Xinyu Ge, Qingshu Meng, Xuan Liu, Shanshan Shi, Xuedi Geng, Enhao Wang, Mimi Li, Xiaoxue Ma, Fang Lin, Qianqian Zhang, Yinzhen Li, Lunxian Tang, Xiaohui Zhou
Extracellular vesicles (EVs) exist throughout our bodies. We recently revealed the important role of intracardiac EVs induced by myocardial ischemia/reperfusion on cardiac injury and dysfunction. However, the role of EVs isolated from normal tissues remains unclear. Here we found that EVs, derived from murine heart, lung, liver and kidney have similar effects on macrophages and regulate the inflammation, chemotaxis, and phagocytosis of macrophages. Interestingly, EV-treated macrophages showed LPS resistance with reduced expressions of inflammatory cytokines and enhanced phagocytic activity...
January 2024: Bioengineering & Translational Medicine