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https://www.readbyqxmd.com/read/28644715/biological-responses-of-the-american-coot-fulica-americana-in-wetlands-with-contrasting-environmental-conditions-basin-of-m%C3%A3-xico
#1
María Eugenia López-Islas, Itzel Ibarra-Meza, Esperanza Ortiz-Ordóñez, Liliana Favari, J Elías Sedeño-Díaz, Eugenia López-López
Wetland ecosystems are subject to severe impacts (physical and chemical) and to the input of various xenobiotics that provoke toxicological consequences. Waterbirds are potential sentinel species of these environments. To analyze how habitat conditions affect the health of Fulica americana, early-warning biomarkers, histopathology, somatic indices, and water quality were examined in two wetlands of the Basin of Mexico: Xochimilco, an urban wetland highly eutrophic with a mixture of pollutants, and Tecocomulco (the reference site), a rural wetland with hunting migratory birds in winter, and with some agricultural contaminants...
June 23, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28643677/modulator-effect-of-watercress-against-cyclophosphamide-induced-oxidative-stress-in-mice
#2
Natalia A Casanova, María Fernanda Simoniello, Marcela Mabel López Nigro, Marta A Carballo
Watercress (Nasturtium officinale, Cruciferae; W. Aiton) is a vegetable widely consumed in our country, with nutritional and potentially chemopreventive properties. Previous reports from our laboratory demonstrated the protective effect of watercress juice against DNA damage induced by cyclophosphamide in vivo. In this study, we evaluated the in vivo effect of cress plant on the oxidative stress in mice. Animals were treated by gavage with different doses of watercress juice (0.5 and 1g/kg body weight) for 15 consecutive days before intraperitoneal injection of cyclophosphamide (100 mg/kg body weight)...
2017: Medicina
https://www.readbyqxmd.com/read/28643283/role-of-cation-structure-in-the-phytotoxicity-of-ionic-liquids-growth-inhibition-and-oxidative-stress-in-spring-barley-and-common-radish
#3
Robert Biczak, Barbara Pawłowska, Arkadiusz Telesiński, Janusz Kapuśniak
The present study determines the influence of three ionic liquids (ILs) containing cations with diversified structure on the growth and development of spring barley seedlings and common radish leaves. Increasing amounts of 1-butyl-1-methylpyrrolidinium hexafluorophosphate [Pyrrol][PF6], 1-butyl-1-methylpiperidinium hexafluorophosphate [Piper][PF6], and 1-butyl-4-methylpyridinium hexafluorophosphate [Pyrid][PF6] were added to the soil on which both plants were cultivated. The results of this studies showed that the applied ILs were highly toxic for plants, demonstrated by the inhibition of length of plant shoots and roots, decrease of fresh mass, and increase of dry weight content...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28642096/pine-needle-extract-prevents-hippocampal-memory-impairment-in-acute-restraint-stress-mouse-model
#4
Jin-Seok Lee, Hyeong-Geug Kim, Hye-Won Lee, Won-Yong Kim, Yo-Chan Ahn, Chang-Gue Son
ETHNOPHARMACOLOGICAL RELEVANCE: The Pinus densiflora leaf has been traditionally used to treat mental health disorders as a traditional Chinese medicine. Here we examined the ethnopharmacological relevance of pine needle on memory impairment caused by stress. AIM OF THE STUDY: To elucidate the possible modulatory actions of 30% ethanolic pine needle extract (PNE) on stress-induced hippocampal excitotoxicity, we adopted an acute restraint stress mouse model. MATERIALS AND METHODS: Mice were orally administered with PNE (25, 50, or 100mg/kg) or ascorbic acid (100mg/kg) for 9 days, and were then subjected to restraint stress (6h/day) for 3 days (from experimental day 7 to 9)...
June 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28641197/effects-of-organophosphorus-flame-retardant-tdcpp-on-normal-human-corneal-epithelial-cells-implications-for-human-health
#5
Ping Xiang, Rong-Yan Liu, Chao Li, Peng Gao, Xin-Yi Cui, Lena Q Ma
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is one of the most detected organophosphorus flame retardants (OPFRs) in the environment, especially in indoor dust. Continuous daily exposure to TDCPP-containing dust may adversely impact human cornea. However, its detrimental effects on human corneal epithelium are largely unknown. In this study, we investigated the cell apoptosis in normal human corneal epithelial cells (HCECs) after TDCPP exposure and elucidated the underlying molecular mechanisms. Our data indicated a dose-dependent decrease of cell viability after TDCPP exposure with LC50 at 202 μg/mL...
June 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28640931/ischemia-responsive-protein-94-is-a-key-mediator-of-ischemic-neuronal-injury-induced-microglial-activation
#6
Rajiv Tikamdas, Sarthak Singhal, Ping Zhang, Justin A Smith, Eric G Krause, Stanley M Stevens, Sihong Song, Bin Liu
Neuroinflammation, especially activation of microglia, the key immune cells in the brain, has been proposed to contribute to the pathogenesis of ischemic stroke. However, the dynamics and the potential mediators of microglial activation following ischemic neuronal injury are not well understood. In this study, using oxygen/glucose deprivation and reoxygenation (OGD/R) with neuronal and microglial cell cultures as an in vitro model of ischemic neuronal injury, we set out to identify neuronal factors released from injured neurons that are capable of inducing microglial activation...
June 22, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28640451/cardiac-fibrosis-and-arrhythmogenesis
#7
My-Nhan Nguyen, Helen Kiriazis, Xiao-Ming Gao, Xiao-Jun Du
Myocardial injury, mechanical stress, neurohormonal activation, inflammation, and/or aging all lead to cardiac remodeling, which is responsible for cardiac dysfunction and arrhythmogenesis. Of the key histological components of cardiac remodeling, fibrosis either in the form of interstitial, patchy, or dense scars, constitutes a key histological substrate of arrhythmias. Here we discuss current research findings focusing on the role of fibrosis, in arrhythmogenesis. Numerous studies have convincingly shown that patchy or interstitial fibrosis interferes with myocardial electrophysiology by slowing down action potential propagation, initiating reentry, promoting after-depolarizations, and increasing ectopic automaticity...
June 18, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28640253/a-role-for-tspo-in-mitochondrial-ca-2-homeostasis-and-redox-stress-signaling
#8
Jemma Gatliff, Daniel A East, Aarti Singh, Maria Soledad Alvarez, Michele Frison, Ivana Matic, Caterina Ferraina, Natalie Sampson, Federico Turkheimer, Michelangelo Campanella
The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquitination via a peri-organelle accumulation of reactive oxygen species (ROS). Here we describe that TSPO deregulates mitochondrial Ca(2+) signaling leading to a parallel increase in the cytosolic Ca(2+) pools that activate the Ca(2+)-dependent NADPH oxidase (NOX) thereby increasing ROS...
June 22, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28639234/novel-biomarkers-of-subclinical-cardiac-dysfunction-in-the-general-population
#9
REVIEW
Kamal Shemisa, Anish Bhatt, Daniel Cheeran, Ian J Neeland
PURPOSE OF REVIEW: Recognition of subclinical myocardial dysfunction offers clinicians and patients an opportunity for early intervention and prevention of symptomatic cardiovascular disease. We review the data on novel biomarkers in subclinical heart disease in the general population with a focus on pathophysiology, recent observational or trial data, and potential applicability and pitfalls for clinical use. RECENT FINDINGS: High-sensitivity cardiac troponin and natriuretic peptide assays are powerful markers of subclinical cardiac disease...
June 21, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28638254/inflammation-and-oxidation-biomarkers-in-patients-with-cystic-fibrosis-the-influence-of-azithromycin
#10
Casilda Olveira, Alicia Padilla, Antonio Dorado, Victoria Contreras, Eduardo Garcia-Fuentes, Elehazara Rubio-Martin, Nuria Porras, Esperanza Doña, Ana Carmona, Gabriel Olveira
OBJECTIVE: In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides. MATERIALS AND METHODS: The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28637174/effect-of-prenatal-exposure-to-waterpipe-tobacco-smoke-on-learning-and-memory-of-adult-offspring-rats
#11
Nour Al-Sawalha, Karem Alzoubi, Omar Khabour, Weam Alyacoub, Yehya Almahmmod, Thomas Eissenberg
Introduction: Waterpipe tobacco smoking has increased in prevalence worldwide, including among pregnant women. In this study, we investigated the effect of prenatal maternal waterpipe tobacco smoke (WTS) exposure during different stages of pregnancy on learning and memory of adult offspring rats. Methods: Pregnant rats received either fresh air or mainstream WTS (two hours daily) during early, mid, late, or whole gestational period. Male offspring rats were followed through 20 weeks...
June 20, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28636217/research-on-potential-biomarker-correlates-for-suicidal-behavior-a-review
#12
REVIEW
Sangha Kim, Kyoung-Uk Lee
Suicide is a world health priority. Studies over the last few decades have revealed the complexity underlying the neurobiological mechanisms of suicide. Researchers have found dysregulations in the serotonergic system, the stress system, neural plasticity, lipid metabolism, and cell signaling pathways in relation to suicidal behaviors. These findings have provided more insight into the final path leading to suicide, at which medical intervention should be applied to prevent the action. However, because these molecular mechanisms have been implicated in both depression and suicide, the specificity of the mechanisms has been obscured...
June 21, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/28634813/long-term-excessive-selenium-supplementation-induces-hypertension-in-rats
#13
Denise Grotto, Maria Fernanda Hornos Carneiro, Michele Mazzaron de Castro, Solange Cristina Garcia, Fernando Barbosa Junior
Selenium (Se) is an essential trace element involved in several biological pathways, naturally found in rocks, soils, and food. Even though the daily requirement of Se is achieved through a balanced diet, the use of Se supplements has been frequent. Due to the risk of toxic effects of having Se in excess, supplementation is still under debate. The aim was to evaluate the effects of long-term Se supplementation upon systolic blood pressure (SBP) and redox status of rats exposed to sodium selenite. Male Wistar rats were exposed to 2 and 6 mg/L of sodium selenite in drinking water for 85 days...
June 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28634437/latent-growth-curve-models-for-biomarkers-of-the-stress-response
#14
REVIEW
John M Felt, Sarah Depaoli, Jitske Tiemensma
Objective: The stress response is a dynamic process that can be characterized by predictable biochemical and psychological changes. Biomarkers of the stress response are typically measured over time and require statistical methods that can model change over time. One flexible method of evaluating change over time is the latent growth curve model (LGCM). However, stress researchers seldom use the LGCM when studying biomarkers, despite their benefits. Stress researchers may be unaware of how these methods can be useful...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28632734/choroidal-thickness-in-patients-with-coronary-artery-disease
#15
Meleha Ahmad, Patrick A Kaszubski, Lucy Cobbs, Harmony Reynolds, Roland Theodore Smith
PURPOSE: To evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls. DESIGN: Cross-sectional. METHODS: Setting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure...
2017: PloS One
https://www.readbyqxmd.com/read/28631886/nlrp3-expression-and-urinary-hsp72-in-relation-to-biomarkers-of-inflammation-and-oxidative-stress-in-diabetic-nephropathy-patients
#16
Hemat El-Sayed El-Horany, Rania Nagi Abd-Ellatif, Mona Watany, Yasser M Hafez, Hanaa Ibrahim Okda
Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease. Nod-like receptors nucleotide-binding domain and leucine-rich repeat pyrin-3 domain (NLRP3) inflammasome displays a considerable role in the chronic inflammatory state observed in diabetic patients. Urinary heat shock protein 72 (uHSP72) is a sensitive and specific biomarker for the early detection of acute kidney injury. The aim of this study was to evaluate NLRP3 relative gene expression, its correlation with inflammatory and oxidative stress markers, and to assess the value of uHSP72 in the early detection of DN in type 2 diabetic patients with different degrees of DN...
June 20, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28631839/natural-variability-of-biochemical-biomarkers-in-the-macro-zoobenthos-dependence-on-life-stage-and-environmental-factors
#17
Lucia Scarduelli, Roberto Giacchini, Paolo Parenti, Sonia Migliorati, Agnese Maria Di Brisco, Marco Vighi
Biomarkers are widely used in ecotoxicology as indicators of exposure to toxicants. However, their ability to provide ecologically relevant information remains controversial. One of the major problems is understanding if the measured responses are determined by stress factors or lie within the natural variability range. In a previous work, the natural variability of enzymatic levels in invertebrates sampled in pristine rivers was proved to be relevant across both space and time. In this work, the experimental design was improved by considering different life stages of the selected taxa and by measuring more environmental parameters...
June 20, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28631083/is-there-a-relationship-between-serum-ox-ldl-oxidative-stress-and-pon1-in-knee-osteoarthritis
#18
Cemil Ertürk, Mehmet Akif Altay, Ali Bilge, Hakim Çelik
Previous in vitro studies have shown that oxidized low-density lipoprotein (ox-LDL) plays a role in the pathogenesis of osteoarthritis (OA). Paraoxonase-1 (PON1) protects both low-density lipoproteins (LDLs) and high-density lipoprotein (HDLs) against oxidative damage from circulating cells. In addition, PON1 is inactivated by ox-LDL and preserved by antioxidants. However, the relationship between serum ox-LDL, oxidative stress, and PON1 in knee OA remains unclear. Therefore, we investigated ox-LDL association with oxidative stress and PON1 in knee OA, and evaluated their relationships using radiological and clinical parameters...
June 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28630667/evaluation-of-radical-scavenging-system-in-amoeba-chaos-carolinense-during-nutrient-deprivation
#19
Yuru Deng, Edlyn Li-Hui Lee, Ketpin Chong, Zakaria A Almsherqi
The frequent appearance of non-lamellar membrane arrangements such as cubic membranes (CMs) in cells under stressed or pathological conditions points to an intrinsic cellular response mechanism. CM represents highly curved, three-dimensional nano-periodic structures that correspond to mathematically well-defined triply periodic minimal surfaces. Specifically, cellular membrane may transform into CM organization in response to pathological, inflammatory and oxidative stress conditions. CM organization, thus, may provide an advantage to cope with various types of stress...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28629959/glycemic-control-and-muscle-damage-in-3-athletes-with-type-1-diabetes-during-a-successful-performance-in-a-relay-ultramarathon-a-case-report
#20
Taisa Belli, Denise V de Macedo, Pedro P M Scariot, Gustavo G de Araújo, Ivan G M Dos Reis, Fernanda L Lazarim, Lázaro A S Nunes, René Brenzikofer, Claudio A Gobatto
Ultramarathon races are fairly demanding and impose substantial physiological stress on healthy athletes. These competitions may thus be considerably more challenging for individuals with diabetes. This case study aims to describe glycemic control, muscle damage, inflammation, and renal function in 3 athletes with type 1 diabetes during a successful performance in a relay ultramarathon. The team completed the race in 29 hours and 28 minutes, earning third place. The total distance covered by each athlete was 68...
June 16, 2017: Wilderness & Environmental Medicine
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