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Rebecca A Weiss, Barry Rosenfeld
As the populations of Western countries become more diverse, the risk of inaccurately generalizing knowledge from majority ethnic groups to minority groups is increasing. However, few of the measures used in forensic assessment are based on normative samples that represent the considerable diversity present in forensic settings. This study examined 4 commonly used measures of feigning: the Dot Counting Test (DCT; Boone, Lu, & Herzberg, 2002); the Miller Forensic Assessment of Symptoms (M-FAST; Miller, 2001); the Test of Memory Malingering (TOMM; Tombaugh, 1996); and a validity scale (atypical responding; ATR) on the Trauma Symptom Inventory-2 (Briere, 2011)...
August 15, 2016: Psychological Assessment
Gert Huppertz-Hauss, Eline Aas, Marte Lie Høivik, Ebbe Langholz, Selwyn Odes, Milada Småstuen, Reinhold Stockbrugger, Geir Hoff, Bjørn Moum, Tomm Bernklev
Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis...
2016: Gastroenterology Research and Practice
Svein Oskar Frigstad, Marte Høivik, Jørgen Jahnsen, Sandra Rinne Dahl, Milada Cvancarova, Tore Grimstad, Ingrid Prytz Berset, Gert Huppertz-Hauss, Øistein Hovde, Roald Torp, Tomm Bernklev, Bjørn Moum, Lars-Petter Jelsness-Jørgensen
BACKGROUND AND AIM: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD. METHODS: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014...
September 23, 2016: Scandinavian Journal of Gastroenterology
Nicole Schütze, Stefanie Trojandt, Stephanie Kuhn, Janina M Tomm, Martin von Bergen, Jan C Simon, Tobias Polte
IL-9-secreting Th9 cells have been considered to play a pivotal role in the pathogenesis of atopic diseases. To what extent IL-9-producing cells are induced or regulated by sensitization with naturally occurring allergens is not yet clear. Naturally occurring allergens are capable of inducing IL-6 production in dendritic cells (DCs). Whether allergen-induced IL-6 supports a Th9 subtype by increasing IL-9 production, as observed in in vitro studies, or rather favors Th17 differentiation is not finally resolved...
October 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Laura M Grossi, Debbie Green, Shanah Einzig, Brian Belfi
The present study evaluated the Response Bias scale (RBS), a symptom validity test embedded within the Minnesota Multiphasic Personality Inventory (MMPI)-2 Restructured Form (MMPI-2-RF) that assesses for feigned neurocognitive complaints, in a sample of pretrial incompetent to stand trial (IST) criminal defendants. Additionally, we examined the Improbable Failure (IF) scale, a performance validity test embedded within the Structured Interview of Reported Symptoms, Second Edition (SIRS-2), which similarly assesses for feigned cognitive impairment (FCI)...
August 8, 2016: Psychological Assessment
Graham M L Eglit, Julie K Lynch, Robert J McCaffrey
INTRODUCTION: The Test of Memory Malingering (TOMM) and the Word Memory Test (WMT) are both performance validity tests (PVTs) that use a two-alternative forced-choice (2AFC) recognition memory format. Several studies have reported that these tests are susceptible to cognitive impairment and that the WMT is more susceptible than the TOMM. The current study explored components of recognition memory (i.e., conscious recollection and familiarity) underlying the TOMM and WMT to identify factors that make them susceptible and resilient to cognitive impairment...
August 8, 2016: Journal of Clinical and Experimental Neuropsychology
Markus D Knudsen, Thomas de Lange, Edoardo Botteri, Dung-Hong Nguyen, Helge Evensen, Chloé B Steen, Geir Hoff, Tomm Bernklev, Anette Hjartåker, Paula Berstad
AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia (ACN) in colorectal cancer (CRC) screening. METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero (poorest) to six (best)...
July 21, 2016: World Journal of Gastroenterology: WJG
Rachel L Fazio, John H Denning, Robert L Denney
OBJECTIVE: To determine the effectiveness of the Test of Memory Malingering Trial 1 (TOMM1) as a freestanding Performance Validity Test (PVT) as compared to the full TOMM in a criminal forensic sample. METHOD: Participants included 119 evaluees in a Midwestern forensic hospital. Criterion groups were formed based on passing/failing scores on other freestanding PVTs. This resulted in three groups: +MND (Malingered Neurocognitive Dysfunction), who failed two or more freestanding PVTs; possible MND (pMND), who failed one freestanding PVT; and -MND, who failed no other freestanding PVTs...
July 26, 2016: Clinical Neuropsychologist
Lars-Petter Jelsness-Jørgensen, Bjørn Moum, Tore Grimstad, Jørgen Jahnsen, Randi Opheim, Ingrid Prytz Berset, Øistein Hovde, Roald Torp, Svein Oskar Frigstad, Gert Huppertz-Hauss, Tomm Bernklev
Background and Aims. No patient-reported outcome measures targeting pain have yet been validated for use in IBD patients. Consequently, the aim of this study was to test the psychometrical properties of the brief pain inventory (BPI) in an outpatient population with IBD. Methods. Participants were recruited from nine hospitals in the southeastern and western parts of Norway. Clinical and sociodemographic data were collected, and participants completed the BPI, as well as the Short-Form 36 (SF-36). Results. In total, 410 patients were included...
2016: Canadian Journal of Gastroenterology & Hepatology
Tamar Bar-On Kalfon, Gilad Gal, Ran Shorer, Jacob N Ablin
OBJECTIVE: Fibromyalgia syndrome (FM) patients demonstrate deficits in tests of attention, executive functioning and verbal memory. We assessed the role of effort in the cognitive impairment in FM patients, alongside common symptoms of pain, fatigue and depression. METHOD: 50 FM patients underwent a computerized cognitive assessment battery including memory, executive function, attention and information processing speed (NeuroTrax Corp.). Age and education standardized scores were computed...
August 2016: Journal of Psychosomatic Research
Fränze Vorreiter, Silke Richter, Michel Peter, Sven Baumann, Martin von Bergen, Janina M Tomm
The challenge of performing a time-resolved comprehensive analysis of molecular systems has led to the quest to optimize extraction methods. When the size of a biological sample is limited, there is demand for the simultaneous extraction of molecules representing the four areas of "omics": genomics, transcriptomics, proteomics, and metabolomics. Here we optimized a protocol for the simultaneous extraction of DNA, RNA, proteins, and metabolites and compared it with two existing protocols. Our optimization comprised the addition of a methanol/chloroform metabolite purification before the separation of DNA/RNA and proteins...
September 1, 2016: Analytical Biochemistry
Alexandra M V Wennberg, Adam P Spira, Corinne Pettigrew, Anja Soldan, Vadim Zipunnikov, George W Rebok, Allen D Roses, Michael W Lutz, Michael M Miller, Madhav Thambisetty, Marilyn S Albert
Type II diabetes mellitus (DM) increases risk for cognitive decline and is associated with brain atrophy in older demented and non-demented individuals. We investigated (1) the cross-sectional association between fasting blood glucose level and cortical thickness in a sample of largely middle-aged, cognitively normal adults, and (2) whether these associations were modified by genes associated with both lipid processing and dementia. To explore possible modifications by genetic status, we investigated the interaction between blood glucose levels and the apolipoprotein E (APOE) ε4 allele and the translocase of the outer mitochondrial membrane (TOMM) 40 '523 genotype on cortical thickness...
June 15, 2016: Journal of the Neurological Sciences
Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Magne Henriksen, Ole Høie, Jørgen Jahnsen, Geir Hoff, Bjørn Moum, Tomm Bernklev
BACKGROUND: Data on the long-term observation of health-related quality of life (HRQoL) in the inflammatory bowel diseases (IBD), Crohn's disease (CD), and ulcerative colitis are scarce. Our aim was to determine HRQoL in a population-based cohort of patients with IBD 20 years after diagnosis and its association with demographic and clinical factors and to compare HRQoL of the cohort with that of the background population. METHODS: Patients with IBD from a large population-based inception cohort (the IBSEN cohort) were invited to a prescheduled 20-year follow-up visit with a structured interview, a clinical examination, and laboratory tests...
July 2016: Inflammatory Bowel Diseases
Torkjell Nøstdahl, Tomm Bernklev, Johan Raeder, Leiv Sandvik, Olav Fredheim
OBJECTIVE: Postoperative fatigue is a common problem after otherwise uncomplicated surgery. It may defer patients from resuming their daily activities and is often reported to be among their most severe symptoms. There are few validated instruments for assessing postoperative fatigue. Our aim was to translate into Norwegian and explore a Short Form of the Identity-Consequences Fatigue Scale; a fatigue questionnaire specifically developed to assess postoperative fatigue. METHODS: The fatigue scale was translated to Norwegian through a forward-backward process, and subsequently validated in a large, mixed surgical population...
May 2016: Journal of Psychosomatic Research
Wendel Wohlleben, Marc D Driessen, Simon Raesch, Ulrich F Schaefer, Christine Schulze, Bernhard von Vacano, Antje Vennemann, Martin Wiemann, Christian A Ruge, Herbert Platsch, Sarah Mues, Rainer Ossig, Janina M Tomm, Jürgen Schnekenburger, Thomas A J Kuhlbusch, Andreas Luch, Claus-Michael Lehr, Andrea Haase
Lung lining fluid is the first biological barrier nanoparticles (NPs) encounter during inhalation. As previous inhalation studies revealed considerable differences between surface functionalized NPs with respect to deposition and toxicity, our aim was to investigate the influence of lipid and/or protein binding on these processes. Thus, we analyzed a set of surface functionalized NPs including different SiO2 and ZrO2 in pure phospholipids, CuroSurf(TM) and purified native porcine pulmonary surfactant (nS). Lipid binding was surprisingly low for pure phospholipids and only few NPs attracted a minimal lipid corona...
September 2016: Nanotoxicology
Asta Kristine Håberg, Tommy Arild Hammer, Kjell Arne Kvistad, Jana Rydland, Tomm B Müller, Live Eikenes, Mari Gårseth, Lars Jacob Stovner
OBJECTIVES: Evaluate types and prevalence of all, incidental, and clinically relevant incidental intracranial findings, i.e. those referred to primary physician or clinical specialist, in a cohort between 50 and 66 years from the Nord-Trøndelag Health (HUNT) study. Types of follow-up, outcome of repeated neuroimaging and neurosurgical treatment were assessed. MATERIAL AND METHODS: 1006 participants (530 women) underwent MRI of the head at 1.5T consisting of T1 weighted sagittal IR-FSPGR volume, axial T2 weighted, gradient echo T2* weighted and FLAIR sequences plus time of flight cerebral angiography covering the circle of Willis...
2016: PloS One
Benedicte Kirkøen, Paula Berstad, Edoardo Botteri, Tone Lise Åvitsland, Alvilde Maria Ossum, Thomas de Lange, Geir Hoff, Tomm Bernklev
BACKGROUND: Participation in cancer screening programmes might cause worries in the population outweighting the benefits of reduced mortality. The present study aimed to investigate possible psychological harm of participation in a colorectal cancer (CRC) screening pilot in Norway. METHODS: In a prospective, randomised trial participants (aged 50-74 years) were invited to either flexible sigmoidoscopy (FS) screening, faecal immunochemical test (FIT), or no screening (the control group; 1 : 1: 1)...
March 1, 2016: British Journal of Cancer
Alejandro S Cazzulino, Randy Martinez, Nicole K Tomm, Christine A Denny
Recent studies have focused on the identification and manipulation of memory traces in rodent models. The two main mouse models utilized are either a CreER(T2) /loxP tamoxifen (TAM)- or a tetracycline transactivator/tetracycline-response element doxycycline-inducible system. These systems, however, could be improved to label a more specific population of activated neurons corresponding to behavior. Here, we sought to identify an improved selective estrogen receptor (ER) modulator (SERM) in which we could label an individual memory trace in ArcCreER(T2) mice...
June 2016: Hippocampus
Maike Frye, Martina Dierkes, Verena Küppers, Matthias Vockel, Janina Tomm, Dagmar Zeuschner, Jan Rossaint, Alexander Zarbock, Gou Young Koh, Kevin Peters, Astrid Fee Nottebaum, Dietmar Vestweber
Vascular endothelial (VE)-protein tyrosine phosphatase (PTP) associates with VE-cadherin, thereby supporting its adhesive activity and endothelial junction integrity. VE-PTP also associates with Tie-2, dampening the tyrosine kinase activity of this receptor that can support stabilization of endothelial junctions. Here, we have analyzed how interference with VE-PTP affects the stability of endothelial junctions in vivo. Blocking VE-PTP by antibodies, a specific pharmacological inhibitor (AKB-9778), and gene ablation counteracted vascular leak induction by inflammatory mediators...
December 14, 2015: Journal of Experimental Medicine
D Rivera, P B Perrin, G Weiler, N Ocampo-Barba, A Aliaga, W Rodríguez, Y Rodríguez-Agudelo, A Aguayo, M Longoni, S Trapp, L Esenarro, J C Arango-Lasprilla
BACKGROUND: The Test of Memory Malingering (TOMM) is an instrument used to assess purposeful embellishment or fabrication of memory difficulties for personal gain. Although the TOMM can be use in non-English speaking cultures, it has not been validated in Spanish-speaking Central and South American contexts. OBJECTIVE: To generate normative data on TOMM across 7 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate...
2015: NeuroRehabilitation
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