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Glomerulonephrite

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https://www.readbyqxmd.com/read/26877512/p-201-renal-vasculitis-in-still-disease
#1
S Toujani, F Daoud, Z Aydi, L Baili, B Ben Dhaou, F Boussema
OBJECTIFS: La maladie de Still de l'adulte (MSA) est une affection inflammatoire multisystémique d'étiologie inconnue caractérisée par une atteinte articulaire, une fièvre souvent hectique, une éruption fugace et des atteintes viscérales multiples. Au cours de cette affection systémique, l'atteinte rénale semble rare et polymorphe. Ce type d'atteinte est plus volontiers associé aux arthropathies sévères et à l'amylose de type AA. Des observations de néphropathies tubulo-interstitielles, membrano-polifératives ou mésangiales ont été rapportés...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877497/p-188-blood-pressure-control-in-primary-glomerulonephritis-about-153-cases
#2
F Saada, S Talbi, F Atrouz, S Ouanoughi
OBJECTIFS: Le lien entre hypertension artérielle (HTA) et maladie rénale en général, fût établit par Richard Bright en 1837. L'hypertension artérielle est particulièrement fréquente dans les néphropathies glomérulaires primitives et cette fréquence dépend d'une part de la nature histologique de la lésion et d'autre part du débit de la filtration glomérulaire. l'objectif principal de notre étude est de déterminer la fréquence de l'hypertension artérielle chez des patients présentant des néphropathies glomérulaires primitives et d'en préciser le mécanisme physiopathologique selon les différentes lésions anatomopathologiques...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877494/p-186-iga-nephropathy-clinical-and-hispathological-findings
#3
M Najjar, H Jebali, R Kheder, L Raïs, L Ben Fatma, W Smaoui, M Krid, F Ben Moussa, S Beji, K Zouaghi
OBJECTIFS: La néphropathie à IgA (NIgA) est une des glomérulonéphrites les plus communes caractérisée par le dépôt d'IgA dans le mésangium glomérulaire. Elle progresse vers l'insuffisance rénale (IR) terminale dans 10 à 30 % des cas après 20 ans d'évolution. MéTHODES: Il s'agit d'une étude rétrospective incluant 41 patients présentant un NIgA colligés sur une période de sept ans (2007-2015). Les données cliniques et para cliniques ont été recueillies à partir des observations médicales...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877486/p-178-diuretics-prescription-and-assessment-of-practices-in-pediatric-intensive-care-unit-university-hospital-of-oran
#4
D Batouche, K Elhalimi, N Benatta, N Chaib, S Abas-Sini, Y Touhami, M A Negadi, Z Mentouri
OBJECTIFS: Les indications de prescription des diurétiques sont diverses notamment en milieu de réanimation. Elles peuvent être bien conduites sous réserve d'un monitorage de la volémie. Ce travail, a pour objectif d'évaluer l'utilisation des diurétiques en réanimation au niveau des indications de prescriptions. MéTHODES: Étude monocentrique rétrospective incluant tous les patients hospitalisés en réanimation pédiatrique sur une période de janvier 1997 à décembre 2014, chez qui une prescription des diurétiquesétait indiquée...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877366/p-067-feature-of-secondary-hypertension
#5
S Derbal, B Ben Kaab, M T Jomni, S Bellakhel, A Mestiri, H Smida, M H Dougui
OBJECTIFS: L'hypertension artérielle secondaire, ne représente que 10 % de l'ensemble de l'HTA tout venant. Les causes d'HTA secondaire sont multiples, regroupant des pathologies essentiellement endocriniennes, rénales et vasculaires. Le but de notre travail est de décrire le profil des sujets explorés pour une HTA secondaire, les étiologies et l'évolution sous traitement. MéTHODES: Nous rapportons le résultat d'une étude rétrospective sur les patients explorés pour une suspicion d'HTA secondaire que nous avons colligé au Service de Médecine Interne de l'Hôpital FSI de Tunis...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877327/p4-31-clinical-and-etiological-profile-malignant-hypertension-in-children-in-pediatric-intensive-care
#6
D Batouche, K Elhalimi, N Benatta, L Sadaoui, S Zohret, N Boucherit, M Berexi-Reguig, F Benhamed, M Negadi, Z Mentouri
OBJECTIFS: L'hypertension artérielle maligne (HTAm), affection rare en pédiatrie, est particulière par sa présentation clinique qui est souvent trompeuse et par ses étiologies. Nous décrivons l'aspect clinique et étiologique de HTAm. MéTHODES: Étude rétrospective des dossiers d'enfants admis durant 20 ans en réanimation pédiatrique où nous avons relevé les cas ayant présenté une HTAm. RéSULTATS: 66 patients ont été inclus soit une prévalence de 0,6 %. L'âge des patients varie de 12 mois à 16 ans...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26656595/the-anti-membranous-glomerulonephritic-activity-of-purified-polysaccharides-from-irpex-lacteus-fr
#7
Juan Wang, Jingjing Song, Di Wang, Na Zhang, Jiahui Lu, Qingfan Meng, Yulin Zhou, Ning Wang, Yang Liu, Di Wang, Lesheng Teng
The present study aims to identify the major active component from mutant Irpex lacteus, which protects against cationic bovine serum albumin (C-BSA)-induced membranous glomerulonephropathy (MGN). The candidate component ILN3A (MW: 2264 kDa) was purified from mutant Irpex lacteus water extract. The backbone of ILN3A comprises (1→2) and (1→4) linkages, and (1)H NMR spectrum suggests the existence of α- and β-glycosidic anomeric carbon. In tissue culture study, ILN3A inhibits mesangial cell proliferation...
March 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/24710788/-tonsillitis-and-sore-throat-in-childhood
#8
REVIEW
K Stelter
Surgery of the tonsils is still one of the most frequent procedures during childhood. Due to a series of fatal outcome after hemorrhage in children in Austria in 2006, the standards and indications for tonsillectomy slowly change in Germany since that. However, there exist no national guidelines and the frequency of tonsil surgery varies in the country. In some districts eight times more children were tonsillectomized than in others. A tonsillectomy in children under 6 years should only be done if the child suffers from recurrent acute bacterially tonsillitis...
March 2014: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/24206602/targeting-therapeutics-to-the-glomerulus-with-nanoparticles
#9
REVIEW
Jonathan E Zuckerman, Mark E Davis
Nanoparticles are an enabling technology for the creation of tissue-/cell-specific therapeutics that have been investigated extensively as targeted therapeutics for cancer. The kidney, specifically the glomerulus, is another accessible site for nanoparticle delivery that has been relatively overlooked as a target organ. Given the medical need for the development of more potent, kidney-targeted therapies, the use of nanoparticle-based therapeutics may be one such solution to this problem. Here, we review the literature on nanoparticle targeting of the glomerulus...
November 2013: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/24165783/renoprotective-effects-of-direct-renin-inhibition-in-glomerulonephritis
#10
Kayoko Miyata, Ryousuke Satou, Daisuke Inui, Akemi Katsurada, Dale Seth, Allison Davis, Maki Urushihara, Hiroyuki Kobori, Kenneth D Mitchell, L Gabriel Navar
The development of glomerulonephritis causes glomerular injury and renal dysfunction and is thought to increase renin release, thus activating the renin-angiotensin system (RAS). The aims of this study were to demonstrate activation of the intrarenal RAS and determine the effects of direct renin inhibition (DRI) on the progression of glomerulonephritis. Rats were treated with anti-Thy1.1 antibody with or without DRI, aliskiren (30 mg/kg/d). In the glomerulonephritic rats, protein, microalbumin excretion levels, urinary angiotensinogen excretion, glomerular expansion score and intrarenal transforming growth factor-β and plasminogen activator inhibitor-1 mRNA levels were augmented compared with control rats; however, hypertension was not observed in the glomerulonephritic rats, and aliskiren treatment did not modify their blood pressure...
October 2014: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/23344476/selective-estrogen-receptor-modulation-attenuates-proteinuria-induced-renal-tubular-damage-by-modulating-mitochondrial-oxidative-status
#11
Yuko Nishi, Minoru Satoh, Hajime Nagasu, Hiroyuki Kadoya, Chieko Ihoriya, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara
Proteinuria is an independent risk factor for progressive renal diseases because it initiates or aggravates tubulointerstitial injury. Clinically, females are less susceptible to progression of chronic kidney disease; however, the mechanisms underlying the renoprotective effect of estrogen receptor stimulation have yet to be clarified. Recently, inflammasome-dependent inflammatory responses were shown to be triggered by free fatty acids, and mitochondria-derived reactive oxygen species were shown to be required for this response...
April 2013: Kidney International
https://www.readbyqxmd.com/read/22982912/expression-of-angiotensin-converting-enzyme-mrna-gene-in-the-kidneys-of-patients-with-glomerulonephrites
#12
Alsayed Ahmed Alnahal, Usama Ahmed Khalil, Magada Alsayed Diab, Ali Fahmy Zanaty
A little is known about the behavior of the renin-angiotensin system (RAS) in glomerulo-nephritis (GN), although it is activated in other models of injury. To study renal angiotensin-converting enzyme (ACE) messenger ribonucleic acid (mRNA) gene expression in patients with GN to determine its role in the disease process and other factors that may influence the course of the disease and the prognosis, e.g. treatment with ACE inhibitor (ACEI) drugs, we studied 20 patients with GN allocated to two groups: ten patients received an ACEI drug and ten patients did not receive ACEI in addition to a control group of ten healthy subjects...
September 2012: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/22028268/-diverse-histological-lesions-in-a-patient-with-antiphospholipid-syndrome-aps
#13
Ermanno Salvatore, Remo Luciani, Annamaria Di Palma, Arturo Aversano, Davide Stellato, Marco Liuzzi, Emilio Iele, Vinicio Martignetti, Enrico Spagnuolo, Luigi Morrone
Antiphospholipid syndrome (APS) is a rare autoimmune disorder. It can be secondary to systemic lupus erythematosus (SLE) or occur in the absence of autoimmune disease. The hallmark of this so-called primary APS is the presence of circulating antiphospholipid antibodies. Renal involvement in primary APS is caused by thrombosis within the renal vasculature. Recently, nonthrombotic glomerulonephritic renal lesions have been described in primary APS as a new histological entity. We here report a patient with primary APS in whom both lesion types were present...
September 2011: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/21111456/immunoglobulin-a-dominant-postinfectious-glomerulonephritis-frequent-occurrence-in-nondiabetic-patients-with-staphylococcus-aureus-infection
#14
Suchin Worawichawong, Louis Girard, Kiril Trpkov, James C Gough, Daniel B Gregson, Hallgrimur Benediktsson
Immunoglobin A-dominant postinfectious glomerulonephritis is a distinct clinicopathologic entity that has been linked to staphylococcal infection, including methicillin-resistant Staphylococcus aureus. An association with diabetic nephropathy has been suggested. Although the morphologic features resemble other forms of postinfectious glomerulonephritis, immunofluorescence shows dominant or codominant immunoglobulin A immune-complex deposits. We encountered 7 patients with immunoglobulin A-dominant postinfectious glomerulonephritis over 2½ years at a single center...
February 2011: Human Pathology
https://www.readbyqxmd.com/read/20613715/decreased-renal-corin-expression-contributes-to-sodium-retention-in-proteinuric-kidney-diseases
#15
Danny Polzin, Henriette J Kaminski, Christian Kastner, Wei Wang, Stephanie Krämer, Stepan Gambaryan, Michael Russwurm, Harm Peters, Qingyu Wu, Alain Vandewalle, Sebastian Bachmann, Franziska Theilig
Patients with proteinuric kidney diseases often have symptoms of salt and water retention. It has been hypothesized that dysregulated sodium absorption is due to increased proteolytic cleavage of epithelial sodium channels (ENaCs) and increased Na,K-ATPase expression. Microarray analysis identified a reduction in kidney corin mRNA expression in rat models of puromycin aminonucleoside-induced nephrotic syndrome and acute anti-Thy1 glomerulonephritis (GN). As atrial natriuretic peptide (ANP) resistance is a mechanism accounting for volume retention, we analyzed the renal expression and function of corin; a type II transmembrane serine protease that converts pro-ANP to active ANP...
October 2010: Kidney International
https://www.readbyqxmd.com/read/18689958/-new-horizon-of-glomerulonephritic-model
#16
REVIEW
Tadashi Nagamatsu
No abstract text is available yet for this article.
August 2008: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/18046678/-full-house-proliferative-glomerulonephritis-an-unreported-presentation-of-subacute-infective-endocarditis
#17
L-C Lee, K-K Lam, C-T Lee, J-B Chen, T-H Tsai, S-C Huang
A severely ill 65-year-old man presented with symptoms of shortness of breath, edema and vasculitidic purpura over his lower extremities. He had severe mitral regurgitation which had not been surgically treated. Hematologic examination demonstrated leukocytosis with profound anemia. Other blood tests revealed impaired renal function, hypoalbuminemia, hypocomplementemia and mixed-type cryoglobulinemia. Urinalysis showed proteinuria, hematuria and pyuria, typical of a nephritic sediment. Renal biopsy indicated diffuse proliferative glomerulonephritis and a "full house" deposition in immunofluorescence study (positive for C3, C4, C1q, IgG, IgA and IgM), resembling the pathologic findings in class IV lupus nephritis...
November 2007: Journal of Nephrology
https://www.readbyqxmd.com/read/17803478/trends-in-incidence-of-treated-end-stage-renal-disease-overall-and-by-primary-renal-disease-in-persons-aged-20-64-years-in-europe-canada-and-the-asia-pacific-region-1998-2002
#18
John H Stewart, Margaret R E McCredie, Sheila M Williams, Kitty J Jager, Lilyanna Trpeski, Stephen P McDonald et al.
AIMS: To determine if rates of diabetic and non-diabetic end-stage renal disease (ESRD), which had been rising in young and middle-aged adults in all populations up to the mid-1990s, had started to decline, and if so, whether improvement had occurred in respect of each of the principal primary renal diseases causing ESRD. METHODS: Poisson regression of age- and sex-standardized incidence of ESRD for persons aged 20-64 years in 18 populations from Europe, Canada and the Asia-Pacific region, for 1998-2002...
October 2007: Nephrology
https://www.readbyqxmd.com/read/17497465/paraoxonase-activity-in-glomerulonephritic-patients
#19
Mustafa Gullulu, Serdar Kahvecioglu, Melahat Dirican, Ibrahim Akdag, Nihal Ocak, Celalettin Demircan, Kamil Dilek, Alpaslan Ersoy, Mahmut Yavuz, Mustafa Yurtkuran
BACKGROUND: Cardiovascular disease is the most common cause of morbidity and mortality in patients with chronic renal failure. Glomerulonephritic patients have an increased risk for cardiovascular disease, but its etiology is unclear. It is known that an increase in oxidizability of apolipoprotein B-containing lipoproteins has a key role in the initiation of atherosclerosis, and paraoxonase enzyme activity particularly has a preventive role against atherosclerosis. The aim of the present study was to evaluate the oxidizability of apolipoprotein B-containing lipoproteins, serum, and urinary paraoxonase/arylesterase activities in glomerulonephritis patients who had normal lipid parameters and creatinine levels...
2007: Renal Failure
https://www.readbyqxmd.com/read/17372685/advances-in-targeting-drug-delivery-to-glomerular-mesangial-cells-by-long-circulating-cationic-liposomes-for-the-treatment-of-glomerulonephritis
#20
Katsumi Morimoto, Masayo Kondo, Kazuo Kawahara, Hideto Ushijima, Yasuhiko Tomino, Masaharu Miyajima, Junji Kimura
PURPOSE: Newly designed polyethylene glycol (PEG)-modified cationic liposomes, containing a novel cationic lipid TRX-20 (3,5-dipentadecyloxybenzamidine hydrochloride), bind specifically to cultured human mesangial cells, and not to endothelial cells. In this study, we investigated targeting the delivery of PEG-modified liposomes containing TRX-20 (TRX-liposomes) to mesangial cells and evaluated their pharmacokinetic behavior in a rat experimental glomerulonephritis model, using prednisolone phosphate (PSLP) as a model drug...
May 2007: Pharmaceutical Research
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