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Nitrate supplementation

Colin R Carriker, Paige Rombach, Brooke M Stevens, Roger A Vaughan, Ann L Gibson
PURPOSE: To investigate changes in oxidative stress, arterial oxygen saturation (SaO2), blood pressure (BP), and heart rate (HR) while exercising in hypobaric hypoxia following acute dietary nitrate supplementation. METHODS: Nine well-trained (60.8±7.8 ml/kg/min) males (29±7 years) visited the lab on 3 occasions, each separated by 1 week. Visit 1 included a maximal aerobic cycling test (VO2max) and 5 five-minute increasing intensity exercise bouts in a normobaric environment (1600m)...
May 18, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit, Veerachat Muangsombut, Varintip Srinon, Usa Boonyuen, Parameth Thiennimitr, Paiboon Vattanaviboon, Felipe Cia, Sam Willcocks, Gregory J Bancroft, Brendan W Wren, Sunee Korbsrisate
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial cell membranes. At present, their significance in B. pseudomallei pathogenesis is poorly understood. We report here characterization of the BPSL1039-1040 ABC transporter. B. pseudomallei cultured in M9 medium supplemented with nitrate, demonstrated that BPSL1039-1040 is involved in nitrate transport for B...
2018: PloS One
Tatsuro Amano, Dai Okushima, Brynmor C Breese, Stephen J Bailey, Shunsaku Koga, Narihiko Kondo
PURPOSE: We investigated the influence of inorganic nitrate ([Formula: see text]) supplementation on local sweating and cutaneous vascular responses during exercise in hot conditions. METHOD: Eight healthy, young subjects were assigned in a randomized, double-blind, crossover design to receive [Formula: see text]-rich beetroot (BR) juice (140 mL/day, containing ~ 8 mmol of [Formula: see text]) and [Formula: see text]-depleted placebo (PL) juice (140 mL/day, containing ~ 0...
May 15, 2018: European Journal of Applied Physiology
Catchia Hermes-Uliana, Flávia Cristina Vieira Frez, Camila Caviquioli Sehaber, Francielle Veiga Ramalho, Fernando Pinheiro de Souza Neto, Rubens Cecchini, Flávia Alessandra Guarnier, Jacqueline Nelisis Zanoni
Diabetes mellitus is a syndrome with multiple etiologies, characterized by chronic hyperglycemia that increases the production of reactive oxygen species and decreases antioxidant defenses. The present study evaluated oxidative stress parameters and protein nitration in myenteric neurons in the jejunum in diabetic rats supplemented with l-glutathione. Rats (90 days of age) were distributed into four groups (n = 6/group): normoglycemic (N), normoglycemic supplemented with l-glutathione (NGT), diabetic (D), and diabetic supplemented with l-glutathione (DGT)...
May 11, 2018: Experimental and Molecular Pathology
Philippe Richard, Lymperis P Koziris, Mathieu Charbonneau, Catherine Naulleau, Jonathan Tremblay, François Billaut
PURPOSE: Nitrate supplementation can increase tolerance to high-intensity work rates, however limited data exist on the recovery of performance. We tested whether 5 days of nitrate supplementation could improve repeated time-trial performance in speed skating. METHODS: Using a double-blind, placebo-controlled, crossover design, 9 international-level short-track speed skaters ingested one high (juice blend, ~6.5mmol nitrate; HI) or low dose (juice blend, ~1mmol nitrate; LO) per day on days 1-4...
May 10, 2018: International Journal of Sports Physiology and Performance
Mario Siervo, Filippo Scialò, Oliver M Shannon, Blossom C M Stephan, Ammar W Ashor
CVD are characterised by a multi-factorial pathogenesis. Key pathogenetic steps in the development of CVD are the occurrence of endothelial dysfunction and formation of atherosclerotic lesions. Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade. NO is a free radical with multiple physiological functions including the regulation of vascular resistance, coagulation, immunity and oxidative metabolism. The synthesis of NO proceeds via two distinct pathways identified as enzymatic and non-enzymatic...
May 2018: Proceedings of the Nutrition Society
Peter Sandner, Eva-Maria Becker-Pelster, Johannes Peter Stasch
The NO/sGC/cGMP signaling cascade plays a pivotal role in regulation of cardiovascular, cardiopulmonary and cardiorenal diseases and impairment of this cascade results in severe pathologies. Therefore, pharmacological interventions, targeting this pathway are promising strategies for treating a variety of diseases. Nitrates, supplementing NO and, PDE5 inhibitors preventing cGMP degradation, are used for angina pectoris treatment and the treatment of pulmonary arterial hypertension (PAH), respectively. More recently, a new class of drugs which directly stimulate the sGC enzyme and trigger NO-independent cGMP production was introduced and termed sGC stimulators...
May 5, 2018: Nitric Oxide: Biology and Chemistry
Xiuchuan Li, Juanni Hou, Jin Du, Jian Feng, Yi Yang, Yang Shen, Sha Chen, Juan Feng, Dachun Yang, De Li, Haifeng Pei, Yongjian Yang
Cardiac microvascular injury often occurs in patients with type 2 diabetes mellitus (T2DM) who develop hyperglycemia and hyperlipidemia. However, besides reported contradictory roles in cardiac diseases, the function of TRPV1 (transient receptor potential vanilloid 1) in cardiac microvessels is not well defined. This study was performed to determine the detailed role of TRPV1 in cardiac microvascular endothelial cells (CMECs) in T2DM. T2DM mice were established by multiple injections of low-dose streptozotocin and high-fat feeding...
May 7, 2018: Hypertension
Awoke Guadie, Amare Gessesse, Siqing Xia
Considering the saline-alkaline nature of textile wastewater and treatment requirements, microbial samples were collected from Ethiopian Rift Valley Soda Lakes. A large number of bacteria (121) were isolated from dye-uncontaminated Lakes Chitu (81.0%), Abijata (15.7%) and Arenguadie (3.3%), of which 95 isolates (78.5%) were found dye decolorizer. Many dye decolorizer from Lake Chitu positively correlated with higher pH (10.3 ± 0.1), salinity (64.6 ± 2.0%), conductivity (6.1 ± 0.3 mS cm-1 ) and Na+ (18...
April 23, 2018: Chemosphere
Neale A Tillin, Sarah Moudy, Kirsty M Nourse, Christopher J Tyler
PURPOSE: Evidence suggests dietary nitrate supplementation enhances low-frequency (≤20 Hz) involuntary, but not voluntary, forces in unfatigued human muscle. We investigated the hypotheses that nitrate supplementation would also attenuate low-frequency fatigue and the loss of explosive-voluntary forces in fatigued conditions. METHODS: In a counterbalanced double-blinded order, 17 male participants completed two experimental trials following 7 days of dietary supplementation with either nitrate-rich (NIT) or nitrate-depleted (PLA) beetroot juice...
April 27, 2018: Medicine and Science in Sports and Exercise
Ramachandran Srinivasan, Anbazhagan Mageswari, Parthiban Subramanian, Chandrasekaran Suganthi, Amballa Chaitanyakumar, Velmurugan Aswini, Kodiveri Muthukalianan Gothandam
The unicellular marine alga Dunaliella salina is a most interesting green cell factory for the production of carotenes and lipids under extreme environment conditions. However, the culture conditions and their productivity are the major challenges faced by researchers which still need to be addressed. In this study, we investigated the effect of bicarbonate amendment on biomass, photosynthetic activity, biochemical constituents, nutrient uptake and antioxidant response of D. salina during macronutrient deficit conditions (N- , P- and S- )...
May 3, 2018: Scientific Reports
Jesse C Craig, Ryan M Broxterman, Joshua R Smith, Jason David Allen, Thomas J Barstow
Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile efficiency during large muscle mass exercise in humans, and on skeletal muscle blood flow (Q̇) in rats. However, concurrent measurement of these effects has not been performed in humans. Therefore, we assessed the influence of nitrate supplementation on Q̇ and muscle oxygenation characteristics during moderate (40%peak) and severe (85%peak) intensity handgrip exercise in a randomized, double-blind, crossover-design...
May 3, 2018: Journal of Applied Physiology
Faheem Afzal Shah, Jun Ni, Jing Chen, Qiaojian Wang, Wenbo Liu, Xue Chen, Caiguo Tang, Songling Fu, Lifang Wu
Sapium sebiferum , an ornamental and bio-energetic plant, is propagated by seed. Its seed coat contains germination inhibitors and takes a long time to stratify for germination. In this study, we discovered that the S. sebiferum seed coat (especially the tegmen) and endospermic cap (ESC) contained high levels of proanthocyanidins (PAs). Seed coat and ESC removal induced seed germination, whereas exogenous application with seed coat extract (SCE) or PAs significantly inhibited this process, suggesting that PAs in the seed coat played a major role in regulating seed germination in S...
2018: PeerJ
Masashi Tawa, Takahide Furukawa, Hiroko Tongu, Mai Sugihara, Satoko Taguwa, Misaki Yamanaka, Yoko Yano, Hiroaki Matsumori, Rie Kitada, Tatsuya Sawano, Ryosuke Tanaka, Mamoru Ohkita, Yasuo Matsumura
AIMS: In this study, we examined whether a disruption in the balance between nitric oxide (NO)-sensitive and -insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO-enhancing drugs can halt disease progression. MAIN METHODS: Rats were injected subcutaneously with saline or 60 mg/kg monocrotaline (MCT). At 14 days after injection, the vascular reactivity of isolated extralobar pulmonary arteries was assessed by organ chamber technique...
April 26, 2018: Life Sciences
Julia A Maresca, Kelsey J Miller, Jessica L Keffer, Chandran R Sabanayagam, Barbara J Campbell
Although sunlight is an abundant source of energy in surface environments, less than 0.5% of the available photons are captured by (bacterio)chlorophyll dependent photosynthesis in plants and bacteria. Metagenomic data indicate that 30-60% of the bacterial genomes in some environments encode rhodopsins, retinal-based photosystems found in heterotrophs, suggesting that sunlight may provide energy for more life than previously suspected. However, quantitative data on the number of cells that produce rhodopsins in environmental systems is limited...
April 27, 2018: Applied and Environmental Microbiology
Peter J Joris, Ronald P Mensink, Tanja C Adam, Thomas T Liu
Improving cerebrovascular function may be a key mechanism whereby a healthy lifestyle, of which a healthy diet combined with increased physical activity levels is a cornerstone, protects against cognitive impairments. In this respect, effects on cerebral blood flow (CBF)—a sensitive physiological marker of cerebrovascular function—are of major interest. This review summarizes the impact of specific dietary determinants and physical exercise on CBF in adults and discusses the relation between these effects with potential changes in cognitive function...
April 25, 2018: Nutrients
Letizia Rasica, Simone Porcelli, Mauro Marzorati, Desy Salvadego, Alessandra Vezzoli, Fiorenza Agosti, Alessandra De Col, Gabriella Tringali, Andrew M Jones, Alessandro Sartorio, Bruno Grassi
Previous studies showed a higher O2 cost of exercise, and therefore a reduced exercise tolerance, in obese patients during constant work rate (CWR) exercise compared to healthy subjects. Among the ergogenic effects of dietary nitrate (NO3 -) supplementation in sedentary healthy subjects, a reduced O2 cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice supplementation, rich in NO3 -, on physiological variables associated with exercise tolerance in obese adolescents...
April 25, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Kyriaki Kiskira, Stefano Papirio, Chloé Fourdrin, Eric D van Hullebusch, Giovanni Esposito
Fe(II)-mediated autotrophic denitrification in the presence of copper (Cu), nickel (Ni) and zinc (Zn) with four different microbial cultures was investigated in batch bioassays. In the absence of metals, complete nitrate removal and Fe(II) oxidation were achieved with a Thiobacillus-dominated mixed culture and Pseudogulbenkiania sp. 2002 after 7 d. A nitrate removal of 96 and 91% was observed with a pure culture of T. denitrificans and an activated sludge enrichment, respectively, after 10 d of incubation...
April 19, 2018: Journal of Environmental Management
Hajar Naseri, Asghar Sharifi, Mehrorang Ghaedi, Kheibar Dashtian, Seyed Sajad Khoramrooz, Leila Manzouri, Seyed Abdolmajid Khosravani, Vahid Pezeshkpour, Farzad Sadri, Marzieh Askarinia
The cytosine embedded copper based metal-organic framework (Bio-MOF) was synthesized by facile one-step sonochemical method by simply mixing of 4-4, biphenyldicarboxylic, cytosine and copper nitrate (Bio-Cu-H2 bpdc-Cy). The prepared bio-MOF was characterized by XRD, FTIR and FE-SEM techniques. The effect of Cu-H2 bpdc-Cy on the expression of the rsbA gene was evaluated in the clinical and standard Proteus mirabilis and study of MIC of Cu-H2 bpdc-Cy by microdilution against them that have the rsbA gene. According to different concentrations of MIC, MBC concentrations was cultured on blood agar culture medium...
June 2018: Ultrasonics Sonochemistry
Sheng-Nan Zhou, Jun-Xiu Lu, Xue-Qing Wang, Mei-Rong Shan, Zhang Miao, Guo-Pin Pan, Xu Jian, Peng Li, Song Ping, Xin-Yan Pang, Yong-Ping Bai, Chao Liu, Shuang-Xi Wang
Development of nitrate tolerance is a major drawback to nitrate therapy. Prostacyclin (PGI2) is a powerful vasodilator produced from prostaglandin (PGH2) by prostacyclin synthase (PGIS) in endothelial cells. This study was to determine the role of PGIS S-nitrosylation in nitrate tolerance induced by nitroglycerin (GTN). In endothelial cells, GTN increased PGIS S-nitrosylation and disturbed PGH2 metabolism, which were normalized by mutants of PGIS cysteine 231/441 to alanine (C231/441A). Clearance of NO by carboxy-PTIO or inhibition of S-nitrosylation by N-acetyl-cysteine decreased GTN-induced PGIS S-nitrosylation...
April 19, 2018: Clinical Pharmacology and Therapeutics
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