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https://www.readbyqxmd.com/read/29045991/naloxone-counseling-for-harm-reduction-and-patient-engagement
#1
Jonathan K Han, Lucas G Hill, Marianne E Koenig, Niladri Das
BACKGROUND AND OBJECTIVES: The United States is experiencing an epidemic of opioid-related deaths. Naloxone, the drug of choice for reversing acute opioid overdose, is not routinely prescribed for outpatient use. The aims of this project were to improve naloxone awareness, increase naloxone prescribing, and prevent opioid overdoses. METHODS: A naloxone counseling intervention was implemented in three family health centers by an interprofessional team of providers including family medicine physicians, clinical pharmacists, and social workers...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045434/opportunities-challenges-and-systems-requirements-for-developing-post-abortion-family-planning-services-perceptions-of-service-stakeholders-in-china
#2
Hong Jiang, Jieshuang Xu, Esther Richards, Xu Qian, Weihong Zhang, Lina Hu, Shangchun Wu, Rachel Tolhurst
Post-abortion family planning (PAFP) has been proposed as a key strategy to decrease unintended pregnancy and repeat induced abortions. However, the accessibility and quality of PAFP services remain a challenge in many countries including China where more than 10 million unintended pregnancies occur each year. Most of these unwanted pregnancies end in repeated induced abortions. This paper aims to explore service providers' perceptions of the current situation regarding family planning and abortion service needs, provision, utilization, and the feasibility and acceptability of high quality PAFP in the future...
2017: PloS One
https://www.readbyqxmd.com/read/29045266/travel-distance-as-a-barrier-to-receipt-of-adjuvant-radiation-therapy-after-radical-prostatectomy
#3
David D Yang, Vinayak Muralidhar, Brandon A Mahal, Clair J Beard, Kent W Mouw, Neil E Martin, Peter F Orio, Martin T King, Paul L Nguyen
OBJECTIVES: Following radical prostatectomy (RP), adjuvant radiation therapy (RT) decreases biochemical recurrence and potentially improves metastasis-free and overall survival for patients with high-risk pathologic features. Since adjuvant RT typically occurs daily over several weeks, the logistical challenges of extensive traveling may be a significant barrier to its use. We examined the association between distance to treatment facility and use of adjuvant RT. MATERIALS AND METHODS: We identified 97,568 patients in the National Cancer Database diagnosed from 2004 through 2011 with cT1-4N0-xM0-x prostate cancer and found to have high-risk pathologic features (pT3-4 stage and/or positive surgical margins) at RP...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29042673/simultaneous-hydrolysis-of-carbaryl-and-chlorpyrifos-by-stenotrophomonas-sp-strain-yc-1-with-surface-displayed-carbaryl-hydrolase
#4
Chao Yang, Xiaoqing Xu, Yanping Liu, Hong Jiang, Yunbo Wu, Ping Xu, Ruihua Liu
Many sites are often co-contaminated with multiple pesticides. To date, there are no reports on simultaneous degradation of different classes of pesticides by a natural microorganism. In this work, we aim at constructing a live biocatalyst able to simultaneously hydrolyze carbaryl and chlorpyrifos. For this purpose, carbaryl hydrolase (CH) was displayed on the cell surface of a chlorpyrifos-degrading bacterium Stenotrophomonas sp. strain YC-1 using N- and C-terminal domain of ice nucleation protein (INPNC) from Pseudomonas syringae INA5 as an anchoring motif...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042660/composition-dependent-nanoelectronics-of-amido-phenazines-non-volatile-rram-and-worm-memory-devices
#5
Dilip K Maiti, Sudipto Debnath, Sk Masum Nawaz, Bapi Dey, Enakhi Dinda, Dipanwita Roy, Sudipta Ray, Abhijit Mallik, Syed A Hussain
A metal-free three component cyclization reaction with amidation is devised for direct synthesis of DFT-designed amido-phenazine derivative bearing noncovalent gluing interactions to fabricate organic nanomaterials. Composition-dependent organic nanoelectronics for nonvolatile memory devices are discovered using mixed phenazine-stearic acid (SA) nanomaterials. We discovered simultaneous two different types of nonmagnetic and non-moisture sensitive switching resistance properties of fabricated devices utilizing mixed organic nanomaterials: (a) sample-1(8:SA = 1:3) is initially off, turning on at a threshold, but it does not turn off again with the application of any voltage, and (b) sample-2 (8:SA = 3:1) is initially off, turning on at a sharp threshold and off again by reversing the polarity...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040994/sorafenib-regorafenib-sequential-therapy-in-advanced-hepatocellular-carcinoma-a-single-institute-experience
#6
Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo
OBJECTIVES: Previously, no therapeutic agent has been known to improve the overall survival compared with placebo in patients with hepatocellular carcinoma (HCC), who have progressed after sorafenib. In this patient population, regorafenib was first demonstrated to confer a survival benefit in the RESORCE trial, and subsequently it was approved as a second-line treatment for patients with advanced HCC. An open-label expanded access program (EAP) of regorafenib was implemented for compassionate use...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040913/generation-of-human-erythroblast-derived-ipsc-line-using-episomal-reprogramming-system
#7
Eszter Varga, Marten Hansen, Tatjana Wüst, Marieke von Lindern, Emile van den Akker
Peripheral blood mononuclear cells were isolated and cultured to a pure pro-EBL population and reprogrammed using episomal plasmids. The pluripotency of transgene-free induced pluripotent stem cell (iPSC) line was verified by the expression of pluripotency-associated markers and by in vitro spontaneous differentiation towards the 3 germ layers. The iPSC line showed normal karyotype. Peripheral blood is a non-invasive easy accessible cell source and combined with EBL outgrowth in vitro, a routine process obtaining sufficient amount of homogenous cells can be obtained within a week...
October 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29040656/barriers-to-the-success-of-an-electronic-pharmacovigilance-reporting-system-in-kenya-an-evaluation-three-years-post-implementation
#8
Oscar O Agoro, Sarah W Kibira, Jenny V Freeman, Hamish S F Fraser
Objective: Electronic pharmacovigilance reporting systems are being implemented in many developing countries in an effort to improve reporting rates. This study sought to establish the factors that acted as barriers to the success of an electronic pharmacovigilance reporting system in Kenya 3 years after its implementation. Materials and Methods: Factors that could act as barriers to using electronic reporting systems were identified in a review of literature and then used to develop a survey questionnaire that was administered to pharmacists working in government hospitals in 6 counties in Kenya...
October 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040591/revised-distribution-of-bactrocera-tryoni-in-eastern-australia-and-effect-on-possible-incursions-of-mediterranean-fruit-fly-development-of-australia-s-eastern-trading-block
#9
Bernard C Dominiak, Richard Mapson
Bactrocera tryoni (Froggatt) (Diptera: Tephritidae), commonly called 'Queensland fruit fly' in Australia, and Mediterranean fruit fly (Ceratitis capitata Wiedemann) (Diptera: Tephritidae) are the two most economically important fruit fly in Australia with B. tryoni in the east and Mediterranean fruit fly in the west. The two species coexisted for several decades, but it is believed that B. tryoni displaced Mediterranean fruit fly. In southeastern Australia, this was deemed inadequate for export market access, and a large fruit fly free zone (fruit fly exclusion zone) was developed in 1996 where B...
October 11, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040161/prognostic-factor-analysis-in-325-patients-with-graves-disease-treated-with-radioiodine-therapy
#10
Danrong Yang, Jianjun Xue, Wenxia Ma, Furong Liu, Yameng Fan, Jie Rong, Aimin Yang, Yan Yu
INTRODUCTION: I therapy is a choice for Graves' hyperthyroidism. Several factors that affect the success of I treatment in Graves' disease (GD) patients have been put forward. The aim of this retrospective study was to evaluate the factors influencing the success of I therapy and the occurrence of hypothyroidism after I therapy. PATIENTS AND METHODS: We reviewed 325 GD patients, who were well documented out of 779 cases, treated with I in the First Affiliated Hospital of Xi'an Jiaotong University between 2010 and 2016...
October 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29040082/determinants-of-the-use-of-alternatives-to-arsenic-contaminated-shallow-groundwater-an-exploratory-study-in-rural-west-bengal-india
#11
Caroline Delaire, Abhijit Das, Susan Amrose, Ashok Gadgil, Joyashree Roy, Isha Ray
Shallow groundwater containing toxic concentrations of arsenic is the primary source of drinking water for millions of households in rural West Bengal, India. Often, this water also contains unpleasant levels of iron and non-negligible fecal contamination. Alternatives to shallow groundwater are increasingly available, including government-built deep tubewells, water purchased from independent providers, municipal piped water, and household filters. We conducted a survey of 501 households in Murshidabad district in 2014 to explore what influenced the use of available alternatives...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29038235/rare-tumor-clinic-the-university-of-california-san-diego-moores-cancer-center-experience-with-a-precision-therapy-approach
#12
Shumei Kato, Kellie Kurasaki, Sadakatsu Ikeda, Razelle Kurzrock
BACKGROUND: Patients with rare tumors may lack approved treatments and clinical trial access. Although each rare tumor is uncommon, cumulatively they account for approximately 25% of cancers. We recently initiated a Rare Tumor Clinic that emphasized a precision medicine strategy. MATERIALS AND METHODS: We investigated the first 40 patients presenting at the Rare Tumor Clinic. Next-generation sequencing (NGS) of tissue and plasma-derived, circulating-tumor DNA (ctDNA), and protein markers were assessed...
October 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29036536/wft4galaxy-a-workflow-testing-tool-for-galaxy
#13
Marco Enrico Piras, Luca Pireddu, Gianluigi Zanetti
Motivation: Workflow managers for scientific analysis provide a high-level programming platform facilitating standardization, automation, collaboration and access to sophisticated computing resources. The Galaxy workflow manager provides a prime example of this type of platform. As compositions of simpler tools, workflows effectively comprise specialized computer programs implementing often very complex analysis procedures. To date, no simple way to automatically test Galaxy workflows and ensure their correctness has appeared in the literature...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035458/concordance-of-mutation-detection-in-circulating-tumor-dna-in-early-clinical-trials-using-different-blood-collection-protocols
#14
Lise B Ahlborn, Mette Madsen, Lars Jonson, Finn C Nielsen, Ulrik Lassen, Christina W Yde, Morten Mau-Sorensen
BACKGROUND: Small fragments of tumor DNA can be found in the circulation of cancer patients, providing a noninvasive access to tumor material (liquid biopsy). Analysis of circulating tumor DNA (ctDNA) has been used for diagnosis, treatment decisions, and detection of therapy resistance, including in patients with tumors inaccessible for biopsy, making ctDNA an important alternative source of tumor material. Immediate separation of plasma is widely used in standard isolation of cell-free DNA to ensure high quality plasma DNA...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035038/dynamics-and-morphology-of-nanoparticle-linked-polymers-elucidated-by-nmr
#15
Yongqian Zhang, Charles G Fry, Joel A Pedersen, Robert J Hamers
Nanoparticles are frequently modified with polymer layers to control their physical and chemical properties, but little is understood about the morphology and dynamics of these polymer layers. We report here an NMR-based investigation of a model polymer-modified nanoparticle using multiple NMR techniques including 1H NMR, DOSY, TOCSY, and T2 relaxometry to characterize the dynamics of the nanoparticle-polymer interface. Using 5 nm detonation nanodiamond covalently linked to poly(allylamine) hydrochloride as model system, we demonstrate the use of NMR to distinguish between free and bound polymer and to characterize the degree to which the segments of the nanoparticle-wrapping polymer are mobile (loops and tails) vs...
October 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29034235/coagulofibrinolytic-changes-in-patients-with-post-cardiac-arrest-syndrome
#16
REVIEW
Takeshi Wada
Whole-body ischemia and reperfusion due to cardiac arrest and subsequent return of spontaneous circulation constitute post-cardiac arrest syndrome (PCAS), which consists of four syndromes including systemic ischemia/reperfusion responses and post-cardiac arrest brain injury. The major pathophysiologies underlying systemic ischemia/reperfusion responses are systemic inflammatory response syndrome and increased coagulation, leading to disseminated intravascular coagulation (DIC), which clinically manifests as obstruction of microcirculation and multiple organ dysfunction...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033206/pediatric-environmental-health-using-data-on-toxic-chemical-emissions-in-practice
#17
Kara Koehrn, Jocelyn Hospital, Alan Woolf, Jennifer Lowry
Children's unique behavioral and physiological characteristics can increase their exposure and susceptibility to environmental chemicals. The link between exposure to environmental chemicals and specific health outcomes, however, is often uncertain. This article introduces several resources to help health practitioners identify potential environmental exposures and risks related to toxic chemicals. It focuses on the U.S. Environmental Protection Agency's (EPA's) free and public environmental data, including the Toxics Release Inventory (TRI) data that contain information about toxicants released to the environment...
October 12, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29032949/correction-of-hyperleucinemia-in-msud-patients-on-leucine-free-dietary-therapy
#18
Anna I Scott, Kristina Cusmano-Ozog, Gregory M Enns, Tina M Cowan
PURPOSE: Maple Syrup Urine Disease (MSUD) is a rare disorder of branched-chain amino acid catabolism associated with encephalopathy from accumulation of leucine. Leucine is closely monitored during normal growth and particularly during acute illness. As most hospitals do not have access to rapid plasma amino acid quantification, the initial management is often empirical. A model describing the reduction of plasma leucine in hyperleucinemic patients on leucine-free formula would help to guide management and optimize testing frequency...
October 5, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29031885/multiple-signal-amplification-via-ag-and-tio2-decorated-3d-nitrogen-doped-graphene-hydrogel-for-fabricating-sensitive-label-free-photoelectrochemical-thrombin-aptasensor
#19
Nan Hao, Rong Hua, Saibo Chen, Ying Zhang, Zhou Zhou, Jing Qian, Qian Liu, Kun Wang
In this study, Ag/TiO2/3D nitrogen doped graphene hydrogel (3DNGH) was prepared for the first time and the photocurrent intensity of this material was greatly enhanced, which was attributed to the multiple enhancements accomplished in one step. The porous structure of 3DNGH could provide an exceptionally large accessible surface area, which was beneficial for the anchoring of Ag and TiO2 nanoparticles. The introduction of nitrogen doped graphene and metal nanoparticles was capable to facilitate the charge separation efficiency and accelerate the transfer rate of the photogenerated electron-hole pairs...
October 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29030753/successful-implementation-of-virtual-environment-for-radiotherapy-training-vert-in-medical-physics-education-the-university-of-sydney-s-initial-experience-and-recommendations
#20
Yobelli A Jimenez, Christian Rønn Hansen, Prabhjot Juneja, David I Thwaites
This report outlines the University of Sydney's initial experience with the Virtual Environment for Radiotherapy Training (VERT) system in the Master of Medical Physics program. VERT is a commercially available system, simulating linear accelerators, patient computed tomography (CT) sets, plans and treatment delivery. It was purpose built for radiation therapy (RT) education and offers learners the opportunity to gain knowledge and skills within an interactive, risk-free environment. The integration of VERT into the RT physics module of the Master of Medical Physics program was intended to enhance student knowledge and skills relevant to the curriculum's learning objectives, and to alleviate some of the burden associated with student access to clinical equipment...
October 13, 2017: Australasian Physical & Engineering Sciences in Medicine
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