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Intersexuality in newborn

Cynthia Kraus
The groundbreaking and prophetic rhetoric of neuroscience has recently highlighted the fetal brain as the most promising organ for understanding why transsexuals feel "trapped in the wrong body", and for predicting whether children born with "ambiguous" genitalia will grow up to feel like a man or a woman.This article proposes a recent history of the cerebralization of intersexuality and of transsexuality as atypical neurodevelopmental conditions. It examines the ways in which the organizational theory of brain sex differentiation developed in the late 1950s in behavioral neuroendocrinology has gained increased prominence in and through controversies over best practice issues in the case management of intersex newborns, and the etiology of transsexuality...
2011: Gesnerus
Gönül Öçal
Disorders of sex development (DSD) with or without ambiguous genitalia require medical attention to reach a definite diagnosis. Advances in identification of molecular causes of abnormal sex, heightened awareness of ethical issues and this necessitated a re-evaluation of nomenclature. The term DSD was proposed for congenital conditions in which chromosomal, gonadal or anatomical sex is atypical. In general, factors influencing sex determination are transcriptional regulators, whereas factors important for sex differentiation are secreted hormones and their receptors...
2011: Journal of Clinical Research in Pediatric Endocrinology
Anke Lux, Siegfried Kropf, Eva Kleinemeier, Martina Jürgensen, Ute Thyen
BACKGROUND: The German Network of Disorders of Sex Development (DSD)/Intersexuality carried out a large scale clinical evaluation study on quality of life, gender identity, treatment satisfaction, coping, and problems associated with diagnoses and therapies in individuals with disorders of sex development (DSD). DSD are a heterogeneous group of various genetic disorders of sex determination or sex differentiation, all of which are rare conditions. In about half of all cases the molecular genetic diagnosis is unknown and diagnosis rests on clinical features...
2009: BMC Public Health
Paula Machado
This paper reports of the socio-medical management of intersexuality in a teaching hospital in southern Brazil. Findings reveal that the 'search for sex' in the body treats sex as a medical-diagnostic category constructed during decision-making negotiations. In the course of the various bodily 'regulations' and 'corrections' imposed, the insufficiency of a model in which categories are based around a sexual dichotomy is revealed. By questioning this dichotomy, it is possible to examine theoretical and ethical limits circumscribing the field of bioethics and the notion of sexual rights as human rights...
April 2009: Culture, Health & Sexuality
Jeong Rae Rho, Robert Baxter Srygley, Jae Chun Choe
We investigated mutual grooming by Jeju pony (Equus caballus) foals to determine whether male foals preferentially interact with potential future sexual partners or competitors. We predicted that relative to female foals, male foals would exchange grooming more frequently with young mares and that in general, foals would mutually groom more frequently with the opposite sex rather than the same sex. Observing 53 foals between April and October 1998, we recorded 113 mutual grooming events. Male foals exchanged grooming with yearling mares more frequently than with their mother, while female foals exchanged grooming with their mother more frequently than with yearling mares...
August 2007: Zoological Science
Durval Damiani, Gil Guerra-Júnior
Disorders of sex development have posed a tremendous challenge not only in the diagnosis but also in the treatment, placing the patient, the family members, and the health team in the difficult task of attributing the best sex of rearing for that specific patient. A confusing and stigmatizing nomenclature has been employed and the Chicago Consensus tried to minimize the discomfort with modifications of the current terminology. The authors perform a critical analysis of the Consensus, raising the question that the new terminology does not solve the problems and persist being stigmatizing to the patient and to the family...
August 2007: Arquivos Brasileiros de Endocrinologia e Metabologia
U Thyen, S Krege
No abstract text is available yet for this article.
September 2007: Der Urologe. Ausg. A
Manuel Nistal, José I Rodríguez, Eugenia García-Fernández, Mariana M Cajaiba, Miguel Reyes-Múgica
Fetal gonadoblastoid testicular dysplasia (FGTD) is an extremely rare lesion, which, in its original description, appeared in association with hydrops fetalis and other malformations. Its phenotype strongly resembles gonadoblastoma, although in contrast with that rare tumor, FGTD is not associated with the intersexual states or gonadal dysgenesis that accompany such neoplasm. Two reports described an association of FGTD and a morphologically similar lesion with Walker-Warburg syndrome. However, we have not confirmed such an observation, although a nonspecific muscle disorder was found in one of the examples we describe in this article...
July 2007: Pediatric and Developmental Pathology
Olaf Hiort, Ute Thyen, Paul-Martin Holterhus
Sex assignment of patients with disorders of somatosexual differentiation is a controversial topic. The aim is to enable the patient to develop a stable gender identity during childhood, adolescence and adulthood. Enormous advances have recently been made in our knowledge of the molecular mechanisms of sexual differentiation and it is understood that long-term outcome may depend on the underlying diagnosis. There is increasing evidence that genital development is dependent on the action of androgenic steroids; moreover, both androgens and oestrogens may have an impact on other developing organs including neuronal structures such as the brain...
2005: Hormone Research
Heino F L Meyer-Bahlburg
This review addresses the long-term gender outcome of gender assignment of persons with intersexuality and related conditions. The gender assignment to female of 46,XY newborns with severe genital abnormalities despite a presumably normal-male prenatal sex-hormone milieu is highly controversial because of variations in assumptions about the role of biological factors in gender identity formation. This article presents a literature review of gender outcome in three pertinent conditions (penile agenesis, cloacal exstrophy of the bladder, and penile ablation) in infancy or early childhood...
August 2005: Archives of Sexual Behavior
Sharon Sytsma
No abstract text is available yet for this article.
2004: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
Grace Hyun, Thomas F Kolon
Sexual determination is a complex process that occurs in an organized sequential manner. When chromosomal, gonadal, or phenotypic sex determination goes awry,intersexuality develops. Advances in molecular biology have made it easier to understand the various phenotypes that are encountered. It is easy to be overwhelmed when reviewing the testosterone synthesis pathway and the intersex differential diagnosis. This article presents a useful approach to the evaluation of the newborn with ambiguous genitalia.
August 2004: Urologic Clinics of North America
C Piró Biosca, L Audi Parera, M Feránndez Cancio, J A Martín Osorio, N Toran Fuentes, M Asensio Llorente, A Carrascosa Lezcano
The birth of a child with ambiguous genitalia represents a very stressing situation for the family, and afterwards has great social and psychological repercussion for the patient itself. Until now, the sex assignation is being done according to the phenotype. Now, with the molecular diagnosis of the genes that play a role in the sexual development, the assignation must also take into account the prognosis of response to androgens. The aim of this work is to review the 40 male pseudohermaphroditism cases controlled in our hospital and the genetic molecular diagnosis done in 19 cases, thus obtaining the certainty diagnosis...
April 2004: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Heino F L Meyer-Bahlburg, Curtis Dolezal, Susan W Baker, Ann D Carlson, Jihad S Obeid, Maria I New
Gender assignment of children with intersexuality and related conditions has recently become highly controversial. On the basis of extensive animal research and a few human case reports, some authors have proposed the putative masculinization of the brain by prenatal hormones-indicated by the degree of genital masculinization-as the decisive criterion of gender assignment and have derived the recommendation that 46,XX newborns with congenital adrenal hyperplasia (CAH) and full genital masculinization should be assigned to the male gender...
April 2004: Archives of Sexual Behavior
M Westenfelder
Treatment of intersexuality is demanding and requires experience and interdisciplinary cooperation. Preconditions for normal development and clear gender identification are correct (not emergency) diagnosis and gender assignment and adequate hormonal and surgical treatment. Surgery should be done early (6th to 15th month) as atraumatically as possible with cosmetically and functionally satisfying results. These preconditions are not met consistently, resulting in a 20-25% rate of mistakes in diagnosis and treatment...
April 2004: Der Urologe. Ausg. A
Knut Werner-Rosen
No abstract text is available yet for this article.
March 2002: Kinderkrankenschwester: Organ der Sektion Kinderkrankenpflege
No abstract text is available yet for this article.
1965: Urologia Internationalis
No abstract text is available yet for this article.
April 1964: Radiology
No abstract text is available yet for this article.
March 24, 1959: La Semaine des Hôpitaux: Organe Fondé Par L'Association D'enseignement Médical des Hôpitaux de Paris
No abstract text is available yet for this article.
January 1954: La Rassegna di Clinica, Terapia e Scienze Affini
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