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risk factors in cardiovascular diseases

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https://www.readbyqxmd.com/read/27926642/ovarian-conservation-and-overall-survival-in-young-women-with-early-stage-cervical-cancer
#1
Koji Matsuo, Hiroko Machida, Donna Shoupe, Alexander Melamed, Laila I Muderspach, Lynda D Roman, Jason D Wright
OBJECTIVE: To identify predictors of ovarian conservation at hysterectomy and to examine the association of ovarian conservation and survival of young women with early-stage cervical cancer. METHODS: This is a retrospective cohort study using the Surveillance, Epidemiology, and End Results Program to identify hysterectomy-based surgically treated patients with stage I cervical cancer diagnosed between 1983 and 2012 (N=16,511). Multivariable models were used to identify independent factors associated with ovarian conservation...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926633/effects-of-calcium-vitamin-d-and-hormone-therapy-on-cardiovascular-disease-risk-factors-in-the-women-s-health-initiative-a-randomized-controlled-trial
#2
Peter F Schnatz, Xuezhi Jiang, Aaron K Aragaki, Matthew Nudy, David M OʼSullivan, Mark Williams, Erin S LeBlanc, Lisa W Martin, JoAnn E Manson, James M Shikany, Karen C Johnson, Marcia L Stefanick, Martha E Payne, Jane A Cauley, Barbara V Howard, John Robbins
OBJECTIVE: To analyze the treatment effect of calcium+vitamin D supplementation, hormone therapy, both, and neither on cardiovascular disease risk factors. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled trial among Women's Health Initiative (WHI) participants. The predefined primary outcome was low-density lipoprotein cholesterol (LDL-C). RESULTS: Between September 1993 and October 1998, a total of 68,132 women aged 50-79 years were recruited and randomized to the WHI-Dietary Modification (n=48,835) and WHI-Hormone Therapy trials (n=27,347)...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926474/the-association-of-thyroid-function-and-the-risk-of-kidney-function-decline-a-population-based-cohort-study
#3
Layal Chaker, Sanaz Sedaghat, Ewout J Hoorn, Wendy P J Den Elzen, Jacobijn Gussekloo, Albert Hofman, M Arfan Ikram, Oscar H Franco, Abbas Dehghan, Robin P Peeters
OBJECTIVES: Thyroid dysfunction has been associated with kidney function decline, but mainly in cross-sectional studies. Therefore, we aimed to determine the association between thyroid and kidney function in a prospective population-based cohort study longitudinally. DESIGN: Prospective cohort study. METHODS: Participants aged ≥45 years from the Rotterdam Study with thyroid and kidney function assessment were included. Kidney function and new onset chronic kidney disease (CKD) were defined using estimated glomerular filtration ate (eGFR), with CKD defined as eGFR <60 mL/min/1...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27925053/risk-factor-paradox-in-the-occurrence-of-cardiac-arrest-in-acute-coronary-syndrome-patients
#4
Silvia Aguiar Rosa, Ana Teresa Timóteo, Marta Afonso Nogueira, Adriana Belo, Rui Cruz Ferreira
Objective: To compare patients without previously diagnosed cardiovascular risk factors) and patients with one or more risk factors admitted with acute coronary syndrome. Methods: This was a retrospective analysis of patients admitted with first episode of acute coronary syndrome without previous heart disease, who were included in a national acute coronary syndrome registry. The patients were divided according to the number of risk factors, as follows: 0 risk factor (G0), 1 or 2 risk factors (G1 - 2) and 3 or more risk factors (G ≥ 3)...
December 1, 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27925041/wake-up-stroke-clinical-characteristics-sedentary-lifestyle-and-daytime-sleepiness
#5
Deborath Lucia de Oliveira Diniz, Pedro Rodrigues Barreto, Pedro Felipe Carvalhedo de Bruin, Veralice Meireles Sales de Bruin
Objective: Wake-up stroke (WUS) is defined when the exact time of the beginning of the symptoms cannot be determined, for the deficits are perceived upon awakening. Sleep alterations are important risk factors for stroke and cardiovascular diseases. This study evaluates the characteristics of patients with and without WUS, the presence of daytime sleepiness, and associated risk factors. Method: Patients with ischemic stroke were investigated about the presence of WUS...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27924921/birth-weight-and-risk-of-ischemic-heart-disease-a-mendelian-randomization-study
#6
Shiu Lun Au Yeung, Shi Lin Lin, Albert Martin Li, C Mary Schooling
Low birth weight is a risk factor for cardiovascular disease. However, the association could be confounded by many factors. We used Mendelian randomization to clarify the role of birth weight in ischemic heart disease (IHD) and lipids. We used all 7 single nucleotide polymorphisms (SNPs) independently contributing to birth weight at genome wide significance (p < 5 × 10(-8)) in separate sample instrumental variable analysis to estimate the effect of birth weight on IHD using the CARDIoGRAMplusC4D 1000 Genomes based GWAS case (n = 60,801)-control (n = 123,504) study and on lipids using GLGC (n = 188,577)...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924645/cardiovascular-outcomes-and-tumour-necrosis-factor-antagonists-in-chronic-inflammatory-rheumatic-disease-a-focus-on-rheumatoid-arthritis
#7
Giuliano Tocci, Delia Goletti, Valentina Marino, Andrea Matucci, Giuseppe Maria Milano, Fabrizio Cantini, Raffaele Scarpa
Many chronic rheumatic diseases have an inflammatory etiology, leading to accelerated atherosclerosis and increased occurrence of vascular diseases. In rheumatoid arthritis (RA), a reduction in cardiovascular (CV) events has been reported under treatments reducing systemic inflammation. Areas covered: Given the central role of tumour necrosis factor alpha (TNFα) in chronic inflammatory conditions and in atherosclerosis, it has been suggested that TNFα-antagonists may reduce CV risk and mortality. Although there are no randomized controlled or head-to-head trials investigating the effect of specific anti-TNF-agents on CV outcomes, observational cohort studies, national registry data, and meta-analyses in RA have reported improved CV outcomes with anti-TNF therapy...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27924618/cardiovascular-disease-risk-factors-and-health-outcomes-among-american-indians-in-oklahoma-the-thrive-study
#8
Valarie Blue Bird Jernigan, Marianna Wetherill, Jordan Hearod, Tvli Jacob, Alicia L Salvatore, Tamela Cannady, Mandy Grammar, Joy Standridge, Jill Fox, Jennifer Spiegel, AnDina Wiley, Carolyn Noonan, Dedra Buchwald
INTRODUCTION: Limited available data document higher prevalences of cardiovascular disease (CVD) risk factors and health outcomes among American Indians (AIs) compared to other racial/ethnic groups. METHODS: As part of a randomized control trial to improve tribal food and physical activity environments, our tribal-academic partnership surveyed a cross-sectional sample of American Indian adults (n = 513) to assess the prevalence of type 2 diabetes, obesity, hypertension, tobacco use, physical activity, and vegetable and fruit intake...
December 6, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27924211/circulating-mir-126-and-mir-499-reflect-progression-of-cardiovascular-disease-correlations-with-uric-acid-and-ejection-fraction
#9
Masoud Khanaghaei, Fereshtah Tourkianvalashani, Seyedhossein Hekmatimoghaddam, Nasrin Ghasemi, Mahdi Rahaie, Vahid Khorramshahi, Akhtar Sheikhpour, Zahra Heydari, Fatemeh Pourrajab
BACKGROUND: The aim of this study was to assess plasma levels of endothelium- and heart-associated microRNAs (miRNAs) miR-126 and miR-499, respectively, using quantitative reverse transcriptase polymerase chain reaction. METHODS: A two-step analysis was conducted on 75 patients undergoing off-pomp coronary artery bypass graft (CABG) surgery. Five biomarkers of inflammation and cardiac injury were assessed in addition to the above-mentioned miRNAs. RESULTS: Plasma concentrations of miRNAs were found to be significantly correlated with plasma levels of cardiac troponin I (cTnI) (miR-499, r 0...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924055/lifestyle-interventions-to-prevent-cardiovascular-events-after-stroke-and-transient-ischemic-attack-systematic-review-and-meta-analysis
#10
Inger A Deijle, Sander M Van Schaik, Erwin E H Van Wegen, Henry C Weinstein, Gert Kwakkel, Renske M Van den Berg-Vos
BACKGROUND AND PURPOSE: Patients with a transient ischemic attack or ischemic stroke have an increased risk of subsequent cardiovascular events. The purpose of this systematic review and meta-analysis was to determine whether lifestyle interventions focusing on behaviorally modifiable risk factors with or without an exercise program are effective in terms of (1) preventing recurrent cardiovascular events, (2) reducing mortality, and (3) improving modifiable risk factors associated with cardiovascular disease in patients after a transient ischemic attack or ischemic stroke...
December 6, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27923433/circulating-anti-coatomer-protein-complex-subunit-epsilon-cope-autoantibodies-as-a-potential-biomarker-for-cardiovascular-and-cerebrovascular-events-in-patients-with-obstructive-sleep-apnea
#11
Takuma Matsumura, Jiro Terada, Taku Kinoshita, Yoriko Sakurai, Misuzu Yahaba, Ryogo Ema, Atsuko Amata, Seiichiro Sakao, Kengo Nagashima, Koichiro Tatsumi, Takaki Hiwasa
STUDY OBJECTIVES: Although moderate to severe obstructive sleep apnea (OSA) is an independent risk factor for severe arteriosclerotic diseases such as cardiovascular disease (CVD) and stroke, the development of atherosclerosis-related diseases cannot yet be predicted in OSA patients. In a pilot study, we identified autoantibodies against the coatomer protein complex, subunit epsilon [circulating anti-coatomer protein complex subunit epsilon autoantibody (COPE-Ab)], a cytosolic complex that mediates protein transport in the Golgi compartment, as a potential novel biomarker of atherosclerosis...
November 28, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27923154/socioeconomic-position-john-henryism-and-incidence-of-acute-myocardial-infarction-in-finnish-men
#12
Mahasin S Mujahid, Sherman A James, George A Kaplan, Jukka T Salonen
Previous cross-sectional studies examining whether John Henryism (JH), or high-effort coping with socioeconomic adversity, potentiates the inverse association between socioeconomic position (SEP) and cardiovascular health have focused mainly on hypertension in African Americans. We conducted the first longitudinal test of this hypothesis on incident acute myocardial infarction (AMI) using data from the Kuopio Ischemic Heart Disease Risk Factor Study in Finland (N = 1405 men, 42-60 years). We hypothesized that the expected inverse gradient between SEP and AMI risk would be stronger for men scoring high on JH than for those scoring low...
November 25, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27922933/the-cross-sectional-association-between-vasomotor-symptoms-and-hemostatic-parameter-levels-in-postmenopausal-women
#13
Laura B Harrington, Marc Blondon, Mary Cushman, Andrew M Kaunitz, Jacques E Rossouw, Matthew A Allison, Lisa W Martin, Karen C Johnson, Jan Rosing, Nancy F Woods, Andrea Z LaCroix, Susan R Heckbert, Barbara McKnight, Nicholas L Smith
OBJECTIVE: Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants. METHODS: This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922919/association-between-sarcopenia-and-metabolic-syndrome-in-cancer-survivors
#14
Su Jung Lee, Nam Cho Kim
BACKGROUND: Advanced cancer treatments have improved survival from cancer, but the incidence of cardiovascular disease in survivors has recently increased. Sarcopenia and metabolic syndrome (MetS) are related to cancer survival, and sarcopenia is an emerging risk factor for cardiovascular disease. However, evidence of a relationship between sarcopenia and MetS in cancer survivors is lacking. OBJECTIVES: The aims of this study were to determine the prevalence of sarcopenia and MetS in cancer survivors and to investigate independent predictors of MetS in cancer survivors...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27922121/sex-differences-in-prevalence-of-and-risk-factors-for-carotid-plaque-among-adults-a-population-based-cross-sectional-study-in-rural-china
#15
Wei Zhao, Yanan Wu, Min Shi, Lingling Bai, Jun Tu, Zaiyu Guo, Rongcai Jiang, Jianning Zhang, Xianjia Ning, Jinghua Wang
Although the associations between carotid plaque and cardiovascular disease risk factors have been identified in previous studies, there is limited information on sex-related differences in factors associated with the development of carotid plaque. We aimed to determine sex differences in the prevalence of carotid plaque and associated risk factors in rural China. A total of 3,789 subjects aged ≥45 years without history of stroke or cardiovascular disease were recruited to the study. B-mode ultrasonography was performed to determine the presence of carotid plaque...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921430/-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#16
Andrea Plíhalová, Kateřina Westlake, Jan Polák
Obstructive sleep apnoea syndrome (OSA) is a disease very frequently occurring in people with type 2 diabetes, that significantly increases cardiovascular morbidity and mortality. In a number of studies, OSA has been identified as an independent risk factor for the development of insulin resistance, glucose intolerance and type 2 diabetes mellitus. Disorders of glucose homeostasis in patients with OSA are probably mediated by chronic intermittent hypoxia and/or sleep fragmentation through activation of the sympathetic nervous system, the hypothalamic-pituitary-adrenal stress axis, pro-inflammatory paths or oxidative stress...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921419/-metabolic-syndrome-in-patients-with-diabetes-mellitus-type-1-prevalence-impact-on-morbidity-and-mortality
#17
Jitka Brožová, Daniela Čechurová, Silvie Lacigová
: Aim of this retrospective observational study was to determine the prevalence of metabolic syndrome (MS) in patients with diabetes mellitus type 1 (DM1Z) at baseline (in 2003) and find the parameters that determine the difference between group with (MS+) and without MS (MS-). Did the presence of MS affect morbidity and mortality in the subsequent 10 years? METHODS: 278 patients were enrolled to the study with age average 39 ± 13 years with medical history of diabetes 15...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921174/spatiotemporal-variations-of-extreme-low-temperature-for-emergency-transport-a-nationwide-observational-study
#18
Daisuke Onozuka, Akihito Hagihara
Although recent studies have investigated the effect of extreme heat on emergency transport, few have investigated the spatiotemporal variations of extreme low temperature for emergency transport on a national scale. Data pertaining to emergency ambulance transport and weather variation in the 47 prefectures of Japan between 2007 and 2010 were obtained. Nonlinear and delayed relationships between temperature and morbidity were assessed using a two-stage analysis. First, a Poisson regression analysis allowing for overdispersion in a distributed lag nonlinear model was used to estimate the prefecture-specific effects of temperature on morbidity...
December 5, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27921044/non-alcoholic-fatty-liver-disease-cause-or-effect-of-metabolic-syndrome
#19
REVIEW
Christoph Grander, Felix Grabherr, Alexander R Moschen, Herbert Tilg
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease throughout the world. Pathophysiological insights into this disease have recently illustrated that various factors such as insulin resistance, innate immunity, metabolic inflammation, and the microbiota are of relevance. NAFLD, metabolic syndrome (MS), and type 2 diabetes (T2D) share many pathophysiological aspects, and inflammatory processes in the adipose tissue, gut, and liver have evolved to be of exceptional importance. Most of NAFLD patients are obese and encounter a high risk of developing MS and T2D...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27921043/metabolic-vascular-syndrome-new-insights-into-a-multidimensional-network-of-risk-factors-and-diseases
#20
REVIEW
Gerhard H Scholz, Markolf Hanefeld
BACKGROUND: Since 1981, we have used the term metabolic syndrome to describe an association of a dysregulation in lipid metabolism (high triglycerides, low high-density lipoprotein cholesterol, disturbed glucose homeostasis (enhanced fasting and/or prandial glucose), gout, and hypertension), with android obesity being based on a common soil (overnutrition, reduced physical activity, sociocultural factors, and genetic predisposition). We hypothesized that main traits of the syndrome occur early and are tightly connected with hyperinsulinemia/insulin resistance, procoagulation, and cardiovascular diseases...
October 2016: Visceral Medicine
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