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https://www.readbyqxmd.com/read/28920800/cutaneous-t-cell-lymphoma-with-lymph-node-metastasis-in-an-adult-addax-addax-nasomaculatus
#1
Zoltan S Gyimesi, Roy B Burns, Sheryl Coutermarsh-Ott, Chris A Schiller, Rita McManamon
A 13-yr-old male addax (Addax nasomaculatus) presented with locally extensive alopecia, slight erythema, and skin thickening on the medial aspect of the left rear leg between the stifle and tarsus. Cutaneous T-cell lymphoma was diagnosed after histopathology and immunohistochemical staining of representative skin-punch biopsies. No treatment was elected, and the addax was euthanized 3 yr later because of poor body condition, chronic dental disease, and confirmed spread of lymphoma to other cutaneous locations...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28905340/german-heart-surgery-report-2016-the-annual-updated-registry-of-the-german-society-for-thoracic-and-cardiovascular-surgery
#2
Andreas Beckmann, Anne-Katrin Funkat, Jana Lewandowski, Michael Frie, Markus Ernst, Khosro Hekmat, Wolfgang Schiller, Jan F Gummert, Wolfgang Harringer
No abstract text is available yet for this article.
September 13, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28901357/an-ortho-c-methylation-o-glycosylation-motif-on-a-hydroxy-coumarin-scaffold-selectively-installed-by-biocatalysis
#3
Alexander Gutmann, Margaretha Schiller, Mandana Gruber-Khadjawi, Bernd Nidetzky
Various bioactive natural products, like the aminocoumarin antibiotics novobiocin and coumermycin, exhibit an aromatic C-methyl group adjacent to a glycosylated phenolic hydroxyl group. Therefore, tailoring of basic phenolic scaffolds to contain the intricate C-methyl/O-glycosyl motif is of high interest for structural and functional diversification of natural products. We demonstrate site-selective 8-C-methylation and 7-O-β-d-glucosylation of 4,5,7-trihydroxy-3-phenyl-coumarin (1) by S-adenosyl-l-methionine dependent C-methyltransferase (from Streptomyces niveus) and uridine 5'-diphosphate glucose dependent glycosyltransferase from apple (Malus × domestica)...
September 13, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28899865/lasker-awards-honor-three-cancer-researchers
#4
(no author information available yet)
Three top cancer researchers were among recipients of the prestigious Albert and Mary Lasker Foundation awards. Douglas R. Lowy, MD, and John T. Schiller, PhD, were honored for research leading to the development of the first human papillomavirus vaccine. The prize for basic medical research went to Michael N. Hall, PhD, who discovered the TOR signaling pathway and its role in regulating cell growth and metabolism.
September 12, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28899122/the-primitive-edge-of-creativity-destruction-and-reparation-in-louise-bourgeois-s-art
#5
Britt-Marie Schiller
Viewed within the psychic geography of Thomas Ogden's modes of generating and organizing experience, in particular the autistic-contiguous mode, Louise Bourgeois's creative imagination can be seen as originating on what Ogden (1989) has called the primitive edge of experience. This mode, dominated by the sensory, is characterized by chaos, fragmentation, and a loss of boundaries. In dynamic movements between the depressive and the autistic-contiguous positions, between destructive and reparative impulses, Bourgeois transforms experiences of chaos, as well as destructive aggression, into aesthetic order and form, into works of art...
April 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/28888324/a-prize-for-cancer-prevention
#6
Harold Varmus
This year's Lasker-DeBakey Prize for Clinical Research to Douglas Lowy and John Schiller celebrates the science behind one of the greatest advances in the history of cancer research: the development of vaccines that prevent infection and thus prevent tumor induction by pathogenic strains of human papilloma virus (HPV).
September 6, 2017: Cell
https://www.readbyqxmd.com/read/28888323/two-basic-scientists-walk-into-a-translational-space
#7
(no author information available yet)
When John Schiller first joined Douglas Lowy's lab at the National Cancer Institute of the NIH, he could have not predicted that their common interest in the molecular biology of oncogenes would set them in path for discoveries that ultimately enabled the development of a vaccine for the human papillomavirus, which causes the majority of cervical cancers worldwide. John and Doug, the recipients of the 2017 Lasker-DeBakey Clinical Award, have joined Cell editor João Monteiro in a Conversation about science, public health, and the joys and challenges of being basic scientists in a translational space...
August 23, 2017: Cell
https://www.readbyqxmd.com/read/28882984/transient-apoptosis-inhibition-in-donor-stem-cells-improves-hematopoietic-stem-cell-transplantation
#8
Matthias Kollek, Gesina Voigt, Christian Molnar, Fabronia Murad, Daniela Bertele, Christopher Felix Krombholz, Sheila Bohler, Verena Labi, Stefan Schiller, Mirjam Kunze, Stephan Geley, Charlotte M Niemeyer, Ana Garcia-Saez, Miriam Erlacher
During hematopoietic stem cell transplantation, a substantial number of donor cells are lost because of apoptotic cell death. Transplantation-associated apoptosis is mediated mainly by the proapoptotic BCL-2 family proteins BIM and BMF, and their proapoptotic function is conserved between mouse and human stem and progenitor cells. Permanent inhibition of apoptosis in donor cells caused by the loss of these BH3-only proteins improves transplantation outcome, but recipients might be exposed to increased risk of lymphomagenesis or autoimmunity...
September 7, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28881008/drivers-of-nitrogen-transfer-in-stream-food-webs-across-continents
#9
B C Norman, M R Whiles, S M Collins, A S Flecker, S K Hamilton, S L Johnson, E J Rosi-Marshall, L R Ashkenas, W B Bowden, C L Crenshaw, T Crowl, W K Dodds, R O Hall, R El-Sabaawi, N A Griffiths, E Marti, W H McDowell, S D Peterson, H M Rantala, T Riis, K S Simon, J L Tank, S A Thomas, D von Schiller, J R Webster
Studies of trophic-level material and energy transfers are central to ecology. The use of isotopic tracers has now made it possible to measure trophic transfer efficiencies of important nutrients and to better understand how these materials move through food webs. We analyzed data from thirteen (15) N-ammonium tracer addition experiments to quantify N transfer from basal resources to animals in headwater streams with varying physical, chemical, and biological features. N transfer efficiencies from primary uptake compartments (PUCs; heterotrophic microorganisms and primary producers) to primary consumers was lower (mean: 11...
September 7, 2017: Ecology
https://www.readbyqxmd.com/read/28879796/assessment-of-the-pulmonary-cyp1a1-metabolism-of-mavoglurant-afq056-in-rat
#10
Yildiz Yilmaz, Kenichi Umehara, Gareth Williams, Thomas Faller, Hilmar Schiller, Markus Walles, Stephan Kraehenbuehl, Gian Camenisch, Nenad Manevski
1. AFQ056 phenotyping results indicate that CYP1A1 is responsible for the formation of the oxidative metabolite, M3. In line with the predominant assumption that CYP1A1 is mainly expressed in extrahepatic tissues, only traces of M3 were detected in hepatic systems. The aim of this study was to investigate the pulmonary CYP1A1 mediated metabolism of AFQ056 in rat. 2. Western blot analysis confirmed that CYP1A1 is expressed in rat lung albeit at low levels. M3 formation was clearly observed in recombinant rat CYP1A1, lung microsomes and lung tissue slices and was strongly inhibited by ketoconazole in the incubations...
September 7, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28876473/sydney-playground-project-a-cluster-randomized-trial-to-increase-physical-activity-play-and-social-skills
#11
Anita Bundy, Lina Engelen, Shirley Wyver, Paul Tranter, Jo Ragen, Adrian Bauman, Louise Baur, Wendy Schiller, Judy M Simpson, Anita N Niehues, Gabrielle Perry, Glenda Jessup, Geraldine Naughton
BACKGROUND: We assessed the effectiveness of a simple intervention for increasing children's physical activity, play, perceived competence/social acceptance, and social skills. METHODS: A cluster-randomized controlled trial was conducted, in which schools were the clusters. Twelve Sydney (Australia) primary schools were randomly allocated to intervention or control conditions, with 226 children (5-7 years old) selected randomly to participate. Data were collected at baseline and after 13 weeks...
October 2017: Journal of School Health
https://www.readbyqxmd.com/read/28876435/preventing-cancer-and-other-diseases-caused-by-human-papillomavirus-infection-2017-lasker-debakey-clinical-research-award
#12
Douglas R Lowy, John T Schiller
No abstract text is available yet for this article.
September 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28875100/development-of-an-advanced-diagnostic-concept-for-intestinal-inflammation-molecular-visualisation-of-nitric-oxide-in-macrophages-by-functional-poly-lactic-co-glycolic-acid-microspheres
#13
Kathleen Lange, Christian Lautenschläger, Maria Wallert, Stefan Lorkowski, Andreas Stallmach, Alexander Schiller
We here describe a new approach to visualise nitric oxide (NO) in living macrophages by fluorescent NO-sensitive microspheres based on poly(lactic-co-glycolic acid) (PLGA). PLGA microspheres loaded with NO550 dye were prepared through a modified solvent-evaporation method. Microparticles were characterized by a mean hydrodynamic diameter of 3000 nm, zeta potential of -26.000 ± 0.351 mV and a PDI of 0.828 ± 0.298. Under abiotic conditions, NO release was triggered through UV radiation (254 nm) of 10 mM sodium nitroprusside dehydrate (SNP)...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28872487/validation-of-radial-artery-based-uncalibrated-pulse-contour-method-pulsioflex-in-an-unselected-cohort-of-critically-ill-patients
#14
Jörn Grensemann, Jerome M Defosse, Meike Willms, Uwe Schiller, Frank Wappler, Samir G Sakka
BACKGROUND: Because of their simplicity, uncalibrated pulse contour (UPC) methods have been introduced into clinical practice in critical care but are often validated with a femoral arterial waveform. OBJECTIVE: We aimed to test the accuracy of cardiac index (CI) measurements and trending ability from a radial artery with one UPC. SETTING: Tertiary care mixed-surgical ICU. Data were obtained from April 2015 to July 2016. PATIENTS: We studied 20 critically ill mechanically ventilated patients monitored by UPC (PulsioFlex; Pulsion Medical Systems SE, Munich, Germany)...
September 1, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28869986/diagnostic-accuracy-of-novel-and-traditional-rapid-tests-for-influenza-infection-compared-with-reverse-transcriptase-polymerase-chain-reaction-a-systematic-review-and-meta-analysis
#15
Joanna Merckx, Rehab Wali, Ian Schiller, Chelsea Caya, Genevieve C Gore, Caroline Chartrand, Nandini Dendukuri, Jesse Papenburg
Background: Rapid and accurate influenza diagnostics can improve patient care. Purpose: To summarize and compare accuracy of traditional rapid influenza diagnostic tests (RIDTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) in children and adults with suspected influenza. Data Sources: 6 databases from their inception through May 2017. Study Selection: Studies in English, French, or Spanish comparing commercialized rapid tests (that is, providing results in <30 minutes) with reverse transcriptase polymerase chain reaction reference standard for influenza diagnosis...
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28858279/-dental-health-maintenance-of-military-personnel-under-orthodontic-treatment
#16
L N Soldatova, F Ya Horoshilkina, A K Iordanishvili
The aim of the study was to estimate dental health of servicemen of young and middle age using PMA index, Schiller-Pisarev assay, iodic number of Svrakov, OHI-S. Hundred and six servicemen were enrolled in the study: control group (n=35) with no orthodontic treatment and groups 2 (n=34) and 3 (n=37) group undergoing orthodontic treatment with bracket-systems. All patients had professional oral hygiene and received standard oral care recommendations. Group 3 participants additionally used dental foam (Splat, Russia) after meal...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28844107/impacts-of-a-care-process-model-and-inpatient-electrophysiology-service-on-cardiovascular-implantable-electronic-device-infections-a-preliminary-evaluation
#17
Eugene M Tan, Avish Nagpal, Daniel C DeSimone, Brenda Anderson, Jane Linderbaum, Thomas De Ziel, Zhuo Li, Muhammad R Sohail, Yong-Mei Cha, Erica Loomis, Raul Espinosa, Paul A Friedman, Kevin Greason, Henry Schiller, Abinash Virk, Walter R Wilson, James M Steckelberg, Larry M Baddour
PURPOSE: Cardiovascular implantable electronic device infection (CIEDI) rates are rising. To improve outcomes, our institution developed an online care process model (CPM) and a specialized inpatient heart rhythm service (HRS). METHODS: This retrospective review compared hospital length of stay (LOS), mortality, and times to subspecialty consultation and procedures before and after CPM and HRS availability. RESULTS: CPM use was associated with shortened time to surgical consultation (median 2 days post-CPM vs...
August 26, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28843041/the-social-hippocampus
#18
Alison Montagrin, Catarina Saiote, Daniela Schiller
The concept of cognitive map has been proposed as a way to organize our experiences and guide behavior across all domains of cognition. The hippocampus has been identified as the neural substrate supporting cognitive maps for navigating physical space. Recent evidence is broadening the role of the hippocampus to mapping other manner of spaces. Here we focus on the case of social space as a candidate for hippocampal representation, because it combines multiple continuous dimensions and requires dynamic navigation through social contexts...
August 26, 2017: Hippocampus
https://www.readbyqxmd.com/read/28835800/design-and-optimization-of-benzopiperazines-as-potent-inhibitors-of-bet-bromodomains
#19
David S Millan, Katherine J Kayser-Bricker, Matthew W Martin, Adam C Talbot, Shawn E R Schiller, Torsten Herbertz, Grace L Williams, George P Luke, Stephen Hubbs, Monica A Alvarez Morales, Daniel Cardillo, Paul Troccolo, Rachel L Mendes, Crystal McKinnon
A protein structure-guided drug design approach was employed to develop small molecule inhibitors of the BET family of bromodomains that were distinct from the known (+)-JQ1 scaffold class. These efforts led to the identification of a series of substituted benzopiperazines with structural features that enable interactions with many of the affinity-driving regions of the bromodomain binding site. Lipophilic efficiency was a guiding principle in improving binding affinity alongside drug-like physicochemical properties that are commensurate with oral bioavailability...
August 10, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28815472/comparison-of-pet-ct-and-whole-mount-histopathology-sections-of-the-human-prostate-a-new-strategy-for-voxel-wise-evaluation
#20
F Schiller, T Fechter, C Zamboglou, A Chirindel, N Salman, C A Jilg, V Drendel, M Werner, P T Meyer, A-L Grosu, M Mix
BACKGROUND: Implementation of PET/CT in diagnosis of primary prostate cancer (PCa) requires a profound knowledge about the tracer, preferably from a quantitative evaluation. Direct visual comparison of PET/CT slices to whole prostate sections is hampered by considerable uncertainties from imperfect coregistration and fundamentally different image modalities. In the current study, we present a novel method for advanced voxel-wise comparison of histopathology from excised prostates to pre-surgical PET...
August 17, 2017: EJNMMI Physics
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