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https://www.readbyqxmd.com/read/28636380/a-free-radical-promoted-copper-catalyzed-decarboxylative-alkylation-of-%C3%AE-%C3%AE-unsaturated-carboxylic-acids-with-ich2cf3-and-its-analogues
#1
Yan Zhu, Juwen Gong, Yonghui Wang
A novel and efficient free radical promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides with a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.
June 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28636350/integrating-a-semi-transparent-fullerene-free-organic-solar-cell-in-tandem-with-a-bivo4-photoanode-for-unassisted-solar-water-splitting
#2
Yuelin Peng, Gokul V Govindaraju, Dong Ki Lee, Kyoung-Shin Choi, Trisha L Andrew
We report an unassisted solar water splitting system powered by a diketopyrrolopyrrole (DPP)-containing semi-transparent organic solar cell. Two major merits of this fullerene-free solar cell enable its integration with a BiVO4 photoanode. First is the high open circuit voltage and high fill factor displayed by this single junction solar cell, which yields sufficient power to effect water splitting when serially-connected to an appropriate electrode/catalyst. Second, the wavelength-resolved photoaction spectrum of the DPP-based solar cell has minimal overlap with that of the BiVO4 photoanode, thus ensuring that light collection across these two components can be optimized...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28635566/stone-size-is-a-predictor-for-residual-stone-and-multiple-procedures-of-endoscopic-combined-intrarenal-surgery
#3
Shimpei Yamashita, Yasuo Kohjimoto, Akinori Iba, Kazuro Kikkawa, Isao Hara
OBJECTIVES: The aim of this study was to identify the predictors of treatment results after endoscopic combined intrarenal surgery (ECIRS). MATERIALS AND METHODS: A retrospective analysis was conducted of 75 patients with renal stones who underwent ECIRS and a preoperative non-contrast computed tomography (NCCT) examination. The stone-free rate (SFR), number of primary procedures and perioperative complications were investigated, and the predictors contributing to these three outcomes were analyzed...
February 13, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28635521/assessment-of-an-innovative-voluntary-substance-abuse-treatment-program-designed-to-replace-compulsory-drug-detention-centers-in-malaysia
#4
Farrah Khan, Archana Krishnan, Mansur A Ghani, Jeffrey A Wickersham, Jeannia J Fu, Sin How Lim, Sangeeth Kaur Dhaliwal, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: As part of an ongoing initiative by the Malaysian government to implement alternative approaches to involuntary detention of people who use drugs, the National Anti-Drug Agency has created new voluntary drug treatment programs known as Cure and Care (C&C) Centers that provide free access to addiction treatment services, including methadone maintenance therapy, integrated with social and health services. OBJECTIVES:   We evaluated early treatment outcomes and client satisfaction among patients accessing C&C treatment and ancillary services at Malaysia's second C&C Center located in Kota Bharu, Kelantan...
February 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28634701/the-50-most-cited-articles-in-facial-plastic-surgery
#5
Michael T Chang, Zachary G Schwam, Christopher A Schutt, Emily M Kamen, Boris Paskhover
Bibliometric analysis is a common method to determine the most influential articles in medical specialties, as it is an objective measure of peer recognition of scientific work. This study is the first bibliometric analysis of the literature in facial plastic surgery, to determine the most cited papers in the field. Bibliometric analysis was performed using the Science Citation Index from the Institute for Scientific Information, accessed through the Web of Science™. Filter terms relevant to the field of facial plastic surgery were used to identify the 50 most cited journal articles between 1900 and 2016...
June 20, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28634590/the-immune-epitope-database-how-data-are-entered-and-retrieved
#6
REVIEW
Ward Fleri, Kerrie Vaughan, Nima Salimi, Randi Vita, Bjoern Peters, Alessandro Sette
Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epitope and assay information related to infectious diseases, autoimmune diseases, allergic diseases, and transplant/alloantigens for humans, nonhuman primates, mice, and any other species studied. It contains T cell, B cell, MHC binding, and MHC ligand elution experiments...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28632830/-declaration-of-the-chilean-academy-of-medicine-of-law-20-850-on-clinical-trials-of-pharmaceutical-products-and-medical-devices-and-of-the-bylaw-that-will-regulate-its-application
#7
Gloría López, Gloría Valdés, Emilio Roessler, Vicente Valdivieso
In Chile, high cost treatments required by selected medical conditions are financed by the State, according to Law 20.850. A bylaw under discussion by the Senate regulates clinical trials, posing complex issues that will endanger local interest in front-line research: 1) The exclusive and mandatory control bestowed to the Institute of Public Health during all stages of the trials and also the surveillance of institutions performing clinical trials, overriding their Clinical Research Review Boards; 2) The 10 year period during which any adverse event is assumed to have been caused by the medication or devise evaluated by the trial, unless the contrary is proven in a judicial process; 3) Individuals submitted to the trials are entitled to free post trial access to the treatment received during the study, financed by the trial supporting entities and as long as the drug or devise is considered to be useful...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28631903/-solitary-stones-of-the-lower-renal-calyx-how-to-treat
#8
A G Martov, D V Ergakov, A S Andronov, S V Dutov, R A Takhaev, Z I Kil'chukov, S A Moskalenko
INTRODUCTION: The choice of treatment for the stones of the lower renal calyx is one of the challenging issues of modern urology. The aim of this retrospective and prospective study was to investigate the clinical effectiveness and safety of 3 modern minimally invasive techniques for treating renal stones: percutaneous (PNL) and transurethral (TNL) nephrolithotripsy and extracorporeal shock wave lithotripsy (ESWL) in patients with solitary lower calyx stones sized from 10 to 15 mm. MATERIALS AND METHODS: The study included 136 patients with symptomatic stones of the lower calyces, who underwent ESWL, PNL and TNL from November 2010 to the present day...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28631403/-pseudomonas-protegens-pf-5-favors-self-produced-siderophore-over-free-loading-in-interspecies-competition-for-iron
#9
D Joseph Sexton, Rochelle C Glover, Joyce E Loper, Martin Schuster
Many microorganisms compete for extracellular iron using strain-specific chelators known as siderophores. The ferric-siderophore complex limits local access to iron because import requires a suitable cognate receptor. Interestingly, many species carry receptors that enable "cross-feeding" on heterologous siderophores made by neighboring organisms, although little is known about how this ubiquitous behavior is regulated. Here, we investigated the soil bacterium Pseudomonas protegens Pf-5, a strain remarkable for its ability to use dozens of heterologous siderophores...
June 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28627289/snap-n-send-a-valid-and-reliable-method-for-assessing-the-energy-intake-of-elite-adolescent-athletes
#10
Nessan Costello, Kevin Deighton, Joshua Dyson, Jim Mckenna, Ben Jones
To ensure that elite adolescent athletes meet their unique training, growth and maturation demands, it is imperative to have access to valid measures of energy intake. Contemporary methods demand close attention-to-detail, meaning that athletes often do not fully adhere to real-time protocols. This study represents the first investigation of a real-time dietary assessment designed using a comprehensive behaviour change framework (COM-B). In a crossover design, 12 elite adolescent male rugby players recorded their energy intake via an estimated food diary (est-FD) and photography-based mobile assessment ('Snap-n-Send'), combined with a 24-h dietary recall interview...
June 17, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28626249/knowledge-of-free-delivery-policy-among-women-who-delivered-at-health-facilities-in-oudomxay-province-lao-pdr
#11
Tengbriacheu Chankham, Eiko Yamamoto, Joshua A Reyer, Rahman Arafat, Innoukham Khonemany, Sayamoungkhoun Panome, Dalavong Hongkham, Phommalaysith Bounfeng, Xeuthvongsa Anonh, Nobuyuki Hamajima
To promote the utilization of maternal health services and reduce financial barriers, the Laos government introduced its "Free Maternal Health Services Policy" in 2012. This policy provides free maternal health services for pregnant women, which includes costs related to treatment, transportation, food fees, referral and an incentive for four antenatal care appointments. This study aims to ascertain the knowledge level regarding this policy among Lao women and determine their level of satisfaction with the maternal service provision...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28625597/structural-heart-disease-australia-shda
#12
EDITORIAL
Sharon Kay, David Celermajer, Michael Vallely
Structural Heart Disease Australia (SHDA) is a rapidly evolving multidisciplinary group of health care professionals which provides a forum focussed on understanding the rapidly advancing management of structural cardiac disease via Free Open Access Medical Education (FOAM).
May 4, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28624543/impact-of-health-care-insurance-status-on-treatment-outcomes-of-acute-myeloid-leukemia
#13
Samer A Srour, Michael Machiorlatti, Namali T Pierson, Usman Z Bhutta, Mohamad Cherry, George B Selby, David M Thompson, Sara K Vesely, Carla D Kurkjian
INTRODUCTION: Insurance status has been found to influence treatment outcomes in various solid tumors. Limited data with conflicting results are available in patients with acute myeloid leukemia (AML). We examined the impact of health insurance at diagnosis on AML treatment outcomes. PATIENTS AND METHODS: All consecutive adult patients (≥ 18 years of age) diagnosed with AML between 2002 and 2011 and followed through August 2013 were included. Survival estimates were calculated by Kaplan-Meier survival curves...
May 10, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28624284/comparing-the-effect-of-homogenization-and-heat-processing-on-the-properties-and-in-vitro-digestion-of-milk-from-organic-and-conventional-dairy-herds
#14
D L Van Hekken, M H Tunick, D X Ren, P M Tomasula
We compared the effects of homogenization and heat processing on the chemical and in vitro digestion traits of milk from organic and conventional herds. Raw milk from organic (>50% of dry matter intake from pasture) and conventional (no access to pasture) farms were adjusted to commercial whole and nonfat milk fat standards, and processed with or without homogenization, and with high-temperature-short-time or UHT pasteurization. The milk then underwent in vitro gastrointestinal digestion. Comparison of milk from organic and conventional herds showed that the milks responded to processing in similar ways...
June 14, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28623919/effects-of-karela-bitter-melon-momordica-charantia-on-genes-of-lipids-and-carbohydrates-metabolism-in-experimental-hypercholesterolemia-biochemical-molecular-and-histopathological-study
#15
Dalia Yossri Saad, Mohamed Mohamed Soliman, Ahmed A Baiomy, Magdy Hassan Yassin, Hanan Basiouni El-Sawy
BACKGROUND: Hypercholesterolemia is a serious diseases associated with type-2 diabetes, atherosclerosis, cardiovascular disorders and liver diseases. Humans seek for safe herbal medication such as karela (Momordica charantia/bitter melon) to treat such disorders to avoid side effect of pharmacotherapies widely used. METHODS: Forty male Wistar rats were divided into four equal groups; control group with free access to food and water, cholesterol administered group (40 mg/kg BW orally); karela administered group (5 g /kg BW orally) and mixture of cholesterol and karela...
June 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28623168/access-to-nicotine-in-drinking-water-reduces-weight-gain-without-changing-caloric-intake-on-high-fat-diet-in-male-c57bl-6j-mice
#16
Cali A Calarco, Somin Lee, Marina R Picciotto
Nicotine and tobacco use is associated with lower body weight, and many smokers report concerns about weight. In animal studies, nicotine reduces weight gain, reduces food consumption, and alters energy expenditure, but these effects vary with duration and route of nicotine administration. Previous studies have used standardized nicotine doses, however, in this study, male and female mice had free access to nicotine drinking water for 30 days while fed either a high fat diet (HFD) or chow, allowing animals to titrate their nicotine intake...
June 13, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28622627/changes-in-nonhuman-primate-brain-function-following-chronic-alcohol-consumption-in-previously-na%C3%A3-ve-animals
#17
Jared A Rowland, Jennifer R Stapleton-Kotloski, Greg E Alberto, April T Davenport, Robert J Kotloski, David P Friedman, Dwayne W Godwin, James B Daunais
INTRODUCTION: Chronic alcohol abuse is associated with neurophysiological changes in brain activity; however, these changes are not well localized in humans. Non-human primate models of alcohol abuse enable control over many potential confounding variables associated with human studies. The present study utilized high-resolution magnetoencephalography (MEG) to quantify the effects of chronic EtOH self-administration on resting state (RS) brain function in vervet monkeys. METHODS: Adolescent male vervet monkeys were trained to self-administer ethanol (n=7) or an isocaloric malto-dextrin solution (n=3)...
May 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28622332/comparison-of-monocyte-gene-expression-among-patients-with-neurocysticercosis-associated-epilepsy-idiopathic-epilepsy-and-idiopathic-headaches-in-india
#18
Vasudevan Prabhakaran, Douglas A Drevets, Govindan Ramajayam, Josephine J Manoj, Michael P Anderson, Jay S Hanas, Vedantam Rajshekhar, Anna Oommen, Hélène Carabin
BACKGROUND: Neurocysticercosis (NCC), a neglected tropical disease, inflicts substantial health and economic costs on people living in endemic areas such as India. Nevertheless, accurate diagnosis using brain imaging remains poorly accessible and too costly in endemic countries. The goal of this study was to test if blood monocyte gene expression could distinguish patients with NCC-associated epilepsy, from NCC-negative imaging lesion-free patients presenting with idiopathic epilepsy or idiopathic headaches...
June 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28621820/the-efficacy-of-internet-based-cognitive-behavioral-therapy-for-severely-fatigued-survivors-of-breast-cancer-compared-with-care-as-usual-a-randomized-controlled-trial
#19
Harriët J G Abrahams, Marieke F M Gielissen, Rogier R T Donders, Martine M Goedendorp, Agnes J van der Wouw, Constans A H H V M Verhagen, Hans Knoop
BACKGROUND: Severe fatigue is a common and distressing symptom affecting approximately one in four survivors of breast cancer. The current study examined the efficacy of Internet-based cognitive behavioral therapy (ICBT) for severe fatigue in survivors of breast cancer compared with care as usual (CAU). METHODS: The authors conducted a parallel-group randomized controlled trial. Severely fatigued, disease-free survivors of breast cancer who had completed cancer treatment at least 3 months previously were eligible...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28619414/health-information-needs-and-reliability-of-sources-among-nondegree-health-sciences-students-a-prerequisite-for-designing-ehealth-literacy
#20
Hussein Haruna, Ndumiso Tshuma, Xiao Hu
BACKGROUND: Understanding health information needs and health-seeking behavior is a prerequisite for developing an electronic health information literacy (EHIL) or eHealth literacy program for nondegree health sciences students. At present, interest in researching health information needs and reliable sources paradigms has gained momentum in many countries. However, most studies focus on health professionals and students in higher education institutions. OBJECTIVE: The present study was aimed at providing new insight and filling the existing gap by examining health information needs and reliability of sources among nondegree health sciences students in Tanzania...
March 2017: Annals of Global Health
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