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Nitrate supplementation

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https://www.readbyqxmd.com/read/29327458/lead-induced-dna-damage-and-cell-apoptosis-in-human-renal-proximal-tubular-epithelial-cell-attenuation-via-n-acetyl-cysteine-and-tannic-acid
#1
Manushi Siddarth, Diwesh Chawla, Alpana Raizada, Neelam Wadhwa, Basu D Banerjee, Meera Sikka
This study investigates the exposure of lead-induced reactive oxygen species (ROS) generation, DNA damage, and apoptosis and also evaluates the therapeutic intervention using antioxidants in human renal proximal tubular cells (HK-2 cells). Following treatment of HK-2 cells with an increasing concentration of lead nitrate (0-50 μM) for 24 h, the intracellular ROS level increased whereas the GSH level decreased significantly in a dose-dependent manner. Comet assay results revealed that lead nitrate showed the ability to increase the levels of DNA strand breaks in HK-2 cells...
January 12, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29311764/effects-of-beetroot-juice-supplementation-on-intermittent-high-intensity-exercise-efforts
#2
REVIEW
Raúl Domínguez, José Luis Maté-Muñoz, Eduardo Cuenca, Pablo García-Fernández, Fernando Mata-Ordoñez, María Carmen Lozano-Estevan, Pablo Veiga-Herreros, Sandro Fernandes da Silva, Manuel Vicente Garnacho-Castaño
Beetroot juice contains high levels of inorganic nitrate (NO3-) and its intake has proved effective at increasing blood nitric oxide (NO) concentrations. Given the effects of NO in promoting vasodilation and blood flow with beneficial impacts on muscle contraction, several studies have detected an ergogenic effect of beetroot juice supplementation on exercise efforts with high oxidative energy metabolism demands. However, only a scarce yet growing number of investigations have sought to assess the effects of this supplement on performance at high-intensity exercise...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29307111/inorganic-nitrate-alleviates-the-senescence-related-decline-in-liver-function
#3
Haifeng Wang, Lei Hu, Le Li, Xiaoshan Wu, Zhipeng Fan, Chunmei Zhang, Jinsong Wang, Jidong Jia, Songlin Wang
Senescence-related decline in liver function is a common complication in the elderly that can lead to impaired health in older individuals. Dietary nitrate supplements have physiological and therapeutic effects on organ function by nitrate (NO3-)-nitrite (NO2-)-nitric oxide (NO) pathway. However, the role of dietary nitrate on the senescence-related decline in liver function is unclear. The findings of the present study showed that nitrate levels in the serum and liver decreased, whereas the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum increased in ageing mice...
January 3, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29305240/a-pilot-study-of-a-non-invasive-oral-nitrate-stable-isotopic-method-suggests-that-arginine-and-citrulline-supplementation-increases-whole-body-no-production-in-tanzanian-children-with-sickle-cell-disease
#4
Alphonce I Marealle, Mario Siervo, Sara Wassel, Les Bluck, Andrew M Prentice, Omary Minzi, Philip Sasi, Appolinary Kamuhabwa, Deogratias Soka, Julie Makani, Sharon E Cox
BACKGROUND: Low bioavailability of nitric oxide (NO) is implicated in the pathophysiology of sickle cell disease (SCD). We designed a nested pilot study to be conducted within a clinical trial testing the effects of a daily ready-to-use supplementary food (RUSF) fortified with arginine (Arg) and citrulline (Citr) vs. non-fortified RUSF in children with SCD. The pilot study evaluated 1) the feasibility of a non-invasive stable isotope method to measure whole-body NO production and 2) whether Arg+Citr supplementation was associated with increased whole-body NO production...
January 2, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29304531/dietary-nitrate-supplementation-reduces-circulating-platelet-derived-extracellular-vesicles-in-coronary-artery-disease-patients-on-clopidogrel-therapy-a-randomised-double-blind-placebo-controlled-study
#5
Nicholas Burnley-Hall, Fairoz Abdul, Vitaliy Androshchuk, Keith Morris, Nick Ossei-Gerning, Richard Anderson, D Aled Rees, Philip E James
Extracellular vesicles (EVs) are implicated in the pathogenesis of cardiovascular disease (CVD). Specifically, platelet-derived EVs are highly pro-coagulant, promoting thrombin generation and fibrin clot formation. Nitrate supplementation exerts beneficial effects in CVD, via an increase in nitric oxide (NO) bioavailability. Clopidogrel is capable of producing NO-donating compounds, such as S-nitrosothiols (RSNO) in the presence of nitrite and low pH. The aim of this study was to assess the effect of nitrate supplementation with versus without clopidogrel therapy on circulating EVs in coronary artery disease (CAD) patients...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29298384/iron-robustly-stimulates-simultaneous-nitrification-and-denitrification-under-aerobic-conditions
#6
Hong Chen, Xuhao Zhao, Yuying Cheng, Mingji Jiang, Xiang Li, Gang Xue
Simultaneous nitrification and denitrification (SND) is a promising single-reactor biological nitrogen-removal method. Activated sludge with and without iron scrap supplementation (Sludge-Fe and Sludge-C, respectively) was acclimated under aerobic condition. The total nitrogen (TN) content of Sludge-Fe substantially decreased from 25.0±1.0 to 11.2±0.4 mg/L, but Sludge-C did not show the TN-removal capacity. Further investigations excluded a chemical reduction of NO3--N by iron and a decrease of NH4+-N by microbial assimilation, and the contribution of SND was verified...
January 3, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29244746/effects-of-beetroot-juice-supplementation-on-a-30-s-high-intensity-inertial-cycle-ergometer-test
#7
Raul Domínguez, Manuel Vicente Garnacho-Castaño, Eduardo Cuenca, Pablo García-Fernández, Arturo Muñoz-González, Fernando de Jesús, María Del Carmen Lozano-Estevan, Sandro Fernandes da Silva, Pablo Veiga-Herreros, José Luis Maté-Muñoz
Background: Beetroot juice (BJ) is rich in inorganic nitrates and has proved effective at increasing blood nitric oxide (NO) levels. When used as a supplement BJ has shown an ergogenic effect on cardiorespiratory resistance exercise modalities, yet few studies have examined its impact on high intensity efforts. Objective: To assess the effects of BJ intake on anaerobic performance in a Wingate test. Methods: Fifteen trained men (age 21.46 ± 1.72 years, height 1.78 ± 0.07 cm and weight 76.90 ± 8.67 kg) undertook a 30-s maximum intensity test on an inertial cycle ergometer after drinking 70 mL of BJ (5...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244743/hematological-and-hemodynamic-responses-to-acute-and-short-term-creatine-nitrate-supplementation
#8
Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Patrick B Collins, Adriana M Coletta, Aimee G Reyes, Brittany Sanchez, Majid Koozehchian, Yanghoon P Jung, Christopher Rasmussen, Mike Greenwood, Peter S Murano, Conrad P Earnest, Richard B Kreider
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men and women ingested a placebo (PLA), 3 g of creatine nitrate (CNL), and 6 g of creatine nitrate (CNH) for 6 days. Participants repeated the experiment with the alternate supplements after a 7-day washout. Hemodynamic responses to a postural challenge, fasting blood samples, and bench press, leg press, and cycling time trial performance and recovery were assessed. Data were analyzed by univariate, multivariate, and repeated measures general linear models (GLM)...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29241129/improving-biocathode-community-multifunctionality-by-polarity-inversion-for-simultaneous-bioelectroreduction-processes-in-domestic-wastewater
#9
Hui Yun, Bin Liang, Deyong Kong, Aijie Wang
Bioelectrochemical systems (BESs) have been tentatively applied for wastewater treatment processes, but the complex composition of wastewater could lead to difficulties in establishing functional biofilm or result in performance instability. Few studies have investigated the enrichment of biocathode with domestic wastewater (DW) and the function. A biocathode with multi-pollutant removal capabilities was enriched based on polarity inverted bioanode, which was established with DW. The biocathode function was examined using model pollutants (nitrate, nitrobenzene and Acid Orange 7) supplemented as sole or mixed electron acceptors...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29229321/the-role-of-aspirin-heparin-and-other-interventions-in-the-prevention-and-treatment-of-fetal-growth-restriction
#10
REVIEW
Katie M Groom, Anna L David
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth, and placental abruption are believed to arise in early pregnancy when inadequate remodeling of the maternal spiral arteries leads to persistent high-resistance and low-flow uteroplacental circulation. The consequent placental ischaemia, reperfusion injury, and oxidative stress are associated with an imbalance in angiogenic/antiangiogenic factors. Many interventions have centered on the prevention and/or treatment of preeclampsia with results pertaining to fetal growth restriction and small-for-gestational-age pregnancy often included as secondary outcomes because of the common pathophysiology...
December 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29223585/influence-of-dietary-nitrate-food-forms-on-nitrate-metabolism-and-blood-pressure-in-healthy-normotensive-adults
#11
Sinead T J McDonagh, Lee J Wylie, James M A Webster, Anni Vanhatalo, Andrew M Jones
Inorganic nitrate (NO3-) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3- administration can influence NO3- metabolism and the subsequent blood pressure response. Ten healthy males consumed an acute equimolar dose of NO3- (∼5.76 mmol) in the form of a concentrated beetroot juice drink (BR; 55 mL), a non-concentrated beetroot juice drink (BL; 456 mL) and a solid beetroot flapjack (BF; 60 g). A drink containing soluble beetroot crystals (BC; ∼1...
December 6, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29211752/getting-the-full-picture-assessing-the-complementarity-of-citizen-science-and-agency-monitoring-data
#12
Jeneen Hadj-Hammou, Steven Loiselle, Daniel Ophof, Ian Thornhill
While the role of citizen science in engaging the public and providing large-scale datasets has been demonstrated, the nature of and potential for this science to supplement environmental monitoring efforts by government agencies has not yet been fully explored. To this end, the present study investigates the complementarity of a citizen science programme to agency monitoring of water quality. The Environment Agency (EA) is the governmental public body responsible for, among other duties, managing and monitoring water quality and water resources in England...
2017: PloS One
https://www.readbyqxmd.com/read/29211505/the-effect-of-dietary-nitrate-on-nocturnal-sleep-disordered-breathing-and-arterial-oxygen-desaturation-at-high-altitude
#13
Alexander Patrician, Harald Engan, David Lundsten, Ludger Grote, Helena Vigetun-Haughey, Erika Schagatay
Patrician, Alexander, Harald Engan, David Lundsten, Ludger Grote, Helena Vigetun-Haughey, and Erika Schagatay. The effect of dietary nitrate on nocturnal sleep-disordered breathing and arterial oxygen desaturation at high altitude. High Alt Med Biol 00:000-000, 2017.-Sleep-disordered breathing and fluctuations in arterial oxygen saturation (SaO2) are common during sleep among lowlanders ascending to high altitude. Dietary nitrate (NO3-) supplementation has been shown to lower the O2 consumption in various conditions...
December 6, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29202488/acute-tadalafil-administration-increases-plasma-fatty-acids-without-changes-in-the-inflammatory-response-in-healthy-men
#14
Roberta Ceci, Guglielmo Duranti, Paolo Sgrò, Stefania Sabatini, Luigi Di Luigi
PURPOSE: Tadalafil, the phosphodiesterase type 5 inhibitor (PDE5I), has been shown to reduce visceral adipose tissue in rabbit and to improve lean mass content in non-obese men. In order to clarify this effect in humans, in the present study we determined the impact of an acute oral tadalafil administration on lipolysis by evaluating plasma free fatty acids (FFAs) and glycerol. FFAs are potential modulator of inflammation response that we evaluated through tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), interleukin 8 (IL8) and interleukin 10 (IL10) plasma levels...
December 5, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29199111/changes-in-body-posture-alter-plasma-nitrite-but-not-nitrate-concentration-in-humans
#15
Luke Liddle, Christopher Monaghan, Mia C Burleigh, Luke C McIlvenna, David J Muggeridge, Chris Easton
PURPOSE: This study evaluated the change (Δ) in plasma volume (PV), nitrate [NO3-], and nitrite [NO2-] concentration following changes in posture in the presence and absence of elevated plasma [NO3-] and [NO2-] METHODS: Fourteen healthy participants completed two trials that were preceded by either supplementation with NO3--rich beetroot juice (BR; total of ∼31 mmol NO3-) or no supplementation (CON). Both trials comprised 30 min of lying supine followed by 2 min of standing, 2 min of sitting and 5 min of sub-maximal cycling...
November 30, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29185736/enhancing-fatty-acid-production-of-saccharomyces-cerevisiae-as-an-animal-feed-supplement
#16
Seung Kyou You, Young-Chul Joo, Dae Hee Kang, Sang Kyu Shin, Jeong Eun Hyeon, Han Min Woo, Youngsoon Um, Chulhwan Park, Sung Ok Han
Saccharomyces cerevisiae is used for edible purposes, such as human food or as an animal feed supplement. Fatty acids are also beneficial as feed supplements, but S. cerevisiae produces less fatty acids. In this study, we enhanced fatty acid production of S. cerevisiae by overexpressing acetyl-CoA carboxylase, thioesterase, and malic enzyme associated with fatty acid metabolism. The enhanced strain pAMT showed 2.4-fold higher fatty acids than the wild-type strain. To further increase the fatty acids, various nitrogen sources were analyzed and calcium nitrate was selected as an optimal nitrogen source for fatty acid production...
November 29, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29158724/comparative-proteomic-analysis-between-nitrogen-supplemented-and-starved-conditions-in-magnaporthe-oryzae
#17
Yeonyee Oh, Suzanne L Robertson, Jennifer Parker, David C Muddiman, Ralph A Dean
Background: Fungi are constantly exposed to nitrogen limiting environments, and thus the efficient regulation of nitrogen metabolism is essential for their survival, growth, development and pathogenicity. To understand how the rice blast pathogen Magnaporthe oryzae copes with limited nitrogen availability, a global proteome analysis under nitrogen supplemented and nitrogen starved conditions was completed. Methods: M. oryzae strain 70-15 was cultivated in liquid minimal media and transferred to media with nitrate or without a nitrogen source...
2017: Proteome Science
https://www.readbyqxmd.com/read/29156373/mitochondria-targeted-ubiquinone-mitoq-enhances-acetaldehyde-clearance-by-reversing-alcohol-induced-posttranslational-modification-of-aldehyde-dehydrogenase-2-a-molecular-mechanism-of-protection-against-alcoholic-liver-disease
#18
Liuyi Hao, Qian Sun, Wei Zhong, Wenliang Zhang, Xinguo Sun, Zhanxiang Zhou
Alcohol metabolism in the liver generates highly toxic acetaldehyde. Breakdown of acetaldehyde by aldehyde dehydrogenase 2 (ALDH2) in the mitochondria consumes NAD(+) and generates reactive oxygen/nitrogen species, which represents a fundamental mechanism in the pathogenesis of alcoholic liver disease (ALD). A mitochondria-targeted lipophilic ubiquinone (MitoQ) has been shown to confer greater protection against oxidative damage in the mitochondria compared to untargeted antioxidants. The present study aimed to investigate if MitoQ could preserve mitochondrial ALDH2 activity and speed up acetaldehyde clearance, thereby protects against ALD...
November 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/29156272/a-quantitative-assessment-of-distributions-and-sources-of-tropospheric-halocarbons-measured-in-singapore
#19
Sayantan Sarkar, Wei Hong Fan, Shiguo Jia, Donald R Blake, Jeffrey S Reid, Puji Lestari, Liya E Yu
This work reports the first ground-based atmospheric measurements of 26 halocarbons in Singapore, an urban-industrial city-state in Southeast (SE) Asia. A total of 166 whole air canister samples collected during two intensive 7 Southeast Asian Studies (7SEAS) campaigns (August-October 2011 and 2012) were analyzed for C1-C2 halocarbons using gas chromatography-electron capture/mass spectrometric detection. The halocarbon dataset was supplemented with measurements of selected non-methane hydrocarbons (NMHCs), C1-C5 alkyl nitrates, sulfur gases and carbon monoxide to better understand sources and atmospheric processes...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29141968/the-nitrate-independent-blood-pressure-lowering-effect-of-beetroot-juice-a-systematic-review-and-meta-analysis
#20
REVIEW
Zahra Bahadoran, Parvin Mirmiran, Ali Kabir, Fereidoun Azizi, Asghar Ghasemi
Beetroot is considered a complementary treatment for hypertension because of its high content of inorganic NO3 This systematic review and meta-analysis aimed to clarify several aspects of beetroot juice supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). We searched PubMed, Scopus, and Embase databases, and the reference lists of previous reviews. Randomized clinical trials that investigated the effects of beetroot juice on resting blood pressure in humans were recruited for quality assessment, meta-analyses, subgroup analyses, and meta-regressions; of these, 22 were conducted between 2009 and 2017 and included a total of 47 intervention (n = 650) and 43 control (n = 598) groups...
November 2017: Advances in Nutrition
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