Jose Manuel Merino Arribas, Alfonso Carmona Martínez, Michael Horn, Xavier Maria Perez Porcuna, Maria Del Carmen Otero Reigada, Josep Marès Bermúdez, Fernando Centeno Malfaz, Mariano Miranda, Maria Mendez, Miguel Angel Garcia Cabezas, Wittermann Christoph, Gerhard Bleckmann, Thomas Fischbach, Devayani Kolhe, Marie Van der Wielen, Yaela Baine
BACKGROUND: This study evaluated the immunogenicity and reactogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus virus-Haemophilus influenzae type b vaccine (DTPa-HBV-IPV/Hib) and a 10-valent pneumococcal conjugate vaccine (PHiD-CV) co-administered with a quadrivalent meningococcal conjugate vaccine (MenACWY-TT) in infants/toddlers. METHODS: In this open, controlled, phase III study (NCT01144663), 2095 healthy infants were randomised (1:1:1:1) into 4 groups to receive MenACWY-TT at 2, 3, 4 and 12 months of age, or MenACWY-TT, MenC-CRM197 or MenC-TT at 2, 4 and 12 months of age...
March 31, 2018: Pediatric Infectious Disease Journal