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https://www.readbyqxmd.com/read/28813071/content-validation-clarity-relevance-reliability-and-internal-consistency-of-enunciative-signs-of-language-acquisition
#1
Anelise Henrich Crestani, Anaelena Bragança de Moraes, Ana Paula Ramos de Souza
Purpose: To analyze the results of the validation of building enunciative signs of language acquisition for children aged 3 to 12 months. Methods: The signs were built based on mechanisms of language acquisition in an enunciative perspective and on clinical experience with language disorders. The signs were submitted to judgment of clarity and relevance by a sample of six experts, doctors in linguistic in with knowledge of psycholinguistics and language clinic. In the validation of reliability, two judges/evaluators helped to implement the instruments in videos of 20% of the total sample of mother-infant dyads using the inter-evaluator method...
August 10, 2017: CoDAS
https://www.readbyqxmd.com/read/28807493/homocysteine-and-cognitive-function-in-parkinson-s-disease
#2
Nicole Licking, Charles Murchison, Brenna Cholerton, Cyrus P Zabetian, Shu-Ching Hu, Thomas J Montine, Amie L Peterson-Hiller, Kathryn A Chung, Karen Edwards, James B Leverenz, Joseph F Quinn
INTRODUCTION: Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear whether elevated plasma HC is associated with cognitive impairment in Parkinson's disease (PD). METHODS: The study population includes all participants in the Pacific Northwest Udall Center (PANUC) Clinical cohort at the time of the study, consisting of 294 individuals with PD who had a standardized neuropsychological assessment and plasma collection for HC measurement...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28806425/impact-of-different-surgeons-on-dental-implant-failure
#3
Bruno Ramos Chrcanovic, Jenö Kisch, Tomas Albrektsson, Ann Wennerberg
PURPOSE: To assess the influence of several factors on the prevalence of dental implant failure, with special consideration of the placement of implants by different dental surgeons. MATERIALS AND METHODS: This retrospective study is based on 2,670 patients who received 10,096 implants at one specialist clinic. Only the data of patients and implants treated by surgeons who had inserted a minimum of 200 implants at the clinic were included. Kaplan-Meier curves were stratified with respect to the individual surgeon...
August 14, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28804980/using-bayes-factors-to-evaluate-evidence-for-no-effect-examples-from-the-sips-project
#4
Zoltan Dienes, Simon Coulton, Nick Heather
AIMS: To illustrate how Bayes Factors are important for determining the effectiveness of interventions. METHOD: We consider a case where inappropriate conclusions were publicly drawn based on significance testing, namely the SIPS Project (Screening and Intervention Programme for Sensible drinking), a pragmatic, cluster-randomized controlled trial in each of two healthcare settings and in the criminal justice system. We show how Bayes Factors can disambiguate the non-significant findings from the SIPS Project and thus determine whether the findings represent evidence of absence or absence of evidence...
August 13, 2017: Addiction
https://www.readbyqxmd.com/read/28802925/objective-measurement-and-monitoring-of-nonmotor-symptoms-in-parkinson-s-disease
#5
Lisa Klingelhoefer, Onanong Jitkritsadakul, Roongroj Bhidayasiri
The comprehensive evaluation of nonmotor symptoms (NMS) in Parkinson's disease (PD) starts with the awareness of physicians, patients, and caregivers on their nature, clinical presentation, and effect on patient's daily activities and quality of life. This awareness can be better achieved if the symptoms can be visualized, measured, and monitored. As NMS are largely subjective in nature, a majority of them cannot be visualized (unlike tremor, which is easily seen), making their identification and quantification difficult...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802364/the-reliability-of-flexible-nasolaryngoscopy-in-the-identification-of-vocal-fold-movement-impairment-in-young-infants
#6
Yi-Chun Carol Liu, Tyler McElwee, Mary Musso, Tara L Rosenberg, Julina Ongkasuwan
OBJECTIVE: Flexible nasolaryngoscopy (FNL) is considered the gold standard for evaluation of vocal fold mobility but there has been no data on the reliability of interpretation in the infant population. Visualization may be limited by excessive movement, secretions, or floppy supraglottic structures that prevent accurate diagnosis of vocal fold movement impairment (VFMI). We sought to evaluate the inter- and intra-rater reliability of FNL for the evaluation of VFMI in young infants. STUDY TYPE: Case-control...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801302/improving-patient-centered-care-for-young-people-in-general-practice-with-a-codesigned-screening-app-mixed-methods-study
#7
Marianne Julie Webb, Greg Wadley, Lena Amanda Sanci
BACKGROUND: Despite experiencing a high prevalence and co-occurrence of mental health disorders and health-compromising behaviors, young people tend not to seek professional help for these concerns. However, they do regularly attend primary care, making primary care providers ideally situated to identify and discuss mental health and lifestyle issues as part of young people's routine health care. OBJECTIVE: The aim was to investigate whether using a codesigned health and lifestyle-screening app, Check Up GP, in general practice influenced young people's assessment of the quality of their care (measures of patient-centered care and youth friendliness), and their disclosure of sensitive issues...
August 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28797300/can-routine-clinical-data-identify-older-patients-at-risk-of-poor-healthcare-outcomes-on-admission-to-hospital
#8
Kinda Ibrahim, Charlotte Owen, Harnish P Patel, Carl May, Mark Baxter, Avan A Sayer, Helen C Roberts
OBJECTIVE: Older patients who are at risk of poor healthcare outcomes should be recognised early during hospital admission to allow appropriate interventions. It is unclear whether routinely collected data can identify high-risk patients. The aim of this study was to define current practice with regard to the identification of older patients at high risk of poor healthcare outcomes on admission to hospital. RESULTS: Interviews/focus groups were conducted to establish the views of 22 healthcare staff across five acute medicine for older people wards in one hospital including seven nurses, four dieticians, seven doctors, and four therapists...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28797007/cerebrospinal-fluid-biomarkers-of-pediatric-hydrocephalus
#9
David D Limbrick, Leandro Castaneyra-Ruiz, Roland H Han, Daniel Berger, James P McAllister, Diego M Morales
Hydrocephalus (HC) is a common, debilitating neurological condition that requires urgent clinical decision-making. At present, neurosurgeons rely heavily on a patient's history, physical examination findings, neuroimaging, and clinical judgment to make the diagnosis of HC or treatment failure (e.g., shunt malfunction). Unfortunately, these tools, even in combination, do not eliminate subjectivity in clinical decisions. In order to improve the management of infants and children with HC, there is an urgent need for new biomarkers to complement currently available tools and enable clinicians to confidently establish the diagnosis of HC, assess therapeutic efficacy/treatment failure, and evaluate current and future developmental challenges, so that every child has access to the resources they need to optimize their outcome and quality of life...
August 11, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28793390/interventions-for-maintaining-nasogastric-feeding-after-stroke-an-integrative-review-of-effectiveness-and-acceptability
#10
REVIEW
Catherine Mahoney, Linda Veitch
AIMS AND OBJECTIVES: To investigate the effectiveness and acceptability of interventions for maintaining nasogastric tubes (NGT) in adult stroke patients. BACKGROUND: Internationally, incidence of Cerebral Vascular Disease (CVD) continues to increase and stroke is the largest cause of complex disability in adults. Dysphagia is common following a stroke which necessitates feeding via a NGT. NGT are not well tolerated by stroke patients and may be frequently dislodged...
August 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28789978/a-composite-indicator-to-assess-the-quality-of-care-in-the-management-of-patients-with-rheumatoid-arthritis-in-outpatient-rheumatology-clinics
#11
María Auxiliadora Martín-Martínez, Jose Luis Andreu-Sanchez, Fernando Sanchez-Alonso, Hector Corominas, Jose Javier Perez-Venegas, Jose Andres Roman-Ivorra, Mercedes Alperi, Ricardo Blanco-Alonso, Rafael Caliz, Eugenio Chamizo-Carmona, Jenaro Graña-Gil, Blanca Hernández, Carlos Marras, Ramon Mazzucchelli, Julio Antonio Medina Luezas, Antonio Naranjo-Hernández, Ana Ortiz, Rosa Roselló, Ginés Sanchez-Nievas, Raimon Sanmartí, Paloma Vela-Casasempere
OBJECTIVE: The current guidelines in the treatment of rheumatoid arthritis (RA) include the early diagnosis and early use of disease modifying drugs to achieve remission or low disease activity level, known as "Treat to Target" (T2T). The objective of this study is to develop a composite indicator (CI) to evaluate the quality of care in the management of patients with RA, according to the T2T strategy and other general recommendations concerning the management of these patients. MATERIAL AND METHOD: The phases of the construction of the CI were: 1) selection of quality criteria through expert judgment; 2) prioritization of the criteria, according to relevance and feasibility, applying the Delphi methodology (two rounds) involving 20 experts; 3) design of quality indicators; and 4) calculation of the weighted CI, using the mean value in relevance and feasibility granted by the experts...
August 5, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28782058/consistency-of-brca1-and-brca2-variant-classifications-among-clinical-diagnostic-laboratories
#12
Stephen E Lincoln, Shan Yang, Melissa S Cline, Yuya Kobayashi, Can Zhang, Scott Topper, David Haussler, Benedict Paten, Robert L Nussbaum
BACKGROUND: Genetic tests of the cancer predisposition genes BRCA1 and BRCA2 inform significant clinical decisions for both physicians and patients. Most uncovered variants are benign, and determining which few are pathogenic (disease-causing) is sometimes challenging and can potentially be inconsistent among laboratories. The ClinVar database makes de-identified clinical variant classifications from multiple laboratories publicly available for comparison and review, per recommendations of the American Medical Association (AMA), the American College of Medical Genetics (ACMG), the National Society for Genetic Counselors (NSGC), and other organizations...
July 2017: JCO Precis Oncol
https://www.readbyqxmd.com/read/28781917/long-term-recurrence-of-dysembryoplastic-neuroepithelial-tumor-clinical-case-report
#13
Daniel A Tonetti, William J Ares, R Mark Richardson, Ronald L Hamilton, Frank S Lieberman
BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNETs) are rare, benign brain neoplasms that typically arise in children and adolescents and classically present with intractable, partial complex seizures. DNETs are classically associated with a favorable prognosis after complete surgical resection. CASE DESCRIPTION: We describe a case of long-term recurrence of a DNET, which initially resected and diagnosed as an oligodendroglioma prior to the recognition of DNETs...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28781150/2016-guidelines-for-the-use-of-antifungal-agents-in-patients-with-invasive-fungal-diseases-in-taiwan
#14
REVIEW
Hsiang-Chi Kung, Po-Yen Huang, Wei-Ting Chen, Bor-Sheng Ko, Yee-Chun Chen, Shan-Chwen Chang, Yin-Ching Chuang
The Infectious Diseases Society of Taiwan, Medical Foundation in Memory of Dr. Deh-Lin Cheng, Foundation of Professor Wei-Chuan Hsieh for Infectious Diseases Research and Education, and CY Lee's Research Foundation for Pediatric Infectious Diseases and Vaccines have updated the guidelines for the use of antifungal agents in adult patients with invasive fungal diseases in Taiwan. This guideline replaces the 2009 version. Recommendations are provided for Candida, Cryptococcus, Aspergillus and Mucormycetes. The focus is based on up-to-date evidence on indications for treatment or prophylaxis of the most common clinical problems...
July 25, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28772086/highlights-of-drug-and-herb-induced-liver-injury-in-the-literature-from-2016-how-best-to-translate-new-information-into-clinical-practice
#15
Omar Shahbaz, Sandeep Mahajan, James H Lewis
INTRODUCTION: More than 1500 papers on drug-induced liver injury (DILI) and herb-induced liver injury (HILI) were published in 2016, many of which have the potential to impact clinical practice. AREAS COVERED: Clinical studies and case series that lent themselves to new concepts or directions in diagnosing, preventing, and treating DILI were selected for inclusion. Epidemiology of DILI in large prospective registries was highlighted, including the US DILIN network and Spanish DILI registry...
August 3, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28771999/monitoring-of-plexiform-neurofibroma-in-children-and-adolescents-with-neurofibromatosis-type-1-by-18-f-fdg-pet-imaging-is-it-of-value-in-asymptomatic-patients
#16
Amedeo A Azizi, Irene Slavc, Benjamin Emile Theisen, Ivo Rausch, Michael Weber, Wolfgang Happak, Oskar Aszmann, Azadeh Hojreh, Andreas Peyrl, Gabriele Amann, Thomas M Benkoe, Wolfgang Wadsak, Gregor Kasprian, Anton Staudenherz, Marcus Hacker, Tatjana Traub-Weidinger
PURPOSE: About 10% of patients with neurofibromatosis type 1 (NF-1) develop malignant peripheral nerve sheath tumours (MPNST) mostly arising in plexiform neurofibroma (PN); 15% of MPNST arise in children and adolescents. 2-[(18) F]fluoro-2-deoxy-d-glucose ([(18) F]FDG)-PET (where PET is positron emission tomography) is a sensitive method in differentiating PN and MPNST in symptomatic patients with NF-1. This study assesses the value of [(18) F]FDG-PET imaging in detecting malignant transformation in symptomatic and asymptomatic children with PN...
August 3, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28771385/addressing-the-missing-part-of-evidence-based-practice-the-importance-of-respecting-clinical-judgment-in-the-process-of-adopting-a-new-screening-tool-for-postpartum-depression
#17
Vered Ben-David, Melissa Jonson-Reid, Ron Tompkins
The aim of the present study was to examine the role of nurse's clinical judgment in the uptake of an evidence-based tool assessing postpartum depression, the Edinburgh Postpartum Depression Scale. Nurses in a home visitation program were being asked to regularly screen for postpartum depression. The screener was introduced as a new standard of practice for nurses. A qualitative investigation of the nurses' reactions in addition to an evidence-based screener was conducted. Prior to and during the implementation, several meetings were held with the nurses and the research team to discuss the nurses' experience with the tool...
August 3, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28768738/altered-tactile-sensitivity-in-children-with-attention-deficit-hyperactive-disorder
#18
Nicolaas A J Puts, Ashley D Harris, Mark Mikkelsen, Mark Tommerdahl, Richard Ae Edden, Stewart H Mostofsky
ADHD is characterized by an inability to concentrate, heightened activity, and hypermotoric behavior, but sensory, e.g. tactile, problems are common. The literature on tactile impairments in ADHD is limited, with most work employing clinical observations or questionnaires. Here, we study tactile processing in children with ADHD, and hypothesize that children with ADHD show reduced performance in tasks closely linked to inhibition. Sixty seven children with ADHD and 62 typically developing children performed a battery of tasks grouped in domains: simple and choice reaction time; static and dynamic detection threshold (probing feed-forward inhibition); amplitude discrimination without adaptation, and with dual, and single-site adaptation (probing lateral inhibition and adaptation); sequential and simultaneous frequency discrimination (previously linked to GABA); and temporal order judgment with and without a synchronous carrier stimulus...
August 2, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28765697/eight-week-ledipasvir-sofosbuvir-in-non-cirrhotic-treatment-na%C3%A3-ve-hepatitis-c-genotype-1-patients-with-hepatitis-c-virus-rna-6-million-single-center-real-world-effectiveness-and-safety
#19
Nyan L Latt, Beshoy T Yanny, Derenik Gharibian, Rita Gevorkyan, Amandeep K Sahota
AIM: To evaluate sustained viral response (SVR) of 8-wk ledipasvir/sofosbuvir therapy among non-cirrhotic, genotype-1 hepatitis C virus (HCV) patients with RNA < 6 million IU/mL. METHODS: We performed a retrospective cohort study to examine SVR rates, predictors of treatment failure and safety analysis of 8-wk ledipasvir/sofosbuvir (LDV/SOF) therapy among non-cirrhotic, genotype 1 HCV patients with viral load < 6 million IU/mL. Primary outcome was an achievement of SVR at 12 wk after treatment...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28763182/-multicenter-validation-of-an-evaluation-tool-for-clinical-training-activities-svat-of-the-nursing-students
#20
Sergio Finotto, Cinzia Gradellini, Stefania Bandini, Francesco Burrai, Sandra Lucchi Casadei, Carolina Villani, Simone Vincenzi, Daniela Mecugni
OBJECTIVE: To evaluate the psychometric characteristics of the Scheda di Valutazione delle Attività di Tirocinio (SVAT). METHOD: The degree courses in Nursing of the University of Modena and Reggio Emilia, site of Reggio Emilia, the University of Bologna Formative Section BO1, Imola and training center of Cesena, the University of Ferrara training centers of Ferrara and Codigoro were all enrolled in the research. For the content validation the reactive Delphi method was chosen...
April 2017: Professioni Infermieristiche
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