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https://www.readbyqxmd.com/read/29220492/hbv-derived-synthetic-long-peptide-can-boost-cd4-and-cd8-t-cell-responses-in-chronic-hbv-patients-ex-vivo
#1
Yingying Dou, Nadine van Montfoort, Aniek van den Bosch, Robert A de Man, Gijs G Zom, Willem-Jan Krebber, Cornelis J M Melief, Sonja I Buschow, Andrea M Woltman
Background: Vaccination with Synthetic Long Peptides (SLP ®) is a promising new treatment strategy for chronic HBV (CHB). SLP can induce broad T cell responses for all HLA types. Here we investigated the ability of a prototype HBV-core (HBc)-sequence-derived SLP to boost HBV-specific T cells in CHB patients ex vivo. Methods: HBc-SLP was used to assess cross-presentation by monocyte-derived DC(moDC) and BDCA1+ blood myeloid DC (mDC) to engineered HBV-specific CD8+ T cells...
December 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29214413/new-cancer-cases-in-france-in-2015-attributable-to-infectious-agents-a-systematic-review-and-meta-analysis
#2
Kevin David Shield, Claire Marant Micallef, Catherine de Martel, Isabelle Heard, Francis Megraud, Martyn Plummer, Jérôme Vignat, Freddie Bray, Isabelle Soerjomataram
To provide an assessment of the burden of cancer in France in 2015 attributable to infectious agents. A systematic literature review in French representative cancer cases series was undertaken of the prevalence of infectious agents with the major associated cancer types. PubMed was searched for original studies published up to September 2016; random-effects meta-analyses were performed. Cancer incidence data were obtained from the French Cancer Registries Network, thereby allowing the calculation of national incidence estimates...
December 6, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29202763/classification-and-sensitivity-analysis-of-the-transmission-dynamic-of-hepatitis-b
#3
REVIEW
Tahir Khan, Il Hyo Jung, Amir Khan, Gul Zaman
BACKGROUND: Hepatitis B infection caused by the hepatitis B virus is one of the most serious viral infections and a global health problem. In the transmission of hepatitis B infection, three different phases, i.e. acute infected, chronically infected, and carrier individuals, play important roles. Carrier individuals are especially significant, because they do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model...
December 5, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29201788/prevalence-of-hepatitis-b-virus-and-hepatitis-c-virus-in-a-tea-garden-of-bangladesh
#4
Mamun Al Mahtab, Shamima Akhter, Kutub U Mollick, Mohammad H Uddin, Sakirul I Khan, Sheikh Mf Akbar
Introduction: The overall health status of workers of tea garden of Bangladesh is below the national standard. Also, almost nothing has been reported about status of hepatitis virus infection among these population and there is also a lack of consensus. Materials and methods: Several health-related facts, especially those of liver diseases, were collected from 130 workers of tea garden via questionnaire. Sera were also collected from these subjects to assess positivity of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV)...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201775/chronic-viral-hepatitis-in-malaysia-where-are-we-now
#5
REVIEW
Ruksana Raihan, Rosmawati Mohamed, Muhammad Radzi Abu Hassan, Rosaida Md Said
Malaysia is a country where an estimated 1 million people are chronically infected with hepatitis B virus (HBV) and an estimated 2.5% of the adult population are positive for antibody to hepatitis C virus (HCV). Effective nationwide vaccine coverage seems to be a highly effective measure to prevent new HBV infection. Treatment of HCV infection is also a regular practice in Malaysia. These measures highlight the possibility to reach the World Health Organization elimination target by 2030. To achieve this target, the Health Ministry and other nongovernmental organizations, such as My Commitment to Cure (MyC2C) are working together to develop a strategic road map to reach the global elimination target in Malaysia by 2030...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201630/avoidance-of-harm-from-treatment-for-anca-associated-vasculitis
#6
REVIEW
Catherine King, Lorraine Harper
Purpose of review With established immunosuppressant treatment regimens for anti-neutrophil cytoplasm antibody-associated vasculitides (AAV), prognosis has significantly improved. The mainstay of treatment still comprises high-dose corticosteroids and cyclophosphamide for severe forms, although rituximab is being increasingly utilised instead of cyclophosphamide as induction therapy. AAV patients experience an excess of infections, malignancies and cardiovascular events as compared to the general population, which is a combination of the systemic inflammatory process associated with vasculitis and the adverse events from treatment...
2017: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/29197147/immune-response-to-hepatitis-b-vaccine-in-patients-with-chronic-hepatitis-c-infection-a-systematic-review-and-meta-analysis
#7
REVIEW
Jiaye Liu, Hui Wu, Hui Chen
AIM: Hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection can add to the severity of hepatitis and the risks of liver cirrhosis and hepatocellular carcinoma (HCC). Whether chronic HCV infection decreases antibody response to hepatitis B vaccination is still controversial. METHODS: We evaluate the influence of HCV infection on antibody response to hepatitis B vaccination by performing a systematic review of the literature with a meta-analysis of clinical trials...
December 1, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29195717/the-efficacy-of-two-different-dosages-of-hepatitis-b-immunoglobulin-combined-with-hepatitis-b-vaccine-in-preventing-mother-to-child-transmission-of-hepatitis-b-virus-a-prospective-cohort-study
#8
Kai-Ping Wei, Feng-Cai Zhu, Jian-Xun Liu, Ling Yan, Ying Lu, Xiang-Jun Zhai, Zhan-Jun Chang, Ying Zeng, Jie Li, Hui Zhuang
BACKGROUND/AIMS: A birth dose of hepatitis B immunoglobulin (HBIG), in combination with hepatitis B vaccine (HepB), is recommended for infants born to hepatitis B surface antigen (HBsAg)-positive mothers. However, the optimal dosage of HBIG remains to be resolved. This prospective cohort study aimed to compare the efficacy of two dosages of HBIG combined with HepB to prevent mother-to-child transmission (MTCT) of HBV. METHODS: From 2009 to 2011, we prospectively enrolled mother-infant pairs with positive maternal HBsAg in China...
November 28, 2017: Vaccine
https://www.readbyqxmd.com/read/29183287/hiv-and-hepatitis-b-and-c-co-infection-among-people-who-inject-drugs-in-zanzibar
#9
Ahmed Khatib, Eva Matiko, Farhat Khalid, Susie Welty, Ameir Ali, Asha Othman, Shaaban Haji, Mohammed Dahoma, George Rutherford
BACKGROUND: People who inject drugs are at high risk of acquiring hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) due to risky injection and sexual practices. The objective of this study is to investigate the epidemiology of HIV, hepatitis B, and hepatitis C, and co-infection of these viruses among people who inject drugs in Zanzibar, Tanzania. METHODS: We used respondent-driven sampling to identify 408 participants, from whom we collected demographic data, information on sexual behaviours and injection drug practices, and blood samples for biological testing...
November 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29182219/hepatitis-b-in-poland-in-2015
#10
Małgorzata Stępień, Katarzyna Piwowarow, Mirosław P. Czarkowski
OBJECTIVE: Assessment of the epidemiological situation of hepatitis B in Poland in 2015 in relation to previous years. MATERIAL AND METHODS: Evaluation of the epidemiological situation carried out based on analysis of data from individual reports on acute hepatitis B cases registered by the sanitary-epidemiological stations, aggregate data published in annual bulletins “Infectious diseases and poisonings in Poland” and data from annual bulletin “Vaccinations in Poland”...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29181424/comparative-effectiveness-of-prophylactic-strategies-for-perinatal-transmission-of-hepatitis-b-virus-a-network-meta-analysis-of-randomized-controlled-trials
#11
Zhi-Xian Chen, Xun Zhuang, Xiao-Hong Zhu, Yan-Li Hao, Gui-Fang Gu, Meng-Zhi Cai, Gang Qin
Background: Perinatal transmission is the main route of hepatitis B virus (HBV) transmission. While several measures have been attempted as means of preventing perinatal HBV transmission, the optimal strategy remains inconclusive. Methods: We conducted a comprehensive search, through December 2016, for randomized controlled trials (RCTs) that compared the following measures among pregnant women with HBV infection: placebo/none, active immunoprophylaxis (hepatitis B vaccine series starting at birth [HBVac]), passive-active immunoprophylaxis (hepatitis B immunoglobulin and vaccine [HBIG+HBVac]), prenatal HBIG administration (HBIG/HBIG+HBVac), and prenatal antiviral therapy (AVT/HBIG+HBVac)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29179600/nanovaccine-for-immunotherapy-and-reduced-hepatitis-b-virus-in-humanized-model
#12
Hitesh Kumar Dewangan, Tarun Pandey, Sanjay Singh
Chronic Hepatitis B Virus (HBV) infections are severe with weak antiviral immune responses. The lack of an appropriate small animal model for chronic hepatitis, a major hurdle for studying the immunotolerance and immunopathogenesis induced by hepatitis B viral (HBV) infection. In this study, for enhancing the antibody production efficiency the prepared polymeric HBsAg-loaded nanoparticles (nanovaccine) will be tested in immune-deficit mice, which suffer from chronic Hepatitis B virus. Vaccination of Balb/c mice by this prepared nanoparticles that were engrafted with peripheral blood mononuclear cells (PBMCs), which was already lethally irradiated and transplanted by the bone marrow of NOD (knockout mice) mice...
November 27, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29176801/increasing-vaccine-production-using-pulsed-ultrasound-waves
#13
Jida Xing, Shrishti Singh, Yupeng Zhao, Yan Duan, Huining Guo, Chenxia Hu, Allan Ma, Rajan George, James Z Xing, Ankarao Kalluri, Isaac Macwan, Prabir Patra, Jie Chen
Vaccination is a safe and effective approach to prevent deadly diseases. To increase vaccine production, we propose that a mechanical stimulation can enhance protein production. In order to prove this hypothesis, Sf9 insect cells were used to evaluate the increase in the expression of a fusion protein from hepatitis B virus (HBV S1/S2). We discovered that the ultrasound stimulation at a frequency of 1.5 MHz, intensity of 60 mW/cm2, for a duration of 10 minutes per day increased HBV S1/S2 by 27%. We further derived a model for transport through a cell membrane under the effect of ultrasound waves, tested the key assumptions of the model through a molecular dynamics simulation package, NAMD (Nanoscale Molecular Dynamics program) and utilized CHARMM force field in a steered molecular dynamics environment...
2017: PloS One
https://www.readbyqxmd.com/read/29174317/status-and-progress-of-hepatitis-b-control-through-vaccination-in-the-south-east-asia-region-1992-2015
#14
REVIEW
Lana Childs, Sigrun Roesel, Rania A Tohme
In 2016, the Immunization Technical Advisory Group of the South-East Asia Region (SEAR) endorsed a regional goal to achieve ≤1% prevalence of hepatitis B surface antigen (HBsAg) among 5-year-old children by 2020. Chronic hepatitis B virus (HBV) infection is largely preventable with a birth dose of hepatitis B vaccine (HepB-BD) followed by two to three additional doses. We reviewed the progress towards hepatitis B control through vaccination in SEAR during 1992-2015. We summarized hepatitis B vaccination data and reviewed the literature to determine the prevalence of chronic HBV infection pre- and post-vaccine introduction...
November 21, 2017: Vaccine
https://www.readbyqxmd.com/read/29170919/current-advances-in-the-elimination-of-hepatitis-b-in-china-by-2030
#15
REVIEW
Shuye Zhang, Fusheng Wang, Zheng Zhang
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading public health challenges in China. Over the last two decades, China has made great progress on the prevention of HBV transmission through national vaccination programs. Zero transmission from mother to infant has been proposed as the current goal. Available anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completely cure patients with chronic hepatitis B and even requires lifelong treatment...
November 23, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29167460/early-vaccination-protects-against-childhood-leukemia-a-systematic-review-and-meta-analysis
#16
Mostafa Ebraheem Morra, Nguyen Dang Kien, Ahmed Elmaraezy, Omar Ayman M Abdelaziz, Ahmed Lotfy Elsayed, Oday Halhouli, Ahmed Mosaad Montasr, Tran Le-Huy Vu, Chau Ho, Amr Sayed Foly, Anh Phan Phi, Wessam Magdy Abdullah, Marina Mikhail, Elizabeth Milne, Kenji Hirayama, Nguyen Tien Huy
Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings presented in the published literature are inconsistent. Therefore, we conducted a PRISMA systematic review and meta-analysis. 14 studies were identified and meta-analyzed. Vaccinations studied comprised Bacillus Calmette-Guérin (BCG) vaccine, Triple vaccine, Hepatitis B vaccine (HBV), Polio, Measles, Rubella, Mumps, trivalent MMR vaccine and Haemophilus influenza type B (HiB) vaccine...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29159414/hepatitis-b-vaccination-screening-and-linkage-to-care-best-practice-advice-from-the-american-college-of-physicians-and-the-centers-for-disease-control-and-prevention
#17
Winston E Abara, Amir Qaseem, Sarah Schillie, Brian J McMahon, Aaron M Harris
Background: Vaccination, screening, and linkage to care can reduce the burden of chronic hepatitis B virus (HBV) infection. However, recommendations vary among organizations, and their implementation has been suboptimal. The American College of Physicians' High Value Care Task Force and the Centers for Disease Control and Prevention developed this article to present best practice statements for hepatitis B vaccination, screening, and linkage to care. Methods: A narrative literature review of clinical guidelines, systematic reviews, randomized trials, and intervention studies on hepatitis B vaccination, screening, and linkage to care published between January 2005 and June 2017 was conducted...
November 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29156049/management-of-pregnant-women-and-children-focusing-on-preventing-mother-to-infant-transmission
#18
Huey-Ling Chen, Wan-Hsin Wen, Mei-Hwei Chang
Hepatitis B virus (HBV) immunization has been effectively preventing chronic HBV infection with >90% efficacy in countries with universal neonatal immunization. Perinatal mother-to-infant transmission of HBV remains the major cause of chronic HBV infection despite immunization. Maternal hepatitis B e-antigen (HBeAg) and high viral load have been noted to be the most important risk factors for transmission. In recent years, short-term antiviral therapy for pregnant women in the third trimester has been shown to be highly effective in reducing 90% of vaccine failure in children...
November 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29145470/active-immunization-in-patients-transplanted-for-hepatitis-b-virus-related-liver-diseases-a-prospective-study
#19
Anli Yang, Zhiyong Guo, Qingqi Ren, Linwei Wu, Yi Ma, Anbin Hu, Dongping Wang, Haidan Ye, Xiaofeng Zhu, Weiqiang Ju, Xiaoshun He
INTRODUCTION: Prophylactic administration of hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogues (NAs) is the standard treatment for controlling hepatitis B virus (HBV) recurrence after liver transplantation (LT). Since lifelong use of HBIG is expensive and inconvenient and the antibodies level in anti-hepatitis B surface (HBs) is not sustainable and stable, an alternative strategy is to produce anti-HBs antibodies by active immunization. Our present study aimed to prospectively investigate the efficacy and safety of procedural HBV vaccination in transplanted patients...
2017: PloS One
https://www.readbyqxmd.com/read/29145268/seroconverting-nonresponder-of-high-dose-intramuscular-hbv-vaccine-with-intradermal-hbv-vaccine-a-case-report
#20
Manjusha Das, Vishwas Vanar, Daniel K Martin, Saqib Walayat, Jaymon Patel, Maaz B Badshah, Nikhil R Kalva, Watcoun-Nchinda Pisoh, Sonu Dhillon
INTRODUCTION: Liver disease is a leading cause of death among human immunodeficiency virus (HIV)-infected patients in the United States. Patients with HIV and hepatitis B virus (HBV) coinfection have accelerated liver disease, higher rates of cirrhosis, and liver cancer, and markedly increased liver-related mortality. The CDC and US Advisory Committee on Immunization Practices recommend hepatitis B vaccination for all HIV-infected individuals. Unfortunately, HIV-infected patients have a worse response rate after standard HBV vaccination...
November 2017: Medicine (Baltimore)
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