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https://www.readbyqxmd.com/read/29467596/cost-effectiveness-of-antiviral-prophylaxis-during-pregnancy-for-the-prevention-of-perinatal-hepatitis-b-infection-in-south-korea
#1
Donghoon Lee, Hyun-Young Shin, Sang Min Park
Background: In Korea, hepatitis B virus (HBV) infection accounts for approximately 65-75% of HBV-related diseases, such as chronic hepatitis and liver cancer, and mother-to-child transmission is presumed to be a major source of the infection. To tackle this issue, the Korean government launched the national Perinatal Hepatitis B Prevention Program (PHBPP) in 2002. This study analyzed the cost-effectiveness of the PHBPP with antiviral prophylaxis compared with the current PHBPP and/or universal vaccination, as well as identified the optimal strategy to eliminate mother-to-child transmission of HBV in Korea...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29465694/hepatitis-b-vaccination-and-infection-prevalence-among-men-who-have-sex-with-men-who-travel-internationally
#2
Hong-Ha M Truong, Robin Fatch, Tri D Do, Willi McFarland
Among MSM traveling internationally, self-reported HBV vaccination prevalence was 77% and less prevalent among older men and those with HBV infection. HBV infection prevalence was 25% and was associated with older age and HIV infection. Testing for chronic infection, universal vaccination, and treatment for populations with multiple risks is needed.
October 19, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29462103/hospital-maternal-and-birth-factors-associated-with-hepatitis-b-vaccination-at-birth-west-virginia-2015
#3
Joel Massey, Anil Nair, Stephanie Dietz, Deborah Snaman, Danae Bixler
BACKGROUND: Hepatitis B virus (HBV) is a bloodborne pathogen typically transmitted through sexual contact, injection drug use, or perinatally. A hepatitis B vaccine (HepB) is available; the first dose is recommended at birth. We sought to identify hospital policy, maternal characteristics, and birth factors associated with HepB receipt at birth in West Virginia (WV). METHODS: We conducted a retrospective cohort study of WV live births in 2015 using vital records matched to immunization registry records to determine frequency of HepB birth dose receipt (<3 days postdelivery)...
February 16, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29461329/cancer-in-adolescents-and-young-adults-living-with-hiv
#4
Julia Bohlius, Caroline Foster, Gita Naidu, Mazvita Sengayi, Anna Turkova
PURPOSE OF REVIEW: Adults living with HIV have an increased risk of malignancy yet there is little data for adolescents and young adults. We reviewed recently published cancer epidemiology, treatment, and outcome data for adolescents and young adults living with HIV (AYALHIV) aged 10 to less than 25 years between 2016 and 2017. RECENT FINDINGS: AYALHIV are at increased risk of developing cancer compared to their uninfected peers. Kaposi sarcoma and non-Hodgkin lymphoma occur most frequently with variation by geographical region...
February 15, 2018: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29459143/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-soluble-immune-effector-molecules-i-anti-tumour-necrosis-factor-%C3%AE-agents
#5
REVIEW
J W Baddley, F Cantini, D Goletti, J J Gómez-Reino, E Mylonakis, R San-Juan, M Fernández-Ruiz, J Torre-Cisneros
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting tumour necrosis factor-α (TNF-α) and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 6, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29456414/high-prevalence-of-hepatitis-b-antibody-loss-and-a-case-report-of-de-novo-hepatitis-b-virus-infection-in-a-child-after-living-donor-liver-transplantation
#6
Palittiya Sintusek, Nawarat Posuwan, Piyaporn Wanawongsawad, Suttiruk Jitraruch, Yong Poovorawan, Voranush Chongsrisawat
AIM: To assess the seroprevalence of hepatitis B virus (HBV) immunity among previously vaccinated pediatric liver transplant recipients and present a case report of de novo hepatitis B infection after liver transplantation. METHODS: This study focused on children with chronic liver diseases who received primary hepatitis B immunization and had a complete dataset of anti-HBs before and after liver transplantation between May 2001 and June 2017. Medical records were retrospectively reviewed for potential factors relating to HBV immunity loss...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29450123/epidemiology-and-treatment-of-hepatitis-b-in-prisoners
#7
Jacob M Smith, A Ziggy Uvin, Alexandria Macmadu, Josiah D Rich
Purpose of Review: The review details recent literature reports regarding Hepatitis B Virus (HBV) and, in particular, Hepatitis B prevalence/incidence in incarcerated populations around the world. Furthermore, the review will summarize the national/international guidelines regarding HBV and look at diagnosis, vaccination, treatment, and linkage to care after release. Recent Findings: HBV affects prisoners at a much higher rate than the general populations. Many who are at increased risk for HBV infection are also at increased risk for incarceration...
September 2017: Current Hepatology Reports
https://www.readbyqxmd.com/read/29449582/use-of-elispot-assay-to-study-hbs-specific-b-cell-responses-in-vaccinated-and-hbv-infected-humans
#8
Chen Tian, Yuxin Chen, Yong Liu, Shixia Wang, Yang Li, Guiyang Wang, Juan Xia, Xiang-An Zhao, Rui Huang, Shan Lu, Chao Wu
Hepatitis B surface antibody (HBsAb) plays a critical role in protecting against infection of hepatitis B virus (HBV) and were extensively studied in literature. At the same time, the status of hepatitis B surface antigen (HBs)-specific B cells in both vaccinated and HBV infected people received limited attention. In the current study, we adopted a highly specific B-cell Enzyme Linked ImmunoSpot (ELISpot) assay to analyze HBs-specific B cells in various clinical settings: healthy individuals with the history of HBV vaccination before and after receiving an extra HBV vaccine boost, people chronically infected with HBV (CHB) in various clinical stages, with or without a particular type anti-viral treatment, or whether receiving a dose of HBV vaccine...
February 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29449101/evaluation-of-a-convenient-vaccination-schedule-against-hepatitis-b-in-hiv-patients-with-undetectable-hiv-viral-load
#9
Sofia Kourkounti, Theodoros Retsas, Vassilios Paparizos, Antonios Tsimpidakis, Violetta Kapsimali, Dimitrios Rigopoulos
Vaccination against hepatitis B virus (HBV) is recommended for all HIV-positive individuals but the standard schedule is not satisfactory. High or more doses have also been studied with variable results. We compared a vaccination schedule with a higher dose but fewer shots to the standard scheme (HBVaxPro 40 μg versus Engerix 20 μg at 0, 1, and 6 months). Of the 63 patients vaccinated with HBVaxPro 79%, 65% and 47% seroconverted at month 1, 12 and 24 after vaccination, respectively. A total of 137 patients received Engerix and showed lower response rates (68%, 53% and 38%, respectively)...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29446249/serological-responses-to-revaccination-against-hbv-in-hiv-positive-patients-born-in-the-era-of-nationwide-neonatal-hbv-vaccination
#10
Yi-Chia Huang, Szu-Min Hsieh, Wang-Huei Sheng, Yu-Shan Huang, Kuan-Yin Lin, Guan-Jhou Chen, Shang-Ping Yang, Wen-Chun Liu, Yi-Ching Su, Hsin-Yun Sun, Chien-Ching Hung, Shan-Chwen Chang
BACKGROUND: Serological responses to revaccination against hepatitis B virus (HBV) are unclear in HIV-positive adults who had undergone neonatal HBV vaccination and whose antibodies against HBV had waned in the era of combination antiretroviral therapy (cART). METHODS: Between 2000 and 2017, 666 HIV-positive men who have sex with men (MSM) who were born after 1986, when nationwide neonatal HBV vaccination program was implemented in Taiwan, were included for analyses...
February 15, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29444185/humoral-and-cell-mediated-immune-responses-after-a-booster-dose-of-hbv-vaccine-in-hiv-infected-children-adolescents-and-young-adults
#11
Vania Giacomet, Michela Masetti, Pilar Nannini, Federica Forlanini, Mario Clerici, Gian Vincenzo Zuccotti, Daria Trabattoni
OBJECTIVE: HBV vaccine induces protective antibodies only in 23-56% of HIV-infected children. The aim of our study is to evaluate the immunologic effects of a booster dose of HBV vaccine in HIV-infected youth. DESIGN: 53 young HIV-infected patients in whom HBV vaccination did not elicit protective Ab titers were enrolled. All patients were on ART with optimal immunological and viral response. METHOD: All patients received a booster dose of HBV vaccine (HBVAXPRO 10 μg i...
2018: PloS One
https://www.readbyqxmd.com/read/29442226/molecular-evolution-and-phylodynamics-of-hepatitis-b-virus-infection-circulating-in-iran
#12
Sayed-Hamidreza Mozhgani, Seyed Amir Malekpour, Mehdi Norouzi, Fatemeh Ramezani, Seyed Abdolrahim Rezaee, Vahdat Poortahmasebi, Mehdi Sadeghi, Seyed Moayed Alavian, Mohadeseh Zarei-Ghobadi, Azam Ghaziasadi, Hadi Karimzadeh, Reza Malekzadeh, Masood Ziaee, Farshid Abedi, Behrooz Ataei, Majid Yaran, Babak Sayad, Hamid Reza Jahantigh, Mohammad Hossein Somi, Gholamreza Sarizadeh, Ismail Sanei-Moghaddam, Fariborz Mansour-Ghanaei, Hossein Keyvani, Ebrahim Kalantari, Zahra Fakhari, Babak Geravand, Seyed Mohammad Jazayeri
Previous local and national Iranian publications indicate that all Iranian hepatitis B virus (HBV) strains belong to HBV genotype D. The aim of this study was to analyze the evolutionary history of HBV infection in Iran for the first time, based on an intensive phylodynamic study. The evolutionary parameters, time to most recent common ancestor (tMRCA), and the population dynamics of infections were investigated using the Bayesian Monte Carlo Markov chain (BMCMC). The effective sample size (ESS) and sampling convergence were then monitored...
February 13, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29439751/impact-of-hepatitis-b-vaccination-on-acute-hepatitis-b-epidemiology-in-european-union-european-economic-area-countries-2006-to-2014
#13
Alessandro Miglietta, Chantal Quinten, Pier Luigi Lopalco, Erika Duffell
Hepatitis B prevention in European Union/European Economic Area (EU/EEA) countries relies on vaccination programmes. We describe the epidemiology of acute hepatitis B virus (HBV) at country and EU/EEA level during 2006-2014. Using a multi-level mixed-effects Poisson regression model we assessed differences in the acute HBV infection notification rates between groups of countries that started universal HBV vaccination before/in vs after 1995; implemented or not a catch-up strategy; reached a vaccine coverage ≥ 95% vs < 95% and had a hepatitis B surface antigen prevalence ≥ 1% vs < 1%...
February 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29428913/anti-hbs-titers-following-pentavalent-immunization-dtwp-hbv-hib-in-term-normal-weight-vs-low-birth-weight-infants
#14
Chandrika Verma, M M A Faridi, Manish Narang, Iqbal R Kaur
OBJECTIVE: To compare anti HBs titers between term low birth weight (1800-2499 g) infants and normal birth weight infants, 6 weeks after last dose of primary immunization with pentavalent vaccine, and to study adverse events following immunization (AEFI) with pentavalent vaccine. DESIGN: Cohort study. SETTING: Tertiary-care hospital predominantly catering to urban poor population of East Delhi. PARTICIPANTS: 265 low birth weight (1800-2499 g) and 265 normal birth weight (2500-4000 g) infants Monovalent Hepatitis B vaccine was administered within 24 hours of birth followed by three primary doses of pentavalent vaccine at 6, 10 and 14 weeks...
February 9, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29428874/a-novel-hepatitis-b-virus-species-discovered-in-capuchin-monkeys-sheds-new-light-on-the-evolution-of-primate-hepadnaviruses
#15
Breno Frederico de Carvalho Dominguez Souza, Alexander König, Andrea Rasche, Ianei de Oliveira Carneiro, Nora Stephan, Victor Max Corman, Pia Luise Roppert, Nora Goldmann, Ramona Kepper, Simon Franz Müller, Christof Völker, Alex Junior Souza de Souza, Michele Soares Gomes-Gouvêa, Andrés Moreira-Soto, Andreas Stöcker, Michael Nassal, Carlos Roberto Franke, João Renato Rebello Pinho, Manoel do Carmo Pereira Soares, Joachim Geyer, Philippe Lemey, Christian Drosten, Eduardo Martins Netto, Dieter Glebe, Jan Felix Drexler
BACKGROUND & AIMS: All known hepatitis B virus (HBV) genotypes occur in humans and hominoid Old World nonhuman primates (NHP). The divergent Woolly Monkey HBV (WMHBV) forms another orthohepadnavirus species. The evolutionary origins of HBV are unclear. METHODS: We analyzed sera from 124 Brazilian monkeys collected during 2012-2016 for hepadnaviruses using molecular and serological tools and conducted evolutionary analyses. RESULTS: We identified a novel orthohepadnavirus species in capuchin monkeys (CMHBV)...
February 8, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29427490/how-to-control-highly-endemic-hepatitis-b-in-asia
#16
REVIEW
Shan Shan, Fuqian Cui, Jidong Jia
Chronic hepatitis B virus (HBV) infection is an enormous economic and social burden. Asian countries such as Vietnam, Mongolia, Laos, China, the Philippines, South Korea, Singapore and Cambodia have high or high-intermediate HBsAg prevalence. Most of the chronic HBV carriers in this region acquire their infection during early childhood or through mother-to-child transmission (MTCT). Asia has been highly successful in controlling HBV in the last 2 decades. For example, China has adopted a comprehensive strategy to control HBV and has offered universal HBV vaccination to infants since 1992...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29427482/how-to-improve-access-to-therapy-in-hepatitis-b-patients
#17
REVIEW
Miroslava Subic, Fabien Zoulim
Despite the availability of a preventive vaccine and active antiviral treatments that stop disease progression and reduce the risk of hepatocellular carcinoma, hepatitis B is still a major public health problem. Only an estimated 10% of the 257 million people living with HBV have been diagnosed and as few as 1% are being adequately treated. Barriers to diagnosis and treatment include: (i) limited awareness and lack of knowledge about HBV infection and HBV-related diseases; (ii) under-diagnosis with insufficient screening and referral to care; (iii) limited treatment due to drug availability, costs, reimbursement policies and the need for long-term or life-long therapy...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29427444/antibody-response-to-hepatitis-b-vaccine-in-hiv-exposed-infants-in-malawi-and-correlation-with-hbv-infection-acquisition
#18
Sandro Mancinelli, Maria Franca Pirillo, Giuseppe Liotta, Mauro Andreotti, Robert Mphwere, Roberta Amici, Maria Cristina Marazzi, Stefano Vella, Leonardo Palombi, Marina Giuliano
The aim of this study was to assess the immune response to HBV vaccine in HIV-exposed infants and to correlate it to HBV infection acquisition. Protective anti-HBs levels (> 10 mIU/ml) were found in 54/58 (93.2%) infants at 6 months, 126/144 (87.5%) at 12 months and 141/176 (80.1%) children at 24 months. HBV infection (7 children were HBsAg+ at Month 24) occurred also in the presence of levels above 10 mIU/ml. Our findings indicate limited impact of HIV exposure on anti-HBV immune response, but suggest that levels > 10 mIU/ml may be required to confer protection in this context...
February 10, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29423229/recognition-criteria-for-occupational-cancers-in-relation-to-hepatitis-b-virus-and-hepatitis-c-virus-in-korea
#19
REVIEW
Hogil Kim, Yun Kyung Chung, Inah Kim
The goal of this study was to review the scientific basis for the recognition of occupational cancer, in relation to hepatitis viral infections in Korea. Most Hepatitis B virus (HBV) infections in Korea occur as vertical infections, but these are decreasing rapidly due to vaccination. Hepatitis C virus (HCV) is known to be transmitted through parenteral routes, but the transmission route is often unclear. Most occupational infections of hepatitis virus involve accidental injuries of medical institution workers while using virus-contaminated medical devices...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29417356/evaluation-of-hepatitis-b-virus-screening-vaccination-and-linkage-to-care-among-newly-arrived-refugees-in-four-states-2009-2011
#20
Kiren Mitruka, Clelia Pezzi, Brittney Baack, Heather Burke, Jennifer Cochran, Jasmine Matheson, Kailey Urban, Marisa Ramos, Kathy Byrd
Many U.S.-bound refugees originate from countries with intermediate or high hepatitis B virus (HBV) infection prevalence and have risk for severe liver disease. We evaluated HBV screening and vaccination of newly arrived refugees in four states to identify program improvement opportunities. Data on HBV testing at domestic health assessments (1/1/2009-12/31/2011) were abstracted from state refugee health surveillance systems. Logistic regression identified correlates of infection. Over 95% of adults aged ≥19 years (N = 24,647) and 50% of children (N = 12,249) were tested...
February 7, 2018: Journal of Immigrant and Minority Health
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