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https://www.readbyqxmd.com/read/29449275/circulating-tumor-dna-reveals-genetics-clonal-evolution-and-residual-disease-in-classical-hodgkin-lymphoma
#1
Valeria Spina, Alessio Bruscaggin, Annarosa Cuccaro, Maurizio Martini, Martina Di Trani, Gabriela Forestieri, Martina Manzoni, Adalgisa Condoluci, Alberto Arribas, Lodovico Terzi-Di-Bergamo, Silvia Laura Locatelli, Elisa Cupelli, Luca Ceriani, Alden A Moccia, Anastasios Stathis, Luca Nassi, Clara Deambrogi, Fary Diop, Francesca Guidetti, Alessandra Cocomazzi, Salvatore Annunziata, Vittoria Rufini, Alessandro Giordano, Antonino Neri, Renzo Boldorini, Bernhard Gerber, Francesco Bertoni, Michele Ghielmini, Georg Stüssi, Armando Santoro, Franco Cavalli, Emanuele Zucca, Luigi Maria Larocca, Gianluca Gaidano, Stefan Hohaus, Carmelo Carlo-Stella, Davide Rossi
The rarity of neoplastic cells in the biopsy imposes major technical hurdles that have so far limited genomic studies in classical Hodgkin lymphoma (cHL). By using a highly sensitive and robust deep-next-generation-sequencing approach for circulating tumor DNA (ctDNA), here we aimed at tracking the genetics of cHL in different clinical phases, and its modifications upon treatment. The analysis was based on specimens collected from 80 newly diagnosed and 32 refractory cHL patients, including longitudinal samples collected under ABVD chemotherapy and longitudinal samples from relapsing patients treated with chemotherapy and immunotherapy...
February 15, 2018: Blood
https://www.readbyqxmd.com/read/29449086/progress-in-the-use-of-dental-pulp-stem-cells-in-regenerative-medicine
#2
REVIEW
Eduardo Anitua, María Troya, Mar Zalduendo
The field of tissue engineering is emerging as a multidisciplinary area with promising potential for regenerating new tissues and organs. This approach requires the involvement of three essential components: stem cells, scaffolds and growth factors. To date, dental pulp stem cells have received special attention because they represent a readily accessible source of stem cells. Their high plasticity and multipotential capacity to differentiate into a large array of tissues can be explained by its neural crest origin, which supports applications beyond the scope of oral tissues...
February 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29447358/factors-associated-with-maternal-utilization-of-health-facilities-for-delivery-in-ethiopia
#3
Sanni Yaya, Ghose Bishwajit, Michael Ekholuenetale, Vaibhav Shah, Bernard Kadio, Ogochukwu Udenigwe
Background: As a signatory of the Millennium Development Goals, Ethiopia has made significant achievements towards meeting the maternal mortality related goals since 1990. Despite that, the country is still experiencing unacceptably high maternal mortality rates, and challenges to improving the coverage and utilisation of health facility delivery services which represent a key strategy to combat maternal mortality. Currently, there is limited evidence on the factors associated with health facility delivery in Ethiopia...
February 13, 2018: International Health
https://www.readbyqxmd.com/read/29447298/effects-of-voluntary-running-exercise-on-bone-histology-in-type-2-diabetic-rats
#4
Yuri Takamine, Noriko Ichinoseki-Sekine, Takamasa Tsuzuki, Toshinori Yoshihara, Hisashi Naito
The incidence of obesity in children and adolescents, which may lead to type 2 diabetes, is increasing. Exercise is recommended to prevent and improve diabetes. However, little is known about the bone marrow environment at the onset of diabetes in the young, and it is unclear whether exercise training is useful for maintaining bone homeostasis, such as mechanical and histological properties. Thus, this study clarified the histological properties of bone and whether exercise contributes to maintaining bone homeostasis at the onset of type 2 diabetes in rats...
2018: PloS One
https://www.readbyqxmd.com/read/29446212/free-dialysis-in-nepal-logistical-challenges-explored
#5
John Mcgee, Bimal Pandey, Abhishek Maskey, Tifany Frazer, Theodore Mackinney
Nepal's Ministry of Health began offering free lifetime hemodialysis (HD) in 2016. There has been a large growth in renal replacement therapy (RRT) services offered in Nepal since 2010, when the last known data on the subject was published. In 2016, 42 HD centers existed (223% increase since 2010) serving 1975 end stage renal disease patients (303% increase since 2010); 36 nephrologists were registered (200% increase since 2010), 12 were trained in transplantation, and 790 transplants had been performed to date...
February 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29446151/organisational-framework-and-outputs-of-international-medical-evacuation-in-guinea-a-need-for-change
#6
Timothé Guilavogui, Alioune Camara, Elhadj Marouf Diallo, Akoï Koïvogui, Aminatou Barry, Koligna Zoumanigui, Alpha Ahmadou Diallo, Alexandre Delamou, Moussa Koulibaly
The study aims to describe the organizational framework of International Medical Evacuation (IME), the profile of persons evacuated, and the associated cost of IME in Guinea. This was a descriptive study of IME policy in Guinea. We described the politico-structural organization of IME and the profile of patient accessing IME through the Ministry of Health (MOH: 2001-2015) and through the National Social Security Fund (NSSF: 2011-2015). From 1958 to 1992 since the health system was restricted, the country negotiated the free medical treatment with Socialist countries...
February 15, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29445211/bronchoscopic-fibered-confocal-fluorescence-microscopy-for-longitudinal-in-vivo-assessment-of-pulmonary-fungal-infections-in-free-breathing-mice
#7
Liesbeth Vanherp, Jennifer Poelmans, Amy Hillen, Kristof Govaerts, Sarah Belderbos, Tinne Buelens, Katrien Lagrou, Uwe Himmelreich, Greetje Vande Velde
Respiratory diseases, such as pulmonary infections, are an important cause of morbidity and mortality worldwide. Preclinical studies often require invasive techniques to evaluate the extent of infection. Fibered confocal fluorescence microscopy (FCFM) is an emerging optical imaging technique that allows for real-time detection of fluorescently labeled cells within live animals, thereby bridging the gap between in vivo whole-body imaging methods and traditional histological examinations. Previously, the use of FCFM in preclinical lung research was limited to endpoint observations due to the invasive procedures required to access lungs...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444997/efficacy-of-multicomponent-culturally-tailored-hiv-sti-prevention-interventions-targeting-foreign-female-entertainment-workers-a-quasi-experimental-trial
#8
Raymond B T Lim, Olive N Y Cheung, Bee Choo Tai, Mark I-C Chen, Roy K W Chan, Mee Lian Wong
OBJECTIVES: We assessed the efficacy of a multicomponent culturally tailored HIV/STI prevention intervention programme on consistent condom use and STI incidence among foreign Thai and Vietnamese female entertainment workers (FEWs) in Singapore. METHODS: We conducted a quasi-experimental pretest and post-test intervention trial with a comparison group. We recruited 220 participants (115 Vietnamese and 105 Thai) for the comparison group, followed by the intervention group (same number) from the same sites which were purposively selected after a 3-month interval period...
February 14, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29444775/persistent-inequalities-in-hospice-at-home-provision
#9
Jackie Buck, Liz Webb, Lorraine Moth, Lynn Morgan, Stephen Barclay
OBJECTIVE: To describe the nature and scope of a new Hospice at Home (H@H) service and to identify its equality of provision. METHODS: Case note review of patients supported by a H@H service for 1 year from September 2012 to August 2013 (n=321). Descriptive analysis to report frequencies and proportions of quantitative data extracted from service logs, referral forms and care records; thematic analysis of qualitative data from care record free text. RESULTS: Demand outstripped supply...
February 14, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29444685/prevalence-and-correlates-of-hiv-infection-among-men-who-inject-drugs-in-a-remote-area-of-vietnam
#10
Van T Nghiem, Thanh C Bui, Patrick P Nadol, Son H Phan, Binh T Kieu, Ryan Kling, Theodore M Hammett
BACKGROUND: Lack of information on the HIV epidemic among men who inject drugs (MWID) in northwestern Vietnam, a remote area, may hamper national efforts to control the disease. We examined HIV prevalence, needle-syringe sharing behaviors, and associated factors among MWID in three areas of northwestern Vietnam. METHODS: We used descriptive analysis to report the characteristics, frequency of risk behaviors, and of access to healthcare services among the MWID. Univariable logistic regression was used to assess the associations between the HIV infection, needle-syringe sharing behaviors, and their independent variables...
February 14, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29444630/congenital-ocular-abnormalities-in-free-ranging-white-tailed-deer
#11
Lorelei L Clarke, Kevin D Niedringhaus, K Paige Carmichael, M Kevin Keel, Heather Fenton
Congenital ocular abnormalities in cervids have been previously reported as individual cases from various regions of the United States and include microphthalmia, anophthalmia, congenital cataracts, dermoids, and colobomata. A common underlying cause for these abnormalities, such as nutritional deficiencies, environmental toxin exposures, or genetic mutations, has not been established. This retrospective study summarized and compared cases of suspected congenital ocular abnormalities in free-ranging white-tailed deer ( Odocoileus virginianus) submitted to the Southeastern Cooperative Wildlife Disease Study (SCWDS) in Athens, Georgia, to the preexisting literature...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29444388/the-virtual-microscopy-database-sharing-digital-microscope-images-for-research-and-education
#12
Lisa M J Lee, Haviva M Goldman, Michael Hortsch
Over the last 20 years, virtual microscopy has become the predominant modus of teaching the structural organization of cells, tissues, and organs, replacing the use of optical microscopes and glass slides in a traditional histology or pathology laboratory setting. Although virtual microscopy image files can easily be duplicated, creating them requires not only quality histological glass slides but also an expensive whole slide microscopic scanner and massive data storage devices. These resources are not available to all educators and researchers, especially at new institutions in developing countries...
February 14, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29443827/a-comparison-of-hla-molecular-mismatch-methods-to-determine-hla-immunogenicity
#13
C Wiebe, V Kosmoliaptsis, D Pochinco, C Taylor, P Nickerson
BACKGROUND: Antibody-mediated rejection is a major cause of premature graft loss in kidney transplantation. Multiple scoring systems are available to assess the HLA mismatch between donors and recipients at the molecular level, however, their correlation with the development of de novo donor-specific antibody (dnDSA) has not been compared in recipients on active immunosuppression. METHODS: HLA-DRβ1/3/4/5/DQα1β1 molecular mismatch was determined using eplet analysis, amino acid mismatch, and electrostatic mismatch for 596 renal transplant recipients and correlated with HLA-DR/DQ dnDSA development...
February 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29443824/improving-hip-worn-accelerometer-estimates-of-sitting-using-machine-learning-methods
#14
Jacqueline Kerr, Jordan Carlson, Suneeta Godbole, Lisa Cadmus-Bertram, John Bellettiere, Sheri Hartman
PURPOSE: To improve estimates of sitting time from hip worn accelerometers used in large cohort studies by employing machine learning methods developed on free living activPAL data. METHODS: Thirty breast cancer survivors concurrently wore a hip worn accelerometer and a thigh worn activPAL for 7 days. A random forest classifier, trained on the activPAL data, was employed to detect sitting, standing and sit-stand transitions in 5 second windows in the hip worn accelerometer...
February 13, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29443338/recent-advances-in-molecular-rearrangements-involving-aryne-intermediates
#15
Tony Roy, Akkattu T Biju
This Feature Article is aimed at highlighting the recent developments in the transition-metal-free molecular rearrangements involving arynes. The chemistry of arynes has shown incredible developments especially in transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions in the last three decades. The rapid growth in this field is mainly due to the development of mild methods for the generation of arynes. One aspect of the recent developments in the chemistry of arynes involves the molecular rearrangements proceeding via this electrophilic intermediate...
February 14, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29442503/improved-access-to-1-8-diformyl-carbazoles-leads-to-metal-free-carbazole-based-2-2-schiff-base-macrocycles-with-strong-turn-on-fluorescence-sensing-of-zinc-ii-ions
#16
Stuart J Malthus, Scott A Cameron, Sally Brooker
Development of a new and high yielding synthetic route to 1,8-diformyl-carbazoles 3 (3a 3,6-di-tert-butyl substituted; 3b 3,6-unsubstituted) is reported. Use of a Heck coupling reaction, followed by ozonolysis, has greatly facilitated the preparation of these interesting head units in useful quantities. An initial foray into the new generations of Schiff base macrocycles that ready access to these head units (3) opens up, has led to the direct (i.e., metal-free) synthesis of two [2 + 2] macrocycles from 3a or 3b with 1,2-diaminoethane, H2LtBu(4a) and H2LH(4b), respectively, obtained as yellow powders in high yields (87-88%)...
February 14, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29442128/semantic-imaging-features-predict-disease-progression-and-survival-in-glioblastoma-multiforme-patients
#17
Jan C Peeken, Josefine Hesse, Bernhard Haller, Kerstin A Kessel, Fridtjof Nüsslin, Stephanie E Combs
BACKGROUND: For glioblastoma (GBM), multiple prognostic factors have been identified. Semantic imaging features were shown to be predictive for survival prediction. No similar data have been generated for the prediction of progression. The aim of this study was to assess the predictive value of the semantic visually accessable REMBRANDT [repository for molecular brain neoplasia data] images (VASARI) imaging feature set for progression and survival, and the creation of joint prognostic models in combination with clinical and pathological information...
February 13, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29438526/magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-for-glioblastoma-of-the-corpus-callosum
#18
Thomas L Beaumont, Alireza M Mohammadi, Albert H Kim, Gene H Barnett, Eric C Leuthardt
BACKGROUND: Glioblastoma of the corpus callosum is particularly difficult to treat, as the morbidity of surgical resection generally outweighs the potential survival benefit. Laser interstitial thermal therapy (LITT) is a safe and effective treatment option for difficult to access malignant gliomas of the thalamus and insula. OBJECTIVE: To assess the safety and efficacy of LITT for the treatment of glioblastoma of the corpus callosum. METHODS: We performed a multicenter retrospective analysis of prospectively collected data...
February 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29438439/mother-to-child-transmission-of-hiv-in-brazil-data-from-the-birth-in-brazil-study-a-national-hospital-based-study
#19
Rosa Maria Soares Madeira Domingues, Valeria Saraceni, Maria do Carmo Leal
AIMS: to estimate the mother to child transmission (MTCT) of HIV among infected pregnant women identified in the "Birth in Brazil" study and to evaluate care practices provided in order to identify missed opportunities at preventing the MTCT of HIV infection in the country. METHODS: Descriptive study using data obtained from the consultation of different databases: the "Birth in Brazil" study database and the Brazilian National Information Systems (NIS) databases...
2018: PloS One
https://www.readbyqxmd.com/read/29437985/comparing-the-characteristics-of-users-of-an-online-service-for-sti-self-sampling-with-clinic-service-users-a-cross-sectional-analysis
#20
Sharmani Barnard, Caroline Free, Ioannis Bakolis, Katy M E Turner, Katharine J Looker, Paula Baraitser
OBJECTIVES: Online services for self-sampling at home could improve access to STI testing; however, little is known about those using this new modality of care. This study describes the characteristics of users of online services and compares them with users of clinic services. METHODS: We conducted a cross-sectional analysis of routinely collected data on STI testing activity from online and clinic sexual health services in Lambeth and Southwark between 1January 2016 and 31March 2016...
February 7, 2018: Sexually Transmitted Infections
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