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https://www.readbyqxmd.com/read/28625477/challenges-and-advances-in-the-diagnosis-biology-and-treatment-of-urothelial-upper-tract-and-bladder-carcinomas
#1
REVIEW
Jeanny B Aragon-Ching
Urothelial carcinomas span the bladder, ureter, and renal pelvis, and while there had been stagnation in the field of drug approval for the past two decades, there is now accelerated and regular US FDA approval of 5 immunotherapy agents. However, patients who inherently do not respond or progress on such therapies still represent an area of increased unmet need. In this special Seminars issue, we explore varying aspects of bladder urothelial carcinoma treatment with targeted therapies, the unique presentation and challenges in the treatment of upper tract and renal pelvis tumors, as well as new and emerging diagnostic imaging tools for varying genitourinary cancers...
July 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28606776/extraperitoneal-laparoscopic-radical-nephroureterectomy-and-lymph-node-dissection-in-modified-supine-position
#2
Pengchao Li, Jun Tao, Xiaheng Deng, Chao Qin, Yidong Cheng, Peng Li, Jiexiu Zhang, Yongke Cao, Xiao Yang, Chengdi Yang, Qiang Lu
Objective To explore the feasibilty of extraperitoneal laparoscopic radical nephroureterectomy (RNU) and lymph node dissection in modified supine position for managing urothelial carcinomas in renal pelvis or upper 2/3 ureter. Subjects / Patients and Methods Consecutively from January 2014 to October 2015, 15 patients with high-risk urothelial carcinoma in renal pelvis or upper 2/3 ureter underwent extraperitoneal laparoscopic radical nephroureterectomy (EL-RNU) and extraperitoneal laparoscopic lymph node dissection (EL-LND)...
June 9, 2017: Urology
https://www.readbyqxmd.com/read/28589387/non-invasive-papillary-urothelial-carcinoma-of-the-vagina-molecular-analysis-of-a-rare-case-identifies-clonal-relationship-to-non-invasive-urothelial-carcinoma-of-the-bladder
#3
Hind N Warzecha, Falko Fend, Julia Steinhilber, Harald Abele, Melanie Henes, Niklas Harland, Annette Staebler
We present a rare case of non-invasive papillary urothelial carcinoma of the vagina as the initial presentation of a multicentric urothelial carcinoma also involving bladder and renal pelvis and report for the first time in the literature the molecular alterations observed in the vaginal urothelial lesion and the synchronous lesions of the urinary tract. In this case, the non-invasive papillary urothelial carcinoma in the vagina displayed the same genetic alterations in the FGFR3 and PIK3CA genes as those seen in the non-invasive papillary urothelial carcinoma of the bladder contrasting with the wild phenotype observed in the invasive urothelial carcinoma of the renal pelvis...
June 7, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28588718/renal-cell-carcinoma-with-synchronous-ipsilateral-urothelial-carcinoma-of-the-renal-pelvis
#4
Qun Lu, Junlong Zhuang, Hongqian Guo
The simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma (UC) in the same kidney is extraordinarily rare, and is also known as multiple primary malignant tumors. The present study reports the case of a 76-year-old female with synchronous ipsilateral RCC and UC of the renal pelvis, who underwent operation, chemotherapy and reoperation when recurrence of RCC or UC was identified. Cluster of differentiation 44 (CD44) is one of the promising markers for identifying cancer stem cells in various solid tumors, along with aldehyde dehydrogenase 1 A1 (ALDH1A1)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28587578/extra-vascular-findings-in-patients-undergoing-magnetic-resonance-angiography-of-the-abdomen-pelvis-and-lower-extremities-a-retrospective-study-of-352-patients
#5
Jan M Sohns, Jan Menke, Leonard Bergau, Bernhard G Weiss, Sebastian Schmuck, Desiree Weiberg, Wieland Staab, Thorsten Derlin, Marc Dorenkamp, Christian Sohns
Background The aim of this study was to assess the prevalence and clinical significance of extra-vascular findings in patients undergoing magnetic resonance angiography of the abdomen, pelvis and lower extremities. Materials and methods Three hundred fifty-two patients underwent abdominal, pelvic and lower extremity 1.5 T magnetic resonance angiography. Clinically relevant vascular and extra-vascular findings were identified. Relevant vascular findings were classified as stenosis, occlusion, aneurysm, sclerosis, dissection or vasculitis...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28567328/squamous-cell-carcinoma-of-the-renal-pelvis-atypical-presentation-of-a-rare-malignancy
#6
Kyrollis Attalla, Kenneth Haines, Daniel Labow, Reza Mehrazin
Primary squamous cell carcinoma (SCC) of the renal pelvis is exceedingly rare and is associated with advanced stage at diagnosis and a poor prognosis. Diagnosis is often difficult due to vague presenting symptoms and nonspecific radiologic findings. The mainstay of treatment is nephrectomy, with cisplatin based chemotherapy and palliative radiation reserved for metastatic disease. We report a SCC of the renal pelvis in a 72 year-old female who presented with abdominal pain. To date, this is the largest SCC originating from the renal pelvis reported in the literature, made even more exceptional by the lack of antecedent risk factors...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28554752/diagnostic-utility-of-ki-67-immunohistochemistry-in-small-endoscopic-biopsies-of-the-ureter-and-renal-pelvis
#7
Yuichi Koyama, Teppei Morikawa, Jimpei Miyakawa, Yu Miyama, Tohru Nakagawa, Yukio Homma, Masashi Fukayama
Diagnosis of upper urinary tract urothelial carcinoma in ureteroscopic biopsies is challenging. Therefore, an immunohistochemical marker that can differentiate between malignant and benign urothelium and predict final pathological features is necessary. In this study, we investigated Ki-67 expression in 26 ureteroscopic biopsies of the ureter and renal pelvis diagnosed with urothelial carcinoma (UC) and in 13 biopsies with non-neoplastic urothelium, using digital image analysis. The median Ki-67 labeling index was 1...
April 20, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28554748/nephrogenic-adenoma-of-the-urinary-tract-a-6-year-single-center-experience
#8
Didem Turcan, Mustafa Fuat Acikalin, Evrim Yilmaz, Funda Canaz, Deniz Arik
BACKGROUND: Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers. MATERIALS AND METHODS: A retrospective series of 21 cases of nephrogenic adenoma in 18 patients, which were diagnosed in our department between 2010 and 2016, were analyzed...
March 25, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28543959/epidemiology-of-urothelial-carcinoma
#9
REVIEW
Jun Miyazaki, Hiroyuki Nishiyama
The epithelium lining is defined as the mucosal surfaces of the renal collecting tubules, calyces and pelvis, as well as the ureter, bladder and urethra. The term "urothelium" is used to refer to these surfaces. Upper tract urothelial carcinoma is a rare subset of urothelial cancers with a poor prognosis. Urinary bladder cancer is the most common malignancy involving the urinary system. Upper tract urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2:1. The incidence of urinary bladder cancer is also higher in men...
May 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28538387/prognostic-significance-of-urothelial-carcinoma-with-divergent-differentiation-in-upper-urinary-tract-after-radical-nephroureterectomy-without-metastatic-diseases-a-retrospective-cohort-study
#10
Chuan Qin, En-Li Liang, Zhi-Yong Du, Xiao-Yu Qiu, Gang Tang, Fei-Ran Chen, Bo Zhang, Da-Wei Tian, Hai-Long Hu, Chang-Li Wu
To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28503239/a-case-of-renal-cell-carcinoma-in-a-patient-with-situs-inversus-operative-considerations-and-a-review-of-the-literature
#11
Justin Oake, Darrel Drachenberg
Situs inversus, an uncommon mirror-image reversal of the major visceral and thoracic organs, is seldom of medical significance. However, the recognition of their unique anatomy is extremely important for those requiring surgical intervention. There are very few reported cases of renal cell carcinoma (RCC) developing in people with situs inversus. To our knowledge, this is the first reported case in Canada. A review of the literature only identified nine published cases worldwide. Here, we review and summarize pertinent information, including patient age and sex, size and location of tumour, method of surgery, and pathology...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28481800/incidental-diagnosis-of-a-large-retroperitoneal-urine-accumulation-urinoma-on-an-18f-fdg-pet-ct-scan-performed-for-primary-staging-of-urothelial-carcinoma
#12
André H Dias, Pia Ipsen, Kirsten Bouchelouche
F-FDG PET/CT performed for primary staging 3 days after ureteroscopy demonstrated a large, unexpected retroperitoneal urinoma in a 62-year-old man with urothelial carcinoma in the right renal pelvis.
May 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28455741/lymphoepithelioma-like-carcinoma-of-the-upper-urinary-tract
#13
Antonio Lopez-Beltran, Gladell Paner, Ana Blanca, Rodolfo Montironi, Toyonori Tsuzuki, Yoji Nagashima, Shi-Sung Chuang, Khin Than Win, Leo Madruga, Maria R Raspollini, Liang Cheng
In this report, we summarized the clinicopathologic features of ten cases of lymphoepithelioma-like carcinoma (LELC) of the upper urinary tract (ureter n = 6; renal pelvis n = 4), a rare variant of urothelial cancer characterized by a malignant epithelial component densely infiltrated by lymphoid cells. The initial diagnosis was made on radical nephrectomy in five cases, nephroureterectomy in three cases, and ureterectomy in two others. Four patients had pathologic stage T1 (n = 2) or T2 (n = 2) tumors, and six patients had stage pT3 disease...
June 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28422039/-urinary-tract-lymphoepithelial-carcinoma-report-of-two-cases-and-bibliographic-review
#14
Sebastian Valverde Martínez, Waleska Salcedo Mercado, Isabel Rodríguez Cruz, Sara Belén Prieto Nogal, Mario Martín Hernández, Luis Miguel Gómez Tejeda
OBJECTIVE: We report two cases of patients diagnosed with lymphoepithelioma-like carcinomas of the urinary tract. We review the literature of this rare entity. The objective is to clarify the clinical and therapeutic characteristics. METHODS: We present a retrospective review of medical records of two patients diagnosed with lymphoepithelioma-like carcinomas, one in the renal pelvis and the other in the bladder. We review the epidemiology, diagnosis and therapeutic alternatives...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28391777/remarkable-response-to-fluorouracil-leucovorin-oxaliplatin-and-irinotecan-therapy-in-urothelial-cancer-of-the-renal-pelvis-a-case-report
#15
Takuya Tsujino, Kiyoshi Takahara, Tomohisa Matsunaga, Yuki Yoshikawa, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Teruo Inamoto, Haruhito Azuma
BACKGROUND: No standard chemotherapy regimen for advanced urothelial cancer has been established, except for cisplatin-based regimens. We report the case of a patient with double primary cancer, urothelial carcinoma of the upper urinary tract and colorectal cancer, who underwent oxaliplatin-based chemotherapies. CASE PRESENTATION: A 56-year-old Japanese man presented to our hospital with the diagnosis of a left renal pelvic tumor and rectal cancer. Several examinations including ureteroscopic biopsy and computed tomography-guided biopsy were performed; however, the diagnosis of renal pelvic cancer could not be made...
April 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28329636/correlation-between-cancer-incidences-and-google-searches-in-the-united-states
#16
Mackenzie R Wehner, Kevin T Nead, Eleni Linos
IntroductionDespite being highly prevalent, keratinocyte carcinomas (basal cell and squamous cell carcinomas lack nationwide registries. Internet search data has emerged as a new method to evaluate previously difficult to quantify public health outcomes and may be useful in keratinocyte carcinoma research.ObjectiveWe aimed to evaluate whether Google search density correlated with known incidences of common cancers in the United States.MethodsWe used the Center for Disease Control's National Program of Cancer Registries ageTadjusted cancer incidences (2008T2012 ...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28314541/risk-of-subsequent-primary-kidney-cancer-after-another-malignancy-a-population-based-study
#17
Omar Abdel-Rahman
BACKGROUND: Population-based data on the development of kidney cancer as a second malignant neoplasm following the diagnosis of other common malignancies are rare. This clinical scenario has been evaluated within the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: The SEER-9 database (1973-2013) was queried using the SEER*Stat program to determine the standardized incidence ratios (SIRs) of kidney cancer development following each one of 10 common invasive malignancies (colorectal, breast, prostate, lung, thyroid, corpus uteri, urinary bladder, kidney/renal pelvis, cutaneous melanoma, and non-Hodgkin lymphoma)...
February 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28296764/case-report-of-primary-renal-pelvis-squamous-cell-carcinoma-coexisting-with-long-standing-calculi-in-left-kidney-on-18f-fdg-pet-ct
#18
Shengming Deng, Bin Zhang, Ying Huang, Jihui Li, Shibiao Sang, Wei Zhang
RATIONALE: Primary renal pelvis squamous cell carcinoma (SCC) is an extremely rare neoplasm. In many patients, the SCC was associated with renal calculi. PATIENT CONCERNS: A 61-year-old male presented with intermittent pain at the left lumbar region for 3 days. The PET/CT images demonstrated increased F-FDG uptake in the upper pole of the left kidney and left renal hilar lymph nodes. DIAGNOSES: Pathologic examination revealed well-moderately differentiated renal pelvis SCC with lymphatic metastasis...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28251485/endoscopic-treatment-of-upper-tract-urothelial-carcinoma
#19
REVIEW
Daniel P Verges, Costas D Lallas, Scott G Hubosky, Demetrius H Bagley
PURPOSE OF REVIEW: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. RECENT FINDINGS: The PubMed database was queried using the following medical subject headings (MeSH terms): "carcinoma, transitional cell," "ureter," "ureteral neoplasms," "kidney pelvis," "endoscopy," "laser therapy," "ureteroscopy," "urologic surgical procedures," and "ureteroscopes...
April 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28249616/tumor-to-tumor-metastases-papillary-thyroid-carcinoma-into-a-clear-cell-renal-cell-carcinoma
#20
Jin Soo Andy Song, S Mark Taylor, Jonathan Trites, Matthew H Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon, Robert D Hart
BACKGROUND: Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8-3.8% for papillary and 6-20% for follicular variants of well-differentiated thyroid cancers (WDTCs). In rare instances, tumor-to-tumor metastasis between two true primary neoplasms can occurs. This medical phenomenon has previously occurred as a clear cell renal cell carcinoma (CCRCC) spreading to a WDTC...
March 1, 2017: Journal of Otolaryngology—Head & Neck Surgery
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