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https://www.readbyqxmd.com/read/28891140/other-helicobacters-gastric-and-gut-microbiota
#1
REVIEW
Christelle Péré-Védrenne, Bram Flahou, Mun Fai Loke, Armelle Ménard, Jamuna Vadivelu
The current article is a review of the most important and relevant literature published in 2016 and early 2017 on non-Helicobacter pylori Helicobacter infections in humans and animals, as well as interactions between H. pylori and the microbiota of the stomach and other organs. Some putative new Helicobacter species were identified in sea otters, wild boars, dogs, and mice. Many cases of Helicobacter fennelliae and Helicobacter cinaedi infection have been reported in humans, mostly in immunocompromised patients...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28831408/shotgun-metagenomic-data-on-the-human-stool-samples-to-characterize-shifts-of-the-gut-microbial-profile-after-the-helicobacter-pylori-eradication-therapy
#2
Eugenia A Boulygina, Maria I Markelova, Dilyara R Khusnutdinova, Maria N Siniagina, Sergey Yu Malanin, Rustam A Abdulkhakov, Sayar R Abdulkhakov, Vladislav M Chernov, Tatiana V Grigoryeva
The shotgun sequencing data presented in this report are related to the research article named "Gut microbiome shotgun sequencing in assessment of microbial community changes associated with H. pylori eradication therapy" (Khusnutdinova et al., 2016) [1]. Typically, the H. pylori eradication protocol includes a prolonged two-week use of the broad-spectrum antibiotics. The presented data on the whole-genome sequencing of the total DNA from stool samples of patients before the start of the eradication, immediately after eradication and several weeks after the end of treatment could help to profile the gut microbiota both taxonomically and functionally...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28801429/multicentric-randomised-study-of-helicobacter-pylori-eradication-and-pepsinogen-testing-for-prevention-of-gastric-cancer-mortality-the-gistar-study
#3
Marcis Leja, Jin Young Park, Raul Murillo, Inta Liepniece-Karele, Sergejs Isajevs, Ilze Kikuste, Dace Rudzite, Petra Krike, Sergei Parshutin, Inese Polaka, Arnis Kirsners, Daiga Santare, Valdis Folkmanis, Ilva Daugule, Martyn Plummer, Rolando Herrero
INTRODUCTION: Population-based eradication of Helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. However, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. An alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. The primary objective of GISTAR is to determine whether H pylori eradication combined with pepsinogen testing reduces mortality from gastric cancer among 40-64-year-old individuals...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28765474/mucosal-microbiome-dysbiosis-in-gastric-carcinogenesis
#4
Olabisi Oluwabukola Coker, Zhenwei Dai, Yongzhan Nie, Guijun Zhao, Lei Cao, Geicho Nakatsu, William Kk Wu, Sunny Hei Wong, Zigui Chen, Joseph J Y Sung, Jun Yu
OBJECTIVES: We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. DESIGN: We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi'an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China...
August 1, 2017: Gut
https://www.readbyqxmd.com/read/28733944/the-gastric-and-intestinal-microbiome-role-of-proton-pump-inhibitors
#5
REVIEW
Artem Minalyan, Lilit Gabrielyan, David Scott, Jonathan Jacobs, Joseph R Pisegna
PURPOSE OF REVIEW: The discovery of Helicobacter pylori and other organisms colonizing the stomach and the intestines has shed some light on the importance of microbiome in maintaining overall health and developing pathological conditions when alterations in biodiversity are present. The gastric acidity plays a crucial role in filtering out bacteria and preventing development of enteric infections. In this article, we discuss the physiology of gastric acid secretion and bacterial contribution to the composition of gastric and intestinal barriers and review the current literature on the role of proton pump inhibitors (PPIs) in the microbial biodiversity of the gastrointestinal tract...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28587343/alteration-of-stomach-microbiota-compositions-in-the-progression-of-gastritis-induces-nitric-oxide-in-gastric-cell
#6
Tianyi Dong, Qiang Feng, Fengyan Liu, Lap Kam Chang, Xiangyu Zhou, Mingyong Han, Xingsong Tian, Ning Zhong, Shili Liu
Atrophic gastritis is considered to be an antecedent to intestinal metaplasia and gastric cancer. A previous study identified that Helicobacter pylori was absent at the severe atrophic gastritis stage, and alterations in the gastric microbial composition resembled those in gastric cancer. To explore the role of the bacteria absence of H. pylori in gastric carcinogenesis, in the current study, we compared the microbiota of clinically collected H. pylori-free gastric fluids from 30 patients with non-atrophic gastritis (N) and 22 patients with severe atrophic gastritis (S)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28299869/helicobacter-pylori-infection-is-associated-with-reduced-prevalence-of-colonic-diverticular-disease
#7
Lars Erik Bartels, Peter Jepsen, Anders Tøttrup, Hendrik Vilstrup, Jens Frederik Dahlerup
BACKGROUND: Colonic diverticular disease is a common disorder with increasing incidence in Western societies. The intestinal microbiome may be among etiological factors. Helicobacter pylori may protect against some intestinal diseases, and incidence of H. pylori is decreasing in Western societies. Thus, we aimed to determine whether H. pylori is associated to decreased prevalence of registered colonic diverticular disease. MATERIALS AND METHODS: In a historical cohort study, patients were enrolled from primary health care centers after urea breath test for H...
August 2017: Helicobacter
https://www.readbyqxmd.com/read/28275685/the-clinical-evidence-linking-helicobacter-pylori-to-gastric-cancer
#8
REVIEW
Steven F Moss
Gastric cancer has long been recognized to be accompanied and preceded by chronic gastritis, lasting decades. Arguably, the most important development in our understanding of gastric cancer pathogenesis over the past 50 years has been the realization that, for most cases of gastric cancer, Helicobacter pylori is the cause of the underlying gastritis. Gastritis can promote gastric carcinogenesis, typically via the Correa cascade of atrophic gastritis, intestinal metaplasia, and dysplasia. Nested case-control studies have shown that H pylori infection increases the risk of gastric cancer significantly, both of the intestinal and diffuse subtypes, and that H pylori is responsible for approximately 90% of the world's burden of noncardia gastric cancer...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28164846/the-esophageal-and-gastric-microbiome-in-health-and-disease
#9
REVIEW
Richard H Hunt, Mohammad Yaghoobi
The esophagus and stomach are host to their own population of bacteria, which differs in health and disease. Helicobacter pylori uniquely colonizes only gastric mucosa, but an increasing number of bacteria is now isolated from the gastric juice and gastric mucosa, including Lactobacillus. The presence of H pylori alters populations of other gastric bacteria with a marked reduction in diversity. Alterations in intragastric acidity may be the cause or the consequence of changes in the microbial populations of the stomach...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28120843/helicobacter-pylori-infection-is-associated-with-an-altered-gastric-microbiota-in-children
#10
K M Brawner, R Kumar, C A Serrano, T Ptacek, E Lefkowitz, C D Morrow, D Zhi, K R Kyanam-Kabir-Baig, L E Smythies, P R Harris, P D Smith
The intestinal microbiome in early life influences development of the mucosal immune system and predisposition to certain diseases. Because less is known about the microbiome in the stomach and its relationship to disease, we characterized the microbiota in the stomachs of 86 children and adults and the impact of Helicobacter pylori infection on the bacterial communities. The overall composition of the gastric microbiota in children and adults without H. pylori infection was similar, with minor differences in only low abundance taxa...
September 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/27866909/unsaturated-fatty-acid-synthesis-in-the-gastric-pathogen-helicobacter-pylori-proceeds-via-a-backtracking-mechanism
#11
Hongkai Bi, Lei Zhu, Jia Jia, Liping Zeng, John E Cronan
Helicobacter pylori is a Gram-negative bacterium that inhabits the upper gastrointestinal tract in humans, and the presence of this pathogen in the gut microbiome increases the risk of peptic ulcers and stomach cancer. H. pylori depends on unsaturated fatty acid (UFA) biosynthesis for maintaining membrane structure and function. Although some of the H. pylori enzymes involved in UFA biosynthesis are functionally homologous with the enzymes found in Escherichia coli, we show here that an enzyme HP0773, now annotated as FabX, uses an unprecedented backtracking mechanism to not only dehydrogenate decanoyl-acyl carrier protein (ACP) in a reaction that parallels that of acyl-CoA dehydrogenase, the first enzyme of the fatty acid β-oxidation cycle, but also isomerizes trans-2-decenoyl-ACP to cis-3-decenoyl-ACP, the key UFA synthetic intermediate...
December 22, 2016: Cell Chemical Biology
https://www.readbyqxmd.com/read/27820723/characterization-of-the-gastric-microbiota-in-a-pediatric-population-according-to-helicobacter-pylori-status
#12
Laura Llorca, Guillermo Pérez-Pérez, Pedro Urruzuno, Maria Josefa Martinez, Tadasu Iizumi, Zhan Gao, Jiho Sohn, Jennifer Chung, Laura Cox, Aurea Simón-Soro, Alex Mira, Teresa Alarcón
BACKGROUND: Helicobacter pylori colonizes the human stomach of approximately 50% of the world's population, and increases the risk of several gastric diseases. The goal of this study is to compare the gastric microbiota in pediatric patients with and without H. pylori colonization. METHODS: We studied 51 children who underwent gastric endoscopy because of dyspeptic symptoms (18 H. pylori positive and 33 negative). Gastric biopsies were obtained for rapid urease test, culture, histology and DNA extraction...
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27806126/chronic-opisthorchis-viverrini-infection-changes-the-liver-microbiome-and-promotes-helicobacter-growth
#13
Upsornsawan Itthitaetrakool, Porntip Pinlaor, Somchai Pinlaor, Chariya Chomvarin, Rungtiwa Dangtakot, Apisit Chaidee, Chotechana Wilailuckana, Arunnee Sangka, Aroonlug Lulitanond, Puangrat Yongvanit
Adults of Opisthorchis viverrini reside in the biliary system, inducing inflammation of bile ducts and cholangitis, leading to hepatobiliary disease (HBD) including cholangiocarcinoma. O. viverrini infection also has major implications for the bacterial community in bile ducts and liver. To investigate this in chronic O. viverrini infection (≥ 8 months p.i.), bacterial genomic DNA from livers of hamsters and from worms was investigated using culture techniques, PCR for Helicobacter spp. and high-throughput next-generation sequencing targeting the V3-V4 hypervariable regions of prokaryotic 16S rRNA gene...
2016: PloS One
https://www.readbyqxmd.com/read/27729513/spatial-and-temporal-shifts-in-bacterial-biogeography-and-gland-occupation-during-the-development-of-a-chronic-infection
#14
Daniela Keilberg, Yana Zavros, Benjamin Shepherd, Nina R Salama, Karen M Ottemann
Gland colonization may be one crucial route for bacteria to maintain chronic gastrointestinal infection. We developed a quantitative gland isolation method to allow robust bacterial population analysis and applied it to the gastric pathobiont Helicobacter pylori After infections in the murine model system, H. pylori populations multiply both inside and outside glands in a manner that requires the bacteria to be motile and chemotactic. H. pylori is able to achieve gland densities averaging 25 to 40 bacteria/gland after 2 to 4 weeks of infection...
October 11, 2016: MBio
https://www.readbyqxmd.com/read/27688750/nutrition-and-helicobacter-pylori-host-diet-and-nutritional-immunity-influence-bacterial-virulence-and-disease-outcome
#15
REVIEW
Kathryn P Haley, Jennifer A Gaddy
Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated with an increased risk for more severe disease outcomes including B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma) and invasive adenocarcinoma. Research aimed at elucidating determinants that mediate disease progression has revealed genetic differences in both humans and H...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27532494/stool-microbiome-reveals-diverse-bacterial-ureases-as-confounders-of-oral-urea-breath-testing-for-helicobacter-pylori-and-mycobacterium-tuberculosis-in-bamako-mali
#16
Mamoudou Maiga, Keira Cohen, Bocar Baya, Geetha Srikrishna, Sophia Siddiqui, Moumine Sanogo, Anou M Somboro, Bassirou Diarra, Mariam H Diallo, Varun Mazumdar, Christian Yoder, Susan Orsega, Michael Belson, Hamadoun Kassambara, Drissa Goita, Robert L Murphy, Sounkalo Dao, Michael Polis, Souleymane Diallo, Graham S Timmins, Lori Dodd, Ashlee M Earl, William R Bishai
Detection of bacterial urease activity has been utilized successfully to diagnose Helicobacter pylori (H. pylori). While Mycobacterium tuberculosis (M. tuberculosis) also possesses an active urease, it is unknown whether detection of mycobacterial urease activity by oral urease breath test (UBT) can be exploited as a rapid point of care biomarker for tuberculosis (TB) in humans. We enrolled 34 individuals newly diagnosed with pulmonary TB and 46 healthy subjects in Bamako, Mali and performed oral UBT, mycobacterial sputum culture and H...
August 17, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27531909/hydrogen-metabolism-in-helicobacter-pylori-plays-a-role-in-gastric-carcinogenesis-through-facilitating-caga-translocation
#17
Ge Wang, Judith Romero-Gallo, Stéphane L Benoit, M Blanca Piazuelo, Ricardo L Dominguez, Douglas R Morgan, Richard M Peek, Robert J Maier
UNLABELLED: A known virulence factor of Helicobacter pylori that augments gastric cancer risk is the CagA cytotoxin. A carcinogenic derivative strain, 7.13, that has a greater ability to translocate CagA exhibits much higher hydrogenase activity than its parent noncarcinogenic strain, B128. A Δhyd mutant strain with deletion of hydrogenase genes was ineffective in CagA translocation into human gastric epithelial AGS cells, while no significant attenuation of cell adhesion was observed...
August 16, 2016: MBio
https://www.readbyqxmd.com/read/27341527/analysis-of-the-effects-of-microbiome-related-confounding-factors-on-the-reproducibility-of-the-volatolomic-test
#18
Marcis Leja, Haitham Amal, Ieva Lasina, Roberts Skapars, Armands Sivins, Guntis Ancans, Ivars Tolmanis, Aigars Vanags, Juozas Kupcinskas, Rima Ramonaite, Salam Khatib, Shifaa Bdarneh, Rasha Natour, Areen Ashkar, Hossam Haick
Volatile organic compound (VOC) testing in breath has potential in gastric cancer (GC) detection. Our objective was to assess the reproducibility of VOCs in GC, and the effects of conditions modifying gut microbiome on the test results. Ten patients with GC were sampled for VOC over three consecutive days; 17 patients were sampled before and after H. pylori eradication therapy combined with a yeast probiotic; 61 patients were sampled before and after bowel cleansing (interventions affecting the microbiome)...
June 24, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27028228/helicobacter-pylori-and-other-gastric-microbiota-in-gastroduodenal-pathologies
#19
REVIEW
Christian Schulz, Kerstin Schütte, Peter Malfertheiner
The discovery of Helicobacter pylori changed the traditional view of the stomach as a hostile organ to bacterial survival. H. pylori induces chronic gastritis, which has the potential to progress to severe complications such as peptic ulcer disease and gastric neoplasia. The development of modern nucleotide sequencing techniques and new biocomputational tools allow the possibility of studying the diversity and complexity of the microbiome in the whole gastrointestinal (GI) tract and overcome the limitations of culturing techniques...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/26991862/changes-in-the-functional-potential-of-the-gut-microbiome-following-probiotic-supplementation-during-helicobacter-pylori-treatment
#20
Bumjo Oh, Ji Won Kim, Bong-Soo Kim
BACKGROUND: Probiotic supplementation is utilized to alleviate the side effects associated with antibiotic therapy for Helicobacter pylori infection. Several studies have described the effects of administration of probiotics on the gut microbiota during antibiotic therapy. However, most of these studies have focused on specific bacteria, thereby providing limited information on the functional roles of the altered microbiota. Therefore, we examined the impact of probiotic supplementation on the structure and functional dynamics of the gut microbiota during H...
December 2016: Helicobacter
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