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Tuberculosis

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https://www.readbyqxmd.com/read/29161696/the-protein-expression-level-of-a-heterogeneous-gene-inserted-in-lipi-1-of-the-listeria-ivanovii-genome-relies-on-its-insertion-orientation
#1
Sijing Liu, Mingjuan Jiang, Lin Su, Tian Tang, Xiang Zhang, Yongyu Li, Qikang Pu, Chenyan Ren, Chuan Wang
Due to its capability to multiply in either phagocytic or nonphagocytic cells, and to subsequently elicit a robust cellular immune response, Listeria ivanovii (LI) is thought to be feasible for developing bacteria-based live attenuated vaccines. We previously generated several recombinant LI strains expressing Mycobacterium tuberculosis antigens. Since the expression level of heterogeneous protein was sometimes very low, we attempted to elucidate the principle of heterogeneous protein expression in such recombinant LI strains...
November 22, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29161328/use-of-quantiferon%C3%A2-tb-gold-in-tube-culture-supernatants-for-measurement-of-antibody-responses
#2
Simon G Kimuda, Irene Andia-Biraro, Moses Egesa, Bernard S Bagaya, John G Raynes, Jonathan Levin, Alison M Elliott, Stephen Cose
QuantiFERON®-TB Gold in-tube (QFT-GIT) supernatants may be important samples for use in assessment of anti-tuberculosis (TB) antibodies when only limited volumes of blood can be collected and when a combination of antibody and cytokine measurements are required. These analytes, when used together, may also have the potential to differentiate active pulmonary TB (APTB) from latent TB infection (LTBI). However, few studies have explored the use of QFT-GIT supernatants for investigations of antibody responses...
2017: PloS One
https://www.readbyqxmd.com/read/29161276/association-between-diabetes-mellitus-and-active-tuberculosis-a-systematic-review-and-meta-analysis
#3
Rami H Al-Rifai, Fiona Pearson, Julia A Critchley, Laith J Abu-Raddad
The burgeoning epidemic of diabetes mellitus (DM) is one of the major global health challenges. We systematically reviewed the published literature to provide a summary estimate of the association between DM and active tuberculosis (TB). We searched Medline and EMBASE databases for studies reporting adjusted estimates on the TB-DM association published before December 22, 2015, with no restrictions on region and language. In the meta-analysis, adjusted estimates were pooled using a DerSimonian-Laird random-effects model, according to study design...
2017: PloS One
https://www.readbyqxmd.com/read/29161254/lansoprazole-use-and-tuberculosis-incidence-in-the-united-kingdom-clinical-practice-research-datalink-a-population-based-cohort
#4
Tom A Yates, Laurie A Tomlinson, Krishnan Bhaskaran, Sinead Langan, Sara Thomas, Liam Smeeth, Ian J Douglas
BACKGROUND: Recent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity. There is no evidence that, in clinical practice, lansoprazole can treat or prevent incident tuberculosis (TB) disease. METHODS AND FINDINGS: We studied a cohort of new users of lansoprazole, omeprazole, or pantoprazole from the United Kingdom Clinical Practice Research Datalink to determine whether lansoprazole users have a lower incidence of TB disease than omeprazole or pantoprazole users...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29161093/b-cells-producing-type-i-interferon-modulate-macrophage-polarization-in-tuberculosis
#5
Alan Bénard, Imme Sakwa, Pablo Schierloh, André Colom, Ingrid Mercier, Ludovic Tailleux, Luc Jouneau, Pierre Boudinot, Talal Al-Saati, Roland Lang, Jan Rehwinkel, Andre G Loxton, Stefan He Kaufmann, Véronique Anton-Leberre, Anne O'Garra, Maria Del Carmen Sasiain, Brigitte Gicquel, Simon Fillatreau, Olivier Neyrolles, Denis Hudrisier
RATIONALE: In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or non-infectious diseases via antibody-independent mechanisms. In tuberculosis, B cells accumulate in lungs, yet their functional contribution to the host response remains poorly understood. OBJECTIVES: To document the role of B cells in tuberculosis in an unbiased manner. METHODS: We generated the transcriptome of B cells isolated from Mycobacterium tuberculosis (Mtb)-infected mice, and validated the identified key pathways using in vitro and in vivo assays...
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29160920/cobalt-catalyzed-electrophilic-amination-of-aryl-and-heteroaryl-zinc-pivalates-with-n-hydroxylamine-benzoates
#6
Yi-Hung Chen, Simon Graßl, Paul Knochel
Aryl- and heteroaryl-zinc pivalates are aminated with O-benzoylhydroxylamines at 25 °C within 2-4 h in the presence of 2-5% CoCl2*2LiCl furnishing the corresponding tertiary arylated or heteroarylated amines in good yields. This electrophilic amination provides also an access to diarylamines and aryl(heteroaryl)amines. A new tuberculosis drug candidate (Q203) was prepared in 6 steps and 56% overall yield using this cobalt-catalyzed amination as the key step.
November 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#7
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160520/spatial-risk-of-tuberculosis-mortality-and-social-vulnerability-in-northeast-brazil
#8
Thaís Zamboni Berra, Ana Angélica Rêgo de Queiroz, Mellina Yamamura, Luiz Henrique Arroyo, Maria Concebida da Cunha Garcia, Marcela Paschoal Popolin, Danielle Talita Dos Santos, Antonio Carlos Vieira Ramos, Luana Seles Alves, Inês Estevinho Fronteira, Francisco Chiaravalloti, Pedro Fredemir Palha, Ricardo Alexandre Arcêncio
INTRODUCTION: Tuberculosis (TB) is the most common infectious disease in the world. We aimed to analyze the spatial risk of tuberculosis mortality and to verify associations in high-risk areas with social vulnerability. METHODS: This was an ecological study. The scan statistic was used to detect areas at risk, and the Bivariate Moran Index was used to verify relationships between variables. RESULTS: High-risk areas of tuberculosis mortality were statistically significantly associated with domain 2 of the Social Vulnerability Index (I=0...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160511/the-importance-of-audiometric-monitoring-in-patients-with-multidrug-resistant-tuberculosis
#9
Karla Anacleto de Vasconcelos, Silvana Maria Monte Coelho Frota, Antonio Ruffino-Netto, Afrânio Lineu Kritski
INTRODUCTION: A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patients treated for MDR-TB and to identify associations between these complaints and the type of aminoglycoside used...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160484/critical-points-for-the-control-of-tuberculosis-on-primary-health-care
#10
Patrícia Geórgia Oliveira Diniz Pinheiro, Lenilde Duarte de Sá, Pedro Fredemir Palha, Rita de Cássia Cordeiro de Oliveira, Jordana de Almeida Nogueira, Tereza Cristina Scatena Villa
OBJECTIVE: To analyze the discourses of professionals that work on the reference service about the critical points that affects the essential attributes of the Primary Health Care (PHC) related to the control of tuberculosis in the city of João Pessoa. METHOD: The empirical material collected from August to October in 2014, through the interview technique was analyzed through the methodological-theoretical framework of French Discourse Analysis. RESULTS: The discourses demonstrated the critical points on the control of the disease on PHC as being the lack of bond and welcoming from the professionals in relation to patients with tuberculosis...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160448/availability-of-essential-medicines-in-primary-health-care-of-the-brazilian-unified-health-system
#11
Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Isabel Cristina Gomes, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio
OBJECTIVE: To characterize the availability of tracer medicines in pharmaceutical services in primary health care of the Brazilian Unified Health System (SUS). METHODS: This is a cross-sectional and evaluative study, part of the Pesquisa Nacional Sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). To analyze the availability of medicines, we verified 50 items selected from the Relação Nacional de Medicamentos Essenciais (Rename - National List of Essential Medicines) of 2012...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160445/epidemiological-profile-of-tuberculosis-in-s%C3%A3-o-paulo-municipality-from-2006-to-2013
#12
Priscila Fernanda Porto Scaff Pinto, Cássio Silveira, Maria Josefa Penon Rujula, Francisco Chiaravalloti, Manoel Carlos Sampaio de Almeida Ribeiro
BACKGROUND: Tuberculosis is a serious public health problem that still persists in the world and in Brazil. The municipality of São Paulo, Brazil, is among the prioritized ones in the country for disease control. OBJECTIVE: To describe the epidemiological profile of all new tuberculosis cases in São Paulo municipality reported between the years 2006 and 2013. METHODS: The variables selected for the study were: socioeconomic, demographic and clinical-epidemiologic obtained through the online information system TB-WEB...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29160384/current-use-and-acceptability-of-novel-diagnostic-tests-for-active-tuberculosis-a-worldwide-survey
#13
Massimo Amicosante, Lia D'Ambrosio, Marcela Munoz, Fernanda Carvalho de Queiroz Mello, Marc Tebruegge, Novel Njweipi Chegou, Fouad Seghrouchni, Rosella Centis, Delia Goletti, Graham Bothamley, Giovanni Battista Migliori
OBJECTIVE: To determine the current use and potential acceptance (by tuberculosis experts worldwide) of novel rapid tests for the diagnosis of tuberculosis that are in line with World Health Organization target product profiles. METHODS: A multilingual survey was disseminated online between July and November of 2016. RESULTS: A total of 723 individuals from 114 countries responded to the survey. Smear microscopy was the most commonly used rapid tuberculosis test (available to 90...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29159817/long-term-safety-of-adalimumab-in-clinical-trials-in-adult-patients-with-crohn-s-disease-or-ulcerative-colitis
#14
J-F Colombel, W J Sandborn, W Reinisch, L Peyrin-Biroulet, R Panaccione, P Rutgeerts, S B Hanauer, S Ghosh, G Van Assche, A M Robinson, W Lau, J-F Maa, B Huang, B Pappalardo, H Read
BACKGROUND: Adalimumab is used to treat moderate to severe Crohn's disease (CD) and ulcerative colitis (UC) when conventional therapies fail. AIM: To update long-term adalimumab safety from CD and UC trials; the previous report was CD only, 3160 patients/3402 patient-years (PYs). METHODS: Treatment-emergent adverse events (AEs; first dose to 70 days after last dose/December 31, 2015) in adults in phase 2/3 and 3/3b trials and open-label extensions were coded using Medical Dictionary for Regulatory Activities (MedDRA-v18...
November 21, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29159788/the-fight-against-tuberculosis-in-the-mid-nineteenth-century-the-pivotal-contribution-of-edoardo-maragliano-1849-1940
#15
Mariano Martini, Ilaria Barberis, Nicola Luigi Bragazzi, Filippo Paluan
The second half of the nineteenth century saw the development of new medical "specialties", which, like the idea of constitutional disease, had a profound influence on medical practice. Against this lively "backdrop", Edoardo Maragliano played a central role in medicine's "renaissance" in Italy. Having graduated in medicine in 1870 at the University of Naples, he worked as an assistant in the University Medical Clinic. After beginning his academic career as professor of pathology at the Faculty of Medicine in Genoa in 1877, he became full professor of internal medicine in 1881...
November 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29159029/case-report-unusual-cause-of-difficulty-in-intubation-and-ventilation-with-asthmatic-like-presentation-of-endobronchial-tuberculosis
#16
S Praveena Seevaunnamtum, Nazhan Afeef Mohd Ariff Ghazali, Wan Mohd Nazaruddin, Alwi Muhd Besari, N H Nik Fariza, Sanihah Che Omar, Saedah Ali, M Z Rhendra Hardy, Mohd Erham Mat Hassan, N M Nik Abdullah
Endobronchial Tuberculosis is hazardous in causing circumferential narrowing of tracheobronchial tree despite the eradication of tubercle bacilli in the initial insult from Pulmonary Tuberculosis. They may present as treatment resistant bronchial asthma and pose challenge to airway management in the acute setting. We present a 25 year-old lady who was newly diagnosed bronchial asthma with a past history of Pulmonary Tuberculosis that had completed treatment. She presented with sudden onset of difficulty breathing associated with noisy breathing for 3 days and hoarseness of voice for 6 months...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29158866/-tb-hiv-co-infection-associated-with-kaposi-s-sarcoma-under-opioid-substitution-treatment-using-methadone-about-a-case
#17
Viviane Marie Pierre Cisse Diallo, Louise Fortes Deguenonvo, Khardiata Diallo Mbaye, Daye Ka, Ndeye Aissatou Lakhe, Ibrahima Ndiaye, Daouda Thioub, Sylvie Audrey Diop Nyafouna, Aminata Massaly, Alassane Dièye, Moustapha Diop, Cheikh Tidiane Ndour, Moussa Seydi
Late diagnosis of HIV infection can be fatal because it favors the appearance of opportunistic infections whose management requires the use of several molecules which can cause drug interactions. We report the case of a 45-year old female patient under heroin substitution treatment, using methadone and with HIV1 under antiretroviral treatment. This patient had nonspecific pulmonary appearance associated with dry nagging cough and progressive dyspnea evolving in a feverish context. Moreover, clinical examination showed left lower limb lymphedema with painless angiomatous nodules evolving over three years associated with plaques, angiomatous nodules occurred more recently at the level of the anterior face of the thorax...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29158404/cd1b-restricted-gem-t-cell-responses-are-modulated-by-mycobacterium-tuberculosis-mycolic-acid-meromycolate-chains
#18
Andrew Chancellor, Anna S Tocheva, Chris Cave-Ayland, Liku Tezera, Andrew White, Juma'a R Al Dulayymi, John S Bridgeman, Ivo Tews, Susan Wilson, Nikolai M Lissin, Marc Tebruegge, Ben Marshall, Sally Sharpe, Tim Elliott, Chris-Kriton Skylaris, Jonathan W Essex, Mark S Baird, Stephan Gadola, Paul Elkington, Salah Mansour
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major human pandemic. Germline-encoded mycolyl lipid-reactive (GEM) T cells are donor-unrestricted and recognize CD1b-presented mycobacterial mycolates. However, the molecular requirements governing mycolate antigenicity for the GEM T cell receptor (TCR) remain poorly understood. Here, we demonstrate CD1b expression in TB granulomas and reveal a central role for meromycolate chains in influencing GEM-TCR activity. Meromycolate fine structure influences T cell responses in TB-exposed individuals, and meromycolate alterations modulate functional responses by GEM-TCRs...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29158273/revisiting-activation-of-and-the-mechanism-of-resistance-to-the-compound-iqg-607-in-mycobacterium-tuberculosis
#19
Bruno L Abbadi, Anne D Villela, Valnês S Rodrigues-Junior, Fernanda T Subtil, Pedro F Dalberto, Ana P S Pinheiro, Diógenes S Santos, Pablo Machado, Luiz A Basso, Cristiano V Bizarro
IQG-607 is a metal complex previously reported as a promising anti-TB drug against isoniazid (INH)-resistant strains of M. tuberculosis Unexpectedly, we found that INH-resistant clinical isolates were resistant to IQG-607. Spontaneous mutants resistant to IQG-607 were subjected to whole-genome sequencing and all sequenced colonies carried alterations in the katG gene. The katG(S315T) mutation was sufficient to confer resistance to IQG-607 in both MIC assays and inside macrophages. Moreover, overexpressing the InhA(S94A) protein caused IQG-607's resistance...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158203/p2x7-receptor-in-spinal-tuberculosis-gene-polymorphisms-and-protein-levels-in-chinese-han-population
#20
Ying Zhou, Chun-Yan Tan, Zhi-Jiang Mo, Qi-le Gao, Dan He, Jiong Li, Rong-Fu Huang, Yan-Bing Li, Chao-Feng Guo, Qiang Guo, Long-Jie Wang, Guan-Teng Yang, Hong-Qi Zhang
Spinal tuberculosis (TB) accounts for 1%-5% of all TB infections. Host genetic variation influences susceptibility to Mycobacterium tuberculosis (MTB). P2X7 receptor (P2X7R) expressed on cells has been identified as a regulatory molecule in cell death/apoptosis, killing of intercellular pathogens, and bone turnover. This study investigated the P2X7 gene polymorphisms and protein levels in spinal TB. P2X7 gene -762C>T and 489C>T polymorphisms were genotyped. The expression of P2X7R in bone or intervertebral disc (ID) tissues was analyzed by Western blot assay...
November 17, 2017: Infection, Genetics and Evolution
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