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https://www.readbyqxmd.com/read/29222638/meat-intake-and-incidence-of-cardiovascular-disease-in-japanese-patients-with-type-2-diabetes-analysis-of-the-japan-diabetes-complications-study-jdcs
#1
Chika Horikawa, Chiemi Kamada, Shiro Tanaka, Sachiko Tanaka, Atsushi Araki, Hideki Ito, Satoshi Matsunaga, Kazuya Fujihara, Yukio Yoshimura, Yasuo Ohashi, Yasuo Akanuma, Hirohito Sone
PURPOSE: Excessive meat intake has been researched as a major cause of cardiovascular disease (CVD) among healthy adults, but data on this topic in Asian patients with diabetes are sparse. The quantity and variety of available meats vary widely between Asian and Western countries. As part of a nationwide cohort study we investigated the relationship between meat intake and incidence of CVD in Japanese patients with type 2 diabetes aged 40-70 years with HbA1c ≥ 6.5%. METHODS: Analyzed were 1353 responders to a baseline dietary survey assessed by the Food Frequency Questionnaire based on food groups...
December 8, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29222628/one-year-clinical-effectiveness-comparison-of-prasugrel-with-ticagrelor-results-from-a-retrospective-observational-study-using-an-integrated-claims-database
#2
Mark B Effron, Kavita V Nair, Cliff Molife, Stuart Y Keller, Robert L Page, Jason C Simeone, Brian Murphy, Beth L Nordstrom, Yajun Zhu, Patrick L McCollam, George W Vetrovec
BACKGROUND: No direct comparisons of ticagrelor and prasugrel with 1-year clinical follow-up have been reported. OBJECTIVES: Our objective was to compare 1-year clinical outcomes among patients with acute coronary syndrome (ACS) managed with percutaneous coronary intervention (PCI) and treated with either ticagrelor or prasugrel in a real-world setting. METHODS: This retrospective study included patients from a payer database who were aged ≥18 years and had ACS managed with PCI with no history of transient ischemic attack (TIA)/stroke...
December 8, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29221659/cardiovascular-outcomes-with-glucagon-like-peptide-1-receptor-agonists-in-patients-with-type-2-diabetes-a-meta-analysis
#3
M Angelyn Bethel, Rishi A Patel, Peter Merrill, Yuliya Lokhnygina, John B Buse, Robert J Mentz, Neha J Pagidipati, Juliana C Chan, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Peter Öhman, Neil R Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez, Rury R Holman
BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists are effective glucose-lowering drugs. Findings from cardiovascular outcome trials showed cardiovascular safety of GLP-1 receptor agonists, but results for cardiovascular efficacy were varied. We aimed to examine overall cardiovascular efficacy for lixisenatide, liraglutide, semaglutide, and extended-release exenatide. METHODS: In this systematic review and meta-analysis, we analysed data from eligible trials that assessed the safety and efficacy of GLP-1 receptor agonists compared with placebo in adult patients (aged 18 years or older) with type 2 diabetes and had a primary outcome including, but not limited to, cardiovascular mortality, non-fatal myocardial infarction, and non-fatal stroke...
December 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29221453/the-extra-cost-of-comorbidity-multiple-illnesses-and-the-economic-burden-of-non-communicable-diseases
#4
Sébastien Cortaredona, Bruno Ventelou
BACKGROUND: The literature offers competing estimates of disease costs, with each study having its own data and methods. In 2007, the Dutch Center for Public Health Forecasting of the National Institute for Public Health and the Environment provided guidelines that can be used to set up cost-of-illness (COI) studies, emphasising that most COI analyses have trouble accounting for comorbidity in their cost estimations. When a patient has more than one chronic condition, the conditions may interact such that the patient's healthcare costs are greater than the sum of the costs for the individual diseases...
December 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29221444/genome-wide-association-study-of-coronary-artery-calcified-atherosclerotic-plaque-in-african-americans-with-type-2-diabetes
#5
Jasmin Divers, Nicholette D Palmer, Carl D Langefeld, W Mark Brown, Lingyi Lu, Pamela J Hicks, S Carrie Smith, Jianzhao Xu, James G Terry, Thomas C Register, Lynne E Wagenknecht, John S Parks, Lijun Ma, Gary C Chan, Sarah G Buxbaum, Adolfo Correa, Solomon Musani, James G Wilson, Herman A Taylor, Donald W Bowden, John Jeffrey Carr, Barry I Freedman
BACKGROUND: Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences. To identify genes associated with CAC in AAs with type 2 diabetes (T2D), a genome-wide association study (GWAS) was performed using the Illumina 5 M chip in 691 African American-Diabetes Heart Study participants (AA-DHS), with replication in 205 Jackson Heart Study (JHS) participants with T2D...
December 8, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29221204/11%C3%AE-hsd1-inhibition-ameliorates-diabetes-induced-cardiomyocyte-hypertrophy-and-cardiac-fibrosis-through-modulation-of-egfr-activity
#6
Chunpeng Zou, Weixin Li, Yong Pan, Zia A Khan, Jieli Li, Xixi Wu, Yi Wang, Liancheng Deng, Guang Liang, Yunjie Zhao
11β-HSD1 has been recognized as a potential therapeutic target for type 2 diabetes. Recent studies have shown that hyperglycemia leads to activation of 11β-HSD1, increasing the intracellular glucocorticoid levels. Excess glucocorticoids may lead to the clinical manifestations of cardiac injury. Therefore, the aim of this study is to investigate whether 11β-HSD1 activation contributes to the development of diabetic cardiomyopathy. To investigate the role of 11β-HSD1, we administered a selective 11β-HSD1 inhibitor in type 1 and type 2 murine models of diabetes and in cultured cardiomyocytes...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221195/quantification-of-contractile-mechanics-in-the-rat-heart-from-ventricular-pressure-alone
#7
Chih-Hsien Wang, Ru-Wen Chang, Chun-Yi Chang, Ming-Shiou Wu, Hsien-Li Kao, Liang-Chuan Lai, Tai-Horng Young, Hsi-Yu Yu, Yih-Sharng Chen, Kuo-Chu Chang
To quantitate the contractile mechanics of the heart, the ventricle is considered an elastic chamber with known end-systolic elastance (Ees ). Ees can be calculated from a single pressure-ejected volume curve, which requires simultaneous records of left ventricular (LV) pressure and the aortic flow (Qm). In clinical settings, it is helpful to evaluate patients' cardiac contractile status by using a minimally invasive approach to physiological signal monitoring, wherever possible, such as by using LV pressure alone...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220730/effect-of-white-matter-changes-on-risk-score-for-peri-procedural-complications-after-carotid-artery-stenting
#8
Chun Yu, Wen Cheng Guo, Lei Zhu, Jin Yun Tan, Wei Hao Shi, Xiao Long Zhang, Yu Xiang Gu, Xiang Han, Qiang Dong
OBJECTIVES: The presence of more severe white matter changes (WMC) may be associated with a higher risk of peri-procedural strokes in patients undergoing carotid artery stenting (CAS). However, to what extent WMC affects peri-procedural risk of CAS is unclear. We aimed to evaluate the effect of WMC on peri-procedural complications by modifying a CAS peri-procedural risk scale through adding the assessment of WMC. PATIENTS AND METHODS: A database of patients undergoing CAS was sampled from 2007 to 2014 in a single Chinese medical center...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29220556/drug-treatment-of-hypertension-in-sweden-in-relation-to-sex-age-and-comorbidity
#9
Fredrik Wallentin, Björn Wettermark, Thomas Kahan
The authors investigated antihypertensive drug treatment in Sweden using the Stockholm Regional Healthcare Data Warehouse, providing information on all healthcare consultations, diagnoses, hospitalizations, dispensed prescription drugs, sex, and age in 2.1 million persons. This cross-sectional analysis identified 292 428 individuals 20 years or older with hypertension (mean age 68 ± 13 years, 53% women). About half had no diabetes mellitus or cardiovascular comorbidity. The number of dispensed drugs was lower in women than in men (1...
December 8, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29219889/the-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-for-detecting-early-onset-neonatal-sepsis
#10
Emrah Can, Şahin Hamilcikan, Ceren Can
OBJECTIVE: The purpose of this study was to investigate the relationship between neonate early-onset sepsis (EOS) and the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) of term neonates. MATERIALS AND METHODS: This prospective observational study was conducted with term neonates diagnosed with EOS compared with 44 healthy controls. Exclusion criteria were prematurity, postmaturity, small or large for gestational age according to week of pregnancy, preeclampsia, gestational diabetes mellitus, chorioamnionitis, congenital major anomalies, and cyanotic congenital heart disease...
December 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29218612/transoesophageal-echocardiography-prior-to-catheter-ablation-could-be-avoided-in-atrial-fibrillation-patients-with-a-low-risk-of-stroke-and-without-filling-defects-in-the-late-phase-mdct-scan-a-retrospective-analysis-of-783-patients
#11
Zhengqin Zhai, Min Tang, Shu Zhang, Pihua Fang, Yuhe Jia, Tianjie Feng, Jiande Wang
OBJECTIVES: To test whether multidetector computed tomography (MDCT) could completely replace transoesophageal echocardiography (TEE) to detect left atrial appendage (LAA) thrombi in atrial fibrillation (AF) patients using a large sample size. METHODS: 783 patients with AF who underwent MDCT and TEE before catheter ablation were retrospectively included. Demographic data were obtained. Two radiologists blinded to clinical data made the imaging diagnosis. RESULTS: Most of the patients (96...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29217920/correlation-between-serum-lipid-profile-with-anthropometric-and-clinical-variables-in-patients-with-type-2-diabetes-mellitus
#12
Belete Biadgo, Solomon Mekonnen Abebe, Habtamu Wondifraw Baynes, Mohammed Yesuf, Aynadis Alemu, Molla Abebe
Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There is ample evidence that abnormalities in lipid metabolism are important risk factors for increased incidence of diabetes associated complications. The most important risk indicators for these complications are lipid profile abnormalities. Therefore, the aim of this study was to assess the correlation between serum lipid profile with anthropometric and clinical variables among type 2 diabetes mellitus patients...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217881/reduced-baroreflex-sensitivity-decreased-heart-rate-variability-with-increased-arterial-stiffness-in-predialysis
#13
C Lal, M Kaur, A K Jaryal, K K Deepak, D Bhowmik, S K Agarwal
High cardiovascular morbidity and mortality is observed in predialytic chronic kidney disease (CKD) patients. The underlying mechanism of cardiovascular dysfunction often remains unclear. The present study was designed to perform multiparametric assessment of baroreflex sensitivity (BRS), arterial stiffness indices, and cardiovascular variabilities (heart rate variability [HRV] and blood pressure variability [BPV]) together in predialytic CKD patients; compare it with normal healthy controls; and determine their relationships in predialytic nondiabetic CKD patients...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29216956/increased-pit1-and-pit2-expression-in-streptozotocin-stz-induced-diabetic-mice-contributes-to-uptake-of-ias-v
#14
Sha Li Yu, Ling Fei Xu, Jun Xia Wu, Chen Juan Yao, Qiao Yun Hu, Chun Xue Zhang, Xin Yuan Zhao, Hai Yan Wei, Xiao Ke Wang, Gang Chen
OBJECTIVE: This study aimed to investigate the susceptibility of mice with streptozotocin(STZ)-induced diabetes mellitus (TIDM) to the uptake of pentavalent inorganic arsenic (iAsV) and the possible molecular mechanism. METHODS: TIDM was induced in mice by STZ. TIDM and normal mice were treated with 15.0 mg/kg Na2HAsO4·12H2O by intragastric administration. Then, the concentrations of arsenic in various tissues were measured by atomic fluorescence spectrometry. The gene expression levels of Pit1 and Pit2 were quantified by real-time RT-PCR, and their protein levels were detected by Western blotting in mouse heart, kidney, and liver tissues...
November 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29216794/fragmented-qrs-complexes-are-associated-with-left-ventricular-dysfunction-in-patients-with-type-2-diabetes-mellitus-a-two-dimensional-speckle-tracking-echocardiography-study
#15
Adil Bayramoğlu, Hakan Taşolar, Yasemin Kaya, Osman Bektaş, Ahmet Kaya, Mehmet Yaman, Zeki Yüksel Günaydın
BACKGROUND: Heart failure may develop independently of coronary artery disease in diabetes mellitus (DM) patients. Fragmented QRS (fQRS) is a marker of myocardial fibrosis or scar tissue and is related to an increase in cardiovascular adverse events. In this study, we examined the utility of speckle tracking echocardiography (STE) in assessing LV function in DM patients with fQRS. METHODS AND RESULTS: The current study included 178 consecutive patients diagnosed with type-2 DM...
December 7, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29215978/state-public-health-actions-to-prevent-and-control-diabetes-heart-disease-obesity-and-associated-risk-factors-and-promote-school-health
#16
Barbara Z Park, Letitia Cantrell, Holly Hunt, Rosanne P Farris, Patricia Schumacher, Ursula E Bauer
The National Center for Chronic Disease Prevention and Health Promotion at the Centers for Disease Control and Prevention funds a program to boost progress in reducing the prevalence and incidence of multiple chronic diseases and their associated risk factors. This article describes the program, State Public Health Actions to Prevent and Control Diabetes, Heart Disease, Obesity and Associated Risk Factors, and Promote School Health, and the program's action model, design, and administration and management structure...
December 7, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29215977/early-outcomes-of-state-public-health-actions-school-nutrition-strategies
#17
Seraphine Pitt Barnes, Syreeta Skelton-Wilson, Adina Cooper, Caitlin Merlo, Sarah Lee
INTRODUCTION: Since 2013, the State Public Health Actions to Prevent and Control Diabetes, Heart Disease, Obesity and Associated Risk Factors and Promote School Health (State Public Health Actions) program has been implemented to support and reinforce healthy choices and healthy behaviors among the US population. The Centers for Disease Control and Prevention's Division of Population Health's School Health Branch has been a critical component, ensuring that state health departments support schools in adopting nutrition standards and creating a supportive nutrition environment...
December 7, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29215974/evaluating-cross-cutting-approaches-to-chronic-disease-prevention-and-management-developing-a-comprehensive-evaluation
#18
Marla Vaughan, Jan Jernigan, Seraphine Pitt Barnes, Pat Shea, Rachel Davis, Stephanie Rutledge
We provide an overview of the comprehensive evaluation of State Public Health Actions to Prevent and Control Diabetes, Heart Disease, Obesity and Associated Risk Factors and Promote School Health (State Public Health Actions). State Public Health Actions is a program funded by the Centers for Disease Control and Prevention to support the statewide implementation of cross-cutting approaches to promote health and prevent and control chronic diseases. The evaluation addresses the relevance, quality, and impact of the program by using 4 components: a national evaluation, performance measures, state evaluations, and evaluation technical assistance to states...
December 7, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29214834/source-and-size-of-social-support-network-on-sedentary-behavior-among-older-adults
#19
Paul D Loprinzi, Elizabeth A Crush
PURPOSE: To examine the association of source of social support and size of social support network on sedentary behavior among older adults. DESIGN: Cross-sectional. SETTING: National Health and Nutrition Examination Survey 2003 to 2006. PARTICIPANTS: 2519 older adults (60+ years). MEASURES: Sedentary behavior was assessed via accelerometry over a 7-day period. Social support was assessed via self-report...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214777/is-there-a-sex-related-difference-in-the-obesity-paradox-in-systolic-heart-failure-sex-related-difference-in-the-obesity-paradox
#20
Soonchang Hong, Ji Hyun Lee, Kyung Min Kim, Jun Won Lee, Young Jin Youn, Min Soo Ahn, Sung Gyun Ahn, Seung Hwan Lee, Junghan Yoon, Kyung Hoon Choe, Byung Su Yoo
PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group...
January 2018: Yonsei Medical Journal
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