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Davide Sattin, Caroline Schnakers, Marco Pagani, Francesca Arenare, Guya Devalle, Fabrizio Giunco, GianBattista Guizzetti, Maurizio Lanfranchi, Ambra M Giovannetti, Venusia Covelli, Anna Bersano, Anna Nigri, Ludovico Minati, Davide Rossi Sebastiano, Eugenio Parati, MariaGrazia Bruzzone, Silvana Franceschetti, Matilde Leonardi
Pain assessment in patients with disorders of consciousness (DoC) is a controversial issue for clinicians, who require tools and standardised procedures for testing nociception in non-communicative patients. The aims of the present study were, first, to analyse the psychometric properties of the Italian version of the Nociception Coma Scale and, second, to evaluate pressure pain thresholds in a group of patients with DoC. The authors conducted a multi-centre study on 40 healthy participants and 60 DoC patients enrolled from six hospitals in Italy...
February 28, 2017: Neuropsychological Rehabilitation
Adel Nefzi, Guya D Marconi, Maria A Ortiz, Jennifer C Davis, F Javier Piedrafita
Targeting the transcriptional activity of nuclear hormone receptors has proven an effective strategy to treat certain human diseases, and they have become a major focus point to develop novel therapies for the treatment of cancer, inflammation, autoimmune diseases, metabolic disorders, and others. One family of nuclear receptors that has attracted most interest in recent years is the retinoic acid receptor-related orphan receptors (RORs), in particular RORγ. RORγ is a critical regulator of the immune system and RORγ antagonists have shown activity in animal models of inflammatory autoimmune diseases...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
Elisa Barile, Guya D Marconi, Surya K De, Carlo Baggio, Luca Gambini, Ahmed F Salem, Manoj K Kashyap, Januario E Castro, Thomas J Kipps, Maurizio Pellecchia
Upregulation of antiapoptotic Bcl-2 proteins in certain tumors confers cancer cell resistance to chemotherapy or radiations. Members of the antiapoptotic Bcl-2 proteins, including Bcl-2, Mcl-1, Bcl-xL, Bcl-w, and Bfl-1, inhibit apoptosis by selectively binding to conserved α-helical regions, named BH3 domains, of pro-apoptotic proteins such as Bim, tBid, Bad, or NOXA. Five antiapoptotic proteins have been identified that interact with various selectivity with BH3 containing pro-apoptotic counterparts. Cancer cells present various and variable levels of these proteins, making the design of effective apoptosis based therapeutics challenging...
February 17, 2017: ACS Chemical Biology
Silvia Casarotto, Angela Comanducci, Mario Rosanova, Simone Sarasso, Matteo Fecchio, Martino Napolitani, Andrea Pigorini, Adenauer G Casali, Pietro D Trimarchi, Melanie Boly, Olivia Gosseries, Olivier Bodart, Francesco Curto, Cristina Landi, Maurizio Mariotti, Guya Devalle, Steven Laureys, Giulio Tononi, Marcello Massimini
OBJECTIVE: Validating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousness-the Perturbational Complexity Index (PCI)-in a benchmark population who could confirm the presence or absence of consciousness through subjective reports, and then applying the same index to patients with disorders of consciousness (DOCs)...
November 2016: Annals of Neurology
Muhsin Kaya, Şengül Baran, Cemil Güya, Mehmet Ali Kaplan
BACKGROUND AND AIMS: Splenic artery aneurysm (SAA) rarely occurs in the general population. Its increased incidence has been reported in cirrhosis. The aim of this retrospective study was to identify prevalence and predictive factor development of SAA in patients with cirrhosis. METHODS: All patients with cirrhosis who were treated in our clinics between 2010 and 2014 were included in the study. Demographic features and clinical and laboratory findings were reviewed...
May 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Jelena Blagojevic, Guya Piemonte, Laura Benelli, Francesca Braschi, Ginevra Fiori, Francesca Bartoli, Serena Guiducci, Silvia Bellando Randone, Felice Galluccio, Laura Cometi, Sergio Castellani, Maria Boddi, Alberto Moggi Pignone, Laura Rasero, Francesco Epifani, Marco Matucci-Cerinic
OBJECTIVE: To evaluate pathogenesis and clinical features of lower limb ulcers in systemic sclerosis (SSc) and to propose a classification that could be used in clinical practice. METHODS: Charts of 60 patients with SSc who had lower limb cutaneous lesions were reviewed. All patients had videocapillaroscopy and arterial and venous lower limb color Doppler ultrasonography (US). Arteriography was performed if occlusive peripheral arterial disease was suspected. RESULTS: The 554 lesions were classified as hyperkeratosis, ulcers, and gangrenes...
March 2016: Journal of Rheumatology
Andrea Mazzatenta, Guya D Marconi, Veronica Macchi, Andrea Porzionato, Amelia Cataldi, Camillo Di Giulio, Mieczyslaw Pokorski
The carotid body is a highly specialized chemoreceptive organ of neural crest origin whose role is to detect changes in arterial oxygen content. The sensory units are the chemoreceptor cells, which are neuronal-like cells, surrounded by sustentacular or glial-like cells. It is suggested that the carotid body contains self-renewing multipotent stem cells, which are putatively represented by glial-like sustentacular cells. The mechanisms of renewal of neuronal-like cells are unclear. Recently, we have demonstrated the expression of galanin, a peptide promoting neurogenesis, in chemoreceptor cells in the human CB...
2016: Advances in Experimental Medicine and Biology
Marianna De Colli, Paolo Tortorella, Guya Diletta Marconi, Mariangela Agamennone, Cristina Campestre, Marilena Tauro, Amelia Cataldi, Susi Zara
OBJECTIVES: Bisphosphonates (BPs) are drugs clinically used in resorptive diseases. It was already proved that some clinically relevant BPs can inhibit a class of enzymes called matrix metalloproteinases (MMPs), required during tissue remodelling. Combining the arylsulfonamide function with the bisphosphonic group, several compounds were synthesized to obtain selective inhibitors of MMPs. The aim of the present study was to compare the effect of zoledronic acid (ZA), the most potent bisphosphonate available as therapy, with new sulfonamide containing BPs in an in vitro model of human gingival fibroblasts (HGFs)...
November 2016: Clinical Oral Investigations
Camillo Di Giulio, Guya Diletta Marconi, Susi Zara, Andrea Di Tano, Andrea Porzionato, Mieczyslaw Pokorski, Amelia Cataldi, Andrea Mazzatenta
The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like cell numbers. We are interested in the signals involved in the mechanisms that underlie such response, because they are not well understood and described. Considering that, in literature, galanin is involved in neurotrophic or neuroprotective role in cell proliferation and is expressed in animal carotid body, we investigated its expression in human...
2015: Advances in Experimental Medicine and Biology
Njelembo J Mbewe, Cornelius Mweempwa, Samuel Guya, Florence N Wamwiri
Tsetse flies (Diptera: Glossinidae) are considered primary cyclical vectors that transmit pathogenic trypanosomes in Africa. They harbour a variety of microbes including Wolbachia, Sodalis and the salivary gland hypertrophy virus (SGHV) which are all vertically transmitted. Knowledge on tsetse microbiome and their interactions may identify novel strategies for tsetse fly and trypanosomiasis control. Area-wide application of such strategies requires an understanding of the natural microbiome frequency in the different species and subspecies of Glossina in their geographical populations...
June 30, 2015: Veterinary Parasitology
Vincenzo Luca Zizzari, Guya Diletta Marconi, Marianna De Colli, Susi Zara, Barbara Zavan, Vincenzo Salini, Antonella Fontana, Amelia Cataldi, Adriano Piattelli
OBJECTIVE: The aim of this study was to evaluate in vitro the behavior and the biocompatibility of primary human osteoblasts (HOs) grown onto different implant surface. METHODS AND MATERIALS: HOs were cultured onto sandblasted/acid-etched (control group) and sandblasted/acid-etched followed by coating with inorganic ions (test group) experimental titanium discs. At established times, SEM analysis, LDH assay, MTT assay, and enzyme-linked immunosorbent assay for type 1 collagen, interleukin (IL)-6, and PGE2 secretion were performed...
August 2015: Implant Dentistry
Andrea Mazzatenta, Guya D Marconi, Susi Zara, Amelia Cataldi, Andrea Porzionato, Camillo Di Giulio
The carotid body is a highly specialized chemoreceptive structure for the detection of and reaction to hypoxia, through induction of an increase in hypoxia inducible factor. As tissue hypoxia increases with aging and can have dramatic effects in respiratory depression induced by drug addiction, we investigated the carotid body in young and old healthy subjects in comparison with drug-addicted subjects, including the expression of the neurotransmitter galanin. Galanin expression was recently reported for neuronal-like cells of the human carotid body, and it is implicated in several functions in neurons...
2014: Frontiers in Physiology
Marianna De Colli, Susi Zara, Viviana di Giacomo, Antonia Patruno, Guya Diletta Marconi, Marialucia Gallorini, Vincenzo Luca Zizzari, Giulia Tetè, Amelia Cataldi
OBJECTIVES: The aim of our work was to evaluate the role of nitric oxide (NO) in the in vitro response of human gingival fibroblasts (HGFs) to 1, 5, 10, and 100 μM doses of zoledronic acid (ZA), a bisphosphonate largely used in the clinical practice and for which several adverse effects are reported. MATERIALS AND METHODS: Phase contrast microscopy and live/dead staining were used to evaluate HGFs morphology; cell viability, collagen type I and interleukin 6 (IL-6) secretion were evaluated by 3-[4,5-dimethyl-thiazol-2-yl-]-2,5-diphenyl tetrazolium bromide (MTT) and enzyme-linked immunosorbent assay (ELISA) assays...
July 2015: Clinical Oral Investigations
Carlo Abbate, Pietro D Trimarchi, Isabella Basile, Anna Mazzucchi, Guya Devalle
No abstract text is available yet for this article.
2014: Frontiers in Human Neuroscience
Guya Diletta Marconi, Susi Zara, Marianna De Colli, Valentina Di Valerio, Monica Rapino, Patrizia Zaramella, Arben Dedja, Veronica Macchi, Raffaele De Caro, Andrea Porzionato
Premature newborns are frequently exposed to hyperoxic conditions and experimental data indicate modulation of liver metabolism by hyperoxia in the first postnatal period. Conversely, nothing is known about possible modulation of growth factors and signaling molecules involved in other hyperoxic responses and no data are available about the effects of hyperoxia in postnatal liver haematopoiesis. The aim of the study was to analyse the effects of hyperoxia in the liver tissue (hepatocytes and haemopoietic cells) and to investigate possible changes in the expression of Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinase 9 (MMP-9), Hypoxia-Inducible Factor-1α (HIF-1α), endothelial Nitric Oxide Synthase (eNOS), and Nuclear Factor-kB (NF-kB)...
2014: PloS One
Susi Zara, Marianna De Colli, Monica Rapino, Valentina Di Valerio, Guya Diletta Marconi, Amelia Cataldi, Veronica Macchi, Raffaele De Caro, Andrea Porzionato
Premature newborns are frequently exposed to hyperoxia ventilation and some literature data indicate the possibility of hyperoxia-induced myocardial damage. Since nuclear factor κB (NF-κB) is a crucial signaling molecule involved in physiological response to hyperoxia in different cell types as well as in various tissues, our attention has been focused on the role played by NF-κB pathway in response to moderate and severe hyperoxia exposure in rat neonatal heart tissue. Akt and IκBα levels, involved in NF-κB activation, along with the balance between apoptotic and survival pathways have also been investigated...
November 2013: Histochemistry and Cell Biology
Federico Zara, Nicola Specchio, Pasquale Striano, Angela Robbiano, Elena Gennaro, Roberta Paravidino, Nicola Vanni, Francesca Beccaria, Giuseppe Capovilla, Amedeo Bianchi, Lorella Caffi, Viviana Cardilli, Francesca Darra, Bernardo Dalla Bernardina, Lucia Fusco, Roberto Gaggero, Lucio Giordano, Renzo Guerrini, Gemma Incorpora, Massimo Mastrangelo, Luigina Spaccini, Anna Maria Laverda, Marilena Vecchi, Francesca Vanadia, Pierangelo Veggiotti, Maurizio Viri, Guya Occhi, Mauro Budetta, Maurizio Taglialatela, Domenico A Coviello, Federico Vigevano, Carlo Minetti
PURPOSE: To dissect the genetics of benign familial epilepsies of the first year of life and to assess the extent of the genetic overlap between benign familial neonatal seizures (BFNS), benign familial neonatal-infantile seizures (BFNIS), and benign familial infantile seizures (BFIS). METHODS: Families with at least two first-degree relatives affected by focal seizures starting within the first year of life and normal development before seizure onset were included...
March 2013: Epilepsia
Z K Njiru, J O Ouma, R Bateta, S E Njeru, K Ndungu, P K Gitonga, S Guya, R Traub
Trypanosoma vivax is major cause of animal trypanosomiasis and responsible for enormous economic burden in Africa and South America animal industry. T. vivax infections mostly run low parasitaemia with no apparent clinical symptoms, making diagnosis a challenge. This work reports the design and evaluation of a loop-mediated isothermal amplification (LAMP) test for detecting T. vivax DNA based on the nuclear satellite repeat sequence. The assay is rapid with results obtained within 35 min. The analytical sensitivity is ∼ 1 trypanosome/ml while that of the classical PCR tests ranged from 10 to 10(3)trypanosomes/ml...
August 25, 2011: Veterinary Parasitology
Afshin Moradi, Maryam Khayamzadeh, Mohammad Mehdi Guya, Hamid Reza Mirzaei, Reza Salmanian, Afshin Rakhsha, Mohammad Esmaeil Akbari
OBJECTIVE: Colorectal cancer is the fourth cause of cancer after stomach, bladder, prostate in men and second cause after breast in women in Iran. It is estimated that 4,000 new cases occur each year with 1,150 deaths annually. The present study aimed to determine survival of colorectal cancers in Iran in a national manner. METHODS AND RESULTS: The data from national cancer registry department of the Ministry of Health and Medical Education (MOH and ME) were used as the main source of incident colorectal cancer information in Iran from March 2000 to March 2005...
October 2009: Asian Pacific Journal of Cancer Prevention: APJCP
Jie Cui, Dorian Counor, Di Shen, Guya Sun, Hongxuan He, Vincent Deubel, Shuyi Zhang
In this study, 336 bats of eight species were collected during 2004-2007 in six provinces of Southern China. Antibodies against Japanese encephalitis virus (JEV) were detected by ELISA in 43 of 336 (12.8%) serum samples. Among those ELISA-positive samples, 11 serum samples had neutralizing antibodies against JEV. No JEV was detected in brain and liver samples using specific real-time reverse transcriptase-polymerase chain reaction. This is the first report of JEV neutralizing antibodies in bats in China, which reinforces that bats can be involved in the life cycle of this virus...
June 2008: American Journal of Tropical Medicine and Hygiene
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