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REVIEW
Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji, Tao Wu
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders worldwide, characterized by chronic abdominal pain or discomfort and altered bowel habits. To date, the exact pathogenesis of IBS remains elusive, but is clearly multifactorial, including environmental and host factors. However, the management of patients with IBS is challenging and the current diagnostic and therapeutic modalities have unsatisfactory outcomes. Therefore, it is important to develop more effective methods to diagnose IBS early...
August 19, 2023: International Immunopharmacology
#22
REVIEW
Francesco Amati, Gabriele Bongiovanni, Antonio Tonutti, Francesca Motta, Anna Stainer, Giuseppe Mangiameli, Stefano Aliberti, Carlo Selmi, Maria De Santis
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically characterized by vascular abnormalities and inflammatory and fibrotic involvement of the skin and internal organs resulting in high morbidity and mortality. The clinical phenotype of SSc is heterogeneous, and serum autoantibodies together with the extent of skin involvement have a predictive value in the risk stratification. Current recommendations include an organ-based management according to the predominant involvement with only limited individual factors included in the treatment algorithm...
August 21, 2023: Clinical Reviews in Allergy & Immunology
#23
JOURNAL ARTICLE
Chao Ma, Liang Mo, Zhangzheng Wang, Deqiang Peng, Chi Zhou, Wei Niu, Yuhao Liu, Zhenqiu Chen
Postmenopausal osteoporosis, a chronic condition that predominantly affects postmenopausal women, presents a significant impediment to their overall well-being. The condition arises from estrogen deficiency, leading to enhanced osteoclast activity. Salvia miltiorrhiza, a well-established Chinese herbal medicine with a history of clinical use for osteoporosis treatment, contains diverse active constituents that have shown inhibitory effects on osteoclast formation and bone loss. Dihydrotanshinone I (DTI), a phenanthrenonequinone compound derived from the root of Salvia miltiorrhiza, has been identified as a potential therapeutic agent, although its mechanism of action on osteoclasts remains elusive...
August 10, 2023: International Immunopharmacology
#24
REVIEW
Wang Bei, Jiang Qian, Qu Zilu, Chen Kai, Jiang Ruili, Hu Feng, Chen Liuqing
BACKGROUND: Immunosuppression is an integral part of treating chronic spontaneous urticaria (CSU), but there is no literature to evaluate the efficacy of multiple immunosuppressive agents. OBJECTIVE: The comparison of the efficacy, safety, and incidence of adverse effects of four immunosuppressive medicines (tripterygium glycosides, methotrexate, cyclosporine A, and azathioprine) in combination with antihistamines in treating CSU provides a clinical reference and evidence-based medicine for treating CSU...
August 9, 2023: International Immunopharmacology
#25
REVIEW
Fabiana Furci, Nicoletta Luxi, Gianenrico Senna, Gianluca Trifirò
PURPOSE OF REVIEW: To provide a better understanding of the risk of anaphylaxis due to antiallergic and antiasthmatic biologics through an analysis of data reported in literature and in clinical trials, and by conducting a retrospective descriptive analysis of individual case safety reports on VigiBase, the WHO International Pharmacovigilance database. RECENT FINDINGS: Analysis of the data, as described, demonstrated safety of the antiallergic and antiasthmatic biologics with a low incidence of anaphylaxis...
October 1, 2023: Current Opinion in Allergy and Clinical Immunology
#26
JOURNAL ARTICLE
Feng Sun, Qi Tang, Wei Cheng, Xi Xie, Fen Li, Jiali Chen
OBJECTIVE: This study aims to describe patients' characteristics and treatment responses with primary Sjögren's syndrome (pSS) who experience immune thrombocytopenia (ITP) and ITP with clinical significance (ITPCS). METHODS: A retrospective study was conducted involving 164 patients diagnosed with pSS-related ITP after excluding secondary ITP. Patients were categorized into subgroups based on the risk of bleeding: major bleeding event (MBG), non-hemorrhagic group (NHG), and hematological involvement-only SS group (HOSG)...
July 26, 2023: International Immunopharmacology
#27
Rochan Sharma, Pravin Bhat
Allergic Rhinitis is an immunological inflammatory response of the nasal mucosa to airborne allergens. Although Allergic Rhinitis is not a life-threatening disease, the symptoms of Allergic Rhinitis can be particularly bothersome and disruptive to a patient's sleep and overall quality of life. The coexistence of other allergic conditions like Asthma is very common. No satisfactory treatment is available in modern medicine for this disease. There is a need to search for satisfactory treatment available in another medical system...
July 19, 2023: Journal of Ayurveda and Integrative Medicine
#28
JOURNAL ARTICLE
Hsi Yen, Hsuan Yen, Chun-Hsien Huang, I-Hsin Huang, Wei-Kai Hung, Hsing-Jou Su, Cheng-Chen Tai, William W Y Haw, Carsten Flohr, Zenas Z N Yiu, Ching-Chi Chi
BACKGROUND: Management of urticaria can be optimized with clinical practice guidelines (CPGs). However, the quality of recent urticaria CPGs remains unclear. OBJECTIVE: To identify and appraise urticaria CPGs worldwide published in the last 5 years. METHODS: A search for relevant urticaria CPGs was conducted between January 1, 2017, and May 31, 2022, using the following databases: MEDLINE, Embase, National Institute for Health and Care Excellence (NICE) Evidence Search, Guidelines International Network, ECRI Guidelines Trust, Australian Clinical Practice Guidelines, Trip Medical Database, and DynaMed...
July 13, 2023: Journal of Allergy and Clinical Immunology in Practice
#29
REVIEW
Kiseleva Viktoriia, Vishnyakova Polina, Elchaninov Andrey, Fatkhudinov Timur, Sukhikh Gennady
Macrophages as innate immune cells with great plasticity are of great interest for cell therapy. There are two main macrophage populations - pro- and anti-inflammatory cells also known as M1 and M2. High potential in cancer research contributed to the in-depth study of the molecular processes leading to the polarization of macrophages into the M1 phenotype, and much less attention has been paid to anti-inflammatory M2 macrophages, which can be successfully used in cell therapy of inflammatory diseases. This review describes ontogenesis of macrophages, main functions of pro- and and-inflammatory cells and four M2 subpopulations characterized by different functionalities...
July 7, 2023: International Immunopharmacology
#30
REVIEW
Emily Robbins, Kirti Johal, Anjeni Keswani
PURPOSE OF REVIEW: The use of telemedicine has greatly increased since the onset of the coronavirus disease 2019 (COVID-19) pandemic. This review discusses the types of telemedicine, current telehealth curricula in medical education, and benefits and disadvantages of incorporation of telemedicine into Allergy/Immunology training programs. RECENT FINDINGS: The majority of Allergists/Immunologists use telemedicine in their clinical practice with leaders in graduate medical education recommending inclusion of telemedicine in training...
July 7, 2023: Current Allergy and Asthma Reports
#31
JOURNAL ARTICLE
Sofia Grigoria Athanasopoulou, Stephanie Leeds, Marc Auerbach
OBJECTIVES: Evidence-based guidelines have been created and disseminated by multiple organizations to standardize the care of pediatric patients with anaphylaxis. Differences across these guidelines can cause confusion and potentially errors in clinical practice leading to patient harm. The aim of this study was to describe and identify patterns of variation in the current guidelines. METHODS: A narrative review with 3 major components was designed. First, a narrative review of current, peer-reviewed, guidelines published by national and international allergy and immunology, pediatric, and emergency medicine organizations was performed...
June 26, 2023: Pediatric Emergency Care
#32
JOURNAL ARTICLE
Hitoshi Sasano, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, Kazuhisa Takahashi
BACKGROUND: Mepolizumab treatment improves symptom control and quality of life and reduces exacerbations in patients with severe eosinophilic asthma. However, biomarkers that predict therapeutic effectiveness must be determined for use in precision medicine. Herein, we elucidated the dynamics of various parameters before and after treatment as well as patient characteristics predictive of clinical responsiveness to mepolizumab after 1-year treatment. METHODS: Twenty-seven patients with severe asthma were treated with mepolizumab for one year...
June 17, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
#33
JOURNAL ARTICLE
Lijia Yuan, Yong Wang, Youlian Chen, Xiaoyin Chen, Shun Li, Xueyan Liu
Sepsis, a life-threatening condition whereby immune dysregulation develops, is one of the major causes of death worldwide. To date, there is still no clinically effective therapeutic method for sepsis. As a natural product from traditional Chinese medicine, Shikonin has been demonstrated to have pleiotropic medical effects, including anti-tumor, anti-inflammation, and relieving sepsis. PD-L1, as the receptor of PD-1, was also involved in exacerbating sepsis by inducing immunosuppression, but the relationship between them is still unclear...
June 9, 2023: International Immunopharmacology
#34
JOURNAL ARTICLE
Alexandra R Sitarik, Ganesa Wegienka, Christine C Johnson, Christine L M Joseph
BACKGROUND: Race-correction for Black patients is standard practice in spirometry testing. History suggests that these corrections are at least partially a result of racist assumptions regarding lung anatomy among Black individuals, which can potentially lead to less frequent diagnoses of pulmonary diseases in this population. OBJECTIVE: The purpose of this study was to evaluate the impact of race-correction in spirometry testing among Black and White pre-adolescents, and examine the frequency of current asthma symptoms in Black children who were differentially classified depending on whether race-corrected or uncorrected reference equations were deployed...
June 8, 2023: Journal of Allergy and Clinical Immunology in Practice
#35
REVIEW
Matthew Greenhawt, Timothy E Dribin, Elissa M Abrams, Marcus Shaker, Derek K Chu, David Bk Golden, Cem Akin, Akterini Anagnostou, Faisal ALMuhizi, Waleed Alqurashi, Peter Arkwright, James L Baldwin, Aleena Banerji, Philippe Bégin, Moshe Ben-Shoshan, Jonathan Bernstein, Theresa A Bingeman, Carsten Bindslev-Jensen, Kim Blumenthal, Aideen Byrne, Julia Cahil, Scott Cameron, Dianne Campbell, Ronna Campbell, Michael Cavender, Edmond S Chan, Sharon Chinthrajah, Pasquale Comberiatti, Jacqueline J Eastman, Anne K Ellis, David M Fleischer, Adam Fox, Pamela A Frischmeyer-Guerrerio, Remi Gagnon, Lene H Garvey, Mitchell H Grayson, Ghislaine Annie Clarisse Isabwe, Nicholas Hartog, David Hendron, Caroline C Horner, Johnathan O'B Hourihane, Edward Iglesia, Manstein Kan, Blanca Kaplan, Constance H Katelaris, Harold Kim, John M Kelso, David A Kahn, David Lang, Dennis Ledford, Michael Levin, Jay A Lieberman, Richard Loh, Douglas P Mack, Bruce Mazer, Ketan Mody, Gissele Mosnaim, Daniel Munblit, S Shahzad Mustafa, Anil Nanda, Richard Nathan, John Oppenheimer, Iris M Otani, Miguel Park, Ruby Pawankar, Kirsten P Perrett, Jonny Peter, Elizabeth J Phillips, Matthieu Picard, Mitchell Pitlick, Allison Ramsey, Trine Holm Rasmussen, Melinda M Rathkopf, Hari Reddy, Kara Robertson, Pablo Rodriguez Del Rio, Steven Sample, Ajay Sheshradi, Javed Shiek, Sayantani B Sindher, Jonathan M Spergel, Cosby A Stone, David Stukus, Mimi Lk Tang, James M Tracy, Paul J Turner, Timothy K Vander Leek, Dana V Wallace, Julie Wang, Susan Wasserman, David Weldon, Anna R Wolfson, Margitta Worm, Mona-Rita Yacoub
This guidance updates 2021 GRADE recomendations regarding immediate allergic reactions following COVID-19 vaccines and addresses re-vaccinating individuals with 1st dose allergic reactions and allergy testing to determine re-vaccination outcomes. Recent meta-analyses assessed the incidence of severe allergic reactions to initial COVID-19 vaccination, risk of mRNA-COVID-19 re-vaccination after an initial reaction, and diagnostic accuracy of COVID-19 vaccine and vaccine excipient testing in predicting reactions...
June 7, 2023: Journal of Allergy and Clinical Immunology
#36
JOURNAL ARTICLE
Yang Yie Sio, Ping Shi, Sri Anusha Matta, Yu Ting Rachel Fok, Wen Chin Chiang, Yee-How Say, Fook Tim Chew
INTRODUCTION: The arachidonic acid (AA) pathway plays a crucial role in allergic inflammatory diseases; however, the functional roles of allergy-associated single nucleotide polymorphisms (SNPs) in this pathway remain incompletely illustrated. METHODS: This study belongs to a part of an ongoing Singapore/Malaysia cross-sectional genetics and epidemiological study (SMCSGES). We performed population genotyping on n = 2,880 individuals from the SMCSGES cohort to assess the associations of SNPs in the AA pathway genes with asthma and allergic rhinitis (AR)...
May 10, 2023: International Archives of Allergy and Immunology
#37
JOURNAL ARTICLE
Kamran Mansouri, Gelavizh Rostaminasab, Touraj Ahmadi Jouybari, Masood Bagheri
Post refractive corneal ulcers is a disastrous complication, can affect healthy individuals, is cumbersome to treat, and sometimes has a poor prognosis with corneal scarring. Accurate diagnosis and prompt treatment of corneal infection is very important; however, until now, there has been no specific protocol for the management of this common eye disease and severe cases may require a corneal transplant. The patient is a 42-year-old male who suffered a corneal ulcer after photo refractive keratectomy (PRK) surgery in which the cornea was completely destroyed...
May 14, 2023: International Immunopharmacology
#38
JOURNAL ARTICLE
Marwa M Khalaf, Mahmoud M El-Sayed, Mohamed A Kandeil, Sanaa Ahmed
Parkinson's disease (PD) drugs treat symptoms without inhibiting progression. In recent years, finding novel therapeutic medications that can halt disease progression has become crucial. Research on antidiabetic medicines is valuable in these investigations because of the parallels between the two disorders. Using Rotenone (ROT), a frequently used PD model, the possible neuroprotective benefits of Dulaglutide (DUL), an extended-acting glucagon-like peptide-1 agonist, were considered. Twenty-four rats were randomly assigned to 4 groups to complete this experiment (n = 6)...
April 17, 2023: International Immunopharmacology
#39
JOURNAL ARTICLE
Eric E Low, Qingyuan Song, Rena Yadlapati, Evan S Dellon, Seema Aceves, Lin Liu, Samir Gupta, Yash A Choksi, Shailja C Shah
BACKGROUND & AIMS: Gaps remain in understanding the epidemiology of eosinophilic esophagitis (EoE). Our aim was to identify and validate a national cohort of individuals with EoE utilizing Veterans Health Administration (VHA) data. METHODS: We used two validation strategies to develop algorithms that identified adults with EoE between 1999-2020. The first validation strategy applied International Classification of Diseases (ICD) code algorithms to a base cohort of individuals who underwent esophagogastroduodenoscopy with esophageal biopsies...
April 7, 2023: Clinical Gastroenterology and Hepatology
#40
JOURNAL ARTICLE
Zhengjun Zhou, You Zhou, Zhengxuan Huang, Ming Wang, Jie Jiang, Min Yan, Wei Xiang, Shenjie Li, Yang Yu, Ligang Chen, Jie Zhou, Wei Dong
Over the past few decades, clinicians and experts applied kinds of therapies for patients with malignant gliomas such as chemotherapy, radiation or surgical extraction. However, they used to ignore the real seriousness of neuropsychiatric symptoms after glioma, including cognitive dysfunction, anxiety, and depression, which severely impeded patients' recovery and prognosis. Interestingly, one of our previous clinical studies have found some behavioral symptoms in glioma patients were associated with systemic inflammation...
March 31, 2023: International Immunopharmacology
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