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heart failure with preserved ejection

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https://www.readbyqxmd.com/read/29773163/epicardial-adipose-tissue-may-mediate-deleterious-effects-of-obesity-and-inflammation-on-the-myocardium
#1
REVIEW
Milton Packer
Epicardial adipose tissue has unique properties that distinguish it from other depots of visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed microcirculation with the underlying myocardium, and in healthy conditions, produces cytokines that nourish the heart. However, in chronic inflammatory disorders (especially those leading to heart failure with preserved ejection fraction), the epicardium becomes a site of deranged adipogenesis, leading to the secretion of proinflammatory adipokines that can cause atrial and ventricular fibrosis...
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29762842/the-role-of-commonly-used-clinical-indicators-in-the-diagnosis-of-acute-heart-failure
#2
X-L Wang, J-M Lei, Y Yuan, L Feng, Y Ning, Y-F Liu
OBJECTIVE: Acute heart failure (AHF) is one of the most commonly seen clinical cases, with a high rate of re-hospitalization and mortality. AHF can be divided into two categories based on the systolic function of the left ventricle, which are heart failure with reduced ejection fraction (HFREF) and heart failure with preserved ejection fraction (HFPEF). Pathogenesis and treatment of the two are quite different. In this article we attempted to explore the value of combined use of clinical and laboratory indicators in the differential diagnosis of AHFREF and AHFPEF...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761090/the-role-of-vascular-calcification-in-heart-failure-and-cognitive-decline
#3
REVIEW
Hao-Min Cheng, Jiun-Jr Wang, Chen-Huan Chen
Vascular calcification is heterogeneous and triggered by multiple mechanisms. It has been implicated in the development of heart failure with preserved ejection fraction (HFpEF) and cognitive function impairment. Understanding the pathophysiology of vascular calcification may help us improve the management of HFpEF, atherosclerosis, accelerated arterial stiffness, hypertension, and cognitive dysfunction. Currently, there are no effective strategies for treating accelerated arterial stiffness. This may indicate that once arterial stiffness or vascular calcification has developed, it may be less likely to stop the ongoing pathophysiology...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29760016/diabetes-induced-cardiomyocyte-passive-stiffening-is-caused-by-impaired-insulin-dependent-titin-modification-and-can-be-modulated-by-neuregulin-1
#4
Anna-Eliane Hopf, Christian Andresen, Sebastian Kötter, Malgorzata Isic, Kamila Ulrich, Senem Sahin, Sabine Bongardt, Wilhelm Roell, Felicitas Drove, Nina Scheerer, Leni Vandekerckhove, Gilles W De Keulenaer, Nazha Hamdani, Wolfgang A Linke, Martina Krüger
<u>Rationale:</u> Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). However, the insulin-related signaling pathways that modify titin-based cardiomyocyte tension, thereby contributing to modulation of diastolic function, are largely unknown. <u>Objective:</u> We aimed to determine how impaired insulin signaling affects titin expression and phosphorylation and thus increases passive cardiomyocyte tension, and whether metformin or neuregulin-1 can correct disturbed titin modifications and increased titin-based stiffness...
May 14, 2018: Circulation Research
https://www.readbyqxmd.com/read/29753564/left-atrium-and-pulmonary-artery-compression-due-to-aortic-aneurysm-causing-heart-failure-symptoms
#5
Antonio José Lagoeiro Jorge, Wolney de Andrade Martins, Victor M Moutinho, Juliano M Rezende, Patricia Y Alves, Humberto Villacorta, Pedro F Silveira, Antonio A Couto
Patients with thoracic aortic aneurysm (TAA) are mostly asymptomatic and TAA is rarely related to heart failure (HF). We report the case of an 80-year-old female patient, with type A TAA without dissection, with right pulmonary artery and left atrium compression, who presented with HF, preserved ejection fraction and acute pulmonary edema.
May 9, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29746913/the-controversy-continues-what-is-the-role-of-diastolic-function-by-echo-doppler-in-patients-with-heart-failure-and-preserved-ejection-fraction
#6
EDITORIAL
John Gorcsan
No abstract text is available yet for this article.
May 7, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29744014/heart-failure-in-women
#7
REVIEW
Biykem Bozkurt, Shaden Khalaf
Heart failure is an important cause of morbidity and mortality in women, and they tend to develop it at an older age compared to men. Heart failure with preserved ejection fraction is more common in women than in men and accounts for at least half the cases of heart failure in women. When comparing men and women who have heart failure and a low left ventricular ejection fraction, the women are more symptomatic and have a similarly poor outcome. Overall recommendations for guideline-directed medical therapies show no differences in treatment approaches between men and women...
October 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29743019/predictive-biomarkers-for-death-and-rehospitalization-in-comorbid-frail-elderly-heart-failure-patients
#8
Cristina Pacho, Mar Domingo, Raquel Núñez, Josep Lupón, Julio Núñez, Jaume Barallat, Pedro Moliner, Marta de Antonio, Javier Santesmases, Germán Cediel, Santiago Roura, M Cruz Pastor, Jordi Tor, Antoni Bayes-Genis
BACKGROUND: Heart failure (HF) is associated with a high rate of readmissions within 30 days post-discharge and in the following year, especially in frail elderly patients. Biomarker data are scarce in this high-risk population. This study assessed the value of early post-discharge circulating levels of ST2, NT-proBNP, CA125, and hs-TnI for predicting 30-day and 1-year outcomes in comorbid frail elderly patients with HF with mainly preserved ejection fraction (HFpEF). METHODS: Blood samples were obtained at the first visit shortly after discharge (4...
May 9, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29741807/genetically-determined-pattern-of-left-ventricular-function-in-normal-and-hypertensive-hearts
#9
Attila Kovács, Andrea Ágnes Molnár, Márton Kolossváry, Bálint Szilveszter, Alexisz Panajotu, Bálint Károly Lakatos, Levente Littvay, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Szilard Voros, György Jermendy, Partho P Sengupta, Béla Merkely, Pál Maurovich-Horvat
We sought to assess the inheritance of left ventricular (LV) function using speckle-tracking echocardiography and the impact of hypertension on modifying the genetically determined pattern of contraction in a population of twins. We recruited 92 Caucasian twin pairs, including 74 hypertensive (HTN) siblings. Beyond standard echocardiographic protocol, a speckle-tracking analysis was performed, including global longitudinal strain (GLS). Systolic function, as assessed by ejection fraction, showed moderate heritability (61%); however, GLS showed higher and dominant heritability (75%)...
May 9, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29735591/the-alchemist-s-nightmare-might-mesenchymal-stem-cells-that-are-recruited-to-repair-the-injured-heart-be-transformed-into-fibroblasts-rather-than-cardiomyocytes
#10
REVIEW
Milton Packer
The injection of mesenchymal stem cells into the injured myocardium to induce cardiac regeneration has yielded disappointing results, conceivably because cells with cardioreparative potential must be supplied for long periods of time to produce a salutary effect. Accordingly, investigators have devised ways of directing such cells to the heart on an ongoing basis: by enhancing the action of endogenous peptides that function as cardiac homing signals (eg, stromal cell-derived factor-1). Stromal cell-derived factor-1 is released during acute cardiac injury and heart failure, but it has a short half-life because of degradation by dipeptidyl peptidase-4...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29734198/exercise-for-preventing-hospitalization-and-readmission-in-adults-with-congestive-heart-failure
#11
Wilbert S Aronow, Tatyana A Shamliyan
We critically appraised all available evidence regarding exercise interventions for improving patient survival and reducing hospital admissions in adults with chronic heart failure (HF). We searched 4 databases up to April 2018 and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group approach. We reviewed 7 meta-analyses and the publications of 48 randomized, controlled trials (RCT). In HF with reduced ejection fraction, low-quality evidence suggests that exercise prevents all-cause hospitalizations (RR 0...
May 4, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29731351/corrigendum-to-mismatch-between-right-and-left-sided-filling-pressures-in-heart-failure-patients-with-preserved-ejection-fraction-int-j-cardiol-257-2018-143-149
#12
Yu Horiuchi, Shuzou Tanimoto, Jiro Aoki, Nozomi Fuse, Kazuyuki Yahagi, Keita Koseki, Taishi Okuno, Hiroyoshi Nakajima, Kazuhiro Hara, Kengo Tanabe
No abstract text is available yet for this article.
May 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29731023/heart-failure-with-preserved-ejection-fraction-in-diabetes-mechanisms-and-management
#13
REVIEW
Patrick Meagher, Mohamed Adam, Robert Civitarese, Antoinette Bugyei-Twum, Kim A Connelly
Diabetes mellitus (DM) is a major cause of heart failure in the Western world, either secondary to coronary artery disease or from a distinct entity known as "diabetic cardiomyopathy." Furthermore, heart failure with preserved ejection fraction (HFpEF) is emerging as a significant clinical problem for patients with DM. Current clinical data suggest that between 30% and 40% of patients with HFpEF suffer from DM. The typical structural phenotype of the HFpEF heart consists of endothelial dysfunction, increased interstitial and perivascular fibrosis, cardiomyocyte stiffness, and hypertrophy along with advanced glycation end products deposition...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29730194/natriuretic-peptides-in-acute-coronary-syndromes-a-new-role-to-predict-recurrent-ischemic-event-related-mortality
#14
Vasiliki Bistola, Eftihia Polyzogopoulou, John Parissis
Risk stratification in acute coronary syndromes (ACS) have been based previously on severity of acute clinical presentation, presence of cardiovascular comorbidities and abnormalities of ischemia-specific biomarkers most importantly troponins. Natriuretic peptides (NPs), which become elevated upon increased myocardial wall stress, are established diagnostic and prognostic biomarkers in patients with heart failure. Recently, their prognostic potential in ACS has been reported, specifically as predictors of future new-onset heart failure or left ventricular systolic dysfunction...
May 3, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29728831/time-trends-in-characteristics-clinical-course-and-outcomes-of-13-791-patients-with-acute-heart-failure
#15
Pere Llorens, Patricia Javaloyes, Francisco Javier Martín-Sánchez, Javier Jacob, Pablo Herrero-Puente, Víctor Gil, José Manuel Garrido, Eva Salvo, Marta Fuentes, Héctor Alonso, Fernando Richard, Francisco Javier Lucas, Héctor Bueno, John Parissis, Christian E Müller, Òscar Miró
OBJECTIVES: To analyse time trends in patient characteristics, clinical course, hospitalisation rate, and outcomes in acute heart failure along a 10-year period (2007-2016). METHODS: The EAHFE registry has prospectively collected 13,971 consecutive AHF patients diagnosed in 41 Spanish emergency departments (EDs) at five different time points (2007/2009/2011/2014/2016). Eighty patient-related variables and outcomes were described and statistically significant changes along time were evaluated...
May 4, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29728137/predictive-potential-of-macrophage-migration-inhibitory-factor-mif-in-patients-with-heart-failure-with-preserved-ejection-fraction-hfpef
#16
Peter Luedike, Georgios Alatzides, Maria Papathanasiou, Martin Heisler, Julia Pohl, Nils Lehmann, Tienush Rassaf
BACKGROUND: Prognostication in heart failure with preserved ejection fraction (HFpEF) is challenging and novel biomarkers are urgently needed. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays a crucial role in cardiovascular and various inflammatory diseases. Whether MIF is involved in HFpEF is unknown. METHODS AND RESULTS: Sixty-two patients with HFpEF were enrolled and followed up for 180 days. MIF plasma levels as well as natriuretic peptide (NP) levels were assessed...
May 4, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29724973/rationale-design-and-methodology-of-the-apollon-trial-a-comprehensive-observational-registry-of-heart-failure-with-midrange-and-preserved-ejection-fraction
#17
Bülent Özlek, Eda Özlek, Oğuzhan Çelik, Cem Çil, Volkan Doğan, Mehmet Tekinalp, Hicaz Zencirkıran Ağuş, Serkan Kahraman, Altuğ Ösken, İbrahim Rencüzoğulları, Veysel Ozan Tanık, Lütfü Bekar, Mustafa Ozan Çakır, Bedri Caner Kaya, Hakan Tibilli, Yunus Çelik, Özcan Başaran, Kadir Uğur Mert, Samet Sevinç, Erkan Demirci, Engin Dondurmacı, Murat Biteker
OBJECTIVE: Although almost half of chronic heart failure (HF) patients have mid-range (HFmrEF) and preserved left-ventricular ejection fraction (HFpEF), no studies have been carried out with these patients in our country. This study aims to determine the demographic characteristics and current status of the clinical background of HFmrEF and HFpEF patients in a multicenter trial. METHODS: A comPrehensive, ObservationaL registry of heart faiLure with mid range and preserved ejectiON fraction (APOLLON) trial will be an observational, multicenter, and noninterventional study conducted in Turkey...
May 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29724346/global-longitudinal-strain-to-predict-mortality-in-patients-with-acute-heart-failure
#18
Jin Joo Park, Jun-Bean Park, Jae-Hyeong Park, Goo-Yeong Cho
BACKGROUND: Heart failure (HF) is currently classified according to left ventricular ejection fraction (LVEF); however, the prognostic value of LVEF is controversial. Myocardial strain is a prognostic factor independently of LVEF. OBJECTIVES: The authors sought to evaluate the prognostic value of global longitudinal strain (GLS) in patients with HF. METHODS: GLS was measured in 4,172 consecutive patients with acute HF. Patients were categorized as either HF with reduced (LVEF <40%), midrange (LVEF 40% to 49%), or preserved ejection fraction (LVEF ≥50%) and were also classified as having mildly (GLS >12...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29723777/circulating-macrophage-migration-inhibitory-factor-mif-in-patients-with-heart-failure
#19
Peter Luedike, Georgios Alatzides, Maria Papathanasiou, Martin Heisler, Julia Pohl, Nils Lehmann, Tienush Rassaf
BACKGROUND: Heart failure (HF) is characterized by impaired systolic ejection capacity and/or diastolic filling of the heart, leading to a multisystem disorder. Remote organ failure, systemic inflammation or pulmonary hypertension (PH) are hallmarks of the pathophysiological changes in HF. The Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is involved in a variety of cardiovascular and inflammatory diseases. Circulating MIF levels and their potential role as a disease marker in the different subgroups of HF have not been investigated yet...
April 30, 2018: Cytokine
https://www.readbyqxmd.com/read/29713818/right-ventriculo-arterial-uncoupling-and-impaired-contractile-reserve-in-obese-patients-with-unexplained-exercise-intolerance
#20
Colm McCabe, Rudolf K F Oliveira, Farbod Rahaghi, Mariana Faria-Urbina, Luke Howard, Richard G Axell, Andrew N Priest, Aaron B Waxman, David M Systrom
BACKGROUND: Right ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV exercise responses, we investigated RV-arterial coupling in obesity with and without development of exercise pulmonary venous hypertension (ePVH). METHODS: RV-arterial coupling defined as RV end-systolic elastance/pulmonary artery elastance (Ees/Ea) was calculated from invasive cardiopulmonary exercise test data in 6 controls, 8 obese patients without ePVH (Obese-ePVH) and 8 obese patients with ePVH (Obese+ePVH) within a larger series...
April 30, 2018: European Journal of Applied Physiology
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