Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Arthur W E Lieveld, Micah L A Heldeweg, Jasper Schouwenburg, Lars Veldhuis, Mark E Haaksma, Rutger M van Haaften, Berend P Teunissen, Jasper M Smit, Jos Twisk, Leo Heunks, Prabath W B Nanayakkara, Pieter Roel Tuinman
BACKGROUND: It is unclear if relevant changes in pulmonary involvement in critically ill COVID-19 patients can be reliably detected by the CT severity score (CTSS) and lung ultrasound score (LUSS), or if these changes have prognostic implications. In addition, it has been argued that adding pleural abnormalities to the LUSS could improve its prognostic value. The objective of this study was to compare LUSS and CTSS for the monitoring of COVID-19 pulmonary involvement through: first, establishing the correlation of LUSS (± pleural abnormalities) and CTSS throughout admission; second, assessing agreement and measurement error between raters for LUSS, pleural abnormalities, and CTSS; third, evaluating the association of the LUSS (± pleural abnormalities) and CTSS with mortality at different timepoints...
February 26, 2023: The ultrasound journal
#22
JOURNAL ARTICLE
Rebecca van Grootveld, Martha T van der Beek, Nico A F Janssen, Mehmet Ergün, Karin van Dijk, Carina Bethlehem, Susanne Stads, Judith van Paassen, Leo M A Heunks, Catherine S C Bouman, Monique H E Reijers, Roger J Brüggeman, Frank L van de Veerdonk, Sjoerd H W van Bree, Charlotte H S B van den Berg, Marnix Kuindersma, Joost Wauters, Albertus Beishuizen, Paul E Verweij, Jeroen A Schouten
PURPOSE: COVID-19 associated pulmonary aspergillosis (CAPA) is associated with increased morbidity and mortality in ICU patients. We investigated the incidence of, risk factors for and potential benefit of a pre-emptive screening strategy for CAPA in ICUs in the Netherlands/Belgium during immunosuppressive COVID-19 treatment. MATERIALS AND METHODS: A retrospective, observational, multicentre study was performed from September 2020-April 2021 including patients admitted to the ICU who had undergone diagnostics for CAPA...
February 16, 2023: Journal of Critical Care
#23
MULTICENTER STUDY
Tài Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, Gaëtan Beduneau, Ewan C Goligher, Giacomo Grasselli, Jon Henrik Laake, Jordi Mancebo, Oscar Peñuelas, Lise Piquilloud, Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G Laffey
BACKGROUND: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. METHODS: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer...
May 2023: Lancet Respiratory Medicine
#24
JOURNAL ARTICLE
Micah LA Heldeweg, Arthur We Lieveld, Robin S Walburgh-Schmidt, Jasper M Smit, Mark E Haaksma, Lars Veldhuis, Harm-Jan de Grooth, Armand Rj Girbes, Leo Ma Heunks, Pieter R Tuinman
BACKGROUND: Lung ultrasound (LUS) can be used to monitor critically ill patients with COVID-19, but the optimal number of examined lung zones is disputed. METHODS: This was a prospective observational study. The objective was to investigate whether concise (6 zones) and extended (12 zones) LUS scoring protocols are clinically equivalent in critically ill ICU subjects with COVID-19. The primary outcome of this study was (statistical) agreement between concise and extended LUS score index evaluated in both supine and prone position...
January 17, 2023: Respiratory Care
#25
JOURNAL ARTICLE
Linghe Wu, Zhu Jiang, Eva R Meulendijks, Umit Baylan, Ingeborg S E Waas, Marianna Bugiani, Pieter R Tuinman, Judith Fronczek, Leo M A Heunks, Joris R de Groot, Albert C van Rossum, Hans W M Niessen, Paul A J Krijnen
BACKGROUND: . Histopathological studies have shown inflammation, cardiomyocyte injury and microvascular thrombosis in the ventricular myocardium of patients with coronavirus disease 2019 (COVID-19). However, although atrial dysfunction is common in COVID-19, little is known about histopathological changes in the atria of the heart. We therefore analyzed inflammation, cardiomyocyte injury and microvascular thrombogenicity in the atria of deceased patients with COVID-19. METHODS: ...
January 14, 2023: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
#26
JOURNAL ARTICLE
Micah L A Heldeweg, Jorge E Lopez Matta, Luigi Pisani, Stefanie Slot, Mark E Haaksma, Jasper M Smit, Amne Mousa, Giovanna Magnesa, Fabrizia Massaro, Hugo R W Touw, Viviane Schouten, Carlos V Elzo Kraemer, David J van Westerloo, Leo M A Heunks, Pieter R Tuinman
OBJECTIVES: To investigate the impact of thoracic ultrasound (TUS) examinations on clinical management in adult ICU patients. DESIGN: A prospective international observational study. SETTING: Four centers in The Netherlands and Italy. PATIENTS: Adult ICU patients (> 18 yr) that received a clinically indicated lung ultrasound examination. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Clinicians performing TUS completed a pre- and post-examination case report form...
March 1, 2023: Critical Care Medicine
#27
JOURNAL ARTICLE
Marloes van den Berg, Eva L Peters, Robbert J van der Pijl, Shengyi Shen, Leo M A Heunks, Henk L Granzier, Coen A C Ottenheijm
Diaphragm weakness frequently develops in mechanically ventilated critically ill patients and is associated with increased morbidity, including ventilator weaning failure, mortality, and health care costs. The mechanisms underlying diaphragm weakness are incompletely understood but may include the elastic properties of titin, a giant protein whose layout in the muscle's sarcomeres makes it an ideal candidate to sense ventilation-induced diaphragm unloading, resulting in downstream signaling through titin-binding proteins...
December 10, 2022: International Journal of Molecular Sciences
#28
JOURNAL ARTICLE
Heder J de Vries, Pieter R Tuinman, Annemijn H Jonkman, Ling Liu, Haibo Qiu, Armand R J Girbes, YingRui Zhang, Angelique M E de Man, Harm-Jan de Grooth, Leo Heunks
BACKGROUND: Monitoring and controlling lung stress and diaphragm effort has been hypothesized to limit lung injury and diaphragm injury. The occluded inspiratory airway pressure (Pocc) and the airway occlusion pressure at 100 ms (P0.1) have been used as noninvasive methods to assess lung stress and respiratory muscle effort, but comparative performance of these measures and their correlation to diaphragm effort is unknown. The authors hypothesized that Pocc and P0.1 correlate with diaphragm effort and lung stress and would have strong discriminative performance in identifying extremes of lung stress and diaphragm effort...
March 1, 2023: Anesthesiology
#29
JOURNAL ARTICLE
Judith Elshof, Evert-Jan Wils, Leo M A Heunks, Peter Dieperink, Marieke L Duiverman
High flow nasal oxygen (HFNO) is proven to be effective in non-COVID-19 hypoxemic respiratory failure. In the beginning of the COVID-19 pandemic, HFNO was quickly introduced into daily clinical practice, although the evidence of its effectiveness in COVID-19 was limited. Randomized controlled trials suggest that HFNO has no effect on survival. However, HFNO may lead to less intubations in comparison with conventional oxygen therapy. The evidence of HFNO use in patients with do-not-intubate orders remains very limited...
September 26, 2022: Nederlands Tijdschrift Voor Geneeskunde
#30
JOURNAL ARTICLE
Reply to: Volume-OXygenation Index to Predict HFNC Failure: How to Capture the Tidal Volume Matters.
Dongyu Chen, Leo Heunks, Haibo Qiu, Yi Yang, Ling Liu
No abstract text is available yet for this article.
October 5, 2022: American Journal of Respiratory and Critical Care Medicine
#31
JOURNAL ARTICLE
Zhonghua Shi, Marloes van den Berg, Sylvia Bogaards, Stefan Conijn, Marinus Paul, Albertus Beishuizen, Leo Heunks, Coen A C Ottenheijm
No abstract text is available yet for this article.
September 30, 2022: American Journal of Respiratory and Critical Care Medicine
#32
JOURNAL ARTICLE
Jasper M Smit, Lotte Exterkate, Arne J van Tienhoven, Mark E Haaksma, Micah L A Heldeweg, Lucas Fleuren, Patrick Thoral, Tariq A Dam, Leo M A Heunks, Diederik Gommers, Olaf L Cremer, Rob J Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Alexander P Vlaar, Dave A Dongelmans, Remko de Jong, Marco Peters, Marlijn J A Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G C A Nooteboom, Wouter de Ruijter, Louise C Urlings-Strop, Ellen G M Smit, D Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P C de Jager, Stefaan H A Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C Reidinga, Barbara Festen-Spanjer, Gert B Brunnekreef, Alexander D Cornet, Walter van den Tempel, Age D Boelens, Peter Koetsier, Judith Lens, Harald J Faber, A Karakus, Robert Entjes, Paul de Jong, Thijs C D Rettig, Sesmu Arbous, Bas Vonk, Tomas Machado, Armand R J Girbes, Elske Sieswerda, Paul W G Elbers, Pieter R Tuinman
BACKGROUND: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. METHODS: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic healthrecord database...
September 8, 2022: Shock
#33
RANDOMIZED CONTROLLED TRIAL
Alexander P J Vlaar, Martin Witzenrath, Pieter van Paassen, Leo M A Heunks, Bruno Mourvillier, Sanne de Bruin, Endry H T Lim, Matthijs C Brouwer, Pieter R Tuinman, José F K Saraiva, Gernot Marx, Suzana M Lobo, Rodrigo Boldo, Jesus A Simon-Campos, Alexander D Cornet, Anastasia Grebenyuk, Johannes M Engelbrecht, Murimisi Mukansi, Philippe G Jorens, Robert Zerbib, Simon Rückinger, Korinna Pilz, Renfeng Guo, Diederik van de Beek, Niels C Riedemann
BACKGROUND: Vilobelimab, an anti-C5a monoclonal antibody, was shown to be safe in a phase 2 trial of invasively mechanically ventilated patients with COVID-19. Here, we aimed to determine whether vilobelimab in addition to standard of care improves survival outcomes in this patient population. METHODS: This randomised, double-blind, placebo-controlled, multicentre phase 3 trial was performed at 46 hospitals in the Netherlands, Germany, France, Belgium, Russia, Brazil, Peru, Mexico, and South Africa...
December 2022: Lancet Respiratory Medicine
#34
JOURNAL ARTICLE
Heder J de Vries, Harm Jan de Grooth, Leo M Heunks
No abstract text is available yet for this article.
September 1, 2022: Critical Care Medicine
#35
JOURNAL ARTICLE
Patrick J Smeele, Lisa Vermunt, Siebe Blok, Jan Willem Duitman, Esther J Nossent, Michiel A van Agtmael, Leo M A Heunks, Janneke Horn, Harm Jan Bogaard, Charlotte E Teunissen
Neurological monitoring in sedated Intensive Care Unit patients is constrained by the lack of reliable blood-based biomarkers. Neurofilament light is a cross-disease biomarker for neuronal damage with potential clinical applicability for monitoring Intensive Care Unit patients. We studied the trajectory of neurofilament light over a month in Intensive Care Unit patients diagnosed with severe COVID-19 and explored its relation to clinical outcomes and pathophysiological predictors. Data were collected over a month in 31 Intensive Care Unit patients (166 plasma samples) diagnosed with severe COVID-19 at Amsterdam University Medical Centre, and in the first week after emergency department admission in 297 patients with COVID-19 (635 plasma samples) admitted to Massachusetts General hospital...
2022: Brain communications
#36
JOURNAL ARTICLE
Mark E Haaksma, Jasper M Smit, Ruben Kramer, Micah L A Heldeweg, Lars I Veldhuis, Arthur Lieveld, Dagnery Pikerie, Amne Mousa, Armand R J Girbes, Leo Heunks, Pieter R Tuinman
BACKGROUND: Given the long ventilation times of patients with COVID-19 that can cause atrophy and contractile weakness of respiratory muscle fibers, assessment of changes at the bedside would be interesting. As such, the aim of this study was to determine the evolution of respiratory muscle thickness assessed by ultrasound. METHODS: Adult (> 18 y old) patients admitted to the ICU who tested positive for SARS-CoV-2 and were ventilated for < 24 h were consecutively included...
July 26, 2022: Respiratory Care
#37
JOURNAL ARTICLE
Micah L A Heldeweg, Marry R Smit, Shelley R Kramer-Elliott, Mark E Haaksma, Jasper M Smit, Laura A Hagens, Nanon F L Heijnen, Annemijn H Jonkman, Frederique Paulus, Marcus J Schultz, Armand R J Girbes, Leo M A Heunks, Lieuwe D J Bos, Pieter R Tuinman
OBJECTIVES: To determine the diagnostic accuracy of lung ultrasound signs for both the diagnosis of interstitial syndrome and for the discrimination of noncardiogenic interstitial syndrome (NCIS) from cardiogenic pulmonary edema (CPE) in a mixed ICU population. DESIGN: A prospective diagnostic accuracy study with derivation and validation cohorts. SETTING: Three academic mixed ICUs in the Netherlands. PATIENTS: Consecutive adult ICU patients that received a lung ultrasound examination...
November 1, 2022: Critical Care Medicine
#38
JOURNAL ARTICLE
Mark E Haaksma, Arne J van Tienhoven, Jasper M Smit, Micah L A Heldeweg, Birgit I Lissenberg-Witte, Myrte Wennen, Annemijn Jonkman, Armand R J Girbes, Leo Heunks, Pieter R Tuinman
Ultrasonography of the diaphragm in the zone of apposition has become increasingly popular to evaluate muscle thickness and thickening fraction. However, measurements in this anatomical location are frequently hindered by factors that constrain physical accessibility or that alter diaphragm position. Therefore, other anatomical positions at the chest wall for transducer placement are used, but the variability in diaphragm thickness across the dome has not been systematically studied. The aim of this study was to evaluate anatomical variation of diaphragm thickness in 46 healthy volunteers on three ventrodorsal lines and two craniocaudal positions on these three lines...
September 2022: Ultrasound in Medicine & Biology
#39
Expiratory Muscle Relaxation-Induced Ventilator Triggering: A Novel Patient-Ventilator Dyssynchrony.
Annemijn H Jonkman, Minke C Holleboom, Heder J de Vries, Marijn Vriends, Pieter R Tuinman, Leo M A Heunks
In critically ill patients receiving mechanical ventilation, expiratory muscles are recruited with high respiratory loading and/or low inspiratory muscle capacity. In this case report, we describe a previously unrecognized patient-ventilator dyssynchrony characterized by ventilator triggering by expiratory muscle relaxation, an observation that we termed expiratory muscle relaxation-induced ventilator triggering (ERIT). ERIT can be recognized with in-depth respiratory muscle monitoring as (1) an increase in gastric pressure (Pga) during expiration, resulting from expiratory muscle recruitment; (2) a drop in Pga (and hence, esophageal pressure) at the time of ventilator triggering; and (3) diaphragm electrical activity onset occurring after ventilator triggering...
June 2022: Chest
#40
LETTER
Dongyu Chen, Leo Heunks, Chun Pan, Jianfeng Xie, Haibo Qiu, Yi Yang, Ling Liu
No abstract text is available yet for this article.
October 1, 2022: American Journal of Respiratory and Critical Care Medicine
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
