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https://www.readbyqxmd.com/read/29352597/potential-drug-targets-in-the-mycobacterium-tuberculosis-cytochrome-p450-system
#1
REVIEW
Paul R Ortiz de Montellano
The Mycobacterium tuberculosis genome encodes twenty cytochrome P450 enzymes, most or all of which appear to have specific physiological functions rather than being devoted to the removal of xenobiotics. However, in many cases their specific functions remain obscure. Considerable spectroscopic, biophysical, crystallographic, and catalytic information is available on nine of these cytochrome P450 enzymes, although gaps exist in our knowledge of even these enzymes. The available evidence indicates that at least three of the better-characterized enzymes are promising targets for antituberculosis drug discovery...
January 12, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29352446/mycobacterium-marinum-infection-in-zebrafish-and-microglia-imitates-the-early-stage-of-tuberculous-meningitis
#2
Zhan Chen, Xiao-Yi Shao, Chao Wang, Min-Hui Hua, Cheng-Niu Wang, Xin Wang, Qian-Jin Wang, Jin-Yi Yao, Yi-Hui Fan, Yong-Wei Qin
Mycobacterium tuberculosis (M. tuberculosis) invading and activating microglia causes the most serious subtypes of tuberculosis called tubercular meningitis. However, the developmental process of tubercular meningitis, especially the early phase, is poorly understood due to lacking well-established and well-accepted visible models in vitro and in vivo. Here, consistent with one recent report, we found Mycobacterium marinum (M. marinum) invade the zebrafish brain and subsequently cause granuloma-like structures...
January 20, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29352388/cutaneous-granulomatosis-a-comprehensive-review
#3
REVIEW
Benedetta Terziroli Beretta-Piccoli, Carlo Mainetti, Marie-Astrid Peeters, Emmanuel Laffitte
Cutaneous granulomatosis is a heterogeneous group of diseases, characterized by a skin inflammatory reaction triggered by a wide variety of stimuli, including infections, foreign bodies, malignancy, metabolites, and chemicals. From a pathogenic point of view, they are divided into non-infectious and infectious granulomas. Pathophysiological mechanisms are still poorly understood. Non-infectious granulomatous skin diseases include granuloma annulare, necrobiosis lipoidica, rheumatic nodules, foreign body granulomas, cutaneous sarcoidosis, and interstitial granulomatous dermatitis...
January 19, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29352107/mycolyltransferase-from-mycobacterium-tuberculosis-in-covalent-complex-with-tetrahydrolipstatin-provides-insights-into-antigen-85-catalysis
#4
Christopher M Goins, Steven Dajnowicz, Micholas D Smith, Jerry M Parks, Donald R Ronning
Mycobacterium tuberculosis Antigen 85 enzymes (Ag85s) catalyze the transfer of mycolic acid (MA) from trehalose monomycolate to produce the mycolyl arabinogalactan (mAG) or trehalose dimycolate (TDM). These lipids define the protective mycomembrane of Mycobacteria. The current model of substrate binding within the active sites of Ag85s for the production of TDM is not sterically and geometrically feasible; additionally, this model does not account for the production of mAG. Furthermore, this model does not address how Ag85s limit the hydrolysis of the acyl-enzyme intermediate while catalyzing acyl transfer...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29352014/effectiveness-of-comprehensive-social-support-interventions-among-elderly-patients-with-tuberculosis-in-communities-in-china-a-community-based-trial
#5
Xuhui Li, Bin Wang, Dixin Tan, Mengyu Li, Dandan Zhang, Cong Tang, Xiaonan Cai, Yaqiong Yan, Sheng Zhang, Bo Jin, Songlin Yu, Xunchang Liang, Qian Chu, Yihua Xu
BACKGROUND: With the increasing of ageing population, tuberculosis in the elderly brings a challenge for the tuberculosis (TB) control in China. Enough social support can promote the treatment adherence and outcome of the elderly patients with TB. Exploring effective interventions to improve the social support of patients is of great significance for TB management and control. METHODS: A community-based, repeated measurement trial was conducted. Patients with TB >65 years of age were allocated into the intervention or control group...
January 19, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29351672/high-treatment-success-rate-among-multidrug-resistant-tuberculosis-patients-in-myanmar-2012-2014-a-retrospective-cohort-study
#6
Myat K Thu, Ajay M V Kumar, Kyaw T Soe, Saw Saw, Saw Thein, Zaw Mynit, Htet M W Maung, Si T Aung
Background: Since 2011, Myanmar has adopted domiciliary care for multidrug-resistant tuberculosis (MDR-TB) patients and implemented several patient-support measures such as community-based directly observed treatment, nutritional support and financial incentives for patients and providers. We assessed treatment outcomes among MDR-TB patients registered for treatment in the Yangon and Mandalay Regions of Myanmar during 2012-2014 and factors associated with unfavourable treatment outcomes...
January 17, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29350178/use-of-rifabutin-to-treat-tuberculosis-in-a-cardiac-transplant-recipient-a-case-report%C3%A2
#7
Maya Takayoshi, Kyoichi Wada, Yuka Terada, Sachi Matsuda, Kazuki Nakagita, Akira Oita, Mitsutaka Takada, Aki Shionoiri, Haruki Sunami, Seiko Nakajima, Kensuke Kuroda, Takuma Sato, Osamu Seguchi, Masanobu Yanase, Norihide Fukushima
OBJECTIVE: Tuberculosis is an important concern following organ transplantation. Unfortunately, several antituberculosis drugs interact with immunosuppressants. This report describes our experience with rifabutin (RBT) in the treatment of acute tuberculosis in a cardiac transplant recipient. CASE: A 61-year-old cardiac transplant recipient developed tuberculosis meningitis during treatment of miliary tuberculosis. RBT was given for 27 days concomitantly with cyclosporine (CsA)...
January 19, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29350153/trends-in-infectious-disease-mortality-south-korea-1983-2015
#8
Young June Choe, Seung-Ah Choe, Sung-Il Cho
We used national statistics from 1983-2015 to evaluate trends in mortality caused by infectious diseases in South Korea. Age-standardized mortality from infectious disease decreased from 43.5/100,000 population in 1983 to 16.5/100,000 in 1996, and then increased to 44.6/100,000 in 2015. Tuberculosis was the most common cause of death in 1983 and respiratory tract infections in 2015. We observed a significant decline in infant deaths caused by infectious diseases, but mortality in persons age >65 years increased from 135 deaths/100,000 population in 1996 to 307/100,000 in 2015...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350004/-posterior-debridement-and-bone-grafting-via-intervertebral-space-combined-with-internal-fixation-for-the-treatment-of-lumbosacral-tuberculosis
#9
Wei-Wei Li, Jun Liu, Liang Duan, Da-Peng Duan, Wen-Bo Wei, Ya-Yi Fan
OBJECTIVE: To explore the clinical effects of posterior debridement, bone grafting via intervertebral space combined with internal fixation for the treatment of lumbosacral tuberculosis. METHODS: The clinical data of 32 patients with lumbosacral tuberculosis underwent the procedure of one-stage posterior intervertebral debridement, bone grafting and internal fixation from January 2007 to July 2013 were retrospectively analyzed. There were 17 males and 15 females, aged from 27 to 63 years with an average of (49...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349532/a-novel-approach-in-treatment-of-tuberculosis-by-targeting-drugs-to-infected-macrophages-using-biodegradable-nanoparticles
#10
REVIEW
Shivangi, Laxman S Meena
Mycobacterium tuberculosis, the causative agent of tuberculosis is now causing death of more than 10 million people. Because of the development of drug-resistant TB, drug delivery to the infected site through nanoparticle had been studied for long time. Nanoparticles indicate different sorts of association with the natural particles of the body. Nanoparticles can be used as controlled or specific drug delivery system. It can be through temporal controlled or can be distribution controlled. Glucose polymer-based nanoparticles might play an important role as drug delivery system in case of targeted drug delivery in the infected site of the body or in infected macrophages, as they are biodegradable so there should not be any side effects of these particles in the body and also they show very slow immune response...
January 19, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29349420/common-carotid-artery-pseudoaneurysm-secondary-to-mycobacterium-tuberculosis-treated-with-resection-and-reconstruction-with-saphenous-vein-graft
#11
Kalenda Kasangana, Michael Shih, Paul Saunders, Robert Rhee
Extracranial carotid artery aneurysms secondary to Mycobacterium tuberculosis infection are exceedingly rare. Despite an uncommon location and offending pathogen, the treatment paradigm follows that of all mycotic aneurysms. We report the case of a right common carotid artery pseudoaneurysm caused by a tuberculous infection, successfully treated with antibiotics, resection, and autologous interposition graft.
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349098/comparison-of-hiv-testing-among-children-and-adults-with-tuberculosis-vietnam
#12
Tyson Volkmann, Binh Nguyen, Ebelechukwu G Anyalechi, Kimberly N Chapman Hedges, Ho Van Anh, Pham Quang Tue, Nguyen Viet Nhung, Eleanor S Click
HIV testing among persons with tuberculosis (TB) results in high-yield identification of persons infected with HIV. To evaluate differences in HIV testing among children versus adults with TB in Vietnam, we collected and analyzed age-disaggregated facility and aggregated provincial data from the National Tuberculosis Program. HIV testing was incompletely documented for >70% of children, whereas adult testing data were >90% complete. Standardized training of personnel for universal HIV testing and documentation for children with TB could improve HIV case-detection and permit linking of children with HIV to antiretroviral treatment to prevent morbidity and mortality...
December 2017: Journal of Tuberculosis Research
https://www.readbyqxmd.com/read/29348888/the-association-analysis-of-tlr2-and-tlr4-gene-with-tuberculosis-in-the-tibetan-chinese-population
#13
Xin Xue, Yi Qiu, Dong Jiang, Tianbo Jin, Mengdan Yan, Xikang Zhu, Yonglie Chu
Background: The present study was undertaken to explore the relationship of Toll-like receptor (TLR) 2, TLR4 genes polymorphisms with Pulmonary tuberculosis (PTB) risk in a sample of Chinese population. Methods: For this study, we recruited 467 subjects with PTB and 504 healthy subjects from a Tibetan population living in near or in Xi'an, China. Association analyses of single-nucleotide polymorphisms (SNPs) in TLR2 and TLR4 were performed with SPSS Statistics (version 17...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348876/genome-wide-transcriptional-profiling-identifies-potential-signatures-in-discriminating-active-tuberculosis-from-latent-infection
#14
Liping Pan, Na Wei, Hongyan Jia, Mengqiu Gao, Xiaoyou Chen, Rongrong Wei, Qi Sun, Shuxiang Gu, Boping Du, Aiying Xing, Zongde Zhang
To better understand the host immune response involved in the progression from latent tuberculosis infection (LTBI) to active tuberculosis (TB) and identify the potential signatures for discriminating TB from LTBI, we performed a genome-wide transcriptional profile of Mycobacterium tuberculosis (M.TB)-specific antigens-stimulated peripheral blood mononuclear cells (PBMCs) from patients with TB, LTBI individuals and healthy controls (HCs). A total of 209 and 234 differentially expressed genes were detected in TB vs...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348586/analogues-of-disulfides-from-allium-stipitatum-demonstrate-potent-anti-tubercular-activities-through-drug-efflux-pump-and-biofilm-inhibition
#15
Cynthia A Danquah, Eleftheria Kakagianni, Proma Khondkar, Arundhati Maitra, Mukhlesur Rahman, Dimitrios Evangelopoulos, Timothy D McHugh, Paul Stapleton, John Malkinson, Sanjib Bhakta, Simon Gibbons
Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethiosulfonate, exhibited antimicrobial activity, with one compound inhibiting the growth of Mycobacterium tuberculosis at 17 µM (4 mg L-1) and other compounds inhibiting Escherichia coli and multi-drug-resistant (MDR) Staphylococcus aureus at concentrations ranging between 32-138 µM (8-32 mg L-1)...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348388/disseminated-histoplasmosis-in-an-indonesian-hiv-positive-patient-a-case-diagnosed-by-fine-needle-aspiration-cytology
#16
Nungki Anggorowati, Rita C Sulistyaningsih, Ahmad Ghozali, Yanri W Subronto
A 30-year-old Javanese-Indonesian man was admitted with complaints of 3 months persistent fever, weight loss, and fatigue. He had never known his past history of unprotected HIV until the admission. His only risk factor is unsafe sex. The patient seemed well nourished. Physical examination revealed blood pressure 100/60 mmHg, pulse 100 beats per minute, respiratory rate 20 times per minute, and temperature 38.8°C. Multiple cervical and inguinal lymphadenopathies were also found. Electrocardiogram showed anterolateral ischemic finding, whereas chest X-ray were normal...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29348383/improving-diagnostic-of-pulmonary-tuberculosis-in-hiv-patients-by-bronchoscopy-a-cross-sectional-study
#17
Prayudi Santoso, Arto Y Soeroto, Rianita Juniati, Yovita Hartantri, Rudi Wisaksana, Bachti Alisjabana, Heda M Nataprawira, Ida Parwati
BACKGROUND: diagnostic of pulmonary TB in HIV patients is a problem due to non specific clinical features, or radiological appearance. HIV patients with CD4≤200 cells/mL infected with M. tuberculosis have less capacity in containing M. tuberculosis, developing granulomas, casseous necrosis, or cavities. This condition is caused by weakend inflammatory which later reduced sputum production and may cause false negative result. This study aimed to assess differences in the positivity level of acid fast bacilli (AFB) and cultures of M...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29348284/laryngeal-tuberculosis-a-rare-cause-of-critical-airway-obstruction
#18
Abigail Elizabeth Cole, Daniel Heaton, Ahmed Chekairi
Laryngeal tuberculosis (TB) is a rare condition, occurring in less than 1% of patients infected with pulmonary TB. We present a case of a 57-year-old male patient, who presented in extremis with audible stridor, increased work of breathing and cyanosis. In addition, the patient had a complex medical history, including a recent diagnosis of congenital malformation of the epiglottis. Emergency intervention was required to secure the airway, and after initial attempts at intubation were unsuccessful, an emergency tracheostomy was performed...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29348276/congenital-tuberculosis-presenting-as-otorrhoea-in-a-preterm-infant
#19
Jose Carlos Aldana-Aguirre, Hamdy El-Hakim, Ernest Phillipos, Marc-Antoine Landry
A premature infant of 25 weeks' gestational age presented at 8 weeks after birth with otorrhoea from the left ear. Following a course of topical and systemic antibiotics, the patient deteriorated developing facial nerve paralysis and cervical lymphadenitis. Contrast-enhanced CT and MRI of the head showed a destructive process of the left temporal bone. These findings prompted the clinicians to send swabs from the purulent discharge from the ear for acid-fast bacilli stain. Furthermore, surgical exploration and debridement were undertaken...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29348181/intensity-of-exposure-to-pulmonary-tuberculosis-determines-risk-of-tuberculosis-infection-and-disease
#20
Carlos Acuña-Villaorduña, Edward C Jones-López, Geisa Fregona, Patricia Marques-Rodrigues, Mary Gaeddert, Carolina Geadas, David Jamil Hadad, Laura F White, Lucilia Pereira Dutra Molina, Solange Vinhas, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J Ellner, Reynaldo Dietze
Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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