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https://www.readbyqxmd.com/read/28229536/the-physical-properties-of-generic-latanoprost-ophthalmic-solutions-are-not-identical
#1
Miriam Kolko, Peter Koch Jensen
PURPOSE: To compare various characteristics of Xalatan(®) and five generic latanoprost ophthalmic solutions. METHODS: Drop size, volume, pH values, buffer capacity, viscosity, hardness of bottles and costs were determined. Drop sizes were measured in triplicates by micropipettes, and the number of drops counted in three separate bottles of each generic product was determined. pH values were measured in triplicates by a calibrated pH meter. Buffer capacity was exploited by titrating known quantities of strong base into 2...
February 22, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28227920/in-vitro-evaluation-of-the-long-term-stability-of-pedot-pss-coated-microelectrodes-for-chronic-recording-and-electrical-stimulation-of-neurons
#2
A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang, A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang, A K Kreiter, W Lang, A Schander, H Stemmann, S Strokov
For the chronic application of neural prostheses long-term stable microelectrodes for electrical stimulation are essential. In recent years many developments were done to investigate different appropriate materials for these electrodes. One of these materials is the electrical conductive polymer PEDOT, which has low impedance and high charge injection capacity. However, the long-term stability of this polymer is still unclear. Thus this paper reports on the in-vitro evaluation of the long-term stability of PEDOT coated gold microelectrodes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224683/confined-amorphous-red-phosphorus-in-mof-derived-n-doped-microporous-carbon-as-a-superior-anode-for-sodium-ion-battery
#3
Weihan Li, Shuhe Hu, Xiangyu Luo, Zhongling Li, Xizhen Sun, Minsi Li, Fanfan Liu, Yan Yu
Red phosphorus (P) has attracted intense attention as promising anode material for high-energy density sodium-ion batteries (NIBs), owing to its high sodium storage theoretical capacity (2595 mAh g(-1) ). Nevertheless, natural insulating property and large volume variation of red P during cycling result in extremely low electrochemical activity, leading to poor electrochemical performance. Herein, the authors demonstrate a rational strategy to improve sodium storage performance of red P by confining nanosized amorphous red P into zeolitic imidazolate framework-8 (ZIF-8) -derived nitrogen-doped microporous carbon matrix (denoted as P@N-MPC)...
February 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28223983/b-cell-homeostasis-and-functional-properties-are-altered-in-an-hypochlorous-acid-induced-murine-model-of-systemic-sclerosis
#4
Sébastien Sanges, Manel Jendoubi, Niloufar Kavian, Carine Hauspie, Silvia Speca, Jean-Charles Crave, Thomas Guerrier, Guillaume Lefèvre, Vincent Sobanski, Ariel Savina, Eric Hachulla, Pierre-Yves Hatron, Myriam Labalette, Frédéric Batteux, Sylvain Dubucquoi, David Launay
INTRODUCTION: During systemic sclerosis (SSc), peripheral B cells display alterations in subset homeostasis and functional properties and are a promising therapeutic target. However, there is only few data regarding whether these anomalies are accurately reproduced in animal models of SSc. OBJECTIVE: In this work, we assessed the B cell homeostasis modifications in an experimental model of SSc [hypochlorous acid (HOCl)-induced mouse], both at a phenotypic and functional level, during the course of the disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28220659/in-situ-self-assembled-reduced-graphene-oxide-aerogel-embedded-with-nickel-oxide-nanoparticles-for-the-high-efficiency-separation-of-ovalbumin
#5
Lei Chen, Dong-Hua Zheng, Ying Zhang, Ya-Ning Wang, Zhang-Run Xu
A three-dimensional reduced graphene oxide aerogel with embedded nickel oxide nanoparticles was prepared by a one-step self-assembly reaction in a short time. The nanoparticles could be captured into the interior of reduced graphene oxide network during the formation of the three-dimensional architecture. The composite exhibited porosity, good biocompatibility and abundant metal affinity binding sites. The aerogel was used to isolate ovalbumin selectively from egg white, and favorable adsorption was achieved at pH 3...
February 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28218313/ultrasmall-fe2o3-nanoparticles-mos2-nanosheets-composite-as-high-performance-anode-material-for-lithium-ion-batteries
#6
Bin Qu, Yue Sun, Lianlian Liu, Chunyan Li, Changjian Yu, Xitian Zhang, Yujin Chen
Coupling ultrasmall Fe2O3 particles (~4.0 nm) with the MoS2 nanosheets is achieved by a facile method for high-performance anode material for Li-ion battery. MoS2 nanosheets in the composite can serve as scaffolds, efficiently buffering the large volume change of Fe2O3 during charge/discharge process, whereas the ultrasmall Fe2O3 nanoparticles mainly provide the specific capacity. Due to bigger surface area and larger pore volume as well as strong coupling between Fe2O3 particles and MoS2 nanosheets, the composite exhibits superior electrochemical properties to MoS2, Fe2O3 and the physical mixture Fe2O3+MoS2...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215707/hsp90-shapes-the-consequences-of-human-genetic-variation
#7
Georgios I Karras, Song Yi, Nidhi Sahni, Máté Fischer, Jenny Xie, Marc Vidal, Alan D D'Andrea, Luke Whitesell, Susan Lindquist
HSP90 acts as a protein-folding buffer that shapes the manifestations of genetic variation in model organisms. Whether HSP90 influences the consequences of mutations in humans, potentially modifying the clinical course of genetic diseases, remains unknown. By mining data for >1,500 disease-causing mutants, we found a strong correlation between reduced phenotypic severity and a dominant (HSP90 ≥ HSP70) increase in mutant engagement by HSP90. Examining the cancer predisposition syndrome Fanconi anemia in depth revealed that mutant FANCA proteins engaged predominantly by HSP70 had severely compromised function...
February 16, 2017: Cell
https://www.readbyqxmd.com/read/28214936/an-assessment-of-strontium-sorption-onto-bentonite-buffer-material-in-waste-repository
#8
Pankaj Pathak
In the present study, changes occurring in sorption characteristics of a representative bentonite (WIn-BT) exposed to SrCl2 (0.001-0.1 M) under the pH range of 1-13 were investigated. Such interaction revealed a significant variation in surface charge density and binding energy of ions with respect to bentonite, and alteration in their physicochemical properties viz., specific surface area, cation exchange capacity, thermal and mechanical behaviour were observed. The distribution coefficients (k d) calculated for sorption onto virgin (UCBT) and contaminated bentonite (CBT) indicated a greater influence of mineralogical changes occurred with variance of pH and strontium concentration...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214630/ph-and-reduction-dual-responsive-dipeptide-cationic-lipids-with-%C3%AE-tocopherol-hydrophobic-tail-for-efficient-gene-delivery
#9
Qiang Liu, Rong-Chuan Su, Wen-Jing Yi, Li-Ting Zheng, Shan-Shan Lu, Zhi-Gang Zhao
A series of tocopherol-based cationic lipid 3a-3f bearing a pH-sensitive imidazole moiety in the dipeptide headgroup and a reduction-responsive disulfide linkage were designed and synthesized. Acid-base titration of these lipids showed good buffering capacities. The liposomes formed from 3 and co-lipid 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) could efficiently bind and condense DNA into nanoparticles. Gel binding and HPLC assays confirmed the encapsulated DNA could release from lipoplexes 3 upon addition of 10 mM glutathione (GSH)...
February 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28214603/the-impact-of-reduced-gastric-acid-secretion-on-dissolution-of-salts-of-weak-bases-in-the-fasted-upper-gastrointestinal-lumen-data-in-biorelevant-media-and-in-human-aspirates
#10
Chara Litou, Maria Vertzoni, Wei Xu, Filippos Kesisoglou, Christos Reppas
PURPOSE: To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric dissolution of salts of weak bases. To evaluate the importance of bicarbonate buffer in biorelevant in vitro dissolution testing when using Level II biorelevant media simulating the environment in the fasted upper small intestine, regardless of gastric acid secretions...
February 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28209191/knowledge-of-caries-risk-factors-indicators-among-japanese-and-irish-adult-patients-with-different-socio-economic-profiles-a-cross-sectional-study
#11
Makiko Nishi, Máiréad Harding, Virginia Kelleher, Helen Whelton, Finbarr Allen
BACKGROUND: A previous study has shown deficient knowledge of caries risk factors/indicators in a Japanese adult population regarded to have a high interest in preventive dentistry. No prior research has investigated caries risk knowledge in an Irish adult population. We hypothesise there may be unexpected differences or similarities in knowledge across countries with similar levels of economic development when comparing groups with different socio-economic and cultural profiles. Understanding what influences knowledge is important for the development of effective and efficient caries prevention strategies...
February 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28207929/optimisation-of-intestinal-microsomal-preparation-in-the-rat-a-systematic-approach-to-assess-the-influence-of-various-methodologies-on-metabolic-activity-and-scaling-factors
#12
Oliver J D Hatley, Christopher R Jones, Aleksandra Galetin, Amin Rostami-Hodjegan
The metabolic capacity of the intestine and its importance as the initial barrier to systemic exposure can lead to under-estimation of first-pass, and thus overestimation of oral bioavailability. However, the in vitro tools informing estimates of in vivo intestinal metabolism are limited by the complexity of the in vitro matrix preparation and uncertainty with the scaling factors for in vitro to in vivo extrapolation. A number of methods currently exist in the literature for the preparation of intestinal microsomes; however, the impact of key steps in the preparation procedure has not been critically assessed...
February 16, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28205623/preventive-effects-of-carnosine-on-lipopolysaccharide-induced-lung-injury
#13
Ken-Ichiro Tanaka, Toshifumi Sugizaki, Yuki Kanda, Fumiya Tamura, Tomomi Niino, Masahiro Kawahara
Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play important roles in ARDS development. New compounds for inhibiting the onset and progression of ARDS are required. Carnosine (β-alanyl-L-histidine) is a small di-peptide with numerous activities, including antioxidant effects, metal chelation, proton buffering capacity and the inhibition of protein carbonylation and glycoxidation...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28201836/working-memory-in-aphasia-considering-discourse-processing-and-treatment-implications
#14
Amy Henderson, Hana Kim, Stephen Kintz, Nicole Frisco, Heather Harris Wright
Evidence suggests that persons with aphasia (PWAs) present with working memory impairments that affect a variety of language tasks. Most of these studies have focused on the phonological loop component of working memory and little attention has been paid to the episodic buffer component. The episodic buffer, as a limited capacity, multimodal system that binds and integrates information from the phonological loop, visuospatial sketchpad, and long-term memory would likely be involved in discourse processing. The purposes of this article were to (1) review discourse level deficits associated with aphasia, (2) describe how a deficit at the level of the episodic buffer could cause such deficits, (3) to review discourse treatment approaches for PWAs, and (4) present preliminary results from a novel discourse treatment study for PWAs...
February 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28193058/development-of-a-biocompatible-in-tube-solid-phase-microextraction-device-a-sensitive-approach-for-direct-analysis-of-single-drops-of-complex-matrixes
#15
Hamed Piri-Moghadam, Sofia Lendor, Janusz Pawliszyn
The aim of the current study is to develop a sensitive solid-phase microextraction (SPME) device for direct and rapid analysis of untreated complex matrixes (i.e., single drop of the samples, V ≤ 2 μL). A thin layer of a biocompatible nanostructured polypyrrole (PPy) was electrochemically deposited inside a medical grade spinal needle, minimizing the matrix effect. Microsampling was facilitated by loading the sample inside the in-tube SPME device (withdraw of sample via plunger), where extraction was performed under static conditions...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28190834/perchlorate-selectivity-of-anion-exchange-resins-as-evaluated-using-ion-selective-electrodes
#16
Kenji Yamamoto, Shin'ya Mitsuda, Naomi Ohtake, Natsuki Murashige, Satoshi Ohmuro, Akio Yuchi
The selectivity coefficients reported for perchlorate of the high selectivity on anion exchange resins (AXRs) have not been consistent with one another. Possible errors by the unique use of four parameters (concentrations of two anions in two phases) were experimentally verified. The concentrations of perchlorate buffered at low levels (10(-6) - 10(-4) mol L(-1)) by two forms of AXRs were successfully determined by potentiometry with a perchlorate ion-selective electrode. This gave reasonable coefficients. The coefficients for perchlorate on several AXRs were independent of the relative exchange (RE), in contrast to the previous reports...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28183648/evaluation-of-an-injectable-bioactive-borate-glass-cement-to-heal-bone-defects-in-a-rabbit-femoral-condyle-model
#17
Xu Cui, Wenhai Huang, Yadong Zhang, Chengcheng Huang, Zunxiong Yu, Lei Wang, Wenlong Liu, Ting Wang, Jie Zhou, Hui Wang, Nai Zhou, Deping Wang, Haobo Pan, Mohamed N Rahaman
There is a need for synthetic biomaterials to heal bone defects using minimal invasive surgery. In the present study, an injectable cement composed of bioactive borate glass particles and a chitosan bonding solution was developed and evaluated for its capacity to heal bone defects in a rabbit femoral condyle model. The injectability and setting time of the cement in vitro decreased but the compressive strength increased (8±2MPa to 31±2MPa) as the ratio of glass particles to chitosan solution increased (from 1...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183592/efficient-adsorption-of-hemoglobin-from-aqueous-solutions-by-hybrid-monolithic-cryogel-column
#18
Nuray Yılmaz Baran, Ömür Acet, Mehmet Odabaşı
In this study, a supermacroporous poly(2-hydroxyethyl methacrylate) (PHEMA)-based Cu(2+)-attached bentonite particles embedded hybrid monolithic cryogel (Cu(2+)-ABPs EHMC) was prepared by radical cryo-copolymerization of HEMA with N,N'-methylene-bis-acrylamide (MBAAm) as a cross-linker directly in a plastic syringe in the presence of Cu(2+)-ABPs, and used for hemoglobin (Hb) separation from aqueous solution. Due to the naturally abundant hydroxyl groups on bentonite, Cu(2)-attached bentonite particles (Cu(2+)-ABPs) embedded hybrid monolithic cryogel (HMC) showed a good adsorption performance for Hb, covering an excellent adsorption capacity of 521...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28163222/salt-disproportionation-a-material-science-perspective
#19
REVIEW
Naveen K Thakral, Ron C Kelly
While screening the counter-ions for salt selection for an active pharmaceutical substance, there is often an uncertainty about disproportionation of the salt and hence physical stability of the final product formulation to provide adequate shelf life. Several examples of disproportionation reactions are reviewed to explain the concepts of pHmax, microenvironmental pH, and buffering capacity of excipients and APIs to gain mechanistic understanding of disproportionation reaction. Miscellaneous factors responsible for disproportionation are examined...
February 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28161046/is-surface-water-acidification-a-serious-regional-issue-in-china
#20
Qian Yu, Ting Zhang, Zhenglin Cheng, Bin Zhao, Jan Mulder, Thorjørn Larssen, Shuxiao Wang, Lei Duan
Acidic deposition used to cause severe surface water acidification in Europe and the North America, but no damage of surface water acidification was reported under continuous heavy acid deposition in China. We present the first detailed study on regional surface water acidification in southern and northeastern China based on a survey of 255 forested headwater streams, which were investigated during 2010-2015 to explore the status and mechanism of surface water acidification. South China has a subtropical climate with high acid deposition, whereas northeast China is located in a cold temperature zone with relatively low acid deposition...
February 1, 2017: Science of the Total Environment
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