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journal of crohns and colitis

Hamed Khalili
In addition to cholesterol depletion, statins also significantly decrease systemic inflammation as measured by C-reactive protein. In this issue of American Journal of Gastroenterology, Ungaro et al. present their results on the associations between statin prescriptions and risk of Crohn's disease (CD) and ulcerative colitis (UC). Using a national medical claims and pharmacy database created by Symphony Health Solutions LLC (SHA), they show that any use of statin is protective against diagnosis of CD and UC...
October 2016: American Journal of Gastroenterology
John G Williams, M Fasihul Alam, Laith Alrubaiy, Clare Clement, David Cohen, Michelle Grey, Mike Hilton, Hayley A Hutchings, Mirella Longo, Jayne M Morgan, Frances L Rapport, Anne C Seagrove, Alan Watkins
BACKGROUND: The efficacy of infliximab and ciclosporin in treating severe ulcerative colitis (UC) is proven, but there has been no comparative evaluation of effectiveness. OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of infliximab and ciclosporin in treating steroid-resistant acute severe UC. METHOD: Between May 2010 and February 2013 we recruited 270 participants from 52 hospitals in England, Scotland and Wales to an open-label parallel-group, pragmatic randomised trial...
June 2016: Health Technology Assessment: HTA
L Kinsey, S Burden
Survey aims were to investigate the dietary concerns, beliefs and opinions of people with inflammatory bowel disease (IBD), and differences between those with Crohn's disease (CD) or ulcerative colitis (UC). A cross-sectional postal questionnaire was sent to people with IBD who were booked into an adult IBD or Gastroenterology clinic over a 6-week period. There were 416 eligible people and 168 (40%) responded. Sixty-four (42%) people indicated that food affects their symptoms a lot or severely. Eighty (51%) respondents indicated that diet was important or extremely important in controlling symptoms...
July 2016: European Journal of Clinical Nutrition
Shamik Polley, Natalie Prescott, Elaine Nimmo, Colin Veal, Ida Vind, Pia Munkholm, Peder Fode, John Mansfield, Paal Skyt Andersen, Jack Satsangi, Christopher G Mathew, Edward J Hollox
Previous work has shown that the gene DMBT1, which encodes a large secreted epithelial glycoprotein known as salivary agglutinin, gp340, hensin or muclin, is an innate immune defence protein that binds bacteria. A deletion variant of DMBT1 has been previously associated with Crohn's disease, and a DMBT1(-/-) knockout mouse has increased levels of colitis induced by dextran sulphate. DMBT1 has a complex copy number variable structure, with two, independent, rapidly mutating copy number variable regions, called CNV1 and CNV2...
August 2016: European Journal of Human Genetics: EJHG
J Delaney, P Laws, P Wille-Jørgensen, A Engel
AIM: The aim of this study was to compare the methodological quality and input paper characteristics of systematic reviews and meta-analyses reported in the medical and surgical literature by performing a systematic 'overview of reviews'. Ulcerative colitis (UC) and Crohn's disease (CD) were used as the framework for this comparison as they are relatively common serious conditions, with both medical and surgical options for therapy. METHOD: Medline, Embase, CINHAL and the Cochrane Database were searched to November 2013...
July 2015: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Anne C Seagrove, M Fasihul Alam, Laith Alrubaiy, Wai-Yee Cheung, Clare Clement, David Cohen, Michelle Grey, Mike Hilton, Hayley Hutchings, Jayne Morgan, Frances Rapport, Stephen E Roberts, Daphne Russell, Ian Russell, Linzi Thomas, Kymberley Thorne, Alan Watkins, John G Williams
INTRODUCTION: Many patients with ulcerative colitis (UC) present with acute exacerbations needing hospital admission. Treatment includes intravenous steroids but up to 40% of patients do not respond and require emergency colectomy. Mortality following emergency colectomy has fallen, but 10% of patients still die within 3 months of surgery. Infliximab and ciclosporin, both immunosuppressive drugs, offer hope for treating steroid-resistant UC as there is evidence of their short-term effectiveness...
2014: BMJ Open
Scott Tenner
Based on the Food and Drug Administration Adverse Event Reporting System (FAERS), the FDA and Hoffman La Roche issued warnings of a possible causal association between isotretinoin and inflammatory bowel disease. While scientists studied the association, trial lawyers used the courts to award large sums of money to plaintiffs despite the absence of clear scientific evidence of a causal effect. In this Issue of the Journal, a well-designed, large pharmaco-epidemiologic study shows no association. The story of isotretinoin highlights the problems that occur when the FAERS is used in litigation prior to further study and scientific analysis...
April 2014: American Journal of Gastroenterology
N Waugh, E Cummins, P Royle, N-B Kandala, D Shyangdan, R Arasaradnam, C Clar, R Johnston
BACKGROUND: Irritable bowel syndrome (IBS) is common, and causes pain, bloating and diarrhoea and/or constipation. It is a troublesome condition that reduces the quality of life but causes no permanent damage. Inflammatory bowel disease (IBD) comprises mainly ulcerative colitis (UC) and Crohn's disease (CD). Both cause serious complications and may lead to sections of the bowel having to be removed, although this is more common with CD. The presenting symptoms of IBS and IBD can be similar...
November 2013: Health Technology Assessment: HTA
Burton I Korelitz
Arbitrarily, modern day treatment of inflammatory bowel disease begins with the introduction of immunosuppressives for ulcerative colitis. Clinical improvement with sulfasalazine had been meaningful but modest. Treatment with adrenocorticotropic hormone and corticosteroids led to clinical responses never before realized but it took much too long to recognize that they were not capable of maintaining remission, that adverse reactions were subtle but potentially devastating and that some other agent would be necessary to capitalize on their transient advantage...
May 28, 2013: World Journal of Gastroenterology: WJG
Jahyang Cho, Bo Bae Kim, Chong-Woo Bae, Sung-Ho Cha
PURPOSE: PubMed is not only includes international medical journals but also has a registration site for the ongoing clinical trials, such as, under the supervision of US National Institutes of Health. We analyzed current status of vaccine clinical trials conducted by Korean investigators in database of MATERIALS AND METHODS: As of October 2012, there are total of 72 trials found on registry of vaccine clinical trials conducted by Korean investigators in database of ClinicalTrial...
January 2013: Clinical and Experimental Vaccine Research
Govind K Makharia, Balakrishnan S Ramakrishna, Philip Abraham, Gourdas Choudhuri, Sri Prakash Misra, Vineet Ahuja, Shobna J Bhatia, Deepak K Bhasin, Sunil Dadhich, Gopal K Dhali, Devendra C Desai, Uday C Ghoshal, B D Goswami, Sanjeev K Issar, Ajay K Jain, Venkataraman Jayanthi, Goundappa Loganathan, C Ganesh Pai, Amarender S Puri, Surinder S Rana, Gautam Ray, Shivaram P Singh, Ajit Sood
INTRODUCTION: Inflammatory bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease (CD), once thought to be uncommon, is now seen commonly in India. The Indian Society of Gastroenterology (ISG) Task Force on IBD decided to collate data on the clinical spectrum of IBD currently prevailing in India. METHODS: An open call to members of ISG was given through publication of a proforma questionnaire in the Indian Journal of Gastroenterology and the web portal of ISG...
December 2012: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Giovanni Latella, Claudio Papi
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic, progressive and disabling disorders. Over the last few decades, new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD. The identification of clinical, genetic and serological prognostic factors has permitted a better stratification of the disease, thus allowing the opportunity to indicate the most appropriate therapy...
August 7, 2012: World Journal of Gastroenterology: WJG
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No abstract text is available yet for this article.
September 2007: Journal of Crohn's & Colitis
Millie D Long, Douglas A Drossman
Many patients with inflammatory bowel disease (IBD) in clinical remission continue to have symptoms of pain and diarrhea despite minimal or no ongoing inflammation. These patients may be considered to have an overlap of IBD and irritable bowel syndrome (IBD-IBS). In this month's Journal, a proposal is made that continued symptoms in patients with elevated calprotectin, a marker of inflammation, is related to IBD. We propose an alternate biopsychosocial model whereby mutual effects of peripheral and central factors influence symptom generation in both IBD and IBS...
August 2010: American Journal of Gastroenterology
Miquel Sans
The notion that the intestinal microbiota plays a key role for the development of intestinal inflammation, initially based on a series of clinical observations both in human inflammatory bowel disease and experimental colitis, has been reinforced by a growing body of evidence demonstrating that the abnormal recognition of bacterial and other microbiota antigens by the innate immune system is one of the earliest events in the pathogenesis of inflammatory bowel disease. In keeping with our present knowledge of inflammatory bowel disease pathophysiology, the search for therapeutic approaches aimed at modifying the composition of the intestinal microbiota to obtain new, more targeted treatments for inflammatory bowel disease that are basically free of side effects has been a subject of intense research activity...
2009: Digestive Diseases
Seamus J Murphy, Thomas A Ullman, Maria T Abreu
Biomarkers in inflammatory bowel disease (IBD) are needed to help in disease diagnosis, prognosis, and assessment of disease activity. The best serologic markers to date measure antibody responses to normal commensal flora. These antibody responses can provide prognostic information as well as clues to disease pathogenesis. There remains room for additional biomarkers to clarify the diagnosis for certain patients with indeterminate colitis or small bowel Crohn's disease (CD) with protean manifestations. In this issue of the Journal, Adams and colleagues describe the presence of antibodies against Bacteroides vulgatus in CD patients...
February 2008: American Journal of Gastroenterology
Ai Ping Bai, Qin Ouyang, Ren Wei Hu
OBJECTIVE: Since the etiology and the pathogenesis of inflammatory bowel disease (IBD) are still not well known, research on IBD often focuses on these topics. Investigative science papers about IBD in Chinese medical journals from 1989 to 2003 were viewed to understand the progress of basic IBD research in China. MATERIALS AND METHODS: The basic science investigative papers about IBD from 1989 to 2003 in Chinese periodicals (VIP and CMCC) were reviewed and analyzed; the key words used were as follows: inflammatory bowel disease, ulcerative colitis, Crohn's disease, basic science investigation, and literature review...
November 2007: Journal of Digestive Diseases
Michael F Picco
The role of smoking in inflammatory bowel disease (IBD) has drawn more interest as our understanding of these diseases has moved beyond the simple designations of Crohn's disease (CD) and ulcerative colitis (UC). In this issue of the journal, Aldous et al. present two papers on the role of smoking in the heterogeneity of IBD. They confirm the findings of many, are at odds with the findings of some, and provide novel observations for us all as we try to understand this complex interaction. Do these studies provide more clarity or just add to the noise? As always, the devil is in the details...
March 2007: American Journal of Gastroenterology
Julia Seiderer, Thomas Ochsenkühn
In this issue of the Journal, Muller and colleagues attempt to define the role of specific bacterial pathogens, particularly Chlamydia pneumoniae, as causative agents in inflammatory bowel disease. Even if a major role for C. pneumoniae in the pathogenesis of inflammatory bowel disease could be ruled out, our current understanding of inflammatory pathways in Crohn's disease and ulcerative colitis implies that the search for other microorganisms as causative agents should continue.
August 2006: European Journal of Gastroenterology & Hepatology
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