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https://www.readbyqxmd.com/read/29321194/polygenic-hazard-score-to-guide-screening-for-aggressive-prostate-cancer-development-and-validation-in-large-scale-cohorts
#1
Tyler M Seibert, Chun Chieh Fan, Yunpeng Wang, Verena Zuber, Roshan Karunamuni, J Kellogg Parsons, Rosalind A Eeles, Douglas F Easton, ZSofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Muir, Henrik Grönberg, Fredrik Wiklund, Markus Aly, Johanna Schleutker, Csilla Sipeky, Teuvo Lj Tammela, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, M Andreas Røder, Peter Iversen, Tim J Key, Ruth C Travis, David E Neal, Jenny L Donovan, Freddie C Hamdy, Paul Pharoah, Nora Pashayan, Kay-Tee Khaw, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski, Dominika Wokolorczyk, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Katarina Cuk, Kai-Uwe Saum, Jong Y Park, Thomas A Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Judith A Clements, Amanda Spurdle, Manuel R Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, David S Karow, Ian G Mills, Ole A Andreassen, Anders M Dale
OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive PCa (that is, not eligible for surveillance according to National Comprehensive Cancer Network guidelines; any of Gleason score ≥7, stage T3-T4, PSA (prostate specific antigen) concentration ≥10 ng/L, nodal metastasis, distant metastasis)...
January 10, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29260427/efficacy-and-safety-of-dabigatran-in-patients-with-atrial-fibrillation-scheduled-for-transoesophageal-echocardiogram-guided-direct-electrical-current-cardioversion-a-prospective-propensity-score-matched-cohort-study
#2
Vincenzo Russo, Anna Rago, Andrea Antonio Papa, Antonio D'Onofrio, Paolo Golino, Gerardo Nigro
Patients with atrial fibrillation (AF) are predisposed to a hypercoagulable state and are at an increased risk for thromboembolic events when undergoing procedures. This study investigated the long-term efficacy and safety of newly initiated anticoagulation with dabigatran versus uninterrupted vitamin K antagonist (VKA) therapy in patients with AF scheduled for transesophageal echocardiogram (TEE)-guided direct electrical current cardioversion (DCC). Consecutive adult patients with persistent AF scheduled to undergo DCC were included in the study...
December 19, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29222602/endoscopic-ultrasound-guided-biliary-drainage-using-a-newly-designed-metal-stent-with-a-thin-delivery-system-a-preclinical-study-in-phantom-and-porcine-models
#3
Kosuke Minaga, Masayuki Kitano, Masahiro Itonaga, Hajime Imai, Takeshi Miyata, Kentaro Yamao, Takashi Tamura, Junya Nuta, Kenji Warigaya, Masatoshi Kudo
PURPOSE: This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). METHODS: This experimental study utilized a porcine model of biliary dilatation involving ten pigs...
December 8, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29174659/impact-of-a-monoplane-hemodynamic-tee-htee-monitoring-device-on-decision-making-in-a-heterogeneous-hemodynamically-unstable-intensive-care-unit-population-a-prospective-observational-study
#4
Maung Hlaing, Jianghua He, Nicholas Haglund, Hiroo Takayama, Brigid C Flynn
OBJECTIVE: This prospective observational study was undertaken to evaluate the utility of a miniature transesophageal echocardiography probe (ImaCor hemodynamic [hTEE]) in the management of hemodynamically unstable intensive care unit patients with and without various forms of mechanical circulatory support. DESIGN: A prospective observational study. SETTING: A single tertiary care cardiothoracic and surgical intensive care unit. PARTICIPANTS: Fifty-three cardiothoracic and surgical intensive care unit patients undergoing miniature transesophageal echocardiography examinations...
October 18, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29167615/vocal-cord-paralysis-and-laryngeal-trauma-in-cardiac-surgery
#5
Yung-Yuan Chen, Yeo-Yee Chia, Pa-Chun Wang, Hsiu-Yen Lin, Chiu-Ling Tsai, Shaw-Min Hou
Background: Cardiac surgery - associated iatrogenic laryngeal trauma is often overlooked. We investigated the risk factors of vocal cord paralysis in cardiac surgery. Methods: Medical records were reviewed from 169 patients who underwent elective or emergency cardiac surgeries. Patients had transesophageal echocardiography (TEE) placed either under video fiberscopic image guidance (guided group) or blind placement (blind group). Routine postoperative otolaryngologist consultation with video laryngoscopic recording were performed...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29151480/the-refinement-of-risk-stratification-for-atrial-thrombus-or-spontaneous-echo-contrast-in-nonvalvular-atrial-fibrillation
#6
Wenna Ning, Yang Li, Chunyan Ma, Liangxian Qiu, Bo Yu
As for nonvalvular atrial fibrillation (NVAF) patients with left atrial thrombus or spontaneous echo contrast (LAT/SEC), we evaluated the additional predictive value of serum uric acid (SUA) and Left atrial diameter (LAD) for CHADS2 and CHA2DS2-VASc, and explored the influence from the level of SUA and LAD to LAT/SEC in moderate risk group. Thus, we put forward the concept of a borderline high risk group to guide clinical anticoagulant therapy in patients with NVAF.A total of 284 NVAF patients without the history of anticoagulant prior to hospitalization were enrolled...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29132805/feasibility-of-the-use-of-transesophageal-echocardiography-as-a-surface-probe-for-puncturing-and-catheterization-of-the-internal-jugular-vein-a-randomized-controlled-pilot-study
#7
Yi Teng, Mengchan Ou, Hai Yu
OBJECTIVE: To compare the transesophageal echocardiography (TEE) probe as a surface probe with the vascular probe for guiding internal jugular vein (IJV) catheterization. DESIGN: Prospective, randomized, controlled pilot study. SETTING: University hospital. PARTICIPANTS: One hundred cardiac surgery patients, including 50 adult and 50 pediatric patients. INTERVENTIONS: Patients in the TEE probe group received right IJV catheterization using the TEE probe, while the vascular probe group used the vascular probe for catheterization...
October 4, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29064261/risk-assessment-for-infected-endocarditis-in-staphylococcus-aureus-bacteremia-patients-when-is-transesophageal-echocardiography-needed
#8
Luca Longobardo, Sarah Klemm, Margaret Cook, Valerie Ravenna, Charles F Brummitt, Tadele Mengesha, Bijoy K Khandheria
AIMS: Echocardiography is the main technique for the diagnosis of endocarditis in patients with Staphylococcus aureus bacteremia (SAB), but a consensus about performing transthoracic echocardiography or transesophageal echocardiography (TEE) as first-line tests is currently lacking. Recently, a new scoring system has been proposed by Palraj et al. to guide the use of TEE in this population. Our aim was to validate this scoring system or modify it, if necessary. METHODS AND RESULTS: Data from SAB patients admitted from 2012 to 2014 were collected...
October 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29056395/3d-transesophageal-echocardiography-a-new-imaging-tool-for-assessment-of-mitral-regurgitation-and-for-guiding-percutaneous-edge-to-edge-mitral-valve-repair
#9
REVIEW
Francesco F Faletra, Alain Berrebi, Giovanni Pedrazzini, Laura Anna Leo, V L Paiocch, G Cautilli, Gabriele Casso, Tiziano Cassina, Tiziano Moccetti, Joseph F Malouf
Real time three dimensional transesophageal echocardiography (3D TEE) is probably the most powerful and convincing imaging method for understanding the complicated multiform morphology and for evaluating geometry, dynamics and function of degenerative and functional mitral valve (MV) regurgitation. Moreover, color Doppler 3D TEE has been valuable to identify the location of the regurgitant orifice and the severity of the mitral regurgitation. 3D TEE has been shown to be of enormous value in helping surgeons to perform MV repair...
October 19, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29028783/three-dimensional-transesophageal-echocardiography-in-the-guide-of-cardiac-mass-biopsy-future-prospectives
#10
Daniela Di Lisi, Donatella Raspante, Vincenzo Lavanco, Mirko Curzi, Francesca Macaione, Massimo Cavallaro, Riccardo Tona, Giuseppina Novo, Salvatore Novo, Renato M Bragato
: Cardiac tumors are rare. Cardiovascular imaging is more important in the differential diagnosis of cardiac masses but no current noninvasive diagnostic tool has the ability to absolutely diagnose cardiac tumors. In effect cardiac biopsy remains the gold standard in the differential diagnosis. In our case we show the advantages of three-dimensional (3D) transesophageal echocardiography as a guide for cardiac biopsy. We believe that 3D TEE is ready to be used in the guide of cardiac mass biopsy. Once interventionalists become confident with 3D imaging, this technique should be used routinely during these procedures...
October 11, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29016458/quantitative-analysis-of-hyperautofluorescent-rings-to-characterize-the-natural-history-and-progression-in-rpgr-associated-retinopathy
#11
James J L Tee, Angelos Kalitzeos, Andrew R Webster, Tunde Peto, Michel Michaelides
PURPOSE: Quantitative analysis of hyperautofluorescent rings and progression in subjects with retinitis pigmentosa associated with retinitis pigmentosa GTPase regulator (RPGR) gene mutations. METHODS: Prospective observational study of 46 subjects. Ring area, horizontal and vertical diameter measurements taken from outer and inner ring borders. Intraobserver repeatability, baseline measurements, progression rates, interocular symmetry, and association with age and genotype were investigated...
October 6, 2017: Retina
https://www.readbyqxmd.com/read/28993798/challenges-for-quality-assurance-of-target-volume-delineation-in-clinical-trials
#12
REVIEW
Amy Tien Yee Chang, Li Tee Tan, Simon Duke, Wai-Tong Ng
In recent years, new radiotherapy techniques have emerged that aim to improve treatment outcome and reduce toxicity. The standard method of evaluating such techniques is to conduct large scale multicenter clinical trials, often across continents. A major challenge for such trials is quality assurance to ensure consistency of treatment across all participating centers. Analyses from previous studies have shown that poor compliance and protocol violation have a significant adverse effect on treatment outcomes...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28956098/how-to-size-asds-for-percutaneous-closure
#13
Isabelle Boon, Katrien Vertongen, Bernard P Paelinck, Laurent Demulier, An Van Berendoncks, Catherine De Maeyer, Fabienne Marchau, Joseph Panzer, Kristof Vandekerckhove, Daniel De Wolf
Percutaneous closure is the treatment of choice for secundum-type atrial septal defects (ASD). Balloon sizing (BS) has been the method of choice for deciding on device size. Improved 2D- and 3D-transesophageal echocardiographic (TEE) imaging challenged the necessity of BS. Balloon sizing was performed with two additional techniques to measure the stretched dimension of the ASD. The 1st method uses a stiff guide wire which stretches the ASD and 2D TEE. The second technique uses 3D TEE. Two hundred and thirty-six patients with minimum 1-year follow-up were enrolled...
September 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28887807/feasibility-of-multiplane-microtransoesophageal-echocardiographic-guidance-in-structural-heart-disease-transcatheter-interventions-in-adults
#14
V J Nijenhuis, A Alipour, N C Wunderlich, B J W M Rensing, G Gijsbers, J M Ten Berg, M J Suttorp, L V A Boersma, J A S van der Heyden, M J Swaans
INTRODUCTION: Structural heart interventions are guided by transoesophageal or intracardiac echocardiography (TEE/ICE). MicroTEE, developed for paediatric purposes, is smaller and therefore less invasive and traumatic, avoiding the need for general anaesthesia. We aimed to show feasibility of procedural guidance by comparing image quality of microTEE with standard TEE and ICE during adult transcatheter interventions, and assess the accuracy in obtaining left atrial appendage (LAA) measurements between the microTEE probe and standard TEE...
December 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28879526/intracardiac-echocardiography-for-structural-heart-and-electrophysiological-interventions
#15
REVIEW
Craig Basman, Yuvrajsinh J Parmar, Itzhak Kronzon
PURPOSE OF REVIEW: With an increasing number of interventional procedures performed for structural heart disease and cardiac arrhythmias each year, echocardiographic guidance is necessary for safe and efficient results. The purpose of this review article is to overview the principles of intracardiac echocardiography (ICE) and describes the peri-interventional role of ICE in a variety of structural heart disease and electrophysiological interventions. RECENT FINDINGS: Both transthoracic (TTE) and transesophageal echocardiography have limitations...
September 6, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28866042/intracardiac-echocardiography-from%C3%A2-the%C3%A2-left-atrium-for-procedural-guidance-of-transcatheter-left-atrial-appendage%C3%A2-occlusion
#16
Kasper Korsholm, Jesper Møller Jensen, Jens Erik Nielsen-Kudsk
OBJECTIVES: The aim of this study was to compare the efficacy and safety of intracardiac echocardiography (ICE) from the left atrium (LA) with transesophageal echocardiography (TEE) for procedural guidance of transcatheter left atrial appendage occlusion (LAAO). BACKGROUND: TEE with general anesthesia is the current gold standard to guide LAAO. By the use of ICE from the LA, LAAO can be performed in local anesthesia and may potentially have advantages over TEE. METHODS: A single-center, cohort study of patients undergoing LAAO with the Amplatzer Cardiac Plug or Amulet (St...
August 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28845004/-application-of-perimembranous-ventricular-septal-defects-closure-solely-by-femoral-vein-approach-under-transesophageal-echocardiography-guidance
#17
Haisong Bu, Lei Gao, Weizhi Zhang, Qin Wu, Wancun Jin, Mi Tang, Tianli Zhao
To investigate the feasibility and safety of perimembranous ventricular septal defects (PmVSD) closure solely by femoral vein approach under transesophageal echocardiography (TEE) guidance.
 Methods: From January 1, 2014 to May 31, 2016, 26 patients with PmVSD in Second Xiangya Hospital were selected, with age at 3.2-6.0 (4.3±0.7) years old and body weight at 15.0-19.5 (16.7±1.4) kg. The diameter of VSD was 3.5-4.8 (4.1±0.3) mm. All patients were treated by percutaneous PmVSD closure solely by femoral vein approach under TEE guidance...
July 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28836342/single-trans-septal-access-technique-for-left-atrial-intracardiac-echocardiography-to-guide-left-atrial-appendage-closure
#18
Daniel Aguirre, Christian Pincetti, Luis Perez, Carlos Deck, Mario Alfaro, Maria Jesus Vergara, Gabriel Maluenda
OBJECTIVE: This registry aimed to describe the safety and feasibility of a single trans-septal (TS) access technique for left intracardiac echocardiography (ICE) guidance of left-atrial appendage (LAA) closure procedure. BACKGROUND: LAA closure is currently accepted as an alternative to oral anticoagulation (OAC) in patients with non-valvular atrial fibrillation (NVAF) who are at high-risk for bleeding. Currently, LAA closure procedure is typically performed under trans-esophageal echocardiogram (TEE) guidance...
August 24, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28826847/transesophageal-echocardiographic-assessment-of-pulmonary-artery-to-ascending-aorta-ratio-for-the-detection-of-pulmonary-hypertension-in-cardiac-surgical-patients
#19
Karthik Narendra Kumar, Naveen G Singh, Nagaraja P S, Thimmangouda A Patil, Manjunath N
OBJECTIVE: The objective of the study was to investigate if the main pulmonary artery (mPA)-to-ascending aorta (AscAo), (mPA:AscAo) ratio could serve as a screening tool in identifying pulmonary artery hypertension (PAH). DESIGN: A prospective observational study. SETTING: Tertiary care center, university hospital. PARTICIPANTS: Fifty-four adult patients undergoing off-pump coronary artery bypass grafting surgery (OPCAB)...
October 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28817542/safety-of-transesophageal-echocardiography%C3%A2-guided-electrical-cardioversion-in-patients-with-atrial-fibrillation-and-inadequate-anticoagulation
#20
Joanna Zaprutko, Artur Baszko, Michał Michalak, Karol Kochman, Radosław Szymański, Jan Kłopocki, Anna Nowicka, Rafał Dankowski, Marek Michalski, Piotr Kałmucki, Andrzej Szyszka
INTRODUCTION    Restoring sinus rhythm in patients with atrial fibrillation (AF)/atrial flutter (AFl) requires adequate oral anticoagulation prior to direct current cardioversion (DCC). Some patients eligible for DCC are not properly anticoagulated. OBJECTIVES    The aim of the study was to assess risk factors for thrombus and spontaneous echo contrast (SEC) in the left atrium (LA) as well as the safety profile of transesophageal echocardiography (TEE)-guided DCC in patients with inadequate anticoagulation...
August 9, 2017: Polish Archives of Internal Medicine
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