydroxide from artificially created grooves on root canals. The study used 32 human mandibular premolar teeth, which were decoronated and instrumented up to ProTaper Universal F5 (Dentsply Maillefer; Ballagiues, Switzerland). The teeth were split longitudinally, two standardised grooves were prepared in the apical and coronal portions and filled with calcium hydroxide...
November 12, 2016: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/27861965/impact-of-the-circadian-clock-on-uv-induced-dna-damage-response-and-photocarcinogenesis
#9
Panshak Dakup, Shobhan Gaddameedhi
The skin is in constant exposure to various external environmental stressors, including solar ultraviolet (UV) radiation. Various wavelengths of UV light are absorbed by the DNA and other molecules in the skin to cause DNA damage and induce oxidative stress. The exposure to excessive ultraviolet (UV) radiation and/or accumulation of damage over time can lead to photocarcinogenesis and photoaging. The nucleotide excision repair (NER) system is the sole mechanism for removing UV photoproduct damage from DNA, and genetic disruption of this repair pathway leads to the photosensitive disorder xeroderma pigmentosum (XP)...
November 12, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27853352/tear-lipid-layer-thickness-with-eye-drops-in-meibomian-gland-dysfunction
#10
Jennifer S Fogt, Matthew J Kowalski, P Ewen King-Smith, Alice T Epitropolous, Andrew J Hendershot, Carrie Lembach, John Paul Maszczak, Lisa A Jones-Jordan, Joseph T Barr
PURPOSE: The aim of this study was to evaluate the efficacy of a lipid containing emollient eye drop, Soothe XP, which was reformulated in 2014 with a more stable preservative and buffer system, compared to a control, non-emollient, eye drop (Systane Ultra) in improving lipid layer thickness (LLT) in subjects with dry eye due to meibomian gland dysfunction (MGD). PATIENTS AND METHODS: This prospective single-center, open-label, cross-over, examiner masked-study enrolled subjects aged 30-75 years with lipid-deficient dry eye and a clinical diagnosis of MGD as determined by a slit lamp examination, an evaluation of meibomian gland drop out with meibography, and a standard patient evaluation of eye dryness questionnaire of >5...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27849400/erbium-yttrium-aluminium-garnet-laser-versus-q-switched-neodymium-yttrium-aluminium-garnet-laser-for-the-treatment-of-xanthelesma-palpebrarum
#11
Ali Balevi, Pelin Ustuner, Mustafa Ozdemir
BACKGROUND: Several lasers have been used for the treatment of xanthelasma palpebrarum (XP), such as Q-switched Neodymium:Yttrium Aluminium Garnet (QSNd:YAG), Erbium:Yttrium Aluminium Garnet (Er:YAG) laser. However, there is no comparemental study among these laser options in the treatment of XP. OBJECTIVE: The aim of this study was to compare the clinical efficacy and response rates of QSNd:YAG and Er:YAG in the treatment of XP. METHODS: Sixty patients with a total of 102 XP lesions were randomly and equally divided into two groups...
November 16, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27846814/lack-of-direct-evidence-for-natural-selection-at-the-candidate-thrifty-gene-locus-ppargc1a
#12
Murray Cadzow, Tony R Merriman, James Boocock, Nicola Dalbeth, Lisa K Stamp, Michael A Black, Peter M Visscher, Phillip L Wilcox
BACKGROUND: The gene PPARGC1A, in particular the Gly482Ser variant (rs8192678), had been proposed to be subject to natural selection, particularly in recent progenitors of extant Polynesian populations. Reasons include high levels of population differentiation and increased frequencies of the derived type 2 diabetes (T2D) risk 482Ser allele, and association with body mass index (BMI) in a small Tongan population. However, no direct statistical tests for selection have been applied. METHODS: Using a range of Polynesian populations (Tongan, Māori, Samoan) we re-examined evidence for association between Gly482Ser with T2D and BMI as well as gout...
November 15, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27836342/influence-of-fireworks-displays-on-the-chemical-characteristics-of-pm2-5-in-rural-and-suburban-areas-in-central-and-east-china
#13
Junmei Zhang, Lingxiao Yang, Jianmin Chen, Abdelwahid Mellouki, Pan Jiang, Ying Gao, Yanyan Li, Yumeng Yang, Wenxing Wang
To explore the spatial and chemical characteristics of PM2.5 pollution and the influence of fireworks displays on PM2.5 and its chemical components in rural areas in Central and East China, PM2.5 samples were collected at three rural sites and one suburban site in Henan and Shandong provinces during the 2016 Chinese New Year, and the chemical composition of PM2.5, including water-soluble inorganic ions (WSIIs), organic carbon (OC), elemental carbon (EC), water-soluble organic carbon (WSOC) and trace elements (TEs) was analysed...
November 8, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27834411/randomized-two-year-clinical-evaluation-of-oxalic-acid-in-restorations-of-noncarious-cervical-lesions
#14
André Mattos Brito de Souza, Nadine Luísa Guimarães Albuquerque, Juliano Sartori Mendonça, Lidiany Karla Azevedo Rodrigues, Sérgio Lima Santiago
PURPOSE: To evaluate the use of oxalic acid in restorations of noncarious cervical lesions. MATERIALS AND METHODS: Twenty volunteers of both sexes between 24 and 55 years old, with at least two lesions that were restored with the techniques to be evaluated, were selected. Ninety teeth were randomly divided into two groups: group 1, two-step etch-and-rinse adhesive technique (control) and group 2, pretreatment with oxalic acid followed by the application of a two-step etch-and-rinse adhesive system...
November 10, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27832181/blood-collection-tubes-and-storage-temperature-should-be-evaluated-when-using-the-siemens-advia-centaur-xp-for-measuring-25-hydroxyvitamin-d
#15
Songlin Yu, Weiyan Zhou, Xinqi Cheng, Huiling Fang, Ruiping Zhang, Qian Cheng, Jianhua Han, Wei Su, Liangyu Xia, Ling Qiu
A significant bias was found when using the Siemens ADVIA Centaur XP system for measurement of 25-hydroxyvitamin D (25OHD) with VACUETTE® tubes with Serum Clot Activator and Gel. Here, we examined whether other commonly used tubes or temperatures affected 25OHD results obtained with the Siemens ADVIA Centaur XP system. Serum was collected into five types of vacuum blood collection tubes from three manufacturers, and 25OHD was analyzed using the Siemens ADVIA Centaur XP system and liquid chromatography tandem mass spectrometry (LC-MS/MS) immediately or after storage at 4°C or -80°C for 48 h...
2016: PloS One
https://www.readbyqxmd.com/read/27827925/transcriptional-and-posttranslational-regulation-of-nucleotide-excision-repair-the-guardian-of-the-genome-against-ultraviolet-radiation
#16
REVIEW
Jeong-Min Park, Tae-Hong Kang
Ultraviolet (UV) radiation from sunlight represents a constant threat to genome stability by generating modified DNA bases such as cyclobutane pyrimidine dimers (CPD) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PP). If unrepaired, these lesions can have deleterious effects, including skin cancer. Mammalian cells are able to neutralize UV-induced photolesions through nucleotide excision repair (NER). The NER pathway has multiple components including seven xeroderma pigmentosum (XP) proteins (XPA to XPG) and numerous auxiliary factors, including ataxia telangiectasia and Rad3-related (ATR) protein kinase and RCC1 like domain (RLD) and homologous to the E6-AP carboxyl terminus (HECT) domain containing E3 ubiquitin protein ligase 2 (HERC2)...
November 4, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27823960/searching-for-a-bnp-standard-glycosylated-probnp-as-a-common-calibrator-enables-improved-comparability-of-commercial-bnp-immunoassays
#17
Alexander G Semenov, Natalia N Tamm, Fred S Apple, Karen M Schulz, Sara A Love, Ranka Ler, Evgenia E Feygina, Alexey G Katrukha
BACKGROUND: Circulating B-type natriuretic peptide (BNP) is widely accepted as a diagnostic and risk assessment biomarker of cardiac function. Studies suggest that there are significant differences in measured concentrations among different commercial BNP immunoassays. The purpose of our study was to compare BNP-related proteins to determine a form that could be used as a common calibrator to improve the comparability of commercial BNP immunoassay results. METHODS: BNP was measured in 40 EDTA-plasma samples from acute and chronic heart failure patients using five commercial BNP assays: Alere Triage, Siemens Centaur XP, Abbott I-STAT, Beckman Access2 and ET Healthcare Pylon...
November 4, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27822979/structure-based-screening-admet-profiling-and-molecular-dynamic-studies-on-mglu2-receptor-for-identification-of-newer-antiepileptic-agents
#18
Ruchi Malik, Pakhuri Mehta, Shubham Srivastava, Bhanwar Singh Choudhary, Manish Sharma
Structure-based screening approach targeting mGlu2 receptor was carried out to identify good chemical starting points for anti-epileptic therapy. Interactive modes of final 12 compounds identified on the basis of screening of Asinex library, binding energy analysis, ADME profiling with special emphasis for CNS ranges, and toxicity analysis were studied and showed good binding modes in the mGluR2-active site. Enrichment studies for validating screening protocol were carried out which gave ROC values 0.98 (AUC = 0...
November 28, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27796911/accelerating-regulated-bioanalysis-for-biotherapeutics-case-examples-using-a-microfluidic-ligand-binding-assay-platform
#19
Rong Liu, Brian Hoffpauir, Shannon D Chilewski, Janice Gamberdella, Uma Kavita, Jia Duo, Carol Gleason, Yan Zhang, Renuka Pillutla, Binodh DeSilva, Lora Hamuro
The Gyrolab™ xP is a microfluidic platform for conducting ligand binding assays (LBAs) and is recognized for its utility in discovery bioanalysis. However, few reports have focused on the technology for regulated bioanalysis. This technology has the advantage of low reagent consumption, low sample volume, and automated ligand binding methods. To improve bioanalysis testing timelines and increase the speed at which biotherapeutics are delivered to patients, we evaluated the technology for its potential to deliver high-quality data at reduced testing timelines for regulated bioanalysis...
October 27, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27793455/effects-of-long-acting-gnrh-antagonist-degarelix-acetate-on-plasma-insulin-like-peptide-3-testosterone-and-luteinizing-hormone-concentrations-and-scrotal-circumference-in-male-goats
#20
M A Hannan, N Kawate, Y Fukami, W W P N Weerakoon, E E Büllesbach, T Inaba, H Tamada
We recently reported that plasma insulin-like peptide 3 (INSL3) concentrations increased soon after endogenous and exogenous stimulations of LH in male goats and bulls. However, the effects of LH suppression on INSL3 secretion are unknown in domestic animals. Here, we examined the effects of a long-acting GnRH antagonist (degarelix acetate; 4 mg/kg) on the secretions of plasma INSL3 and testosterone in two phases, an immediate and a long-term phase in male goats (n = 6; aged, 13-16 months). During the immediate phase, blood was taken at 15-minute intervals for 8 hours on Days -5, 0, and 3...
January 15, 2017: Theriogenology
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