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https://www.readbyqxmd.com/read/29786481/rat-cranial-bone-derived-mesenchymal-stem-cell-transplantation-promotes-functional-recovery-in-ischemic-stroke-model-rats
#1
Masaru Abiko, Takafumi Mitsuhara, Takahito Okazaki, Takeshi Imura, Kei Nakagawa, Takashi Otsuka, Jumpei Oshita, Masaaki Takeda, Yumi Kawahara, Louis Yuge, Kaoru Kurisu
The functional disorders caused by central nervous system (CNS) diseases, such as ischemic stroke, are clinically incurable and current treatments have limited effects. Previous studies suggested that cell-based therapy using mesenchymal stem cells (MSCs) exerts therapeutic effects for ischemic stroke. In addition, the characteristics of MSCs may depend on their sources. Among the derived tissues of MSCs, we have focused on cranial bones originating from the neural crest. We previously demonstrated that the neurogenic potential of human cranial bone-derived MSCs (cMSCs) was higher than that of human iliac bone-derived MSCs...
May 22, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29786167/neuroplasticity-in-stroke-recovery-the-role-of-microglia-in-engaging-and-modifying-synapses-and-networks
#2
REVIEW
Ioanna Sandvig, Ingrid Lovise Augestad, Asta Kristine Håberg, Axel Sandvig
Neuroplasticity after ischemic injury involves both spontaneous rewiring of neural networks and circuits as well as functional responses in neurogenic niches. These events involve complex interactions with activated microglia, which evolve in a dynamic manner over time. Although the exact mechanisms underlying these interactions remain poorly understood, increasing experimental evidence suggests a determining role of pro- and anti-inflammatory microglial activation profiles in shaping both synaptogenesis and neurogenesis...
May 22, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29785658/incidence-and-risk-factors-for-positive-urine-culture-at-the-time-of-pediatric-urologic-surgery
#3
Michael A Maccini, David J Chalmers, Vijaya M Vemulakonda, Jeffrey B Campbell
PURPOSE: Urinary tract infections are relatively common in pediatric patients. Unrecognized bacteriuria at the time of urologic surgery puts patients at increased risk for perioperative complications. Many pediatric urologists obtain preoperative or intraoperative urine cultures prior to surgery, but data are lacking regarding rates and risk factors for positive intraoperative urine cultures. We conducted a retrospective cohort study of patients undergoing pediatric urologic surgery to examine factors associated with positive intraoperative urine cultures...
May 21, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29784434/cell-therapy-with-autologous-mesenchymal-stromal-cells-in-post-traumatic-syringomyelia
#4
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Concepcion Aguayo, Cecilia Fernandez, Gregorio Rodriguez-Boto, Esperanza Marin, Noemi Tapiador, Marta Sevilla, Joaquin Carballido, David Vazquez, Damian Garcia-Olmo, Hector Guadalajara, Miguel Leon, Ignacio Valverde
BACKGROUND AIMS: Recently, clinical studies show that cell therapy with mesenchymal stromal cells (MSCs) improves the sequelae chronically established in paraplegic patients, being necessary to know which of them can obtain better benefit. METHODS: We present here a phase 2 clinical trial that includes six paraplegic patients with post-traumatic syringomyelia who received 300 million MSCs inside the syrinx and who were followed up for 6 months. Clinical scales, urodynamic, neurophysiological, magnetic resonance (MR) and studies of ano-rectal manometry were performed to assess possible improvements...
May 18, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29783723/the-art-of-caring-in-the-treatment-of-thoracic-outlet-syndrome
#5
EDITORIAL
Julie Ann Freischlag
Those who diagnose and treat patients with thoracic outlet syndrome, especially those patientswith neurogenic thoracic outlet syndrome, have a practice, which needs to include many modalities todiagnose, treat, and intervene to improve their quality of life for the present and for the future.[...].
May 19, 2018: Diagnostics
https://www.readbyqxmd.com/read/29783243/-electromyographic-characteristics-of-temporal-and-masticatory-muscles-in-patients-with-compression-dislocation-dysfunction-of-temporomandibular-joints-of-different-severity
#6
Pavlo I Yatsenko, Oleg V Rybalov, Oleg I Yatsenko, Vadym M Novikov, Dmytro M Kоrol, Dmytro D Kindiy, Victor D Kindiy
OBJECTIVE: Introduction: The main causes of dysfunctional conditions of the temporomandibular joints (TMJ), are occlusal, neurogenic, orthodontic disorders. The muscular component of TMJ is determines the dynamic anatomical and functional state of the mandible Therefore, in the diagnosis of dysfunctions and understanding of their pathogenesis belongs to the electromyographic method of investigation. The aim of the work was a comparative assessment of the bioelectrical activity of the actual chewing and temporal muscles in patients with musculo-articular compressiondislocation dysfunction of the TMJ of various severity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782911/estrogen-deficiency-exacerbates-a%C3%AE-induced-memory-impairment-through-enhancement-of-neuroinflammation-amylodogenesis-and-nf-%C3%A4-b-activation-in-ovariectomized-mice
#7
Jaesuk Yun, In Jun Yeo, Chul Ju Hwang, Dong-Young Choi, Hyung-Sik Im, Ji Youg Kim, Won Rak Choi, Myung Hee Jung, Sang-Bae Han, Jin Tae Hong
Estrogen is well known to have a preventative effect in Alzheimer's disease (AD) pathology. Several studies have demonstrated that nuclear factor kappa-B (NF-ĸB) can contribute to the effects of estrogen on the development of AD. We investigated whether NF-ĸB affects amyloid-beta (Aβ)-induced memory impairment in an estrogen-lacking condition. In the present study, nine-week-old Institute cancer research (ICR) mice were ovariectomized to block estrogen stimulation. Ten weeks after the ovariectomization, mice were administered with Aβ (300 pmol) via intracerebroventricular (ICV) infusion for 2 weeks...
May 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29781659/nicotine-deprivation-increases-pain-intensity-neurogenic-inflammation-and-mechanical-hyperalgesia-among-daily-tobacco-smokers
#8
Joseph W Ditre, Emily L Zale, Lisa R LaRowe, Jesse D Kosiba, Martin J De Vita
An evolving reciprocal model posits that pain and tobacco smoking behavior interact in the manner of a positive feedback loop, resulting in greater pain and the maintenance of nicotine dependence. There is also reason to believe that abstaining from smoking may increase pain during the early stages of smoking cessation. The goal of this study was to test the effects of nicotine deprivation on experimental pain reactivity. Daily tobacco cigarette smokers (N = 165; 43% female) were randomized to either extended nicotine deprivation (12-24 hr smoking abstinence), minimal deprivation (2 hr smoking abstinence), or continued smoking conditions, prior to undergoing pain induction via topical capsaicin...
May 21, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29779889/epithelial-sodium-channel-regulates-adult-neural-stem-cell-proliferation-in-a-flow-dependent-manner
#9
David Petrik, Michael H Myoga, Sofia Grade, Niklas J Gerkau, Melanie Pusch, Christine R Rose, Benedikt Grothe, Magdalena Götz
One hallmark of adult neurogenesis is its adaptability to environmental influences. Here, we uncovered the epithelial sodium channel (ENaC) as a key regulator of adult neurogenesis as its deletion in neural stem cells (NSCs) and their progeny in the murine subependymal zone (SEZ) strongly impairs their proliferation and neurogenic output in the olfactory bulb. Importantly, alteration of fluid flow promotes proliferation of SEZ cells in an ENaC-dependent manner, eliciting sodium and calcium signals that regulate proliferation via calcium-release-activated channels and phosphorylation of ERK...
May 9, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29779134/complexity-of-systems-and-actions-underlying-neurogenic-inflammation
#10
EDITORIAL
Tony L Yaksh, Anna Di Nardo
No abstract text is available yet for this article.
May 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29778545/a-descriptive-model-for-a-multidisciplinary-unit-for-colorectal-and-pelvic-malformations
#11
Alejandra Vilanova-Sanchez, Devin R Halleran, Carlos A Reck-Burneo, Alessandra C Gasior, Laura Weaver, Meghan Fisher, Andrea Wagner, Onnalisa Nash, Kristina Booth, Kaleigh Peters, Charae Williams, Sarah Mayer Brown, Peter Lu, Molly Fuchs, Karen Diefenbach, Jeffrey R Leonard, Geri Hewitt, Kate McCracken, Carlo Di Lorenzo, Richard J Wood, Marc A Levitt
INTRODUCTION: Patients with anorectal malformations (ARM), Hirschsprung disease (HD), and colonic motility disorders often require care from specialists across a variety of fields, including colorectal surgery, urology, gynecology, and GI motility. We sought to describe the process of creating a collaborative process for the care of these complex patients. METHODS: We developed a model of a devoted center for these conditions that includes physicians, psychologists, social workers, nurses, and advanced practice nurses...
April 19, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29777374/the-tenascin-c-derived-peptide-vswrapta-promotes-neuronal-branching-via-transcellular-activation-of-the-focal-adhesion-kinase-fak-and-the-erk1-2-signaling-pathway-in-vitro
#12
Marvin Jarocki, Omar Sallouh, Ralf Weberskirch, Andreas Faissner
The central nervous system (CNS) of mammals has a limited regeneration capacity after traumatic events, which causes chronic functional disability. The development of biomaterials aims at providing support for the regeneration process. One strategy integrates peptides that mimic functional domains of extracellular matrix (ECM) or cell adhesion molecules with synthetic polymers designed to present growth-supporting cues to the neuronal microenvironment. Thus, small peptide sequences originating from molecules of the ECM may serve as promising bio-additives, acting as artificial matricryptins to gear cellular processes...
May 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29777182/a-glial-blueprint-for-gliomagenesis
#13
REVIEW
Dylan Laug, Stacey M Glasgow, Benjamin Deneen
Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it produces the vast cellular constituency associated with frank glioma remains poorly defined. We explore glioma tumorigenesis through the lens of glial development, starting with the neurogenic-gliogenic switch and progressing through oligodendrocyte and astrocyte differentiation. Beginning with the factors that influence normal glial linage progression and diversity, a pattern emerges that has useful parallels in the development of glioma and may ultimately provide targetable pathways for much-needed new therapeutics...
May 18, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29775734/defining-the-osteoarthritis-patient-back-to-the-future
#14
REVIEW
Geoffrey P Dobson, Hayley L Letson, Andrea Grant, Peter McEwen, Kaushik Hazratwala, Matthew Wilkinson, Jodie L Morris
The history of osteoarthritis (OA) is important because it can help broaden our perspective on past and present controversies. The naming of OA, beginning with Heberden's nodes, is itself a fascinating story. According to Albert Hoffa, R. Llewellyn Jones and Archibald Edward Garrod, the name OA was introduced in the mid-19th century by surgeon Richard von Volkmann who distinguished it from rheumatoid arthritis and gout. Others preferred the terms 'chronical rheumatism', 'senile arthritis', 'hypertrophic arthritis' or 'arthritis deformans'...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29774817/bladder-reconstruction-with-bowel-robot-assisted-laparoscopic-ileocystoplasty-with-mitrofanoff-appendicovesicostomy-in-pediatric-patients
#15
Nimrod S Barashi, Maria Veronica Rodriguez, Vignesh T Packiam, Mohan S Gundeti
Neurogenic bladder occur as a consequence of several conditions, most commonly posterior urethral valves syndrome, spina bifida, tethered cord, sacral agenesis, and Arnold-Chiari malformation. It is characterized by diminished bladder capacity and/or reduced compliance, associated with high-pressure voiding that can lead to deterioration of renal function if left untreated. When medical management fails, bladder reconstruction with bowel (aumentation ileocystoplasty) becomes the treatment of choice for these patients...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29773953/mir-34a-mediated-regulation-of-xist-in-female-cells-under-inflammation
#16
Botros B Shenoda, Yuzhen Tian, Guillermo M Alexander, Enrique Aradillas-Lopez, Robert J Schwartzman, Seena K Ajit
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of the chronic pain patient population. There is a need to explore novel avenues to elucidate this sex bias in the development of chronic inflammatory pain conditions. Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder, and the incidence of CRPS is greater in women than in men by ~4:1. Since neurogenic inflammation is a key feature of CRPS, dysregulation of inflammatory responses can be a factor in predisposing women to chronic pain...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29772944/hilic-ms-ms-determination-of-amino-acids-in-herbs-of-fumaria-schleicheri-l-ocimum-basilicum-l-and-leaves-of-corylus-avellana-l
#17
Yuliya Prokopenko, Valdas Jakštas, Vaidotas Žvikas, Victoriya Georgiyants, Liudas Ivanauskas
The aim of research was to study the content of amino acids using in extracts of Fumaria schleicheri L., Ocimum basilicum L., and Corylus avellana L. by HILIC MS/MS method. Separation of amino acids in the samples was carried out with Acquity H-class UPLC system (Waters, Milford, USA) equipped with SeQuant ZIC-Hilic collumn (2.1 × 150 mm, 3.5 μm) (Merck Millipore, Darmstadt, Germany). The MS/MS fragment ion chromatograms of the test solutions established the presence of 19 amino acids. The obtained results have shown that O...
May 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29772332/outcomes-following-transaxillary-approach-to-cervical-and-first-rib-resection-for-neurogenic-thoracic-outlet-syndrome
#18
Arjun Jayaraj, Audra A Duncan, Manju Kalra, Thomas C Bower, Peter Gloviczki
OBJECTIVE: Cervical rib can often be symptomatic causing neurogenic thoracic outlet syndrome (nTOS). Surgical treatment involves rib resection through a supraclavicular, transaxillary or combined approach. We review outcomes of different approaches and describe our technique of transaxillary resection through a video. METHODS: Single center retrospective review of peri-operative and short-term outcomes in subjects undergoing cervical rib resection for nTOS between 1994 and 2013...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29770876/reliability-and-validity-of-the-eating-assessment-tool-10-greek-adaptation-in-neurogenic-and-head-and-neck-cancer-related-oropharyngeal-dysphagia
#19
Athanasia Printza, Athanasios Kyrgidis, Elena Pavlidou, Stefanos Triaridis, Jannis Constantinidis
PURPOSE: Dysphagia is a symptom associated with significant morbidity and mortality, with profound impact on physical ability and quality of life. Many questionnaires have been used to assess patient-reported dysphagia, but issues related to developmental and measurement properties affect their wide applicability. The purpose of this study was to assess the validity and reliability of the Eating Assessment Tool-10 (EAT-10, Greek adaptation) in neurogenic and head and neck cancer-related dysphagia...
May 17, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29766366/consensus-statement-on-the-definition-of-neurogenic-supine-hypertension-in-cardiovascular-autonomic-failure-by-the-american-autonomic-society-aas-and-the-european-federation-of-autonomic-societies-efas-endorsed-by-the-european-academy-of-neurology-ean-and-the
#20
REVIEW
Alessandra Fanciulli, Jens Jordan, Italo Biaggioni, Giovanna Calandra-Buonaura, William P Cheshire, Pietro Cortelli, Sabine Eschlboeck, Guido Grassi, Max J Hilz, Horacio Kaufmann, Heinz Lahrmann, Giuseppe Mancia, Gert Mayer, Lucy Norcliffe-Kaufmann, Anne Pavy-Le Traon, Satish R Raj, David Robertson, Isabel Rocha, Walter Struhal, Roland Thijs, Konstantinos P Tsioufis, J Gert van Dijk, Gregor K Wenning
PURPOSE: Patients suffering from cardiovascular autonomic failure often develop neurogenic supine hypertension (nSH), i.e., high blood pressure (BP) in the supine position, which falls in the upright position owing to impaired autonomic regulation. A committee was formed to reach consensus among experts on the definition and diagnosis of nSH in the context of cardiovascular autonomic failure. METHODS: As a first and preparatory step, a systematic search of PubMed-indexed literature on nSH up to January 2017 was performed...
May 15, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
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