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Kwonoh Park, Kyu-Pyo Kim, Seongjoon Park, Heung-Moon Chang
AIM: It remains unclear whether capecitabine combined with cisplatin would show similar effects compared with standard therapy using gemcitabine and cisplatin in advanced biliary tract cancer (BTC). METHODS: Patients with advanced BTC who were treated with first-line chemotherapy at Asan Medical Center were retrospectively analyzed. All patients received either cisplatin followed by gemcitabine on days 1 and 8 every 3 weeks (GP group), or capecitabine on days 1-14 with cisplatin on day 1 every 3 weeks (XP group)...
October 22, 2016: Asia-Pacific Journal of Clinical Oncology
Yoshio Kuga, Shosuke Kitamura, Hideharu Okanobu, Hideto Sakimoto, Toshihiro Nishida
We reported a case of human epidermal growth factor receptor 2(HER2)-positive advanced gastric cancer with multiple liver metastases that responded well to a combination of trastuzumab, capecitabine, and cisplatin(T-XP therapy)as first-line chemotherapy. A 73-year-old man was admitted to our hospital in December 2012 for liver dysfunction. Based on computed tomography(CT)and gastroendoscopy findings, he was diagnosed with advanced gastric cancer with multiple liver metastases. Because HER2 protein overexpression was observed in the primary tumor, he was treated with T-XP therapy...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Núria Segarra, Joan Huguet, Beatriz Fernández-Forner
The objective is to evaluate Grifols' DG-PT L Rec liquid reagent for prothrombin time (PT) determination in comparison to the laboratory's reference reagent (Siemens' Thromborel S). For linearity, the average master curve for PT and five nominal prothrombin concentrations was obtained from five calibration curves. Within-assay precision (repeatability) was calculated after measuring 20 successive tests of normal and pathological controls. For correlation, 581 routine clinical citrated plasma samples were assessed with both reagents...
October 13, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Federica Federici, Aristea Magaraki, Evelyne Wassenaar, Catherina J H van Veen-Buurman, Christine van de Werken, Esther B Baart, Joop S E Laven, J Anton Grootegoed, Joost Gribnau, Willy M Baarends
In mouse female preimplantation embryos, the paternal X chromosome (Xp) is silenced by imprinted X chromosome inactivation (iXCI). This requires production of the noncoding Xist RNA in cis, from the Xp. The Xist locus on the maternally inherited X chromosome (Xm) is refractory to activation due to the presence of an imprint. Paternal inheritance of an Xist deletion (XpΔXist) is embryonic lethal to female embryos, due to iXCI abolishment. Here, we circumvented the histone-to-protamine and protamine-to-histone transitions of the paternal genome, by fertilization of oocytes via injection of round spermatids (ROSI)...
October 2016: PLoS Genetics
Minhui Chen, Dunfei Pan, Hongyan Ren, Jinluan Fu, Junya Li, Guosheng Su, Aiguo Wang, Li Jiang, Qin Zhang, Jian-Feng Liu
BACKGROUND: The identification of signals left by recent positive selection provides a feasible approach for targeting genomic variants that underlie complex traits and fitness. A better understanding of the selection mechanisms that occurred during the evolution of species can also be gained. In this study, we simultaneously detected the genome-wide footprints of recent positive selection that occurred within and between Chinese Holstein and Simmental populations, which have been subjected to artificial selection for distinct purposes...
October 6, 2016: Genetics, Selection, Evolution: GSE
Hua-Jie Liu, Shi-Bo Fang, Si-Wa Liu, Liang-Cheng Zhao, Xiu-Ping Guo, Yun-Jun Jiang, Jian-Sen Hu, Xiao-Di Liu, Yu Xia, Yi-Dan Wang, Qing-Feng Wu
To test the applicability of lichens in the biomonitoring of atmospheric elemental deposition in a typical steppe zone of Inner Mongolia, China, six foliose lichens (Physcia aipolia, PA; P. tribacia, PT; Xanthoria elegans, XE; X. mandschurica, XM; Xanthoparmelia camtschadalis, XPC; and Xp. tinctina, XPT) were sampled from the Xilin River Basin, Xilinhot, Inner Mongolia, China. Twenty-five elements (Al, Ba, Cd, Ce, Cr, Cs, Cu, Fe, K, La, Mn, Mo, Na, Ni, P, Pb, Sb, Sc, Sm, Tb, Th, Ti, Tl, V and Zn) in the lichens were analysed using inductively coupled plasma mass spectrometry (ICP-MS)...
October 4, 2016: Scientific Reports
Liyong Xing, Zhifei Liu, Gang Deng, Huan Wang, Yanfeng Zhu, Peng Shi, Bingyue Huo, Yindong Li
PURPOSE: Xanthogranulomatous prostatitis (XP) is a rare form of nonspecific granulomatous prostatitis that can clinically mimic high-grade prostatic carcinoma. It is difficult to diagnose it definitely in clinical settings. METHODS: We report a case of XP with prostate-rectal fistula and review the relevant literatures. RESULT: A 75-year-old man presented with rectal bleeding when he urinated. A locally advanced carcinoma of prostate was suspected initially following the physical, imaging, and hematologic examinations...
2016: Research and Reports in Urology
C S Sampaio, K-J Chiu, E Farrokhmanesh, M Janal, R M Puppin-Rontani, M Giannini, E A Bonfante, P G Coelho, R Hirata
The present study aimed to characterize the pattern and volume of polymerization shrinkage of flowable resin composites, including one conventional, two bulk fill, and one self-adhesive. Standardized class I preparations (2.5 mm depth × 4 mm length × 4 mm wide) were performed in 24 caries-free human third molars that were randomly divided in four groups, according to the resin composite and adhesive system used: group 1 = Permaflo + Peak Universal Bond (PP); group 2 = Filtek Bulk Fill + Scotchbond Universal (FS); group 3 = Surefil SDR + XP Bond (SX); and group 4 = Vertise flow self-adhering (VE) (n=6)...
September 30, 2016: Operative Dentistry
Chun Tang, Linfeng Gan, Rong Zhang, Wenbo Lu, Xiue Jiang, Abdullah M Asiri, Xuping Sun, Jin Wang, Liang Chen
Replacement of precious Pt with earth-abundant electrocatalysts for the hydrogen evolution reaction (HER) holds great promise for clean energy devices, but the development of low-cost and durable HER catalysts with Pt-like activity is still a huge challenge. In this communication, we report on the development of self-standing ternary FexCo1-xP nanowire array on carbon cloth (FexCo1-xP/CC) as a Pt-free HER catalyst with activities being strongly related to Fe substitution ratio. Electrochemical tests show that Fe0...
October 12, 2016: Nano Letters
Qi Li, Yan Zhang, Junling Shi, Yilin Wang, Haobin Zhao, Dongyan Shao, Qingsheng Huang, Hui Yang, Mingling Jin
Pinoresinol (Pin) and pinoresinol monoglucoside (PMG) are plant-derived lignan molecules with multiple functions. We showed previously that the endophytic fungus Eucommiaulmoides Oliverendophytic Phomopsis sp. XP-8 is able to produce Pin and PMG. Cultured XP-8 showed inhibition on HepG-2 and K562 cells and the major effective compounds were identified. The fungal culture significantly inhibited the activities of HepG-2 and K562 cells by decreasing their viability and inducing apoptosis via up-regulating the expression of apoptosis-related genes...
September 22, 2016: Anti-cancer Agents in Medicinal Chemistry
V Munford, L P Castro, R Souto, L K Lerner, J Brandstetter Vilar, C Quayle, H Asif, A P Schuch, T A de Souza, S Ienne, F I A Alves, L M S Moura, P A V Galante, A A Camargo, R Liboredo, S D J Pena, A Sarasin, S C Chaibub, C F M Menck
BACKGROUND: Xeroderma pigmentosum (XP) is a rare human syndrome associated with hypersensitivity to sunlight and a high frequency of skin tumors at an early age. We identified a community in the state of Goias (central Brazil), a very sunny and tropical region, with a high incidence of XP (17 patients among approximately 1,000 inhabitants). OBJECTIVES: To identify the gene mutations in the affected community and map the distribution of the affected alleles, correlating the mutations with clinical phenotypes...
September 24, 2016: British Journal of Dermatology
Sandra C Koch, Nina Simon, Charlotte Ebert, Thomas Carell
Nucleotide excision repair (NER) is a highly versatile and efficient DNA repair process, which is responsible for the removal of a large number of structurally diverse DNA lesions. Its extreme broad substrate specificity ranges from DNA damages formed upon exposure to ultraviolet radiation to numerous bulky DNA adducts induced by mutagenic environmental chemicals and cytotoxic drugs used in chemotherapy. Defective NER leads to serious diseases, such as xeroderma pigmentosum (XP). Eight XP complementation groups are known of which seven (XPA-XPG) are caused by mutations in genes involved in the NER process...
January 2016: Quarterly Reviews of Biophysics
Flávio R F Alves, Carlos V Andrade-Junior, Marília F Marceliano-Alves, Alejandro R Pérez, Isabela N Rôças, Marco A Versiani, Manoel D Sousa-Neto, José C Provenzano, José F Siqueira
INTRODUCTION: This study evaluated the disinfecting ability of chemomechanical preparation with rotary nickel-titanium instruments, followed by 2 distinct adjunctive procedures in the root canals of extracted mandibular molars by means of a correlative analytical approach. METHODS: Twenty-two extracted mandibular molars were selected and anatomically matched between groups on the basis of micro-computed tomographic analysis. In the first phase of the experiment, root canals were contaminated with Enterococcus faecalis and subjected to chemomechanical preparation with BT RaCe instruments and 2...
September 15, 2016: Journal of Endodontics
Koji Iinuma, Keitaro Kojima, Kiyohisa Okamoto, Kazuya Yuhara
A 72-year-old woman was referred to our hospital with complaints of macro-hematuria. The radiographic evaluation including computed tomography (CT) and magnetic resonance imaging (MRI) suggested it to be renal cell carcinoma (RCC) in her right kidney. She underwent laparoscopic nephrectomy. We diagnosed her with renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion, based on pathological findings and break apart of transcription factor E3 (TFE3)by fluorescence in situ hybridization. She was free of recurrence at 8 months postoperatively...
August 2016: Hinyokika Kiyo. Acta Urologica Japonica
Wen Shen, Kaili Chen, Yanming Sun, Haiying Guo, Dongmei Chen, Yang Cao
The complete coding sequence of Wild Argali SPLUNC1 cDNA was generated by rapid amplification of cDNA ends. The SPLUNC1 cDNA was 1076 bp with an open reading frame of 768 bp, which encoded a 26.49 kDa protein composed of 255 amino acids. Its amino acid sequence shared 98.4%, 96.9%, 94.5%, 90.2%, 80.8 %, 78.4%, 78.3%, 72.5%, 72.3%, 68.8% identity with those of SPLUNC1 cDNA from Ovis aries (accession no. NP_001288334.1), Capra hircus (accession no. XP_005688516.1), Pantholops hodgsonii (accession no. XP_005979709...
September 12, 2016: Asian-Australasian Journal of Animal Sciences
Eray Yihui Zhou, Huijun Wang, Zhimiao Lin, Guiwen Xu, Zhihong Ma, Jiahui Zhao, Cheng Feng, Lina Duo, Jinghua Yin, Yong Yang
Xeroderma pigmentosum (XP) is a rare genetic disorder which is divided into eight complementation groups: XP-A to XP-G and XP-V. Some XP patients demonstrate severe cutaneous and neurological manifestations, management of which requires timely diagnosis and intervention. We performed clinical evaluation and genetic analysis on 19 patients, the largest cohort of XP to date in China. Twenty-three mutations from six groups were identified, 16 of which were novel. All patients developed marked freckle-like pigmentation on sun-exposed sites while patients with XP-A, XP-D, XP-F and XP-G showed acute sunburn reactions...
September 8, 2016: Journal of Dermatology
Carla Carpena-Catoira, Christian D Ortega-Ortiz, Fernando R Elorriaga-Verplancken
RATIONALE: Stable isotope analysis can be used to obtain information on olive ridley sea turtles in the Mexican Central Pacific (MCP). Tissue samples such as scale, muscle, and blood are usually not analyzed immediately and are preserved in different substances such as ethanol, formalin, sodium chloride, the ideal being liquid nitrogen. Due to logistical reasons, that preservation method cannot always be used. The objective of the present study was to evaluate the efficiency of DMSO as a preservation agent for later stable isotope analysis...
September 8, 2016: Rapid Communications in Mass Spectrometry: RCM
Siddharth K Prakash, Carolyn A Bondy, Cheryl L Maslen, Michael Silberbach, Angela E Lin, Laura Perrone, Giuseppe Limongelli, Hector I Michelena, Eduardo Bossone, Rodolfo Citro, Scott A Lemaire, Simon C Body, Dianna M Milewicz
Turner Syndrome (TS) is a developmental disorder caused by partial or complete loss of one sex chromosome. Bicuspid aortic valve and other left-sided congenital heart lesions (LSL), including thoracic aortic aneurysms and acute aortic dissections, are 30-50 times more frequent in TS than in the general population. In 454 TS subjects, we found that LSL are significantly associated with reduced dosage of Xp genes and increased dosage of Xq genes. We also showed that genome-wide copy number variation is increased in TS and identify a common copy number variant (CNV) in chromosome 12p13...
September 8, 2016: American Journal of Medical Genetics. Part A
Luca Marigo, Camillo D'Arcangelo, Francesco De Angelis, Massimo Cordaro, Mirco Vadini, Carlo Lajolo
BACKGROUND: Purpose of this study was to evaluate the push-out bond strengths of four commercially available adhesive luting systems (two self-adhesive and two etch-and-rinse systems) after mechanical aging. METHODS: Forty single-rooted anterior teeth were divided into four groups according to the luting cement system used: G1= Cement-One; G2= One-Q-adhesive Bond + Axia Core Dual; G3 = SmartCem 2; and G4 XP Bond + Core X flow. Anatomical Post were cemented in G1 and G2, and D...
September 7, 2016: Minerva Stomatologica
Y Takahashi, Y Endo, A Kusaka, S Nakamaura, Y Nakazawa, T Ogi, M Uryu, M Tsuji, M Furue, S Moriwaki
A certain relationship between XPA gene mutations and the severity of symptoms has been observed in patients with xeroderma pigmentosum group A (XP-A). Patients with mutations within the DNA-binding domain usually exhibit severe symptoms, whereas splicing mutations in the same domain sometimes cause very mild symptoms. This inconsistency can be explained by a small amount of functional XPA protein produced from normally spliced transcripts. We herein report the case of an adult Japanese XP-A patient with unusually mild symptoms...
September 7, 2016: British Journal of Dermatology
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