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rapid eye movement sleep behavior disorder Parkinson's disease a-synuclein neurodegenerative diseases

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https://www.readbyqxmd.com/read/26156949/long-term-follow-up-investigation-of-isolated-rapid-eye-movement-sleep-without-atonia-without-rapid-eye-movement-sleep-behavior-disorder-a-pilot-study
#1
Ambra Stefani, David Gabelia, Birgit Högl, Thomas Mitterling, Philipp Mahlknecht, Heike Stockner, Werner Poewe, Birgit Frauscher
STUDY OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term follow-up investigation of subjects with isolated RWA. METHODS: Participants were recruited from 50 subjects with isolated RWA who were identified at the sleep laboratory of the Department of Neurology at the Medical University of Innsbruck between 2003 and 2005...
November 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26029267/comprehensive-treatment-of-dementia-with-lewy-bodies
#2
Brendon P Boot
Dementia with Lewy bodies is an under-recognized disease; it is responsible for up to 20 % of all dementia cases. Accurate diagnosis is essential because the management of dementia with Lewy bodies is more complex than many neurodegenerative diseases. This is because alpha-synuclein, the pathological protein responsible for dementia with Lewy bodies (and Parkinson's disease), produces symptoms in multiple domains. By dividing the symptoms into cognitive, neuropsychiatric, movement, autonomic, and sleep categories, a comprehensive treatment strategy can be achieved...
2015: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/26022447/rapid-eye-movement-sleep-behavior-disorder-in-patients-with-probable-alzheimer-s-disease
#3
Pan Wang, Yun Kwok Wing, Jianli Xing, Yong Liu, Bo Zhou, Zengqiang Zhang, Hongxiang Yao, Yan'e Guo, Yanchang Shang, Xi Zhang
BACKGROUND AND AIMS: Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with neurodegenerative disorders characterized by α-synuclein deposition, including Parkinson's disease, multiple system atrophy, and Lewy body dementia. However, this tendency in tauopathy-mediated diseases is rare and only sporadically reported. We systematically illustrate the occurrence of RBD and sleep features among a cohort of patients with Alzheimer's disease (AD), a non-synucleinopathy...
October 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/25867792/rapid-eye-movement-sleep-behavior-disorder-and-neurodegenerative-disease
#4
REVIEW
Michael Joseph Howell, Carlos Hugh Schenck
IMPORTANCE: The dream enactment of rapid eye movement sleep behavior disorder (RBD) is often the first indication of an impending α-synuclein disorder, such as Parkinson disease, multiple-system atrophy, or dementia with Lewy bodies. OBJECTIVE: To provide an overview of RBD from the onset of dream enactment through the emergence of a parkinsonian disorder. EVIDENCE REVIEW: Peer-reviewed articles, including case reports, case series, retrospective reviews, prospective randomized trials, and basic science investigations, were identified in a PubMed search of articles on RBD from January 1, 1986, through July 31, 2014...
June 2015: JAMA Neurology
https://www.readbyqxmd.com/read/24399499/-rem-sleep-behavior-disorder-as-a-prodromal-stage-of-%C3%AE-synucleinopathies-symptoms-epidemiology-pathophysiology-diagnosis-and-therapy
#5
REVIEW
W H Oertel, C Depboylu, M Krenzer, D Vadasz, V Ries, F Sixel-Döring, G Mayer
Rapid eye movement (REM) sleep behavior disorder (RBD) is defined as a parasomnia characterized by loss of REM sleep-associated atonia and the presence of motor activity during dreaming typically presenting with an aggressive dream content. Epidemiological data on the prevalence of RBD are insufficient but it can be idiopathic or symptomatic. A video-audio polysomnography is essential for diagnosis. Clonazepam and melatonin are available as pharmaceutical treatment. Recent studies demonstrated that individuals suffering from idiopathic RBD carry a high specific risk (up to 80 %) for developing a neurodegenerative disorder of the α-synucleinopathy type (e...
January 2014: Der Nervenarzt
https://www.readbyqxmd.com/read/23891697/a-predictive-model-of-neurodegeneration-in-idiopathic-rem-sleep-behavior-disorder
#6
Raúl de la Fuente-Fernández
OBJECTIVE: To investigate whether Parkinson's disease (PD) and dementia are competing risks in subjects with idiopathic rapid-eye-movement sleep behavior disorder (RBD). METHODS: The number of incidental PD cases observed in 11 longitudinal RBD studies was compared with the corresponding expected number as estimated by a simple mathematical model based on population parameters for PD age-of-onset. RESULTS: The expected number of incidental PD cases exceeded observed PD cases (p-value < 0...
November 2013: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/23562390/neurodegenerative-disease-status-and-post-mortem-pathology-in-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-an-observational-cohort-study
#7
Alex Iranzo, Eduard Tolosa, Ellen Gelpi, José Luis Molinuevo, Francesc Valldeoriola, Mónica Serradell, Raquel Sanchez-Valle, Isabel Vilaseca, Francisco Lomeña, Dolores Vilas, Albert Lladó, Carles Gaig, Joan Santamaria
BACKGROUND: We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) represents the prodromal phase of a Lewy body disorder and that, with sufficient follow-up, most cases would eventually be diagnosed with a clinical defined Lewy body disorder, such as Parkinson's disease (PD) or dementia with Lewy bodies (DLB). METHODS: Patients from an IRBD cohort recruited between 1991 and 2003, and previously assessed in 2005, were followed up during an additional period of 7 years...
May 2013: Lancet Neurology
https://www.readbyqxmd.com/read/23532774/rem-sleep-behavior-disorder-and-prodromal-neurodegeneration-%C3%A2-where%C3%A2-are%C3%A2-we-headed
#8
Ronald B Postuma, Jean-Francois Gagnon, Jacques Y Montplaisir
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by loss of normal atonia during REM sleep, such that patients appear to act out their dreams. The most important implication of research into this area is that patients with idiopathic RBD are at very high risk of developing synuclein-mediated neurodegenerative disease (Parkinson's disease [PD], dementia with Lewy bodies [DLB], and multiple system atrophy), with risk estimates that approximate 40-65% at 10 years. Thus, RBD disorder is a very strong feature of prodromal synucleinopathy...
2013: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/23474058/clinicopathologic-correlations-in-172-cases-of-rapid-eye-movement-sleep-behavior-disorder-with-or-without-a-coexisting-neurologic-disorder
#9
B F Boeve, M H Silber, T J Ferman, S C Lin, E E Benarroch, A M Schmeichel, J E Ahlskog, R J Caselli, S Jacobson, M Sabbagh, C Adler, B Woodruff, T G Beach, A Iranzo, E Gelpi, J Santamaria, E Tolosa, C Singer, D C Mash, C Luca, I Arnulf, C Duyckaerts, C H Schenck, M W Mahowald, Y Dauvilliers, N R Graff-Radford, Z K Wszolek, J E Parisi, B Dugger, M E Murray, D W Dickson
OBJECTIVE: To determine the pathologic substrates in patients with rapid eye movement (REM) sleep behavior disorder (RBD) with or without a coexisting neurologic disorder. METHODS: The clinical and neuropathologic findings were analyzed on all autopsied cases from one of the collaborating sites in North America and Europe, were evaluated from January 1990 to March 2012, and were diagnosed with polysomnogram (PSG)-proven or probable RBD with or without a coexisting neurologic disorder...
August 2013: Sleep Medicine
https://www.readbyqxmd.com/read/23375425/morbidities-in-rapid-eye-movement-sleep-behavior-disorder
#10
Poul Jennum, Geert Mayer, Yo-El Ju, Ron Postuma
Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, RBD without any obvious comorbid major neurological disease), is strongly associated with numerous comorbid conditions. The most prominent is that with neurodegenerative disorders, especially synuclein-mediated disorders, above all Parkinson disease (PD). Idiopathic RBD is an important risk factor for the development of synucleinopathies. Comorbidity studies suggest that iRBD is associated with a number of other potential pre-motor manifestations of synucleinopathies such as, cognitive and olfactory impairment, reduced autonomic function, neuropsychiatric manifestations and sleep complaints...
August 2013: Sleep Medicine
https://www.readbyqxmd.com/read/23058689/rapid-eye-movement-sleep-behavior-disorder-as-a-biomarker-for-neurodegeneration-the-past-10-years
#11
REVIEW
Ronald B Postuma, Jean-Francois Gagnon, Jacques Montplaisir
Since its original description, idiopathic rapid eye movement sleep behavior disorder (RBD) has become a well-established risk factor for neurodegenerative disease. Studies from sleep centers have found that at least 40-65% of patients with idiopathic RBD will develop a defined neurodegenerative phenotype over 10 years. This elevated risk of neurodegeneration has been recently confirmed in a population-based study of probable RBD. When a defined syndrome develops, it is almost always a 'synucleinopathy' (Parkinson's disease, Dementia with Lewy Bodies or multiple system atrophy)...
August 2013: Sleep Medicine
https://www.readbyqxmd.com/read/22629254/cognition-in-rapid-eye-movement-sleep-behavior-disorder
#12
Jean-François Gagnon, Josie-Anne Bertrand, Daphné Génier Marchand
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by excessive muscle activity and undesirable motor events during REM sleep. RBD occurs in approximately 0.5% of the general population, with a higher prevalence in older men. RBD is a frequent feature of dementia with Lewy bodies (DLB), but is only rarely reported in Alzheimer's disease. RBD is also a risk factor for α-synuclein-related diseases, such as DLB, Parkinson's disease (PD), and multiple system atrophy. Therefore, RBD has major implications for the diagnosis and treatment of neurodegenerative disorders and for understanding specific neurodegeneration patterns...
2012: Frontiers in Neurology
https://www.readbyqxmd.com/read/21387382/white-and-gray-matter-abnormalities-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder-a-diffusion-tensor-imaging-and-voxel-based-morphometry-study
#13
Christoph Scherfler, Birgit Frauscher, Michael Schocke, Alex Iranzo, Viola Gschliesser, Klaus Seppi, Joan Santamaria, Eduardo Tolosa, Birgit Högl, Werner Poewe
OBJECTIVE: We applied diffusion-tensor imaging (DTI) including measurements of mean diffusivity (MD), a parameter of brain tissue integrity, fractional anisotropy (FA), a parameter of neuronal fiber integrity, as well as voxel-based morphometry (VBM), a measure of gray and white matter volume, to detect brain tissue changes in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: Magnetic resonance imaging (MRI) was performed in 26 patients with iRBD (mean disease duration, 9...
February 2011: Annals of Neurology
https://www.readbyqxmd.com/read/21246603/olfaction-and-color-vision-identify-impending-neurodegeneration-in-rapid-eye-movement-sleep-behavior-disorder
#14
Ronald B Postuma, Jean-François Gagnon, Mélanie Vendette, Catherine Desjardins, Jacques Y Montplaisir
OBJECTIVE: For development of neuroprotective therapy, neurodegenerative disease must be identified as early as possible. However, current means of identifying "preclinical" neurodegeneration are limited. Patients with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) are at >50% risk of synuclein-mediated neurodegenerative disease--this provides a unique opportunity to directly observe preclinical synucleinopathy and to test potential markers of preclinical disease...
May 2011: Annals of Neurology
https://www.readbyqxmd.com/read/21143707/regional-cerebral-blood-flow-changes-in-patients-with-idiopathic-rem-sleep-behavior-disorder
#15
H Hanyu, Y Inoue, H Sakurai, H Kanetaka, M Nakamura, T Miyamoto, T Sasai, T Iwamoto
BACKGROUND: Recent studies have shown an association between rapid eye movement sleep behavior disorder (RBD) and neurodegenerative disorders, especially alpha-synucleinopathies. OBJECTIVE: We investigated regional cerebral blood flow (rCBF) changes using single photon emission computed tomography (SPECT) in patients with idiopathic RBD (iRBD), to determine functional brain alterations associated with the disorder. METHODS: The SPECT data of 24 patients with iRBD were compared with those of 18 age-matched normal controls using statistical parametric mapping 2...
May 2011: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/20846908/decreased-striatal-dopamine-transporter-uptake-and-substantia-nigra-hyperechogenicity-as-risk-markers-of-synucleinopathy-in-patients-with-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-a-prospective-study-corrected
#16
COMPARATIVE STUDY
Alex Iranzo, Francisco Lomeña, Heike Stockner, Francesc Valldeoriola, Isabel Vilaseca, Manel Salamero, Jose Luis Molinuevo, Monica Serradell, Joan Duch, Javier Pavía, Judith Gallego, Klaus Seppi, Birgit Högl, Eduard Tolosa, Werner Poewe, Joan Santamaria
BACKGROUND: Patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) may develop neurodegenerative conditions associated with substantia nigra dysfunction such as Parkinson's disease. In patients with Parkinson's disease, ¹²³I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (¹²³I-FP-CIT) SPECT detects striatal dopamine dysfunction resulting from nigral pathology whereas transcranial sonography (TCS) shows increased substantia nigra echogenic size, even before parkinsonism is clinically evident...
November 2010: Lancet Neurology
https://www.readbyqxmd.com/read/15312274/dementia-with-lewy-bodies-molecular-pathogenesis-and-implications-for-classification
#17
REVIEW
Jeffrey L Cummings
Dementia with Lewy bodies results from the accumulation from Lewy-type pathology (Lewy bodies, Lewy neurites), secondary cellular injury, and apoptotic neurodegeneration. The severity of dementia correlates with the abundance of Lewy bodies in the cortex. Dementia with Lewy bodies co-occurs with 2 specific syndromes, one beginning with dementia complicated by visual hallucinations and parkinsonism; the other beginning with Parkinson's disease and progressing to a parkinsonian-dementia syndrome. Clinical syndromes associated with these 2 pathways to dementia share many clinical features including the type of cognitive impairment, fluctuating attentional disturbances, prominent visual hallucinations and psychosis, depression, and rapid eye movement sleep behavior disorder...
September 2004: Journal of Geriatric Psychiatry and Neurology
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