keyword
MENU ▼
Read by QxMD icon Read
search

diabetes heart

keyword
https://www.readbyqxmd.com/read/29667759/incidence-predictors-and-clinical-management-of-hyperkalaemia-in-new-users-of-mineralocorticoid-receptor-antagonists
#1
Marco Trevisan, Pietro de Deco, Hairong Xu, Marie Evans, Bengt Lindholm, Rino Bellocco, Peter Barany, Tomas Jernberg, Lars H Lund, Juan J Carrero
BACKGROUND: Concerns for hyperkalaemia limit the use of mineralocorticoid receptor antagonists (MRAs). The frequency of MRA-associated hyperkalaemia in real-world settings and the extent of subsequent MRA discontinuation are poorly quantified. METHODS AND RESULTS: Observational study including all Stockholm citizens initiating MRA therapy during 2007-2010. Hyperkalaemias were identified from all potassium (K+ ) measurements in healthcare. MRA treatment lengths and dosages were obtained from complete collection of pharmacy dispensations...
April 18, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29667216/nationwide-routine-data-analysis-of-sex-differences-in-outcome-of-acute-myocardial-infarction
#2
Eva Freisinger, Susanne Sehner, Nasser M Malyar, Anna Suling, Holger Reinecke, Karl Wegscheider
BACKGROUND: Women have been reported to suffer from impaired outcome after acute myocardial infarction (AMI). HYPOTHESIS: Aim of the study was to determine the impact of sex and age on the utilization of inpatient healthcare and outcome in patients with acute myocardial infarction (AMI; STEMI and NSTEMI) in a real-life setting. METHODS: We performed a Routine-data based analysis of 203,106 nationwide in-patient cases hospitalized with STEMI and NSTEMI, focusing on sex differences regarding risk constellation, treatments, and in-hospital outcome...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#3
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29666704/practice-patterns-and-barriers-for-intravenous-thrombolysis-a-survey-of-neurologists-in-saudi-arabia
#4
Mohammed H Alanazy, Rima B Barakeh, Alanood Asiri, Maha F Edrees, Ahmad R Abuzinadah, Bandar N Aljafen, Taim Muayqil
Only a small fraction of patients with acute ischemic stroke receive intravenous thrombolysis (IVT). We sought to assess barriers and practice patterns in using IVT for acute ischemic stroke among neurologists in Saudi Arabia. An electronic survey was sent to all neurologists registered with the Saudi Commission for Health Specialties. A total of 148 (77.5%) neurologists responded. The most common reported barriers for IVT administration were delayed presentation to hospitals (82.4%) and unclear time of symptom onset (50...
2018: Neurology Research International
https://www.readbyqxmd.com/read/29666641/brief-overview-of-a-decade-of-genome-wide-association-studies-on-primary-hypertension
#5
REVIEW
Afifah Binti Azam, Elena Aisha Binti Azizan
Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making identification of susceptibility genes a major challenge. With major advancement in high-throughput genotyping technology, genome-wide association study (GWAS) has become a powerful tool for researchers studying genetically complex diseases. GWASs work through revealing links between DNA sequence variation and a disease or trait with biomedical importance...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29665203/tolvaptan-alleviates-excessive-fluid-retention-of-nephrotic-diabetic-renal-failure-unresponsive-to-furosemide
#6
Tesshu Takada, Tsuguto Masaki, Ayako Hoshiyama, Takuya Toki, Yuji Kamata, Masayoshi Shichiri
Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention. We aimed to investigate the efficacy of tolvaptan, an oral arginine vasopressin type 2 receptor antagonist, in a case series of 14 severe diabetic renal failure patients who were severely refractory to maximal doses of furosemide and had excessive fluid retention despite preserved cardiac function and residual renal function...
April 17, 2018: Nephrology
https://www.readbyqxmd.com/read/29664406/racial-differences-in-characteristics-and-outcomes-of-patients-with-heart-failure-and-preserved-ejection-fraction-in-the-treatment-of-preserved-cardiac-function-heart-failure-trial
#7
Eldrin F Lewis, Brian Claggett, Amil M Shah, Jiankang Liu, Sanjiv J Shah, Inder Anand, Eileen O'Meara, Nancy K Sweitzer, Jean L Rouleau, James C Fang, Akshay S Desai, Tamrat M Retta, Scott D Solomon, John F Heitner, Thomas D Stamos, Robin Boineau, Bertram Pitt, Marc A Pfeffer
BACKGROUND: Black patients have been shown to have different baseline characteristics and outcomes compared with nonblack patients in cohort studies. However, few studies have focused on heart failure (HF) with preserved ejection fraction (HFpEF) patients. We aimed to determine the difference in cardiovascular outcomes in black and nonblack patients with HFpEF and to determine the relative efficacy and safety of spironolactone in black and nonblack patients. METHODS AND RESULTS: Patients with HFpEF, randomized to spironolactone versus placebo in the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) in North and South America, were grouped according to self-described black and nonblack race...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29664200/prevalence-and-determinants-of-left-ventricular-diastolic-dysfunction-in-obese-subjects-and-the-role-of-left-ventricular-global-longitudinal-strain-and-mass-normalized-to-height
#8
Frank Lloyd Dini, Iacopo Fabiani, Mario Miccoli, Gian Giacomo Galeotti, Nicola Riccardo Pugliese, Andreina D'Agostino, Alessandra Scartabelli, Lorenzo Conte, Guido Salvetti, Ferruccio Santini, Roberto Pedrinelli
BACKGROUND: Left ventricular (LV) diastolic dysfunction (DD) is a frequent finding in obesity and may predispose to the development of heart failure (HF). However, no data are available on the prevalence of DD after the introduction of the 2016 Recommendations of the American Society of Echocardiography and the European Association of Cardiovascular Imaging. METHODS AND RESULTS: To assess the impact of the new Recommendations on the prevalence of DD and on their clinical and echocardiographic correlates in obesity, a prospective study was performed in 588 subjects with an ejection fraction (EF) ≥50% and no history of HF either obese (n = 402; mean age: 47 ± 12 years; women 71%; body mass index [BMI]: 44 ± 8 kg/m2 ), overweight (n = 86; BMI: 28 ± 1 kg/m2 ), or with a normal weight (n = 100; BMI: 22 ± 2 kg/m2 )...
April 17, 2018: Echocardiography
https://www.readbyqxmd.com/read/29663894/coenzyme-q10-in-cardiovascular-and-metabolic-diseases-current-state-of-the-problem
#9
Vladlena I Zozina, Serghei Covantev, Olga A Goroshko, Liudmila M Krasnykh, Vladimir G Kukes
The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation...
April 15, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29663586/adiposity-body-composition-and-ventricular-arterial-stiffness-in-the-elderly-the-atherosclerosis-risk-in-communities-study
#10
Miguel M Fernandes-Silva, Amil M Shah, Brian Claggett, Susan Cheng, Hirofumi Tanaka, Odilson M Silvestre, Wilson Nadruz, Barry A Borlaug, Scott D Solomon
AIM: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. METHODS AND RESULTS: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage...
April 16, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29663436/early-effects-of-empagliflozin-on-exercise-tolerance-in-patients-with-heart-failure-a-pilot-study
#11
Julio Núñez, Patricia Palau, Eloy Domínguez, Anna Mollar, Eduardo Núñez, Jose María Ramón, Gema Miñana, Enrique Santas, Lorenzo Fácila, Jose Luis Górriz, Juan Sanchis, Antoni Bayés-Genís
BACKGROUND: Sodium-glucose linked transporter 2 inhibition recently emerged as a promising therapy for reducing the risk of heart failure (HF) in patients with type 2 diabetes mellitus (T2DM). However, there is a lack of data endorsing its role in symptomatic HF patients. We sought to evaluate the short-term effects of empagliflozin on maximal exercise capacity in these patients. HYPOTHESIS: We postulate tretament with empagliflozin may improve functional capacity in patients with T2DM and established HF...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29662512/prediction-of-sudden-death-in-elderly-patients-with-heart-failure
#12
REVIEW
Ana Ayesta, Helena Martínez-Sellés, Antonio Bayés de Luna, Manuel Martínez-Sellés
Most heart failure (HF) related mortality is due to sudden cardiac death (SCD) and worsening HF, particularly in the case of reduced ejection fraction. Predicting and preventing SCD is an important goal but most works include no or few patients with advanced age, and the prevention of SCD in elderly patients with HF is still controversial. A recent reduction in the annual rate of SCD has been recently described but it is not clear if this is also true in advanced age patients. Age is associated with SCD, although physicians frequently have the perception that elderly patients with HF die mainly of pump failure, underestimating the importance of SCD...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29661781/relation-of-aortic-stiffness-to-left-ventricular-remodelling-in-younger-adults-with-type-2-diabetes
#13
Gaurav S Gulsin, Daniel J Swarbrick, William H Hunt, Eylem Levelt, Matthew Pm Graham-Brown, Kelly S Parke, Joanne V Wormleighton, Florence Y Lai, Thomas Yates, Emma G Wilmot, David R Webb, Melanie J Davies, Gerry P McCann
Individuals with type 2 diabetes have a three-to-five-fold increased risk of developing heart failure. Diabetic cardiomyopathy is typified by left ventricular (LV) concentric remodelling, which is a recognised predictor of adverse cardiovascular events. Although the mechanisms underlying LV remodelling in type 2 diabetes are unclear, progressive aortic stiffening may be a key determinant. The aim of this study was to assess the relationship between aortic stiffness and LV geometry in younger adults with type 2 diabetes, using multiparametric cardiovascular magnetic resonance imaging...
April 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29661699/effect-of-neprilysin-inhibition-on-renal-function-in-patients-with-type-2-diabetes-and-chronic-heart-failure-who-are-receiving-target-doses-of-inhibitors-of-the-renin-angiotensin-system-a-secondary-analysis-of-the-paradigm-hf-trial
#14
Milton Packer, Brian Claggett, Martin P Lefkowitz, John J V McMurray, Jean L Rouleau, Scott D Solomon, Michael R Zile
BACKGROUND: Neprilysin inhibition has favourable effects on experimental diabetic nephropathy. We sought to assess the effects of neprilysin inhibition on the course of renal function in patients with type 2 diabetes. METHODS: In the randomised, double-blind PARADIGM-HF trial, the effects of sacubitril/valsartan (97 mg/103 mg twice daily) were compared with enalapril (10 mg twice daily) in 8399 patients with mild-to-moderate chronic heart failure and systolic dysfunction...
April 13, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29661561/clinically-actionable-hypercholesterolemia-and-hypertriglyceridemia-in-children-with-nonalcoholic-fatty-liver-disease
#15
Kathryn E Harlow, Jonathan A Africa, Alan Wells, Patricia H Belt, Cynthia A Behling, Ajay K Jain, Jean P Molleston, Kimberly P Newton, Philip Rosenthal, Miriam B Vos, Stavra A Xanthakos, Joel E Lavine, Jeffrey B Schwimmer
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29661196/the-women-s-heart-health-programme-a-pilot-trial-of-sex-specific-cardiovascular-management
#16
Ting Ting Low, Siew Pang Chan, Shin Hnin Wai, Zhou Ang, Kyu Kyu, Kim Yee Lee, Anne Ching, Sarah Comer, Naomi Qiu Pin Tan, Elizabeth Grace Hui En Thong, Tracy Nang, Mohan Dutta, Carolyn S P Lam
BACKGROUND: There is increasing knowledge of sex-specific differences in cardiovascular disease and recognition of sex disparities in management. In our study, we investigated whether a cardiovascular programme tailored to the specific needs of women could lead to improved outcomes. METHODS: We randomised 100 female patients to receive cardiology follow-up with the conventional sex-neutral cardiac programme (control), or the sex-tailored Women's Heart Health Programme (intervention)...
April 16, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29661060/mental-work-demands-and-late-life-cognitive-impairment-results-from-the-shanghai-aging-study
#17
Xiaoniu Liang, Zhao Chen, Xinqi Dong, Qianhua Zhao, Qihao Guo, Li Zheng, Wei Deng, Jianfeng Luo, Ding Ding
OBJECTIVE: The aim of this study is to explore the association between mental work demands (MWDs) and late-life cognition among Chinese older adults. METHOD: Data were drawn from the baseline of the Shanghai Aging Study. RESULTS: Among 3,546 participants, the mean MWDs index of participants with dementia, mild cognitive impairment (MCI), and cognitive normal were 2.8 ( SD = 0.5), 2.8 ( SD = 0.5), and 2.9 ( SD = 0.4), respectively. Mini Mental State Examination (MMSE) scores in group with low MWDs level decreased more dramatically by increasing age than that in groups with middle and high MWDs level ( p < ...
April 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29660843/mortality-after-a-cerebrovascular-event-in-age-related-macular-degeneration-patients-treated-with-bevacizumab-ocular-injections
#18
Joel Hanhart, Doron S Comaneshter, Shlomo Vinker
PURPOSE: To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed with stroke or transient ischaemic attack (TIA). METHODS: We reviewed bevacizumab-treated AMD patients with a diagnosis of stroke or TIA prior to their first bevacizumab injection (n = 948). Those patients, naïve to any anti-vascular endothelial growth factor (anti-VEGF) at the time of stroke/TIA, were then compared to age- and gender-matched patients who had a stroke/TIA at the same time and had never been exposed to anti-VEGF...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29660382/elevated-plasma-soluble-pro-renin-receptor-levels-are-associated-with-left-ventricular-remodeling-and-renal-function-in-chronic-heart-faiure-patients-with-reduced-ejection-fraction
#19
Linghui Gong, Shenglin Zhang, Linrui Li, Xin Gao, Dongxia Wang, Dachang Wu, Ke Wang, Yan Liu
Soluble (pro)renin receptor [s(P)RR], which is generated from cleavage of (P)RR, can be detected in plasma and urine. s(P)RR levels can reflect the severity of some diseases, such as renal lesions, gestational diabetes mellitus or hypertension, and obstructive sleep apnea syndrome. However, the relationship between s(P)RR levels and the severity of chronic heart failure remains undetermined. We studied s(P)RR levels in 118 patients with chronic heart failure with reduced ejection fraction (HFrEF), including 86 without renal dysfunction (HF) and 32 with renal dysfunction (HF + RF), and 28 healthy subjects (HS) to reveal the relationship between s(P)RR levels and other HFrEF parameters...
April 13, 2018: Peptides
https://www.readbyqxmd.com/read/29659691/perspective-cardiovascular-responses-to-sugar-sweetened-beverages-in-humans-a-narrative-review-with-potential-hemodynamic-mechanisms
#20
Cathriona R Monnard, Erik Konrad Grasser
Cardiovascular diseases are still the primary cause of mortality worldwide, with high blood pressure and type 2 diabetes as major promoters. Over the past 3 decades, almost in parallel with the rise in cardiovascular disease incidence, the consumption of sugar-sweetened beverages (SSBs) has increased. In this context, SSBs are potential contributors to weight gain and increase the risk for elevations in blood pressure, type 2 diabetes, coronary heart disease, and stroke. Nevertheless, the mechanisms underlying the cardiovascular and metabolic responses to SSBs, in particular on blood pressure, are poorly understood...
March 1, 2018: Advances in Nutrition
keyword
keyword
96159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"