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Giulia Anna Follacchio, Francesco Monteleone, Paolo Anibaldi, Giuseppe De Vincentis, Silvia Iacobelli, Raffaele Merola, Valerio D'Orazi, Massimo Monti, Vittorio Pasta
BACKGROUND: The spread of mammographic screening programs has allowed an increasing amount of early breast cancer diagnosis. A modern approach to non-palpable breast lesions requires an accurate intraoperative localization, in order to achieve a complete surgical resection. In addiction, the assessment of lymph node status is mandatory as it represents a major prognostic factor in these patients. The aim of this study is to evaluate the reliability of a modified technical approach using a single nanocolloidal radiotracer to localize both sentinel node and breast occult lesion...
October 6, 2015: Journal of Experimental & Clinical Cancer Research: CR
A Bricou, M A Duval, L Bardet, A Benbara, G Moreaux, F Lefebvre, L Menard, L Pinot, Y Charon, I Tengher Barna, M Soussan, N Sellier, E Barranger
BACKGROUND: Sentinel node and occult lesion localization (SNOLL) calls for a combination of two specific procedures: intraoperative detection of sentinel lymph node (SLN) and radio--guided occult lesion localization (ROLL). The safety and benefits of radio--guided localization in the surgical treatment of non--palpable breast cancer have been confirmed. The aim of this study was to evaluate the potential role for an intra--operative handheld gamma camera (TreCam) in the SNOLL procedure...
March 31, 2015: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Beata Adamczyk, Murawa Dawid, Połom Karol, Spychała Arkadiusz, Nowaczyk Piotr, Murawa Paweł
AIM: The aim of this study was to present one center experience in applying the SNOLL technique to patients with suspected occult breast lesions. BACKGROUND: In the last years, the widespread use of mammographic screening programs resulted in an increasing number of women with nonpalpable suspicious breast lesions requiring further examination. The new method called sentinel node and occult lesion localization (SNOLL) enables the intraoperative detection of nonpalpable breast tumors and sentinel node biopsy in one surgical procedure...
2011: Reports of Practical Oncology and Radiotherapy
Augusto Lombardi, Giuseppe Nigri, Francesco Scopinaro, Stefano Maggi, Mauro Mattei, Adriana Bonifacino, Maria Parisella, Alessandro Soluri, Claudio Amanti
BACKGROUND: Sentinel node and occult lesion localization (SNOLL) calls for a combination of two specific procedures: intraoperative detection of sentinel lymph node (SLN) via gamma probe and radioguided occult lesion localization (ROLL). This applies to nonpalpable invasive breast cancer or high-grade in situ carcinoma. As opposed to standard techniques, today's handheld gamma cameras enable intraoperative scintigraphic images. METHODS: A cohort (N = 186) of consecutive patients with breast cancer was subjected to radioguided conservative surgery (quadrantectomy and SLN biopsy), using a standard gamma probe and a high-resolution handheld camera...
April 2015: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
M Ahmed, M Douek
BACKGROUND: Sentinel node and occult lesion localization (SNOLL) is an alternative to wire-guided localization (WGL) for guiding surgical excision of non-palpable breast cancer and the performance of concurrent sentinel lymph node biopsy (SLNB). This review provides an overview of the available evidence on the accuracy of SNOLL in patients undergoing breast-conserving surgery. METHODS: PubMed, Embase and the Cochrane Library were searched systematically in April 2013 for studies that address localization of non-palpable breast cancer using SNOLL...
December 2013: Breast: Official Journal of the European Society of Mastology
Jack Antonio Díaz Brito, Sofía Vásquez Navarrete, Juan Antonio Muñoz, Yolanda Santaella Guardiola, José González Sánchez, Vicente Vega Ruiz, Miguel Velasco García
OBJECTIVE: Our objective was to determine the identification and the percentage of false negatives in sentinel node biopsies in patients with early breast cancer at the Hospital La Línea (Spain), during the period between November 2007 and September 2010. METHODS: We collected 50 patients with early breast cancer, without clinical and ultrasonographic involvement of axillary nodes, from November 2007 to September 2010. We used the vital dye in the first 20 patients and the combined technique of vital dye and albumin labelled with technetium 99 in the other 30 patients...
2013: Ecancermedicalscience
C Bordea, M Plesca, I Condrea, M Gherghe, A Gociman, A Blidaru
AIMS: Mammographic screening and the increasing resolution output of mammography have raised the identification number of small-size mammary lesions without clinical expression. The aim of this study was to evaluate in a prospective study the localization techique and concomitent sentinel lymph node biopsy for breast cancer (SNOLL - Sentinel lymph Node biopsy and Occult Lesion Localization). METHODS: We identified by means of imaging techniques a number of 107 patients with clinically occult suspicious breast tumors...
November 2012: Chirurgia
Alberto Testori, Stefano Meroni, Oana Codrina Moscovici, Paola Magnoni, Paolo Malerba, Arturo Chiti, Daoud Rahal, Roberto Travaglini, Umberto Cariboni, Marco Alloisio, Sergio Orefice
BACKGROUND: The aim of this pilot trial was to study the feasibility of sentinel node percutaneous preoperative gamma probe-guided biopsy as a valid preoperative method of assessment of nodal status compared to surgical sentinel lymph node biopsy. MATERIAL/METHODS: This prospective study enrolled 10 consecutive patients without evidence of axillary lymph node metastases at preoperative imaging. All patients underwent sentinel node occult lesion localization (SNOLL) using radiotracer intradermic injection that detected a "hot spot" corresponding to the sentinel node in all cases...
September 2012: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
P L Giacalone, A Bourdon, P D Trinh, P Taourel, G Rathat, M Sainmont, H Perocchia, M Rossi, C Rouleau
AIMS: We compared histological patterns after lumpectomy for non-palpable breast cancers preoperatively localized by radioguided occult lesion localization plus sentinel node localization (SNOLL) versus wire-guided localization. METHODS: To ensure a homogeneously treated cohort and rigorous comparisons, only patients with invasive cancer and measurable opacity by imaging were included. Exclusion criteria were one or more parameters that could interfere with localization and/or the surgical procedure...
March 2012: European Journal of Surgical Oncology
C R Thind, S Tan, S Desmond, O Harris, H S J Ramesh, L Chagla, A Ray, R Audisio
AIM: To evaluate the efficacy and safety for use of dual radioisotopes for localization of occult (impalpable) breast lesions and sentinel node biopsy as a combined technique (SNOLL) using a lower dose than previous studies. MATERIALS AND METHODS: One hundred and twenty-seven SNOLL procedures were performed. The impalpable breast lesions were localized with an intra-lesion injection of 0.2 ml of (99m)Tc MAA (1 MBq) with a particle size of 10-90 μm (radio-guided occult lesion localization, or ROLL) 1 to 4 h before surgery...
September 2011: Clinical Radiology
Man Po Chow, Wai Ka Hung, Tiffany Chu, Chun Ying Lui, Marcus Ying, Kong Ling Mak, Miranda Chan
BACKGROUND: The hook-wire technique is used to guide surgical excision of nonpalpable breast lesions. Recently, isotope has been used to guide the excision, and when sentinel node biopsy is performed during the same operation, the procedure is termed Sentinel Node and Occult Lesion Localization (SNOLL). We evaluated the use of this procedure for nonpalpable cancers in Chinese women. METHODS: Seventy-four patients underwent SNOLL before breast-conserving surgery...
January 2011: World Journal of Surgery
Antonio Sierra García
The incorporation of the nuclear medicine to the surgical current practice In the treatment of the cancer of breast, by means of the application of radioactive isotopes, have supposed a great achievement not only in the surgical and predicted results but also in the surgical skills more effective and less aggressive. The systematic research of the marking and extirpation of Sentinel Lymph Node is avoiding in the early cancer the linfadenectomy axilar. The application of the ROLL and SNOLL skills is being determinant in the extirpation with trustworthy margins of the non-palpable lesions cancer, with big safety instead harpoons that we used before...
2009: Anales de la Real Academia Nacional de Medicina
Nikola Besic, Anja Kramaric, Blaze Podnar, Andraz Perhavec, Maja Music, Snjezana Grazio-Frkovic, Janez Zgajnar
Surgical treatment of non-palpable solitary invasive carcinoma consists of localization, tumorectomy and sentinel lymph node biopsy which can successfully be performed with the use of isotopes (SNOLL). The aim of our study was to find out the success rate of SNOLL and the factors that correlated with complete excision of invasive carcinoma. Solitary non-palpable carcinoma was preoperatively diagnosed in 181 cases. After peritumoral injection of nanocolloid labeled with 99mTc under mammographic (N=79) or ultrasound (N=102) guidance, tumorectomy and sentinel node biopsy were performed...
October 2009: Breast: Official Journal of the European Society of Mastology
Vincent Lavoué, Claude Nos, Krishna B Clough, Forouhar Baghaie, Eric Zerbib, Bruno Poulet, Marie-Aude Lefrère Belda, Anne Ducellier, Fabrice Lecuru
BACKGROUND: Radioguided occult lesion localization (ROLL) is a new technique to detect nonpalpable breast tumors. We report our experience using injection of a single radiotracer to localize occult lesions together with sentinel lymph node (SLN) biopsy (SNOLL). The aim of this series was to evaluate the feasibility of the technique, its efficacy, and the rate of reoperation. METHODS: Under sonographic guidance, a nanocolloidal tracer was injected peritumorally above and below the lesion...
September 2008: Annals of Surgical Oncology
Juan Blas Ballester Sapiña, Pedro Juan González Noguera, Juan Antonio Casterá March, Angel Jiménez Sierra, Julia Camps Herrero, Verónica Ricart Selma, José Manuel Cordero García, Ana Tembl Ferrairo, Laia Bernet Vegue
The increase in the detection of occult lesions has led to the development of new localisation methods using radiopharmaceutical products. The use of these products allows us to perform a "thrifty" (less-aggressive) surgical excision and, to simultaneously carry out the biopsy of the sentinel node in cases of breast cancer. On making a search for the most up to date references on this particular topic, we found many articles on radioguided surgery by many leading international work groups. These articles clearly show the advantages of the radioguided surgery method, its effectiveness and attractiveness to surgeons who are very much involved in the search for excellence in their daily work...
April 2008: Cirugía Española
V Ricart Selma, P J González Noguera, J Camps Herrero, C Martínez Rubio, M T Lloret Martí, A Torregrosa Andrés
OBJECTIVE: Surgery on non-palpable breast lesions is becoming increasingly common and new techniques for preoperative lesion localization have appeared. Radio-guided occult lesion localization (ROLL) enables malignant or probably malignant non-palpable breast lesions to be located and biopsy of the sentinel node to be performed (SNOLL: sentinel node and occult lesion localization). MATERIAL AND METHODS: Included were 118 patients with malignant or probably malignant non-palpable breast lesions visible on ultrasonography in whom radio-guided lesion resection and sentinel node biopsy were indicated...
September 2007: Radiología
Simonetta Monti, Viviana Galimberti, Giuseppe Trifiro, Concetta De Cicco, Nicolas Peradze, Fabricio Brenelli, Julia Fernandez-Rodriguez, Nicole Rotmensz, Antuono Latronico, Anastasio Berrettini, Manuela Mauri, Leonidas Machado, Alberto Luini, Giovanni Paganelli
BACKGROUND: Non-palpable breast lesions are diagnosed frequently posing the problem of localization and removal. When such lesions are malignant, axillary node status must be determined. We report our experience using radio-guided occult lesion localization (ROLL) for locating and removing non-palpable breast lesions together with sentinel node biopsy (SNB) to assess axillary status. We call the technique SNOLL. METHODS: From March 1997 to April 2004, 1046 consecutive patients presented suspicious non-palpable breast lesions and were programmed for conservative surgery and SNB...
October 2007: Annals of Surgical Oncology
C De Cicco, G Trifirò, M Intra, G Marotta, A Ciprian, A Frasson, G Prisco, A Luini, G Viale, G Paganelli
The aim of this study was to evaluate the feasibility of sentinel node (SN) biopsy in occult breast lesions with different radiopharmaceuticals and to establish the optimal lymphoscintigraphic method to detect both occult lesions and SNs (SNOLL: sentinel node and occult lesion localisation). Two hundred and twenty-seven consecutive patients suspected to have clinically occult breast carcinoma were enrolled in the study. In addition to the radioguided occult lesion localisation (ROLL) procedure, using macroaggregates of technetium-99m labelled human serum albumin (MAA) injected directly into the lesion, lymphoscintigraphy was performed with nanocolloids (NC) injected in a peritumoral (group I) or a subdermal site (group II)...
March 2004: European Journal of Nuclear Medicine and Molecular Imaging
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