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clinical immunology allergy internal medicine

Aziz Bousfiha, Leïla Jeddane, Waleed Al-Herz, Fatima Ailal, Jean-Laurent Casanova, Talal Chatila, Mary Ellen Conley, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, H Bobby Gaspar, Steven M Holland, Christoph Klein, Shigeaki Nonoyama, Hans D Ochs, Eric Oksenhendler, Capucine Picard, Jennifer M Puck, Kathleen E Sullivan, Mimi L K Tang
There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences...
November 2015: Journal of Clinical Immunology
David Price, Guy Brusselle, Nicolas Roche, Daryl Freeman, Alison Chisholm
EDUCATIONAL AIMS: To improve understanding of: The relative benefits and limitations of evidence derived from different study designs and the role that real-life asthma studies can play in addressing limitations in the classical randomised controlled trial (cRCT) evidence base.The importance of guideline recommendations being modified to fit the populations studied and the model of care provided in their reference studies. KEY POINTS: Classical randomised controlled trials (cRCTs) show results from a narrow patient group with a constrained ecology of care...
March 2015: Breathe
David R Stukus, Todd Green, Shari V Montandon, Kara J Wada
BACKGROUND: Allergic conditions have high prevalence in the general population. Misconceptions regarding the diagnosis and management of allergic disease among physicians can lead to suboptimal clinical care. OBJECTIVE: To determine the extent of allergy-related knowledge deficits among physicians. METHODS: Pediatric and internal medicine resident and attending physicians from 2 separate academic medical centers were asked to answer an anonymous electronic survey...
July 2015: Annals of Allergy, Asthma & Immunology
Luciana Kase Tanno, Moises A Calderon, Bruce J Goldberg, Cezmi A Akdis, Nikolaos G Papadopoulos, Pascal Demoly
BACKGROUND: Although efforts to improve the classification of hypersensitivity/allergic diseases have been made, they have not been considered a top-level category in the International Classification of Diseases (ICD)-10 and still are not in the ICD-11 beta phase linearization. ICD-10 is the most used classification system by the allergy community worldwide but it is not considered as appropriate for clinical practice. The Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) on the other hand contains a tightly integrated classification of hypersensitivity/allergic disorders based on the EAACI/WAO nomenclature and the World Health Organization (WHO) may plan to align ICD-11 with SNOMED CT so that they share a common ontological basis...
2014: Clinical and Translational Allergy
Oliver Pfaar, Ludger Klimek, Roy Gerth van Wijk
PURPOSE OF REVIEW: The purpose of this review is to provide a current overview on both primary and secondary measures of efficacy of therapeutic interventions for clinical trials in allergic rhinoconjunctivitis (ARC) patients. In particular, this review highlights similarities and differences regarding endpoints in trials involving allergen immunotherapy (AIT), pharmacotherapy and allergen avoidance and addresses unmet needs regarding these measures in the future. RECENT FINDINGS: In 2014, the European Academy of Allergy and Clinical Immunology (EAACI) proposed a standard for the definition of the primary endpoint for AIT trials in ARC and, moreover, emphasized the advantages and disadvantages as well as unmet needs considering outcome measures for this treatment...
June 2015: Current Opinion in Allergy and Clinical Immunology
Y T Chan, H K Ho, Christopher K W Lai, C S Lau, Y L Lau, T H Lee, T F Leung, Gary W K Wong, Y Y Wu
Many children in Hong Kong have allergic diseases and epidemiological data support a rising trend. Only a minority of children will grow out of their allergic diseases, so the heavy clinical burden will persist into adulthood. In an otherwise high-quality health care landscape in Hong Kong, allergy services and training are a seriously unmet need. There is one allergy specialist for 1.5 million people, which is low not only compared with international figures, but also compared with most other specialties in Hong Kong...
February 2015: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Jan Willem Cohen Tervaert, Cees G M Kallenberg
Clinical immunology is in the Netherlands a separate clinical specialty within internal medicine and pediatrics. Clinical immunologists work closely together with nephrologists, rheumatologists and many other medical specialists. Apart from research and teaching, clinical immunologists are taking care of patients with immune-deficiencies, vasculitides and systemic auto-immune diseases. Clinical immunology in the Netherlands has always been an important contributor to basic and clinical science in the Netherlands...
December 2014: Immunology Letters
Camillo Ribi, Marten Trendelenburg, Angèle Gayet-Ageron, Clemens Cohen, Eric Dayer, Ute Eisenberger, Thomas Hauser, Thomas Hunziker, Annette Leimgruber, Gregor Lindner, Katrin Koenig, Petra Otto, François Spertini, Thomas Stoll, Johannes Von Kempis, Carlo Chizzolini
OBJECTIVES: To describe disease characteristics and treatment modalities in a multidisciplinary cohort of systemic lupus erythematosus (SLE) patients in Switzerland. METHODS: Cross-sectional analysis of 255 patients included in the Swiss SLE Cohort and coming from centres specialised in Clinical Immunology, Internal Medicine, Nephrology and Rheumatology. Clinical data were collected with a standardised form. Disease activity was assessed using the Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI), an integer physician's global assessment score (PGA) ranging from 0 (inactive) to 3 (very active disease) and the erythrocyte sedimentation rate (ESR)...
2014: Swiss Medical Weekly
Krzysztof Gomułka, Bernard Panaszek
In the group of urticaria, contact urticaria syndrome is a particular variety. In these patients, appearance of typical skin lesions is preceded by contact of the skin and mucous membranes with various inhaled allergens, nutrients or contact details. Furthermore, symptoms connected with contact urticaria syndrome are characterized by gradual, stepwise waveform, which can be easily generalized - patients may develop systemic symptoms similar to those found in the angioedema, asthma or anaphylactic shock. It is an attribute of contact urticaria syndrome in the course of which potentially life-threatening symptoms may develop after contact of the skin with the allergen...
May 2014: Postȩpy Dermatologii i Alergologii
Carlo Selmi
Clinicians are facing unexpected issues in everyday practice, and these may become counterintuitive or challenging. Illustrative examples are provided by the hypersensitivity to universally used immunosuppressants such as corticosteroids or antibiotics such as beta-lactam. Secondly, additional issues are represented by the discovery of new pathogenetic mechanisms involved in rheumatoid and psoriatic arthritis or other chronic inflammatory diseases, genomic susceptibility to enigmatic diseases such as giant cell arteritis, or the shared role of specific mediators such as semaphorins...
August 2014: Clinical Reviews in Allergy & Immunology
T Zuberbier, W Aberer, R Asero, C Bindslev-Jensen, Z Brzoza, G W Canonica, M K Church, L F Ensina, A Giménez-Arnau, K Godse, M Gonçalo, C Grattan, J Hebert, M Hide, A Kaplan, A Kapp, A H Abdul Latiff, P Mathelier-Fusade, M Metz, S S Saini, M Sánchez-Borges, P Schmid-Grendelmeier, F E R Simons, P Staubach, G Sussman, E Toubi, G A Vena, B Wedi, X J Zhu, A Nast, M Maurer
This methods report describes the process of guideline development in detail. It is the result of a systematic literature review using the 'Grading of Recommendations Assessment, Development and Evaluation' (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the EU-funded network of excellence, the Global Allergy and Asthma European Network (GA(2) LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of delegates of 21 national and international societies...
July 2014: Allergy
Bruce S Edwards, Kristine Gouveia, Tudor I Oprea, Larry A Sklar
The University of New Mexico Center for Molecular Discovery (UNMCMD) is an academic research center that specializes in discovery using high throughput flow cytometry (HTFC) integrated with virtual screening, as well as knowledge mining and drug informatics. With a primary focus on identifying small molecules that can be used as chemical probes and as leads for drug discovery, it is a central core resource for research and translational activities at UNM that supports implementation and management of funded screening projects as well as "up-front" services such as consulting for project design and implementation, assistance in assay development and generation of preliminary data for pilot projects in support of competitive grant applications...
March 2014: Combinatorial Chemistry & High Throughput Screening
Takanori Imai, Motohiro Ebisawa
BACKGROUND: Oral Food Challenge (OFC) has been covered by medical insurance and has been acknowledged as a standardized method for diagnosis of food allergies. After 5 years have passed, we would clarify the state of achievement for OFC, list up the problems, and produce the basic information for the policies in our future. METHOD: The investigation had been done toward allergic specialists for Japanese Society of Allergology and the members of Japanese Society of Pediatric Allergy and Clinical Immunology...
June 2013: Arerugī, [Allergy]
Carlo Selmi, Chiara Crotti, Pier Luigi Meroni
Allergy and clinical immunology are examples of areas of knowledge in which working hypotheses are dominant over mechanistic understanding. As such, sometimes scientific efforts follow major streams and overlook some epidemiologically prevalent conditions that thus become underestimated by the research community. For this reason, we welcome the present issue of Clinical Reviews in Allergy and Immunology that is dedicated to uncommon themes in clinical immunology and allergy. First, comprehensive discussions are provided for allergy phenomena of large potential impact in clinical practice such as reactions to cephalosporins or aspirin-induced asthma and in everyday life such as allergies to food additives or legumes...
August 2013: Clinical Reviews in Allergy & Immunology
Ruby Pawankar, Carlos E Baena-Cagnani, Jean Bousquet, G Walter Canonica, Alvaro A Cruz, Michael A Kaliner, Bobby Q Lanier
It is widely recognized that the incidence of allergies and allergic diseases is on the rise globally. As an international umbrella organization for regional and national allergy and clinical immunology societies, the World Allergy Organization is at the forefront of a combined united effort across nations and organizations to address this global concern by promoting the science of allergy and clinical immunology, and advancing exchange of information.The World Allergy Organization's State of World Allergy Reports will provide a biennial review of allergic diseases worldwide, consider their medical and socioeconomic contexts, and propose effective approaches to addressing these problems...
June 2008: World Allergy Organization Journal
Vikram Deshpande, Yoh Zen, John Kc Chan, Eunhee E Yi, Yasuharu Sato, Tadashi Yoshino, Günter Klöppel, J Godfrey Heathcote, Arezou Khosroshahi, Judith A Ferry, Rob C Aalberse, Donald B Bloch, William R Brugge, Adrian C Bateman, Mollie N Carruthers, Suresh T Chari, Wah Cheuk, Lynn D Cornell, Carlos Fernandez-Del Castillo, David G Forcione, Daniel L Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Gregory Y Lauwers, Yasufumi Masaki, Yasuni Nakanuma, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant V Sahani, Thomas C Smyrk, James R Stone, Masayuki Takahira, George J Webster, Motohisa Yamamoto, Giuseppe Zamboni, Hisanori Umehara, John H Stone
IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: a tendency to form tumefactive lesions in multiple sites; a characteristic histopathological appearance; and-often but not always-elevated serum IgG4 concentrations. An international symposium on IgG4-related disease was held in Boston, MA, on 4-7 October 2011. The organizing committee comprising 35 IgG4-related disease experts from Japan, Korea, Hong Kong, the United Kingdom, Germany, Italy, Holland, Canada, and the United States, including the clinicians, pathologists, radiologists, and basic scientists...
September 2012: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Jasna Lipozencić, Branka Marinović, Petra Turcić, Sanja Gregurić
Emergencies in allergology and clinical immunology are quite common and pose a public health problem in Croatia and worldwide. Allergic reactions ranging from mild symptoms such as pruritus to generalized skin eruptions, gastrointestinal and respiratory symptoms to anaphylaxis with cardiovascular emergencies are very common. Reaction develops to inhalant substances, food and food ingredients, various foreign substances (blood, latex, etc.) and many other well known antigens and drugs which are frequent causes of anaphylactic reactions, asthma, generalized urticaria, angioedema...
2011: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Markus Maeurer
This year will see the full-scale roll-out of the LifeGene study. Coordinated by the Karolinska Institutet (Stockholm, Sweden), the project looks set to be one of the largest health studies performed in the world, aiming to enroll 500,000 Swedes in order to determine the relationship between disease and environmental, lifestyle and hereditary factors. International experts from a broad spectrum of scientific fields will collaborate on this project, including Mark Maeurer, Chair of the infections working group in LifeGene (www...
September 2010: Expert Review of Clinical Immunology
Jozélio Freire de Carvalho, Rosa Maria Rodrigues Pereira, M Eric Gershwin
Approximately 1 in 31 people suffers from an autoimmune disease. The clinical care of patients with autoimmunity crosses multiple disciplines within pediatrics and internal medicine, including, forexample, allergy-clinical immunology, rheumatology, nephrology, hematology, pulmonology and neurology. There are two major areas that are considered in the analysis of autoimmunity in human patients. The first of course is etiology and the second, and of even greater importance, is therapy. Towards that end, considerable attention has focused on the role of hematopoietic stem cell transplantation to either reverse or modulate autoimmune disease...
October 2009: Israel Medical Association Journal: IMAJ
L Maródi, J L Casanova
Primary immunodeficiencies (PIDs) are often recognized in adults, either because of delayed diagnosis of a paediatric illness, or increasingly because of the recognition of adult onset forms of these diseases. Moreover, a growing fraction of children diagnosed with PIDs reach adulthood. It has become clear that many of these conditions affect various organs and therefore will be referred to professionals from various fields of internal medicine. It is well known that infectious diseases, allergy, auto-immunity and cancer may result from PIDs...
December 2009: Journal of Internal Medicine
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