Jana De Brandt, Wim Derave, Frank Vandenabeele, Pascal Pomiès, Laura Blancquaert, Charly Keytsman, Marina S Barusso-Grüninger, Fabiano F de Lima, Maurice Hayot, Martijn A Spruit, Chris Burtin
BACKGROUND: Beta-alanine (BA) supplementation increases muscle carnosine, an abundant endogenous antioxidant and pH buffer in skeletal muscle. Carnosine loading promotes exercise capacity in healthy older adults. As patients with chronic obstructive pulmonary disease (COPD) suffer from elevated exercise-induced muscle oxidative/carbonyl stress and acidosis, and from reduced muscle carnosine stores, it was investigated whether BA supplementation augments muscle carnosine and induces beneficial changes in exercise capacity, quadriceps function, and muscle oxidative/carbonyl stress in patients with COPD...
October 2022: Journal of Cachexia, Sarcopenia and Muscle