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Vascular occlusions

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https://www.readbyqxmd.com/read/29656438/renovascular-hypertension-associated-with-jak2-v617f-positive-myeloproliferative-neoplasms-treated-with-angioplasty-2-cases-and-literature-review
#1
Eikan Mishima, Takehiro Suzuki, Yoichi Takeuchi, Kazumasa Seiji, Noriko Fukuhara, Kei Takase, Hideo Harigae, Takaaki Abe, Sadayoshi Ito
Myeloproliferative neoplasms (MPNs) with Janus kinase 2 (JAK2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with JAK2 V617F mutation-positive MPNs and provide a literature review. In Case 1, a 63-year-old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with JAK2 V617F mutation. Renin-angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved...
April 14, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29655642/estimating-medicare-and-patient-savings-from-the-use-of-bevacizumab-for-the-treatment-of-exudative-age-related-macular-degeneration
#2
Philip J Rosenfeld, Matthew A Windsor, William J Feuer, Sissi J J Sun, Kevin D Frick, Eric A Swanson, David Huang
PURPOSE: The Medicare cost savings from the use of bevacizumab in the United States for the treatment of exudative age-related macular degeneration (AMD) were estimated by replacing the use of bevacizumab with ranibizumab and aflibercept. DESIGN: Retrospective trend study. METHODS: Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology (CPT) codes for intravitreal injections (67028) and treatment-specific J-codes (J0178, J2778, J9035, J3490 and J3590) for inhibitors of vascular endothelial growth factor...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29653080/surgical-treatment-of-native-and-prosthetic-aortic-infection-with-xenopericardial-tube-grafts
#3
Maximilian Kreibich, Matthias Siepe, Julia Morlock, Friedhelm Beyersdorf, Stoyan Kondov, Johannes Scheumann, Fabian A Kari, Tim Berger, Holger Schröfel, Bartosz Rylski, Martin Czerny
BACKGROUND: To report our results of surgical treatment of native and prosthetic aortic infection with xenopericardial tube-grafts from the ascending aorta to beyond the bifurcation. METHODS: Within a 28-month period, 20 patients were treated with a bovine self-made pericardial tube graft to replace infected vascular grafts (after conventional surgical aortic replacement or endovascular stentgraft implantation) or to treat a contaminated surgical site. An integrated standardized therapeutic concept was applied in all patients consisting of complete removal of the infected prosthetic material, extensive debridement, and orthotopic vascular reconstruction with self-made tube grafts constructed from a bovine pericardial patch...
April 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29652651/prediction-of-organ-involvement-in-systemic-sclerosis-by-serum-biomarkers-and-peripheral-endothelial-function
#4
Shin-Ya Kawashiri, Ayako Nishino, Takashi Igawa, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Akitomo Okada, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Munetoshi Nakashima, Akinari Mizokami, Naoki Matsuoka, Kiyoshi Migita, Fumihide Ogawa, Satoshi Ikeda, Koji Maemura, Hideki Nakamura, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami
OBJECTIVES: To identify prognostic factors among serum biomarkers and endothelial vasodilator function findings in patients with systemic sclerosis (SSc). METHODS: This is a clinical observational study. We assessed 60 consecutive SSc patients (44 limited cutaneous-type, 16 diffuse cutaneous-type). Circulating growth differentiation factor-15 (GDF-15), placenta growth factor (PlGF), endostatin, vascular endothelial growth factor (VEGF), and pentraxin 3 (PTX3) were measured by ELISA...
April 12, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29652542/sympathoexcitation-constrains-vasodilation-in-the-human-skeletal-muscle-microvasculature-during-post-occlusive-reactive-hyperemia
#5
Masashi Ichinose, Mikie Nakabayashi, Yumie Ono
We used diffuse correlation spectroscopy (DCS) to investigate sympathetic vasoconstriction, local vasodilation, and integration of these two responses in the skeletal muscle microvasculature of 20 healthy volunteers. DCS probes were placed on the flexor carpi radialis muscle (FC) or the vastus lateralis muscle (VL), and a blood flow index (BFI) was derived continuously. We measured hemodynamic responses during sympathoexcitation induced by forehead cooling, after which the effects of the increased sympathetic tone on vasodilatory responses during post-occlusive reactive hyperemia (PORH) were examined...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29650781/anatomic-and-angiographic-analyses-of-ophthalmic-artery-collaterals-in-moyamoya-disease
#6
T Robert, G Cicciò, P Sylvestre, A Chiappini, A G Weil, S Smajda, C Chaalala, R Blanc, M Reinert, M Piotin, M W Bojanowski
BACKGROUND AND PURPOSE: Moyamoya disease is a progressive neurovascular pathology defined by steno-occlusive disease of the distal internal carotid artery and associated with the development of compensatory vascular collaterals. The etiology and exact anatomy of vascular collaterals have not been extensively studied. The aim of this study was to describe the anatomy of collaterals developed between the ophthalmic artery and the anterior cerebral artery in a Moyamoya population. MATERIALS AND METHODS: All patients treated for Moyamoya disease from 2004 to 2016 in 4 neurosurgical centers with available cerebral digital subtraction angiography were included...
April 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29650336/acute-physiological-responses-to-low-intensity-blood-flow-restriction-cycling
#7
H J Thomas, B R Scott, J J Peiffer
OBJECTIVES: Blood flow restriction (BFR) during interval cycling may stimulate aerobic and anaerobic adaptations. However, acute physiological responses to BFR interval cycling have not been extensively investigated. DESIGN: Eighteen males completed low-intensity (LI), low-intensity with BFR (LIBFR ) and high-intensity (HI) interval cycling sessions in randomised and counterbalanced order. These included a standardised warm-up and three two-min intervals interspersed with two-min recovery...
April 9, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29649504/tau-pathology-and-neurochemical-changes-associated-with-memory-dysfunction-in-an-optimised-murine-model-of-global-cerebral-ischaemia-a-potential-model-for-vascular-dementia
#8
Sabah Khan, Nadira Y Yuldasheva, Trevor F C Batten, Alasdair R Pickles, Katherine A B Kellett, Sikha Saha
Cerebral ischemia is known to be a major cause of death and the later development of Alzheimer's disease and vascular dementia. However, ischemia induced cellular damage that initiates these diseases remain poorly understood. This is primarily due to lack of clinically relevant models that are highly reproducible. Here, we have optimised a murine model of global cerebral ischaemia with multiple markers to determine brain pathology, neurochemistry and correlated memory deficits in these animals. Cerebral ischaemia in mice was induced by bilateral common carotid artery occlusion...
April 9, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29643083/headpost-rightly-positioned-or-flat-out-wrong
#9
REVIEW
Anne W Alexandrov, Georgios Tsivgoulis, Michael D Hill, David S Liebeskind, Peter Schellinger, Bruce Ovbiagele, Adam S Arthur, Valeria Caso, Raul G Nogueira, J Claude Hemphill, James C Grotta, Werner Hacke, Andrei V Alexandrov
OBJECTIVE: To critique the Head Positioning in Stroke Trial (HeadPoST) study methods in relation to preceding research findings in an aim to clarify the potential efficacy of positioning interventions and direction for future research. METHODS: Head positioning research prior to the conduct of HeadPoST was reviewed by a team of international stroke experts, and methods and findings were compared to HeadPoST. RESULTS: Methods used to select HeadPoST patients differ substantially from those used in original head positioning studies, in particular enrollment of all types of stroke...
April 11, 2018: Neurology
https://www.readbyqxmd.com/read/29629621/pdgfr-%C3%AE-restores-blood-brain-barrier-functions-in-a-mouse-model-of-focal-cerebral-ischemia
#10
Jie Shen, Guihua Xu, Runxiu Zhu, Jun Yuan, Yoko Ishii, Takeru Hamashima, Takako Matsushima, Seiji Yamamoto, Yusuke Takatsuru, Junichi Nabekura, Masakiyo Sasahara
Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of vascular pericytes into ischemic lesion to restore the blood-brain barrier (BBB) dysfunction, its mechanisms still remain elusive . Compared with control PDGFR-βfloxed / floxed mice (Floxed), postnatally induced systemic PDGFR-β knockout mice (Esr-KO) not only showed severe brain edema, neurologic functional deficits, decreased expression of tight junction (TJ) proteins, abundant endothelial transcytosis, and deformed TJs in the BBB, but also showed reduced expression of transforming growth factor-β (TGF-β) protein after photothrombotic middle cerebral artery occlusion (MCAO)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29629297/influences-of-pinpoint-plantar-long-wavelength-infrared-light-irradiation-stress-free-therapy-on-chorioretinal-hemodynamics-atherosclerosis-factors-and-vascular-endothelial-growth-factor
#11
Keisou Ishimaru, Takuma Nakajima, Yoshihisa Namiki, Kenji Ryotokuji
Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia. Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW)...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29627774/acute-lower-limb-ischaemia-secondary-to-intestinal-occlusion
#12
Francois-Charles Malo, Philippe Acar, Véronique Lapie, Valérie Bédard
In general, acute lower limb ischaemia is caused by embolic, thrombotic or traumatic phenomena. Here, we describe the case of a 67-year-old woman in an emergency room setting who was initially assessed for paralysis and numbness of her lower left limb. On physical examination, the abdomen was distended and non-compressible. An abdominal AngioScan showed complete occlusion of the left iliac artery by extrinsic compression of the dilated small intestine. After a review of the literature, no case was found describing a lower limb ischaemia by extrinsic vascular compression secondary to a compartment syndrome caused by small bowel obstruction...
April 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29623727/myxoid-emboli
#13
Badr AbdullGaffar, Krysztof Waslewski
Emboli are common clinicopathologic findings. Recognition of the type of arterial emboli could be the first clue to the original source. Emboli with myxomatous changes are rare. Myxoma-like features in mural organizing thrombi have been reported. The most challenging differential diagnosis is between embolic cardiac myxomas and myxomatous thromboemboli. Emboli from sarcomas and arteriosclerotic plaques with myxoid features are also potential pitfalls. There is scarcity of studies focusing on myxoid emboli and their clinical and pathologic importance...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29623225/ischemic-colitis-in-sickle-cell-disease-a-case-report-of-a-diagnostic-challenge
#14
Kyle Geary, Jacob Kibrit
Microvascular occlusion serves as the underlying mechanism for the multitude of clinical manifestations of sickle cell disease, one of the most prevalent hemoglobinopathies worldwide. Recurrent painful episodes are the hallmark of this condition. Abdominal pain attributed to an acute painful episode can be indistinguishable from a separate and/or more serious intra-abdominal disease process, representing a significant diagnostic dilemma for clinicians. Here we present a rare case of ischemic colitis due to vascular occlusion in a 28-year-old man with sickle cell disease...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29622971/pattern-of-vascular-remodeling-of-distal-reference-segment-after-recanalization-of-chronic-total-occlusion-long-term-angiographic-follow-up
#15
Wassam El Din Hadad El Shafey
Chronic total occlusion (CTO) is probably caused by thrombus and lipid-rich cholesterol esters that are replaced over time by collagen and calcium deposition. Experimental models showed endothelial cell necrosis in response to vessel ligation, whereas more recent models suggest that the endothelium might retain viability guiding the subsequent development of CTO, including CTO neo-revascularization, which occurs within the lumen and in various layers of the vessel wall, by the release of paracrine substances...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29622711/varicella-zoster-virus-necrotising-retinitis-retinal-vasculitis-and-panuveitis-following-uncomplicated-chickenpox-in-an-immunocompetent-child
#16
Jonathan Yu, Jane Ashworth, Stephen Hughes, Nicholas Jones
A 4-year-old girl presented with acute left visual loss 4 weeks after uneventful chickenpox. She was found to have left necrotising retinitis and profound retinal vasculitis and vitritis. Aqueous humour was PCR positive for varicella-zoster virus. Combined intravenous and intravitreal antiviral treatment led to rapid improvement with settled retinitis, no vascular occlusion and good recovery of vision. Her recent coinfection with Epstein-Barr virus may have acted to provoke the retinitis.
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29622358/arterial-reconstructions-for-pediatric-splanchnic-artery-occlusive-disease
#17
Dawn M Coleman, Jonathan L Eliason, James C Stanley
OBJECTIVE: Pediatric splanchnic arterial occlusive disease is uncommon and a rare cause of clinically relevant intestinal ischemia. This study was undertaken to better define the clinical manifestations and appropriate treatment of celiac artery (CA) and superior mesenteric artery (SMA) occlusive disease in children. METHODS: Clinical courses of 30 consecutive children undergoing operations for splanchnic arterial occlusive disease at the University of Michigan from 1992 to 2017 were retrospectively analyzed...
April 2, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29622159/device-related-thrombosis-after-percutaneous-left-atrial-appendage-occlusion-for-atrial-fibrillation
#18
Laurent Fauchier, Alexandre Cinaud, François Brigadeau, Antoine Lepillier, Bertrand Pierre, Selim Abbey, Marjaneh Fatemi, Frederic Franceschi, Paul Guedeney, Peggy Jacon, Olivier Paziaud, Sandrine Venier, Jean Claude Deharo, Daniel Gras, Didier Klug, Jacques Mansourati, Gilles Montalescot, Olivier Piot, Pascal Defaye
BACKGROUND: Transcatheter left atrial appendage (LAA) occlusion is an alternative strategy for stroke prevention in patients with atrial fibrillation (AF). OBJECTIVES: This study sought to determine the incidence, predictors, and prognosis of thrombus formation on devices in patients with AF who were treated with LAA closure. METHODS: The study retrospectively analyzed data from patients treated with 2 LAA closure devices seen in 8 centers in France from February 2012 to January 2017...
April 10, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29615545/pulmonary-endarterectomy-for-patients-with-chronic-thromboembolic-disease
#19
Şehnaz Olgun Yıldızeli, Alper Kepez, Serpil Taş, Mehmed Yanartaş, Ali Fuad Durusoy, Atakan Erkılınç, Bülent Mutlu, Cihangir Kaymaz, Hasan Sunar, Bedrettin Yıldızeli
OBJECTIVE: Chronic thromboembolic disease (CTED) is characterized by persistent pulmonary thromboembolic occlusions without pulmonary hypertension. Early surgical treatment by performing pulmonary endarterectomy (PEA) may improve symptoms. The goal of the study was to review our experience and early outcome of PEA in patients with CTED. METHODS: Data were prospectively collected on all patients who underwent PEA between 2011 and 2015. Patients with CTED and a mean pulmonary artery pressure (mPAP) of <25 mm Hg were identified...
April 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29614639/microparticles-in-sickle-cell-disease
#20
Marc Romana, Philippe Connes, Nigel S Key
Several pathophysiological pathways in sickle cell disease (SCD), the most prevalent hemoglobinopathy worldwide, result in activation of circulating blood cells and the release of submicron vesicles, so-called microparticles (MPs). MPs are candidate biomarkers in vascular disease that exhibit functional biological properties. Compared to healthy individuals, higher level of plasma MPs, mostly derived from platelets and red blood cells (RBC), has been repeatedly observed in SCD patients in their steady-state condition...
2018: Clinical Hemorheology and Microcirculation
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