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Nitrate supplementation

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https://www.readbyqxmd.com/read/28641022/a-randomized-single-dose-parallel-study-on-enhancement-of-nitric-oxide-in-serum-and-saliva-with-the-use-of-natural-sports-supplement-in-healthy-adults
#1
Joby Jacob, Sreeraj Gopi, Chandradhara Divya
Sports supplements that stimulate the production of nitric oxide (NO) are widely promoted agents in the sports nutrition domain, and nitric oxide plays an important role to enhance the cardiovascular and physical fitness of the sports participants. The purpose of the study is to investigate whether oral intake of a sports nutritional supplement (Fitnox) is able to increase nitrate (NO3(-)) and nitrite (NO2(-)) levels in blood serum and saliva of healthy adults. Fitnox is a unique blend of Kaempferia parviflora methoxy flavones, pomegranate peel polyphenols, and Moringa oleifera leaf saponins...
June 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28623824/dietary-nitrate-attenuates-renal-ischemia-reperfusion-injuries-by-modulation-of-immune-responses-and-reduction-of-oxidative-stress
#2
Ting Yang, Xing-Mei Zhang, Laura Tarnawski, Maria Peleli, Zhengbing Zhuge, Niccolo Terrando, Robert A Harris, Peder S Olofsson, Erik Larsson, A Erik G Persson, Jon O Lundberg, Eddie Weitzberg, Mattias Carlstrom
Ischemia-reperfusion (IR) injury involves complex pathological processes in which reduction of nitric oxide (NO) bioavailability is suggested as a key factor. Inorganic nitrate can form NO in vivo via NO synthase-independent pathways and may thus provide beneficial effects during IR. Herein we evaluated the effects of dietary nitrate supplementation in a renal IR model. Male mice (C57BL/6J) were fed nitrate-supplemented chow (1.0mmol/kg/day) or standard chow for two weeks prior to 30min ischemia and during the reperfusion period...
June 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28623490/enzymatic-saccharification-of-pretreated-rice-straw-by-cellulases-from-aspergillus-niger-bk01
#3
Neeraj Kumar Aggarwal, Varsha Goyal, Anita Saini, Anita Yadav, Ranjan Gupta
Alkali-assisted acid pretreated rice straw was saccharified using cellulase from Aspergillus niger BK01. The cellulase production by the fungus was enhanced by parametric optimization using solid-state fermentation conditions. Maximum cellulase production (12.0 U/gds of carboxymethyl cellulase, CMCase) was achieved in 96 h, using 6.0% substrate concentration, 7.5% inoculum concentration, 1:2 solid to liquid ratio, at pH 5.5, and temperature 28 °C, by supplementation of the fermentation medium with 0.1% carboxymethylcellulose and 0...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28603910/production-of-n2-and-n2-o-from-nitrate-ingested-by-sheep
#4
V de Raphélis-Soissan, J V Nolan, I R Godwin, J R Newbold, B D Eyre, D V Erler, R S Hegarty
Supplementing ruminants with nitrate (NO3-) reduces their enteric methane (CH4 ) emissions; however, the greenhouse gas (GHG) mitigation achieved can be partially offset by small emissions of nitrous oxide (N2 O), a more potent GHG. Sheep were dosed intraruminally with (15) NO3- to investigate whether dietary NO3- is a precursor of N2 O and/or di-nitrogen gas (N2 ), and to quantify the amounts of NO3- recovered as N2 O and N2 in gas emissions from sheep adapted or not adapted to dietary NO3-. Ruminally cannulated sheep were adapted to a hay diet supplemented with NO3- (n = 3; 10 g NO3-/kg DM) or urea (n = 3; 5...
June 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28596764/the-structural-and-functional-capacity-of-ruminal-and-cecal-microbiota-in-growing-cattle-was-unaffected-by-dietary-supplementation-of-linseed-oil-and-nitrate
#5
Milka Popova, Emily McGovern, Matthew S McCabe, Cécile Martin, Michel Doreau, Marie Arbre, Sarah J Meale, Diego P Morgavi, Sinéad M Waters
Microorganisms in the digestive tract of ruminants differ in their functionality and ability to use feed constituents. While cecal microbiota play an important role in post-rumen fermentation of residual substrates undigested in the rumen, limited knowledge exists regarding its structure and function. In this trial we investigated the effect of dietary supplementation with linseed oil and nitrate on methane emissions and on the structure of ruminal and cecal microbiota of growing bulls. Animals were allocated to either a CTL (control) or LINNIT (CTL supplemented with 1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28596274/dietary-nitrate-restores-compensatory-vasodilation-and-exercise-capacity-in-response-to-a-compromise-in-oxygen-delivery-in-the-non-compensator-phenotype
#6
Robert F Bentley, Jeremy J Walsh, Patrick J Drouin, Aleksandra Velickovic, Sarah J Kitner, Alyssa M Fenuta, Michael E Tschakovsky
Recently dietary nitrate supplementation has been shown to improve exercise capacity in healthy individuals through a potential nitrate-nitrite-nitric oxide pathway. Nitric oxide has been shown to play an important role in compensatory vasodilation during exercise under hypoperfusion. Previously we established that certain individuals lack a vasodilation response when perfusion pressure reductions compromise exercising muscle blood flow. Whether this lack of compensatory vasodilation in healthy young individuals can be restored with dietary nitrate supplementation is unknown...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28577258/-beet-ing-the-mountain-a-review-of-the-physiological-and-performance-effects-of-dietary-nitrate-supplementation-at-simulated-and-terrestrial-altitude
#7
Oliver Michael Shannon, Kerry McGawley, Linn Nybäck, Lauren Duckworth, Matthew John Barlow, David Woods, Mario Siervo, John Paul O'Hara
Exposure to altitude results in multiple physiological consequences. These include, but are not limited to, a reduced maximal oxygen consumption, drop in arterial oxygen saturation, and increase in muscle metabolic perturbations at a fixed sub-maximal work rate. Exercise capacity during fixed work rate or incremental exercise and time-trial performance are also impaired at altitude relative to sea level. Recently, dietary nitrate (NO3(-)) supplementation has attracted considerable interest as a nutritional aid during altitude exposure...
June 2, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28572749/the-effect-of-acute-pomegranate-extract-supplementation-on-oxygen-uptake-in-highly-trained-cyclists-during-high-intensity-exercise-in-a-high-altitude-environment
#8
Emma May Crum, Ahmad Munir Che Muhamed, Matthew Barnes, Stephen Robert Stannard
BACKGROUND: Recent research has indicated that pomegranate extract (POMx) may improve performance during aerobic exercise by enhancing the matching of vascular oxygen (O2) provision to muscular requirements. POMx is rich in ellagitannin polyphenols and nitrates (NO3(-)), which are both associated with improvements in blood flow and O2 delivery. Primarily, this study aimed to determine whether POMx improves performance in a cycling time trial to exhaustion at 100%VO2max (TTE100%) in highly-trained cyclists...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28562133/dietary-nitrate-does-not-modify-blood-pressure-and-cardiac-output-at-rest-and-during-exercise-in-older-adults-a-randomised-cross-over-study
#9
C Oggioni, D G Jakovljevic, M Klonizakis, A W Ashor, A Ruddock, M Ranchordas, E Williams, M Siervo
Dietary nitrate (NO3(-)) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20...
May 31, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28551796/nitrite-nitric-oxide-signaling-and-cardioprotection
#10
Matthias Totzeck, Ulrike B Hendgen-Cotta, Tienush Rassaf
Cardioprotective strategies to prevent damage to mitochondria in acute myocardial infarction are warranted to reduce lethal myocardial ischemia/reperfusion (I/R) injury. Mitochondrial antagonists in I/R are reactive oxygen species (ROS), deteriorated calcium signaling, permeabilization of the mitochondrial outer membrane (MOM) and deranged mitochondrial structural dynamism (fusion and fission). Nitric oxide (NO) related signaling can protect hearts from I/R. Albeit the underlying signaling is incompletely resolved, recent data point to a particular involvement of protective posttranslational modification of mitochondrial elements...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28547180/role-of-antioxidant-treatment-on-dna-and-lipid-damage-in-the-brain-of-rats-subjected-to-a-chemically-induced-chronic-model-of-tyrosinemia-type-ii
#11
Emilio L Streck, Samira D T De Prá, Paula Ronsani Ferro, Milena Carvalho-Silva, Lara M Gomes, Jotele F Agostini, Adriani Damiani, Vanessa M Andrade, Patrícia F Schuck, Gustavo C Ferreira, Giselli Scaini
Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain damage are still poorly known. Considering that studies have demonstrated that oxidative stress may contribute, along with other mechanisms, to the neurological dysfunction characteristic of hypertyrosinemia, in the present study we investigated the effects of antioxidant treatment (NAC and DFX) on DNA damage and oxidative stress markers induced by chronic administration of L-tyrosine in cerebral cortex, hippocampus, and striatum of rats...
May 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28536531/caffeine-and-bicarbonate-for-speed-a-meta-analysis-of-legal-supplements-potential-for-improving-intense-endurance-exercise-performance
#12
REVIEW
Peter M Christensen, Yusuke Shirai, Christian Ritz, Nikolai B Nordsborg
A 1% change in average speed is enough to affect medal rankings in intense Olympic endurance events lasting ~45 s to 8 min which for example includes 100 m swimming and 400 m running (~1 min), 1,500 m running and 4000 m track cycling (~4 min) and 2,000 m rowing (~6-8 min). To maximize the likelihood of winning, athletes utilizes legal supplements with or without scientifically documented beneficial effects on performance. Therefore, a continued systematic evidence based evaluation of the possible ergogenic effects is of high importance...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28527336/title-potassium-application-regulates-nitrogen-metabolism-and-osmotic-adjustment-in-cotton-gossypium-hirsutum-l-functional-leaf-under-drought-stress
#13
Rizwan Zahoor, Wenqing Zhao, Muhammad Abid, Haoran Dong, Zhiguo Zhou
To evaluate the role of potassium (K) in maintaining nitrogen metabolism and osmotic adjustment development of cotton functional leaves to sustain growth under soil drought and rewatering conditions, the plants of two cotton cultivars Siza 3 (low-K sensitive) and Simian 3 (low-K tolerant), were grown under three different K rates (K0, K1, and K2; 0, 150, and 300kgK2Oha(-1), respectively) and exposed to drought stress with 40±5% soil relative water content (SRWC). The drought stress was applied at flowering stage by withholding water for eight days followed by rewatering to a well-watered level (75±5% SRWC)...
May 4, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28523645/enhancement-of-total-lipid-yield-by-nitrogen-carbon-and-iron-supplementation-in-isolated-microalgae
#14
Ramachandran Sivaramakrishnan, Aran Incharoensakdi
The biochemical contents and biodiesel production ability of three microalgal strains grown under different sodium nitrate, sodium carbonate, and ferric ammonium citrate (iron) levels were investigated. The highest biomass and lipid contents were found in Scenedesmus sp., Chlorella sp., and Chlamydomonas sp. when grown in normal BG-11 containing sodium carbonate concentration at 0.03 g · L(-1) , and in normal BG-11 containing iron concentration at 0.009 or 0.012 g · L(-1) . Increasing the sodium nitrate level increased the biomass content, but decreased the lipid content in all three microalgae...
May 18, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28511731/dietary-nitrate-and-blood-pressure-evolution-of-a-new-nutrient
#15
Ann Ashworth, Raul Bescos
Dietary nitrate is mainly obtained from vegetables, especially green leafy vegetables and beetroot. As a result of early research, dietary nitrate is currently viewed as a contaminant linked to increased risks of stomach cancer and methaemoglobinaemia. Consequently, nitrate levels are restricted in certain vegetables and in water supplies to ensure exposure levels remain below an acceptable daily intake of 3·7 mg/kg per d. The average nitrate intake in the UK is approximately 70 mg/d, although some population groups, such as vegetarians, may consume three times that amount...
May 17, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28509762/beetroot-juice-increases-human-muscle-force-without-changing-ca2-handling-proteins
#16
Jamie Whitfield, Daniel Gamu, George J F Heigenhauser, Luc J C van Loon, Lawrence L Spriet, A Russell Tupling, Graham P Holloway
Dietary inorganic nitrate (NO3) supplementation improves skeletal muscle (SkM) contractile efficiency, and while rodent literature has suggested improvements in calcium handling or redox modifications as likely explanations, the direct mechanism-of-action in humans remains unknown. PURPOSE: To examine the effects of 7-d of beetroot juice (BRJ) supplementation on SkM contractile characteristics and function. METHODS: Recreationally active males (n=8) underwent transcutaneous electrical muscle stimulation of the vastus lateralis for evaluation of contractile characteristics before (pre) and after (post) 7-d of BRJ supplementation (280 mL/day, ~26 mmol NO3)...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28476923/acute-beetroot-juice-supplementation-on-sympathetic-nerve-activity-a-randomized-double-blind-placebo-controlled-proof-of-concept-study
#17
Karambir Notay, Anthony V Incognito, Philip J Millar
Acute dietary nitrate supplementation reduces resting blood pressure in healthy normotensives. This response is attributed to increased nitric oxide bioavailability and peripheral vasodilation, though nitric oxide also tonically inhibits central sympathetic outflow. We hypothesized that acute dietary nitrate (NO3(-)) supplementation using beetroot (BR) juice would reduce blood pressure and muscle sympathetic nerve activity (MSNA) at rest and during exercise. Fourteen participants (7 men, 25±10 years) underwent blood pressure and MSNA measurements before and after (165-180 minutes) ingestion of 70ml high-nitrate (~6...
May 5, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28475992/enhanced-biodiesel-production-through-phyco-myco-co-cultivation-of-chlorella-minutissima-and-aspergillus-awamori-an-integrated-approach
#18
Archana Dash, Rintu Banerjee
Algae-fungus co-culture was investigated as an alternative biodiesel feedstock. An oleaginous filamentous fungus Aspergillus awamori was co-cultured with Chlorella minutissima MCC 27 and Chlorella minutissima UTEX 2219, respectively in N11 medium furnished with different carbon and nitrogen sources. The biomass and lipid production potential of the two C. minutissima-A. awamori co-cultures was compared against the monocultures. A substantial enhancement in biomass and lipid accumulation was observed in both the co-cultures...
August 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28473807/fnrl-and-three-dnr-regulators-are-used-for-the-metabolic-adaptation-to-low-oxygen-tension-in-dinoroseobacter-shibae
#19
Matthias Ebert, Sebastian Laaß, Andrea Thürmer, Louisa Roselius, Denitsa Eckweiler, Rolf Daniel, Elisabeth Härtig, Dieter Jahn
The heterotrophic marine bacterium Dinoroseobacter shibae utilizes aerobic respiration and anaerobic denitrification supplemented with aerobic anoxygenic photosynthesis for energy generation. The aerobic to anaerobic transition is controlled by four Fnr/Crp family regulators in a unique cascade-type regulatory network. FnrL is utilizing an oxygen-sensitive Fe-S cluster for oxygen sensing. Active FnrL is inducing most operons encoding the denitrification machinery and the corresponding heme biosynthesis. Activation of gene expression of the high oxygen affinity cbb3-type and repression of the low affinity aa3-type cytochrome c oxidase is mediated by FnrL...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28469601/comparative-genomics-and-transcriptional-analysis-of-flavobacterium-columnare-strain-atcc-49512
#20
Hasan C Tekedar, Attila Karsi, Joseph S Reddy, Seong W Nho, Safak Kalindamar, Mark L Lawrence
Flavobacterium columnare is a Gram-negative fish pathogen causing columnaris disease in wild and cultured fish species. Although the pathogen is widespread in aquatic environments and fish worldwide, little is known about biology of F. columnare and mechanisms of columnaris disease pathogenesis. Previously we presented the complete genome sequence of F. columnare strain ATCC 49512. Here we present a comparison of the strain ATCC 49512 genome to four other Flavobacterium genomes. In this analysis, we identified predicted proteins whose functions indicate F...
2017: Frontiers in Microbiology
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