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Nitrate supplementation

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https://www.readbyqxmd.com/read/27921261/attempting-to-compensate-for-reduced-neuronal-nitric-oxide-synthase-protein-with-nitrate-supplementation-cannot-overcome-metabolic-dysfunction-but-rather-has-detrimental-effects-in-dystrophin-deficient-mdx-muscle
#1
Cara A Timpani, Adam J Trewin, Vanesa Stojanovska, Ainsley Robinson, Craig A Goodman, Kulmira Nurgali, Andrew C Betik, Nigel Stepto, Alan Hayes, Glenn K McConell, Emma Rybalka
Duchenne muscular dystrophy arises from the loss of dystrophin and is characterized by calcium dysregulation, muscular atrophy, and metabolic dysfunction. The secondary reduction of neuronal nitric oxide synthase (nNOS) from the sarcolemma reduces NO production and bioavailability. As NO modulates glucose uptake, metabolism, and mitochondrial bioenergetics, we investigated whether an 8-week nitrate supplementation regimen could overcome metabolic dysfunction in the mdx mouse. Dystrophin-positive control (C57BL/10) and dystrophin-deficient mdx mice were supplemented with sodium nitrate (85 mg/l) in drinking water...
December 5, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27909231/influence-of-dietary-nitrate-supplementation-on-physiological-and-muscle-metabolic-adaptations-to-sprint-interval-training
#2
Christopher Thompson, Lee J Wylie, Jamie R Blackwell, Jonathan Fulford, Matthew I Black, James Kelly, Sinead T J McDonagh, James Carter, Stephen J Bailey, Anni Vanhatalo, Andrew M Jones
We hypothesized that 4 weeks of dietary nitrate supplementation would enhance exercise performance and muscle metabolic adaptations to sprint interval training (SIT). Thirty six recreationally-active subjects, matched on key variables at baseline, completed a series of exercise tests before and following a 4 week period in which they were allocated to one of the following groups: 1) SIT and NO3(-)-depleted beetroot juice as a placebo (SIT+PL); 2) SIT and NO3(-)-rich beetroot juice (~13mmol NO3(-)/day; SIT+BR); or 3) no training and NO3(-)-rich beetroot juice (NT+BR)...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27907839/influence-of-picolinic-acid-on-seizure-susceptibility-in-mice
#3
Anna Cioczek-Czuczwar, Piotr Czuczwar, Waldemar Andrzej Turski, Jolanta Parada-Turska
BACKGROUND: The mechanism of drug resistance in epilepsy remains unknown. Picolinic acid (PIC) is an endogenous metabolite of the kynurenine pathway and a chelating agent added to dietary supplements. Both inhibitory and excitatory properties of PIC were reported. The aim of this study was to determine the influence of exogenously applied PIC upon the electroconvulsive threshold and the activity of chemical convulsants in eight models of epilepsy in mice. METHODS: All experiments were performed on adult male Swiss albino mice...
October 12, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27907207/optimized-jasmonic-acid-production-by-lasiodiplodia-theobromae-reveals-formation-of-valuable-plant-secondary-metabolites
#4
Felipe Eng, Sven Haroth, Kirstin Feussner, Dorothea Meldau, Dmitrij Rekhter, Till Ischebeck, Florian Brodhun, Ivo Feussner
Jasmonic acid is a plant hormone that can be produced by the fungus Lasiodiplodia theobromae via submerged fermentation. From a biotechnological perspective jasmonic acid is a valuable feedstock as its derivatives serve as important ingredients in different cosmetic products and in the future it may be used for pharmaceutical applications. The objective of this work was to improve the production of jasmonic acid by L. theobromae strain 2334. We observed that jasmonic acid formation is dependent on the culture volume...
2016: PloS One
https://www.readbyqxmd.com/read/27876107/sodium-butyrate-protects-mice-from-the-development-of-the-early-signs-of-non-alcoholic-fatty-liver-disease-role-of-melatonin-and-lipid-peroxidation
#5
Cheng Jun Jin, Anna Janina Engstler, Cathrin Sellmann, Doreen Ziegenhardt, Marianne Landmann, Giridhar Kanuri, Hakima Lounis, Markus Schröder, Walter Vetter, Ina Bergheim
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide with universally accepted treatments still lacking. Oral supplementation of sodium butyrate (SoB) has been suggested to attenuate liver damage of various aetiologies. Our study aimed to further delineate mechanisms involved in the SoB-dependent hepatic protection using a mouse model of fructose-induced NAFLD and in in vitro models. C57BL/6J mice were either pair-fed a fructose-enriched liquid diet ±0·6 g/kg body weight per d SoB or standard chow for 6 weeks...
November 23, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27834492/single-and-combined-effects-of-beetroot-crystals-and-sodium-bicarbonate-on-4-km-cycling-time-trial-performance
#6
Marcus J Callahan, Evelyn B Parr, John A Hawley, Louise M Burke
When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (V̇O2max 65 mL·kg·min(-1)) male cyclists completed four x 4-km time trials (TT) in a double-blind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g.day(-1) + 15 g 1 h prior to TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg(-1) body mass [BM] in 5 doses every 15 min from 2...
November 11, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27829985/potential-therapeutic-strategies-for-hypertension-exacerbated-cardiotoxicity-of-anticancer-drugs
#7
REVIEW
Robin K Kuriakose, Rakesh C Kukreja, Lei Xi
Despite their recognized cardiotoxic effects, anthracyclines remain an essential component in many anticancer regimens due to their superior antitumor efficacy. Epidemiologic data revealed that about one-third of cancer patients have hypertension, which is the most common comorbidity in cancer registries. The purpose of this review is to assess whether anthracycline chemotherapy exacerbates cardiotoxicity in patients with hypertension. A link between hypertension comorbidity and anthracycline-induced cardiotoxicity (AIC) was first suggested in 1979...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27822169/the-effect-of-six-days-of-dietary-nitrate-supplementation-on-performance-in-trained-crossfit-athletes
#8
Samuel J Kramer, Daniel A Baur, Maria T Spicer, Matthew D Vukovich, Michael J Ormsbee
BACKGROUND: While it is well established that dietary nitrate reduces the metabolic cost of exercise, recent evidence suggests this effect is maintained 24 h following the final nitrate dose when plasma nitrite levels have returned to baseline. In addition, acute dietary nitrate was recently reported to enhance peak power production. Our purpose was to examine whether chronic dietary nitrate supplementation enhanced peak power 24 h following the final dose and if this impacted performance in a heavily power-dependent sport...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27818732/evaluation-of-some-biochemical-parameters-and-brain-oxidative-stress-in-experimental-rats-exposed-chronically-to-silver-nitrate-and-the-protective-role-of-vitamin-e-and-selenium
#9
Mouna Gueroui, Zine Kechrid
Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water...
October 2016: Toxicological Research
https://www.readbyqxmd.com/read/27815856/organic-amendments-enhance-pb-tolerance-and-accumulation-during-micropropagation-of-daphne-jasminea
#10
Alina Wiszniewska, Ewa Muszyńska, Ewa Hanus-Fajerska, Sylwester Smoleń, Michał Dziurka, Kinga Dziurka
The study investigated the effects of organic amendments: pineapple pulp (PP) and agar hydrolyzate (AH), on micropropagation and Pb bioaccumulation and tolerance in a woody shrub Daphne jasminea cultured in vitro. The amendments were analyzed for their content of carbohydrates, phenolic acids, and phytohormones and added at a dose of 10 mL L(-1) to the medium containing 1.0 mM lead nitrate. Micropropagation coefficient increased by 10.2-16.6 % in PP and AH variants, respectively. Growth tolerance index increased by 22...
November 5, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27810375/meta-tyrosine-induces-modification-of-reactive-nitrogen-species-level-protein-nitration-and-nitrosoglutathione-reductase-in-tomato-roots
#11
Urszula Krasuska, Olga Andrzejczak, Paweł Staszek, Wojciech Borucki, Agnieszka Gniazdowska
A non-protein amino acid (NPAA) - meta-Tyrosine (m-Tyr), is a harmful compound produced by fescue roots. Young (3-4 days old) tomato (Solanum lycopersicum L.) seedlings were supplemented for 24-72 h with m-Tyr (50 or 250 μM) inhibiting root growth by 50 or 100%, without lethal effect. Fluorescence of DAF-FM and APF derivatives was determined to show reactive nitrogen species (RNS) localization and level in roots of tomato plants. m-Tyr-induced restriction of root elongation growth was related to formation of nitrated proteins described as content of 3-nitro tyrosine...
October 31, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27794435/dietary-nitrate-markedly-improves-voluntary-running-in-mice
#12
Niklas Ivarsson, Tomas A Schiffer, Andrés Hernández, Johanna T Lanner, Eddie Weitzberg, Jon O Lundberg, Håkan Westerblad
Nitrate supplementation is shown to increase submaximal force in human and mouse skeletal muscles. In this study, we test the hypothesis that the increased submaximal force induced by nitrate supplementation reduces the effort of submaximal voluntary running, resulting in increased running speed and distance. C57Bl/6N male mice were fed nitrate in the drinking water and housed with or without access to an in-cage running wheel. Nitrate supplementation in sedentary mice had no effect on endurance in a treadmill test, nor did it enhance mitochondrial function...
January 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27789891/highly-efficient-long-term-storage-of-carrier-bound-anammox-biomass
#13
Steffen Engelbrecht, Mbengamina Terence Fondengcap, Kristina Rathsack, Marion Martienssen
The anammox process is a potential alternative to the conventional nitrogen removal from wastewater. However, due to large generation times of anammox bacteria, the start-up of treatment reactors may be impeded. An efficient storage technique can handle this drawback and may be also suitable for seasonally operated treatment plants like in touristic areas. In the current study, several storage techniques were investigated with respect to its suitability for the preservation of the specific anammox activity after long-term storage...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27787703/greenhouse-wastewater-treatment-by-baffled-subsurface-flow-constructed-wetlands-supplemented-with-flower-straws-as-carbon-source-in-different-modes
#14
Junjun Chang, Luyao Ma, Jinquan Chen, Yifeng Lu, Xiaoyun Wang
Four laboratory-scale baffled subsurface-flow constructed wetlands (BSCWs) were established for the treatment of greenhouse wastewater containing high levels of nitrate and sulfate in the present study. Each BSCW microcosm involved a treatment zone and another post-treatment zone with a surface area ratio of 2:1. Evenly mixed straws of carnation and rose (w/w: 1/1), two common ornamental flowers, were supplemented as an organic carbon source into the treatment zone through a hydrolysis zone (CW 1), decentralized vertically installed perforated pipes (CW 2), and centralized pipes (CW 3 in the figures), except the blank system...
October 27, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27784687/dietary-nitrate-supplementation-and-exercise-tolerance-in-patients-with-heart-failure-with-reduced-ejection-fraction
#15
Daniel M Hirai, Joel T Zelt, Joshua H Jones, Luiza G Castanhas, Robert F Bentley, Wendy Earle, Patti Staples, Michael E Tschakovsky, John McCans, Denis E O'Donnell, J Alberto Neder
Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity in patients with heart failure with reduced ejection fraction (HFrEF). Oral inorganic nitrate supplementation provides an exogenous source of NO that may enhance locomotor muscle function and oxygenation with consequent improvement in exercise tolerance in HFrEF. Thirteen patients (left ventricular ejection fraction ≤40%) were enrolled in a double-blind, randomized crossover study to receive concentrated nitrate-rich (nitrate) or nitrate-depleted (placebo) beetroot juice for 9 days...
October 26, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27777094/dietary-nitrate-supplementation-improves-sprint-and-high-intensity-intermittent-running-performance
#16
Christopher Thompson, Anni Vanhatalo, Harry Jell, Jonathan Fulford, James Carter, Lara Nyman, Stephen J Bailey, Andrew M Jones
: The influence of dietary nitrate (NO3(-)) supplementation on indices of maximal sprint and intermittent exercise performance is unclear. PURPOSE: To investigate the effects of NO3(-) supplementation on sprint running performance, and cognitive function and exercise performance during the sport-specific Yo-Yo Intermittent Recovery level 1 test (IR1). METHODS: In a double-blind, randomised, crossover study, 36 male team-sport players received NO3(-)-rich (BR; 70 mL·day(-1); 6...
October 21, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27768510/habitual-dietary-nitrate-intake-in-highly-trained-athletes
#17
Kristin L Jonvik, Jean Nyakayiru, Jan-Willem Van Dijk, Floris C Wardenaar, Luc J C Van Loon, Lex B Verdijk
Although beetroot juice, as a nitrate carrier, is a popular ergogenic supplement amongst athletes, nitrate is consumed through the regular diet as well. We aimed to assess the habitual dietary nitrate intake and identify the main contributing food sources in a large group of highly trained athletes. Dutch highly trained athletes (226 women and 327 men) completed 2-4 web-based 24-h dietary recalls and questionnaires within a 2-4 week period. The nitrate content of food products and food groups was determined systematically based on values found in regulatory reports and scientific literature...
October 21, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27744162/application-of-fe-no3-3-based-as-nitrogen-source-and-coagulant-for-cultivation-and-harvesting-of-chlorella-sorokiniana
#18
Jung Ah Choi, Dong-Yeon Kim, Yeong Hwan Seo, Jong-In Han
In this study, Chlorella sorokiniana was successfully cultivated in the recycled medium whose nitrogen was supplied directly from the coagulant, Fe(NO3)3. With a dosage of 0.80g/L, harvesting efficiency of 95% could be achieved. What is more, this amount of nitrate in the coagulant was enough to fully support the growth of C. sorokiniana during the 8day cultivation period, almost as much as the initial nitrogen content in the BG11 culture medium. Other nutrients had to be supplemented, however, with at least 50% amount as in the BG11 recipe...
September 30, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27744007/improvement-in-blood-pressure-after-short-term-inorganic-nitrate-supplementation-is-attenuated-in-cigarette-smokers-compared-to-non-smoking-controls
#19
Stephen J Bailey, Jamie R Blackwell, Lee J Wylie, Terezia Holland, Paul G Winyard, Andrew M Jones
Dietary supplementation with inorganic nitrate (NO3(-)) has been reported to improve cardiovascular health indices in healthy adults. Cigarette smoking increases circulating thiocyanate (SCN(-)), which has been suggested to competitively inhibit salivary nitrate (NO3(-)) uptake, a rate-limiting step in dietary NO3(-) metabolism. Therefore, this study tested the hypothesis that dietary NO3(-) supplementation would be less effective at increasing the circulating plasma nitrite concentration ([NO2(-)]) and lowering blood pressure in smokers (S) compared to non-smokers (NS)...
October 12, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27743687/l-arginine-affects-the-ivm-of-cattle-cumulus-oocyte-complexes
#20
D F Dubeibe, M C Caldas-Bussiere, V L Maciel, W V Sampaio, C R Quirino, P B D Gonçalves, M P De Cesaro, M R Faes, C S Paes de Carvalho
Nitric oxide (NO) is identified as a signaling molecule involved in many cellular or physiological functions, including meiotic maturation of cattle oocytes. This study aimed to evaluate the effect of supplementation of culture medium with the L-arginine (L-arg, NO synthesis precursor) in nuclear maturation of oocytes, concentrations of nitrate/nitrite, progesterone (P4), and 17β-estradiol (E2) in the culture medium; and the cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) intracellular concentrations in the cumulus-oocyte complexes (COCs) during the first hours of maturation in the presence of hemisections (HSs) of the follicular wall (control -ve)...
January 15, 2017: Theriogenology
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