Ahmed Al-Qassabi, Tsu-Shuen Tsao, Adriana Racolta, Thomas Kremer, Marta Cañamero, Anton Belousov, Madison A Santana, Rachel C Beck, Hongjun Zhang, Jeffrey Meridew, Judith Pugh, Fangru Lian, Mark D Robida, Mirko Ritter, Christian Czech, Thomas G Beach, Lidija Pestic-Dragovich, Kirsten I Taylor, Wagner Zago, Lei Tang, Sebastian Dziadek, Ronald B Postuma
BACKGROUND: Recent studies reported abnormal alpha-synuclein deposition in biopsy-accessible sites of the peripheral nervous system in Parkinson's disease (PD). This has considerable implications for clinical diagnosis. Moreover, if deposition occurs early, it may enable tissue diagnosis of prodromal PD. OBJECTIVE: The aim of this study was to develop and test an automated bright-field immunohistochemical assay of cutaneous pathological alpha-synuclein deposition in patients with idiopathic rapid eye movement sleep behavior disorder, PD, and atypical parkinsonism and in control subjects...
April 2021: Movement Disorders: Official Journal of the Movement Disorder Society