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https://www.readbyqxmd.com/read/27919244/surgical-antibiotic-prophylaxis-in-children-a-mixed-method-study-on-healthcare-professionals-attitudes
#1
Angela Giusti, Stefania Spila Alegiani, Marta Luisa Ciofi Degli Atti, Sofia Colaceci, Roberto Raschetti, Pasquale Arace, Raffaele Spiazzi, Massimiliano Raponi
BACKGROUND: Qualitative and quantitative research investigating determinants of adherence to clinical guidelines (GLs) on surgical antibiotic prophylaxis (SAP) are scarce. We conducted a mixed-method study aimed at investigating barriers and at describing attitudes of healthcare professionals (HCPs) regarding SAP in three Italian children's hospitals. METHODS: The study comprised two sequential phases: 1) collection of qualitative data through focus groups; 2) conduction of a survey on HCPs attitudes towards SAP...
December 5, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27910252/memory-performance-on-the-story-recall-test-and-prediction-of-cognitive-dysfunction-progression-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#2
Jong-Hwan Park, Hyuntae Park, Sang Wuk Sohn, Sungjae Kim, Kyung Won Park
AIM: To determine the factors that influence diagnosis and differentiation of patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) by comparing memory test results at baseline with those at 1-2-year follow up. METHODS: We consecutively recruited 23 healthy participants, 44 MCI patients and 27 patients with very mild AD according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorder Association criteria for probable Alzheimer's disease and Petersen's clinical diagnostic criteria...
December 1, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27905654/-conflict-of-interest-disclosure-as-a-tool-to-improve-the-reliability-of-research
#3
Mauricio Soto Subiabre
Conflicts of interest are situations in which professional judgment concerning a primary interest, tends to be influenced by a secondary interest. These conflicts could compromise the reliability of biomedical research and result in the dissemination of biased results. Therefore, it is essential to protect the integrity of them, because this information could be used in the development of health policy, medical education and clinical decision making. Conflicts of interest disclosure, is a bioethical tool that contributes to transparent these conflicts, but it is used inappropriately and insufficiently...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27903135/support-for-relatives-bereaved-by-psychiatric-patient-suicide-national-confidential-inquiry-into-suicide-and-homicide-findings
#4
Alexandra L Pitman, Isabelle M Hunt, Sharon J McDonnell, Louis Appleby, Navneet Kapur
OBJECTIVES: International suicide prevention strategies recommend providing support to families bereaved by suicide. The study objectives were to measure the proportion of cases in which psychiatric professionals contact next of kin after a patient's suicide and to investigate whether specific, potentially stigmatizing patient characteristics influence whether the family is contacted. METHODS: Annual survey data from England and Wales (2003-2012) were used to identify 11,572 suicide cases among psychiatric patients...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27899736/eminence-and-omniscience-statistical-and-clinical-prediction-of-merit
#5
Donald J Foss
In this article, I review, comment upon, and assess some of the suggestions for evaluating scientific merit as suggested by contributors to this symposium. I ask the reader to take the perspective of the individual who has the final say in making a tenure, promotion, or hiring decision. I also ask that one imagine the difference between the fallible human state we are in on such an occasion and what it would be like to be omniscient when making such decisions. After adopting the terminology of "deep" and "surface" eminence, I consider what an omniscient being would take into account to determine eminence and to guide decision-making...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27898705/the-role-of-the-amygdala-in-facial-trustworthiness-processing-a-systematic-review-and-meta-analyses-of-fmri-studies
#6
Sara Santos, Inês Almeida, Bárbara Oliveiros, Miguel Castelo-Branco
BACKGROUND: Faces play a key role in signaling social cues such as signals of trustworthiness. Although several studies identify the amygdala as a core brain region in social cognition, quantitative approaches evaluating its role are scarce. OBJECTIVES: This review aimed to assess the role of the amygdala in the processing of facial trustworthiness, by analyzing its amplitude BOLD response polarity to untrustworthy versus trustworthy facial signals under fMRI tasks through a Meta-analysis of effect sizes (MA)...
2016: PloS One
https://www.readbyqxmd.com/read/27898134/quality-pain-care-for-older-adults-in-an-era-of-suspicion-and-scrutiny
#7
Barbara St Marie, Paul Arnstein
In two decades, the pendulum has swung from focusing on the undertreatment of pain by prescribers who fail to use medically necessary opioid agents to an intense focus on overprescribing opioid medications and the harms they cause. Within these two extremes rests the older adult with pain and in need of safe and effective care. Today, health care providers are practicing in an era of scrutiny, with new guidelines and regulations superseding their compassion and clinical judgment about the best treatment options when older adults have pain across the care continuum...
December 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27895544/mesoporous-silica-chip-enabled-peptide-profiling-as-an-effective-platform-for-controlling-bio-sample-quality-and-optimizing-handling-procedure
#8
Kai Liang, Hongmei Wu, Tony Y Hu, Yan Li
BACKGROUND: High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial for avoiding biased analysis in a clinical setting. A universally applicable method for the evaluation of sample quality and pre-analysis handling is therefore in great demand. METHODS: The fingerprint pattern of low molecular weight (LMW) peptides in sera is directly associated with sample quality and handling process...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/27894438/how-doctors-think-common-diagnostic-errors-in-clinical-judgment-lessons-from-an-undiagnosed-and-rare-disease-program
#9
REVIEW
Robert M Kliegman, Brett J Bordini, Donald Basel, James J Nocton
The scientific process of analysis and deduction is frequently, often subconsciously, used by physicians to develop a differential diagnosis based on patients' symptoms. Common disorders are most frequently diagnosed in general practice. Rare diseases are uncommon and frequently remain undiagnosed for many years. Cognitive errors in clinical judgment delay definitive diagnosis. Whole-exome sequencing has helped identify the cause of undiagnosed or rare diseases in up to 40% of children. This article provides experiences with an undiagnosed or rare disease program, where detailed data accumulation and a multifaceted analytical approach assisted in diagnosing atypical presentations of common disorders...
February 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/27894076/co-expression-of-piwil2-piwil4-in-nucleus-indicates-poor-prognosis-of-hepatocellular-carcinoma
#10
Guangping Zeng, Deying Zhang, Xing Liu, Qing Kang, Yiyao Fu, Bo Tang, Wenhao Guo, Yuanyuan Zhang, Guanghui Wei, Dawei He
PURPOSE: This study aimed to explore the localization and expression of P-element-induced wimpy testis-like 2 (piwil2)/Piwil4 in hepatocellular carcinoma (HCC) tissues, and analyze the correlation between co-expression pattern and prognosis of HCC. RESULTS: Piwil2 showed 100% positive expression in the cell nucleus, with the intensity higher than in the cytoplasm. Piwil4 showed a lower intensity of expression in the cell nucleus than in the cytoplasm. The molecular chaperone Piwil2/Piwil4 had four co-expression patterns: nuclear co-expression, nuclear and cytoplasmic co-expression, cytoplasmic co-expression, and non-coexpression...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893904/clinical-judgment-scripts-as-a-strategy-to-foster-clinical-judgments
#11
Cheryl B Hines, Felecia G Wood
BACKGROUND: Clinical judgment encompasses how nurses use their knowledge of the patient to generate, assess, and prioritize patient care alternatives. Previous research has identified debriefing as critical to developing clinical judgment. Best practice for debriefing has yet to be identified. The purpose of this research was to investigate whether a standard debriefing script, based on Tanner's clinical judgment model, could foster clinical judgment. METHOD: Participants were senior nursing students in their final semester of study...
December 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27893575/variations-in-burn-excision-and-grafting-a-survey-of-the-american-burn-association
#12
Jacqueline S Israel, David G Greenhalgh, Angela L Gibson
It is unknown whether variations in burn care affect outcomes or affect the success of emerging therapeutics. The purpose of this study was to assess burn surgeons' preferences in excision and grafting to determine if surgical technique affects outcomes. A 71-item survey evaluating skin grafting techniques was emailed to members of the American Burn Association in July and August 2015. The survey was anonymous and voluntary. Relationships between variables were evaluated using Fisher's exact test. A P-value of ≤...
November 15, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27893066/symptoms-and-satisfaction-of-patients-in-the-patient-reported-outcomes-with-laser-in-situ-keratomileusis-prowl-studies
#13
Malvina Eydelman, Gene Hilmantel, Michelle E Tarver, Elizabeth M Hofmeister, Jeanine May, Keri Hammel, Ron D Hays, Frederick Ferris
Importance: Patient-reported outcomes should be collected using validated questionnaires prior to and following laser in situ keratomileusis (LASIK) surgery. Objective: To report the frequency of patient-reported visual symptoms, dry eye symptoms, satisfaction with vision, and satisfaction with LASIK surgery in the Patient-Reported Outcomes With LASIK (PROWL) studies. Design, Setting, and Participants: The PROWL-1 and PROWL-2 studies were prospective, observational studies conducted from September 13, 2011, to June 27, 2014...
November 23, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27892670/impact-of-adjuvant-chemotherapy-in-elderly-breast-patients-in-taiwan-a-hospital-based-study
#14
Hsiu-Chuan Lee, Wei-Yu Chen, Wen- Tsung Huang, Kuo- Chen Cheng, Yu-Feng Tian, Chung-Han Ho, Chao- Jung Tsao, Yin- Hsun Feng
Purpose: Decisions as to whether to provide adjuvant treatment in older breast cancer patients remains challenging. Side effects of chemotherapy have to be weighed against life expectancy, comorbidities, functional status, and frailty. To aid decision-making, we retrospectively analyzed 110 women with breast cancer treated with a curative intention from 2006 to 2012. Survival data with clinical and pathological parameters were evaluated to address the role of adjuvant chemotherapy in this study population. Method: A total of 110 elderly (>70 years) patients that received mastectomy at two hospitals in Taiwan were observed retrospectively for a medium of 51 months...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27890107/an-analysis-of-causative-factors-in-closed-criminal-medical-malpractice-cases-of-the-taiwan-supreme-court-2000-2014
#15
Kuan-Han Wu, Shih-Yu Cheng, Yung-Lin Yen, Chien-Hung Wu, Ming-Ta Tsai, Fu-Jen Cheng
Most medical malpractice in Taiwan leads to criminal prosecution. This study examined the epidemiologic factors and clinical errors that led to medical malpractice convictions in Taiwanese criminal prosecutions. A retrospective, 15-year population-based review of criminal Supreme Court judgments pertaining to medical malpractice against physicians and nurses was conducted. Eighty-four cases were reviewed, yielding data that included the number and specialty involved, accused hospitals, the diagnosis, the time interval between incidents to closure, result of adjudication, the origin of cases (private vs...
November 2016: Legal Medicine
https://www.readbyqxmd.com/read/27888954/the-effect-of-internalized-stigma-on-the-self-esteem-in-patients-with-schizophrenia
#16
Sibel Asi Karakaş, Ayşe Okanlı, Emine Yılmaz
AIM: This study has been conducted to determine the relationship between internalized stigma and self-esteem in patients with schizophrenia. MATERIALS AND METHODS: This study was conducted using 60 patients with schizophrenia who were diagnosed as schizophrenic according to the DSM-IV diagnostic criteria in the psychiatric clinics of hospitals in Erzurum. The data were collected using the "Questionnaire on Internalized Stigma of Mental Illness Scale" (ISMI) that determines the socio-demographic characteristics of patients, and the "Short Form of Self-Esteem Scale" (SF-SES)...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27887704/aberrant-modulation-of-brain-activation-by-emotional-valence-during-self-referential-processing-among-patients-with-delusions-of-reference
#17
Todd A Girard, Louis Lakatos, Mahesh Menon
BACKGROUND AND OBJECTIVES: Delusions of reference are thought to reflect abnormally heightened attributions of salience to mundane events or stimuli that lead to convictions that they are personally significant or directed at the observer. Recent findings highlight abnormal recruitment of brain regions associated with self-referential processes among patients with referential delusions. Given the inherent overlap of emotion, incentive salience, and self-relevance, as well as with aberrant thought processes in psychosis, this study investigated the implicit relations between participants' perception of the emotional valence of stimuli on neural correlates of self-referent judgments among schizophrenia-spectrum patients with referential delusions...
November 17, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27882857/learning-from-observation-feedback-and-intervention-in-linear-and-nonlinear-task-environments
#18
Maria P Henriksson, Tommy Enkvist
This multiple-cue judgment study investigates whether we can manipulate the judgment strategy and increase accuracy in linear and nonlinear cue-criterion environments just by changing the training mode. Three experiments show that accuracy in simple linear additive task environments are improved with feedback training and intervention training, while accuracy in complex multiplicative tasks are improved with observational training. The observed interaction effect suggests that the training mode invites different strategies that are adjusted as a function of experience to the demands from the underlying cue-criterion structure...
November 24, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27882636/fear-of-knowledge-clinical-hypotheses-in-diagnostic-and-prognostic-reasoning
#19
Daniele Chiffi, Renzo Zanotti
Patients are interested in receiving accurate diagnostic and prognostic information. Models and reasoning about diagnoses have been extensively investigated from a foundational perspective; however, for all its importance, prognosis has yet to receive a comparable degree of philosophical and methodological attention, and this may be due to the difficulties inherent in accurate prognostics. In the light of these considerations, we discuss a considerable body of critical thinking on the topic of prognostication and its strict relations with diagnostic reasoning, pointing out the distinction between nosographic and pathophysiological types of diagnosis and prognosis, underlying the importance of the explication and explanation processes...
November 24, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27876688/online-concerns-of-parents-suspecting-autism-spectrum-disorder-in-their-child-content-analysis-of-signs-and-automated-prediction-of-risk
#20
Ayelet Ben-Sasson, Elad Yom-Tov
BACKGROUND: Online communities are used as platforms by parents to verify developmental and health concerns related to their child. The increasing public awareness of autism spectrum disorders (ASD) leads more parents to suspect ASD in their child. Early identification of ASD is important for early intervention. OBJECTIVE: To characterize the symptoms mentioned in online queries posed by parents who suspect that their child might have ASD and determine whether they are age-specific...
November 22, 2016: Journal of Medical Internet Research
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