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Non alzheimer,s dementia

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https://www.readbyqxmd.com/read/29188876/association-of-cortical-%C3%AE-amyloid-with-erythrocyte-membrane-monounsaturated-and-saturated-fatty-acids-in-older-adults-at-risk-of-dementia
#1
C Hooper, P De Souto Barreto, P Payoux, A S Salabert, S Guyonnet, S Andrieu, S Sourdet, J Delrieu, B Vellas
OBJECTIVES: We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints. DESIGN: This is a cross-sectional study using data from the Multidomain Alzheimer Preventive Trial (MAPT); a randomised controlled trial. SETTING: French community dwellers aged 70 or over reporting subjective memory complaints, but free from a diagnosis of clinical dementia...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29186278/dependence-levels-as-interim-clinical-milestones-along-the-continuum-of-alzheimer-s-disease-18-month-results-from-the-geras-observational-study
#2
K Kahle-Wrobleski, J S Andrews, M Belger, W Ye, S Gauthier, D M Rentz, D Galasko
BACKGROUND: While functional loss forms part of the current diagnostic criteria used to identify dementia due to Alzheimer's disease, the gradual and progressive nature of the disease makes it difficult to recognize clinically relevant signposts that could be helpful in making treatment and management decisions. Having previously observed a significant relationship between stages of functional dependence (the level of assistance patients require consequent to Alzheimer's disease deficits, derived from the Alzheimer's Disease Cooperative Study - Activities of Daily Living Scale) and cognitive severity, we investigated whether measures of functional dependence could be utilized to identify clinical milestones of Alzheimer's disease progression...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182710/objective-cognitive-impairment-and-progression-to-dementia-in-women-the-prospective-epidemiological-risk-factor-study
#3
J Skov Neergaard, K Dragsbæk, C Christiansen, M Asser Karsdal, S Brix, K Henriksen
BACKGROUND: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer's disease have failed. OBJECTIVES: The objective of this study was to identify subgroups of individuals with objective cognitive impairment (OCI), who were most likely to progress to dementia and to identify the risk factors associated with progression. DESIGN: Prospective cohort study...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29126669/what-can-dti-tell-about-early-cognitive-impairment-differentiation-between-mci-subtypes-and-healthy-controls-by-diffusion-tensor-imaging
#4
Gyula Gyebnár, Ádám Szabó, Enikő Sirály, Zsuzsanna Fodor, Anna Sákovics, Pál Salacz, Zoltán Hidasi, Éva Csibri, Gábor Rudas, Lajos R Kozák, Gábor Csukly
Mild cognitive impairment (MCI) gained a lot of interest recently, especially that the conversion rate to Alzheimer Disease (AD) in the amnestic subtype (aMCI) is higher than in the non-amnestic subtype (naMCI). We aimed to determine whether and how diffusion-weighted MRI (DWI) using the diffusion tensor model (DTI) can differentiate MCI subtypes from healthy subjects. High resolution 3D T1W and DWI images of patients (aMCI, n = 18; naMCI, n = 20; according to Petersen criteria) and controls (n = 27) were acquired at 3T and processed using ExploreDTI and SPM...
October 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29117869/frequency-of-use-of-the-international-classification-of-diseases-icd-10-diagnostic-categories-for-mental-and-behavioural-disorders-across-world-regions
#5
Y Faiad, B Khoury, S Daouk, M Maj, J Keeley, O Gureje, G Reed
AIMS: The study aimed to examine variations in the use of International Classification of Diseases, Tenth Edition (ICD-10) diagnostic categories for mental and behavioural disorders across countries, regions and income levels using data from the online World Psychiatric Association (WPA)-World Health Organization (WHO) Global Survey that examined the attitudes of psychiatrists towards the classification of mental disorders. METHODS: A survey was sent to 46 psychiatric societies which are members of WPA...
November 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29105977/tau-pet-imaging-predicts-cognition-in-atypical-variants-of-alzheimer-s-disease
#6
Jeffrey S Phillips, Sandhitsu R Das, Corey T McMillan, David J Irwin, Emily E Roll, Fulvio Da Re, Ilya M Nasrallah, David A Wolk, Murray Grossman
Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer's disease (AD). (18) F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between (18) F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic-variant primary progressive aphasia (lvPPA, n = 4)...
November 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29102243/tau-amyloid-and-cascading-network-failure-across-the-alzheimer-s-disease-spectrum
#7
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack
Functionally related brain regions are selectively vulnerable to Alzheimer's disease pathophysiology. However, molecular markers of this pathophysiology (i.e., beta-amyloid and tau aggregates) have discrepant spatial and temporal patterns of progression within these selectively vulnerable brain regions. Existing reductionist pathophysiologic models cannot account for these large-scale spatiotemporal inconsistencies. Within the framework of the recently proposed cascading network failure model of Alzheimer's disease, however, these large-scale patterns are to be expected...
October 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29089874/mistakes-too-few-to-mention-impaired-self-conscious-emotional-processing-of-errors-in-the-behavioral-variant-of-frontotemporal-dementia
#8
Carole S Scherling, Jessica Zakrzewski, Samir Datta, Robert W Levenson, Arthur P Shimamura, Virginia E Sturm, Bruce L Miller, Howard J Rosen
Anosognosia, or lack of awareness of one's deficits, is a core feature of the behavioral variant of frontotemporal dementia (bvFTD). We hypothesized that this deficit has its origins in failed emotional processing of errors. We studied autonomic and facial emotional reactivity to errors in patients with bvFTD (n = 17), Alzheimer's disease (AD, n = 20), and healthy controls (HC, n = 35) during performance of a timed two-alternative-choice button press task. Performance-related behavioral responses to errors were quantified using rates of error correction and post-error slowing of reaction times...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29083439/cognitive-changes-with-omega-3-polyunsaturated-fatty-acids-in-non-demented-older-adults-with-low-omega-3-index
#9
C Hooper, P De Souto Barreto, N Coley, C Cantet, M Cesari, S Andrieu, B Vellas
OBJECTIVES: To investigate the changes in specific domains of cognitive function in older adults reporting subjective memory complaints with a low omega-3 index receiving omega 3 polyunsaturated fatty acid (n-3 PUFA) supplementation or placebo. DESIGN: This is a secondary exploratory analysis of the Multidomain Alzheimer Preventive Trial (MAPT) using subjects randomized to the n-3 PUFA supplementation or placebo group. SETTING: French community dwellers aged 70 or over reporting subjective memory complaints, but free from clinical dementia...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29057172/cerebral-and-retinal-neurovascular-changes-a-biomarker-for-alzheimer-s-disease
#10
Karru Venkata Ravi Teja, Tjm Tos Berendschot, Harry Steinbusch, A B Carroll Webers, R Praveen Murthy, P S Mathuranath
OBJECTIVES: Biomarker quest for Alzheimer's disease (AD) has gone a long way by studying various anatomical, physiological and biochemical parameters for detecting disease onset and predicting prognosis. Almost all the studies converge on the single hypothesis of the amyloid and Tau pathway. Recently, vascular hypothesis has evolved drawing attention towards a complex dynamic anatomical and physiological entity, neuro-vascular (NV) unit. Pathological changes at this level, altering the normal physiology such as auto-regulation and dynamics of blood brain barrier have been hypothesized as a probable basis for AD...
August 2017: Journal of Gerontology & Geriatric Research
https://www.readbyqxmd.com/read/29054264/using-artificial-neural-networks-to-select-the-parameters-for-the-prognostic-of-mild-cognitive-impairment-and-dementia-in-elderly-individuals
#11
REVIEW
A J C C Lins, M T C Muniz, A N M Garcia, A V Gomes, R M Cabral, C J A Bastos-Filho
BACKGROUND AND OBJECTIVES: A huge number of solutions based on computational systems have been recently developed for the classification of cognitive abnormalities in older people, so that individuals at high risk of developing neurodegenerative diseases, such as Cognitive Impairment and Alzheimer?s disease, can be identified before the manifestation of the diseases. Several factors are related to these pathologies, making the diagnostic process a hard problem to solve. This paper proposes a computational model based on the artificial neural network to classify data patterns of older adults...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29030451/weighting-and-standardization-of-frequencies-to-determine-prevalence-of-ad-imaging-biomarkers
#12
Rosebud O Roberts, David S Knopman, Jeremy A Syrjanen, Jeremiah A Aakre, Maria Vassilaki, Walter K Kremers, Michelle M Mielke, Mary M Machulda, Jonathan Graff-Radford, Yonas E Geda, Prashanthi Vemuri, Val Lowe, Clifford R Jack, Ronald C Petersen
OBJECTIVE: To estimate the prevalence of elevated brain amyloid and reduced cortical thickness (as a marker for neurodegeneration) in a defined population. METHODS: Mayo Clinic Study of Aging participants underwent MRI to assess a composite Alzheimer disease (AD) signature cortical thickness measure and PET to assess brain amyloid accumulation. Participants were characterized as having elevated amyloid (A+/A-), reduced cortical thickness (N+/N-), and A+N+, A+N-, A-N+, or A-N-...
November 14, 2017: Neurology
https://www.readbyqxmd.com/read/28963439/neuroprotective-astrocyte-derived-insulin-insulin-like-growth-factor-1-stimulates-endocytic-processing-and-extracellular-release-of-neuron-bound-a%C3%AE-oligomers
#13
Jason Pitt, Kyle C Wilcox, Vanessa Tortelli, Luan Pereira Diniz, Maira S Oliveira, Cassandra Dobbins, Xiao-Wen Yu, Sathwik Nandamuri, Flávia C A Gomes, Nadia DiNunno, Kirsten L Viola, Fernanda G De Felice, Sergio T Ferreira, William L Klein
Synaptopathy underlying memory deficits in Alzheimer's disease (AD) is increasingly thought to be instigated by toxic oligomers of the amyloid beta peptide (AβOs). Given the long latency and incomplete penetrance of AD dementia with respect to Aβ pathology, we hypothesized that factors present in the CNS may physiologically protect neurons from the deleterious impact of AβOs. Here we employed physically separated neuron-astrocyte cocultures to investigate potential non-cell autonomous neuroprotective factors influencing AβO toxicity...
October 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28951388/retinal-microperimetry-a-new-tool-for-identifying-type-2-diabetic-patients-at-risk-of-developing-alzheimer%C3%A2-s-disease
#14
Andreea Ciudin, Olga Simó-Servat, Cristina Hernández, Gabriel Arcos, Susana Diego, Ángela Sanabria, Óscar Sotolongo, Isabel Hernández, Mercè Boada, Rafael Simó
Type 2 diabetes is associated with a high risk of cognitive impairment and dementia. Therefore, strategies aimed at identifying those patients at risk of dementia are needed. Given that the retina is a brain-derived tissue it may provide a non-invasive way of examining brain pathology. The aims of the study were to evaluate whether retinal sensitivity: 1) Correlates with the specific parameters of brain imaging related to cognitive impairment; 2) Discriminates diabetic patients with mild cognitive impairment (MCI) from those with normal cognition and Alzheimer's disease (AD)...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28911255/downward-finger-displacement-distinguishes-parkinson-disease-dementia-from-alzheimer-disease
#15
Abraham Lieberman, Aman Deep, Jiong Shi, Rohit Dhall, Saulena Shafer, Guillermo Moguel-Cobos, Ravneet Dhillon, Christopher W Frames, Margaret McCauley
Purpose/Aim of the study: To study finger displacement in patients with Parkinson disease dementia (PDD) and in patients with Alzheimer disease (AD). METHODS: We examined 56 patients with PDD and 35 with AD. Patients were examined during their regular outpatient clinic visit. Finger displacement was measured by observers not actively involved in the study using a creative grid ruler for all PDD and AD patients. Finger displacement was examined by asking patients to point their index fingers toward the grid ruler with the nails facing upward...
September 15, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28865468/brain-ureido-degenerative-protein-modifications-are-associated-with-neuroinflammation-and-proteinopathy-in-alzheimer-s-disease-with-cerebrovascular-disease
#16
Xavier Gallart-Palau, Aida Serra, Benjamin Sian Teck Lee, Xue Guo, Siu Kwan Sze
BACKGROUND: Brain degenerative protein modifications (DPMs) are associated with the apparition and progression of dementia, and at the same time, Alzheimer's disease with cerebrovascular disease (AD + CVD) is the most prevalent form of dementia in the elder population. Thus, understanding the role(s) of brain DPMs in this dementia subtype may provide novel insight on the disease pathogenesis and may aid on the development of novel diagnostic and therapeutic tools. Two essential DPMs known to promote inflammation in several human diseases are the ureido DPMs (uDPMs) arginine citrullination and lysine carbamylation, although they have distinct enzymatic and non-enzymatic origins, respectively...
September 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28863046/cognitive-aging-in-black-and-white-americans-cognition-cognitive-decline-and-incidence-of-alzheimer-disease-dementia
#17
Jennifer Weuve, Lisa L Barnes, Carlos F Mendes de Leon, Kumar B Rajan, Todd Beck, Neelum T Aggarwal, Liesi E Hebert, David A Bennett, Robert S Wilson, Denis A Evans
BACKGROUND: US-based studies have reported that older blacks perform worse than older whites on cognitive tests and have higher risk of Alzheimer disease dementia (AD). It is unclear whether these findings reflect differences in cognitive decline. METHODS: The Chicago Health and Aging Project followed individuals, 65+ years old (64% black, 36% white), for up to 18 years. Participants underwent triennial cognitive assessments; stratified randomized samples underwent assessments for AD...
August 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28835407/sleep-architecture-and-the-risk-of-incident-dementia-in-the-community
#18
Matthew P Pase, Jayandra J Himali, Natalie A Grima, Alexa S Beiser, Claudia L Satizabal, Hugo J Aparicio, Robert J Thomas, Daniel J Gottlieb, Sandford H Auerbach, Sudha Seshadri
OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male)...
September 19, 2017: Neurology
https://www.readbyqxmd.com/read/28818091/non-canonical-soluble-amyloid-beta-aggregates-and-plaque-buffering-controversies-and-future-directions-for-target-discovery-in-alzheimer-s-disease
#19
REVIEW
David L Brody, Hao Jiang, Norelle Wildburger, Thomas J Esparza
The specific amyloid-beta (Aβ) species or other amyloid-precursor protein cleavage products that are most directly related to human neurodegeneration and clinical dementia of the Alzheimer's type have not yet been directly identified. Without a clear understanding of the most relevant species, it is difficult to determine whether therapeutic candidates successfully engaged the correct target(s). Here, we review some of the controversies regarding soluble Aβ aggregates (also termed oligomers, dimers, trimers, Aβ*56, amylospheroids, etc...
August 17, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28794261/neuroprotective-astrocyte-derived-insulin-igf-1-stimulate-endocytic-processing-and-extracellular-release-of-neuron-bound-a%C3%AE-oligomers
#20
Jason Pitt, Kyle C Wilcox, Vanessa Tortelli, Luan Pereira Diniz, Maira S Oliveira, Cassandra Dobbins, Xiao-Wen Yu, Sathwik Nandamuri, Flávia C A Gomes, Nadia DiNunno, Kirsten L Viola, Fernanda G De Felice, Sergio T Ferreira, William L Klein
Synaptopathy underlying memory deficits in Alzheimer's disease (AD) is increasingly thought to be instigated by toxic oligomers of the amyloid beta peptide (AβOs). Given the long latency and incomplete penetrance of AD dementia with respect to Aβ pathology, we hypothesized that factors present in the CNS may physiologically protect neurons from the deleterious impact of AβOs. Here we employed physically-separated neuron-astrocyte co-cultures to investigate potential non cell-autonomous neuroprotective factors influencing AβO toxicity...
August 9, 2017: Molecular Biology of the Cell
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