keyword
MENU ▼
Read by QxMD icon Read
search

Non alzheimer,s dementia

keyword
https://www.readbyqxmd.com/read/29663736/platelets-lymphocytes-and-erythrocytes-from-alzheimer-s-disease-patients-the-quest-for-blood-cell-based-biomarkers
#1
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwar
In elderly population, Alzheimer's disease is a common neurodegenerative disorder and accounts for about 70% of all cases of dementia. The neurodegenerative processes of this disease start presumably 20 years ahead of the clinical beginning of the disorder. The postmortem histopathological examination, brains from Alzheimer's disease patients with characteristic features like amyloid plaques and neurofibrillary tangles, neuronal and synaptic disintegration confirm the final diagnosis of Alzheimer's disease...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29615876/a-method-to-train-marmosets-in-visual-working-memory-task-and-their-performance
#2
Katsuki Nakamura, Reiko Koba, Miki Miwa, Chieko Yamaguchi, Hiromi Suzuki, Atsushi Takemoto
Learning and memory processes are similarly organized in humans and monkeys; therefore, monkeys can be ideal models for analyzing human aging processes and neurodegenerative diseases such as Alzheimer's disease. With the development of novel gene modification methods, common marmosets ( Callithrix jacchus ) have been suggested as an animal model for neurodegenerative diseases. Furthermore, the common marmoset's lifespan is relatively short, which makes it a practical animal model for aging. Working memory deficits are a prominent symptom of both dementia and aging, but no data are currently available for visual working memory in common marmosets...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29558979/cerebrospinal-fluid-in-the-differential-diagnosis-of-alzheimer-s-disease-clinical-utility-of-an-extended-panel-of-biomarkers-in-a-specialist-cognitive-clinic
#3
Ross W Paterson, Catherine F Slattery, Teresa Poole, Jennifer M Nicholas, Nadia K Magdalinou, Jamie Toombs, Miles D Chapman, Michael P Lunn, Amanda J Heslegrave, Martha S Foiani, Philip S J Weston, Ashvini Keshavan, Jonathan D Rohrer, Martin N Rossor, Jason D Warren, Catherine J Mummery, Kaj Blennow, Nick C Fox, Henrik Zetterberg, Jonathan M Schott
BACKGROUND: Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a diagnosis of Alzheimer's disease (AD). Their clinical utility for differentiating AD from non-AD neurodegenerative dementias, such as dementia with Lewy bodies (DLB) or frontotemporal dementia (FTD), is less well established. We aimed to determine the diagnostic utility of an extended panel of CSF biomarkers to differentiate AD from a range of other neurodegenerative dementias. METHODS: We used immunoassays to measure conventional CSF markers of amyloid and tau pathology (amyloid beta (Aβ)1-42, total tau (T-tau), and phosphorylated tau (P-tau)) as well as amyloid processing (AβX-38, AβX-40, AβX-42, soluble amyloid precursor protein (sAPP)α, and sAPPβ), large fibre axonal degeneration (neurofilament light chain (NFL)), and neuroinflammation (YKL-40) in 245 patients with a variety of dementias and 30 controls...
March 20, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29487798/defining-snap-by-cross-sectional-and-longitudinal-definitions-of-neurodegeneration
#4
L E M Wisse, S R Das, C Davatzikos, B C Dickerson, S X Xie, P A Yushkevich, D A Wolk
Introduction: Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis. SNAP has only been identified by cross-sectional neurodegeneration measures, whereas longitudinal measures might better reflect "active" neurodegeneration and might be more tightly linked to prognosis. We compare neurodegeneration defined by cross-sectional 'hippocampal volume' only (SNAP/L-) versus both cross-sectional and longitudinal 'hippocampal atrophy rate' (SNAP/L+) and investigate how these definitions impact prevalence and the clinical and biomarker profile of SNAP in Mild Cognitive Impairment (MCI)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29487403/use-of-an-alzheimer-s-disease-polygenic-risk-score-to-identify-mild-cognitive-impairment-in-adults-in-their-50s
#5
Mark W Logue, Matthew S Panizzon, Jeremy A Elman, Nathan A Gillespie, Sean N Hatton, Daniel E Gustavson, Ole A Andreassen, Anders M Dale, Carol E Franz, Michael J Lyons, Michael C Neale, Chandra A Reynolds, Xin Tu, William S Kremen
Early identification of younger, non-demented adults at elevated risk for Alzheimer's disease (AD) is crucial because the pathological process begins decades before dementia onset. Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive impairment (MCI) in adults who were only in their 50s. Participants were 1176 white, non-Hispanic community-dwelling men of European ancestry in the Vietnam Era Twin Study of Aging (VETSA): 7% with amnestic MCI (aMCI); 4% with non-amnestic MCI (naMCI)...
February 27, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29471022/temporal-lobe-epilepsy-induced-neurodegeneration-and-cognitive-deficits-implications-for-aging
#6
REVIEW
M Vrinda, S Arun, B N Srikumar, Bindu M Kutty, B S Shankaranarayana Rao
Epilepsy is a neurological condition associated with seizures, neurodegeneration, circuit reorganization, and other structural and functional abnormalities. These elements ultimately lead to behavioural alterations such as anxiety, depression, and importantly cognitive impairment like learning disability and memory impairment. These factors can attribute to acceleration of aging and cognitive impairment in middle-aged people, which is otherwise evident in dementia and Alzheimer's disease among elderly people...
February 19, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29456500/auditory-memory-decay-as-reflected-by-a-new-mismatch-negativity-score-is-associated-with-episodic-memory-in-older-adults-at-risk-of-dementia
#7
Daria Laptinskaya, Franka Thurm, Olivia C Küster, Patrick Fissler, Winfried Schlee, Stephan Kolassa, Christine A F von Arnim, Iris-Tatjana Kolassa
The auditory mismatch negativity (MMN) is an event-related potential (ERP) peaking about 100-250 ms after the onset of a deviant tone in a sequence of identical (standard) tones. Depending on the interstimulus interval (ISI) between standard and deviant tones, the MMN is suitable to investigate the pre-attentive auditory discrimination ability (short ISIs, ≤ 2 s) as well as the pre-attentive auditory memory trace (long ISIs, >2 s). However, current results regarding the MMN as an index for mild cognitive impairment (MCI) and dementia are mixed, especially after short ISIs: while the majority of studies report positive associations between the MMN and cognition, others fail to find such relationships...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29454581/emerging-roles-of-microglial-cathepsins-in-neurodegenerative-disease
#8
REVIEW
Jessica R Lowry, Andis Klegeris
Alzheimer's disease (AD) is one of the leading causes of dementia, and its prevalence is expected to increase dramatically due to the aging global population. Microglia-driven neuroinflammation may contribute to the progression of AD. Microglia, the immune cells of the central nervous system (CNS), become chronically activated by the pathological proteins of AD including amyloid-β peptides (Aβ). Such adversely activated microglia secrete mediators that promote inflammation and damage neurons. Cathepsins are proteases that are expressed by all brain cell types, and most of them are found both intra- and extra-cellularly...
February 15, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29453245/early-vs-late-age-at-onset-frontotemporal-dementia-and-frontotemporal-lobar-degeneration
#9
Sang Won Seo, Marie-Pierre Thibodeau, David C Perry, Alice Hua, Manu Sidhu, Isabel Sible, Jose Norberto S Vargas, Stephanie E Gaus, Gil D Rabinovici, Katherine D Rankin, Adam L Boxer, Joel H Kramer, Howard J Rosen, Maria Luisa Gorno-Tempini, Lea T Grinberg, Eric J Huang, Stephen J DeArmond, John Q Trojanowski, Bruce L Miller, William W Seeley
OBJECTIVE: To examine clinicopathologic correlations in early vs late age at onset frontotemporal dementia (FTD) and frontotemporal lobar degeneration (FTLD). METHODS: All patients were clinically evaluated and prospectively diagnosed at the UCSF Memory and Aging Center. Two consecutive series were included: (1) patients with a clinically diagnosed FTD syndrome who underwent autopsy (cohort 1) and (2) patients with a primary pathologic diagnosis of FTLD, regardless of the clinical syndrome (cohort 2)...
March 20, 2018: Neurology
https://www.readbyqxmd.com/read/29424041/neuropsychological-differentiation-of-progressive-aphasic-disorders
#10
Jennifer M Harris, Jennifer A Saxon, Matthew Jones, Julie S Snowden, Jennifer C Thompson
The differentiation of subtypes of primary progressive aphasia (PPA) remains challenging. We aimed to identify optimum neuropsychological measures for characterizing PPA, to examine the relationship between behavioural change and subtypes of PPA and to determine whether characteristic profiles of language, working memory, and behavioural changes occur in PPA. Forty-seven patients with PPA and multi-domain Alzheimer's disease (AD) together with 19 age-matched controls underwent a large battery of working memory and language tests...
February 8, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29413314/accelerated-long-term-forgetting-in-presymptomatic-autosomal-dominant-alzheimer-s-disease-a-cross-sectional-study
#11
Philip S J Weston, Jennifer M Nicholas, Susie M D Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M Schott, Martin N Rossor, Sebastian J Crutch, Christopher R Butler, Adam Z Zeman, Nick C Fox
BACKGROUND: Tests sensitive to presymptomatic changes in Alzheimer's disease could be valuable for clinical trials. Accelerated long-term forgetting-during which memory impairment becomes apparent over longer periods than usually assessed, despite normal performance on standard cognitive testing-has been identified in other temporal lobe disorders. We assessed whether accelerated long-term forgetting is a feature of presymptomatic autosomal dominant (familial) Alzheimer's disease, and whether there is an association between accelerated long-term forgetting and early subjective memory changes...
February 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29397305/spatial-patterns-of-neuroimaging-biomarker-change-in-individuals-from-families-with-autosomal-dominant-alzheimer-s-disease-a-longitudinal-study
#12
Brian A Gordon, Tyler M Blazey, Yi Su, Amrita Hari-Raj, Aylin Dincer, Shaney Flores, Jon Christensen, Eric McDade, Guoqiao Wang, Chengjie Xiong, Nigel J Cairns, Jason Hassenstab, Daniel S Marcus, Anne M Fagan, Clifford R Jack, Russ C Hornbeck, Katrina L Paumier, Beau M Ances, Sarah B Berman, Adam M Brickman, David M Cash, Jasmeer P Chhatwal, Stephen Correia, Stefan Förster, Nick C Fox, Neill R Graff-Radford, Christian la Fougère, Johannes Levin, Colin L Masters, Martin N Rossor, Stephen Salloway, Andrew J Saykin, Peter R Schofield, Paul M Thompson, Michael M Weiner, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinger
BACKGROUND: Models of Alzheimer's disease propose a sequence of amyloid β (Aβ) accumulation, hypometabolism, and structural decline that precedes the onset of clinical dementia. These pathological features evolve both temporally and spatially in the brain. In this study, we aimed to characterise where in the brain and when in the course of the disease neuroimaging biomarkers become abnormal. METHODS: Between Jan 1, 2009, and Dec 31, 2015, we analysed data from mutation non-carriers, asymptomatic carriers, and symptomatic carriers from families carrying gene mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), or amyloid precursor protein (APP) enrolled in the Dominantly Inherited Alzheimer's Network...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29329363/validity-of-teleneuropsychological-assessment-in-older-patients-with-cognitive-disorders
#13
Hannah E Wadsworth, Kaltra Dhima, Kyle B Womack, John Hart, Myron F Weiner, Linda S Hynan, C Munro Cullum
Objective: The feasibility and reliability of neuropsychological assessment at a distance have been demonstrated, but the validity of this testing medium has not been adequately demonstrated. The purpose of this study was to determine the ability of video teleconferencing administration of neuropsychological measures (teleneuropsychology) in discriminating cognitively impaired from non-impaired groups of older adults. It was predicted that measures administered via video teleconference would distinguish groups and that the magnitude of differences between impaired and non-impaired groups would be similar to group differences achieved in traditional administration...
January 10, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29188876/association-of-cortical-%C3%AE-amyloid-with-erythrocyte-membrane-monounsaturated-and-saturated-fatty-acids-in-older-adults-at-risk-of-dementia
#14
C Hooper, P De Souto Barreto, P Payoux, A S Salabert, S Guyonnet, S Andrieu, S Sourdet, J Delrieu, B Vellas
OBJECTIVES: We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints. DESIGN: This is a cross-sectional study using data from the Multidomain Alzheimer Preventive Trial (MAPT); a randomised controlled trial. SETTING: French community dwellers aged 70 or over reporting subjective memory complaints, but free from a diagnosis of clinical dementia...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29186278/dependence-levels-as-interim-clinical-milestones-along-the-continuum-of-alzheimer-s-disease-18-month-results-from-the-geras-observational-study
#15
K Kahle-Wrobleski, J S Andrews, M Belger, W Ye, S Gauthier, D M Rentz, D Galasko
BACKGROUND: While functional loss forms part of the current diagnostic criteria used to identify dementia due to Alzheimer's disease, the gradual and progressive nature of the disease makes it difficult to recognize clinically relevant signposts that could be helpful in making treatment and management decisions. Having previously observed a significant relationship between stages of functional dependence (the level of assistance patients require consequent to Alzheimer's disease deficits, derived from the Alzheimer's Disease Cooperative Study - Activities of Daily Living Scale) and cognitive severity, we investigated whether measures of functional dependence could be utilized to identify clinical milestones of Alzheimer's disease progression...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182710/objective-cognitive-impairment-and-progression-to-dementia-in-women-the-prospective-epidemiological-risk-factor-study
#16
J Skov Neergaard, K Dragsbæk, C Christiansen, M Asser Karsdal, S Brix, K Henriksen
BACKGROUND: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer's disease have failed. OBJECTIVES: The objective of this study was to identify subgroups of individuals with objective cognitive impairment (OCI), who were most likely to progress to dementia and to identify the risk factors associated with progression. DESIGN: Prospective cohort study...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29126669/what-can-dti-tell-about-early-cognitive-impairment-differentiation-between-mci-subtypes-and-healthy-controls-by-diffusion-tensor-imaging
#17
Gyula Gyebnár, Ádám Szabó, Enikő Sirály, Zsuzsanna Fodor, Anna Sákovics, Pál Salacz, Zoltán Hidasi, Éva Csibri, Gábor Rudas, Lajos R Kozák, Gábor Csukly
Mild cognitive impairment (MCI) gained a lot of interest recently, especially that the conversion rate to Alzheimer Disease (AD) in the amnestic subtype (aMCI) is higher than in the non-amnestic subtype (naMCI). We aimed to determine whether and how diffusion-weighted MRI (DWI) using the diffusion tensor model (DTI) can differentiate MCI subtypes from healthy subjects. High resolution 3D T1W and DWI images of patients (aMCI, n = 18; naMCI, n = 20; according to Petersen criteria) and controls (n = 27) were acquired at 3T and processed using ExploreDTI and SPM...
February 28, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29117869/frequency-of-use-of-the-international-classification-of-diseases-icd-10-diagnostic-categories-for-mental-and-behavioural-disorders-across-world-regions
#18
Y Faiad, B Khoury, S Daouk, M Maj, J Keeley, O Gureje, G Reed
AIMS: The study aimed to examine variations in the use of International Classification of Diseases, Tenth Edition (ICD-10) diagnostic categories for mental and behavioural disorders across countries, regions and income levels using data from the online World Psychiatric Association (WPA)-World Health Organization (WHO) Global Survey that examined the attitudes of psychiatrists towards the classification of mental disorders. METHODS: A survey was sent to 46 psychiatric societies which are members of WPA...
November 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29105977/tau-pet-imaging-predicts-cognition-in-atypical-variants-of-alzheimer-s-disease
#19
Jeffrey S Phillips, Sandhitsu R Das, Corey T McMillan, David J Irwin, Emily E Roll, Fulvio Da Re, Ilya M Nasrallah, David A Wolk, Murray Grossman
Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer's disease (AD).18 F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between18 F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic-variant primary progressive aphasia (lvPPA, n = 4)...
February 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29102243/tau-amyloid-and-cascading-network-failure-across-the-alzheimer-s-disease-spectrum
#20
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack
Functionally related brain regions are selectively vulnerable to Alzheimer's disease pathophysiology. However, molecular markers of this pathophysiology (i.e., beta-amyloid and tau aggregates) have discrepant spatial and temporal patterns of progression within these selectively vulnerable brain regions. Existing reductionist pathophysiologic models cannot account for these large-scale spatiotemporal inconsistencies. Within the framework of the recently proposed cascading network failure model of Alzheimer's disease, however, these large-scale patterns are to be expected...
December 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
keyword
keyword
96233
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"