Joseph C Gigliotti, Adrienne Tin, Shirin Pourafshar, Sylvia Cechova, Yves T Wang, Sun-Sang J Sung, Gabor Bodonyi-Kovacs, Janet V Cross, Guang Yang, Nhu Nguyen, Fang Chan, Casey Rebholz, Bing Yu, Megan L Grove, Morgan E Grams, Anna Köttgen, Robert Scharpf, Phillip Ruiz, Eric Boerwinkle, Josef Coresh, Thu H Le
BACKGROUND: GSTM1 encodes glutathione S-transferase μ -1 (GSTM1), which belongs to a superfamily of phase 2 antioxidant enzymes. The highly prevalent GSTM1 deletion variant is associated with kidney disease progression in human cohorts: the African American Study of Kidney Disease and Hypertension and the Atherosclerosis Risk in Communities (ARIC) Study. METHODS: We generated a Gstm1 knockout mouse line to study its role in a CKD model (involving subtotal nephrectomy) and a hypertension model (induced by angiotensin II)...
November 14, 2019: Journal of the American Society of Nephrology: JASN