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https://www.readbyqxmd.com/read/27920484/psychological-effects-of-colorectal-cancer-screening-participants-vs-individuals-not-invited
#1
Benedicte Kirkøen, Paula Berstad, Edoardo Botteri, Linn Bernklev, Badboni El-Safadi, Geir Hoff, Thomas de Lange, Tomm Bernklev
AIM: To investigate the possible long-term psychological harm of participating in colorectal cancer (CRC) screening in Norway. METHODS: In a prospective, randomized trial, 14294 participants (aged 50-74 years) were invited to either flexible sigmoidoscopy (FS) screening, or a faecal immunochemical test (FIT) (1:1). In total, 4422 screening participants (32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life (HRQOL) measurement, when invited to screening and one year after the invitation...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27852169/fatigue-in-a-population-based-cohort-of-patients-with-inflammatory-bowel-disease-20-years-after-diagnosis-the-ibsen-study
#2
Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Randi Opheim, Magne Henriksen, Ole Høie, Øistein Hovde, Iril Kempski-Monstad, Inger Camilla Solberg, Jørgen Jahnsen, Geir Hoff, Bjørn Moum, Tomm Bernklev
OBJECTIVE: Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn's disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel disease (IBD) patients is scarce. Our aims were to assess fatigue scores and the prevalence of chronic fatigue in IBD patients 20 years after diagnosis and to identify variables associated with fatigue in this cohort. METHODS: Twenty years after diagnosis, patients from a cohort with incident IBD were invited to a follow-up visit that included a structured interview, a clinical examination, laboratory tests and the Fatigue Questionnaire (FQ)...
November 17, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27824661/changes-in-health-behavior-1-year-after-testing-negative-at-a-colorectal-cancer-screening-a-randomized-controlled-study
#3
Markus D Knudsen, Anette Hjartåker, Marie K E Olsen, Geir Hoff, Thomas D Lange, Tomm Bernklev, Paula Berstad
When planning national screening programs, it is important to investigate potential changes in health behavior initiated by the screening. Knowledge of the consequences of different colorectal cancer (CRC) screening modalities for health behavior is limited. We aimed to investigate differences in 1-year health behavior changes after testing negative in CRC screening by one of two screening modalities. Participants of both sexes aged 50-74 years assigned randomly to five biennial rounds of fecal immunochemical test (FIT), one round of flexible sigmoidoscopy (FS), or no screening (control) were invited to complete a self-reported lifestyle questionnaire on smoking, body weight, physical activity, alcohol intake, and consumption of selected dietary items at baseline and at 1-year follow-up...
November 7, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27817942/use-of-a-metagenetic-approach-to-monitor-the-bacterial-microbiota-of-tomme-d-orchies-cheese-during-the-ripening-process
#4
Alexandre Ceugniez, Bernard Taminiau, Françoise Coucheney, Philippe Jacques, Véronique Delcenserie, Georges Daube, Djamel Drider
The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade, particularly those performed on milk and cheese derivative products. In this work, we investigated the bacterial content of "Tomme d'Orchies" cheese, an artisanal pressed and uncooked French cheese. To this end, a metagenetic analysis, using Illumina technology, was utilized on samples taken from the surface and core of the cheese at 0, 1, 3, 14 and 21days of ripening process...
October 29, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27816475/proteomics-analysis-of-dendritic-cell-activation-by-contact-allergens-reveals-possible-biomarkers-regulated-by-nrf2
#5
Franz Mussotter, Janina Melanie Tomm, Zeina El Ali, Marc Pallardy, Saadia Kerdine-Römer, Mario Götz, Martin von Bergen, Andrea Haase, Andreas Luch
Allergic contact dermatitis is a widespread disease with high clinical relevance affecting approximately 20% of the general population. Typically, contact allergens are low molecular weight electrophilic compounds which can activate the Keap1/Nrf2 pathway. We performed a proteomics study to reveal possible biomarkers for dendritic cell (DC) activation by contact allergens and to further elucidate the role of Keap1/Nrf2 signaling in this process. We used bone marrow derived dendritic cells (BMDCs) of wild-type (nrf2(+/+)) and Nrf2 knockout (nrf2(-/-)) mice and studied their response against the model contact sensitizers 2,4-dinitrochlorobenzene (DNCB), cinnamaldehyde (CA) and nickel(II) sulfate by 2-dimensional polyacrylamide gel electrophoresis (2D-PAGE) in combination with electrospray ionization tandem mass spectrometry (ESI-MS/MS)...
December 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27784191/longitudinal-study-of-postconcussion-syndrome-not-everyone-recovers
#6
Carmen Hiploylee, Paul Dufort, Hannah Davis, Richard Wennberg, Carmela Tartaglia, David Mikulis, Lili-Naz Hazrati, Charles Tator
We examined recovery from postconcussion syndrome (PCS) in a series of 285 patients, diagnosed with concussion based on international sport concussion criteria, who received a questionnaire regarding recovery . Of 141 respondents, those with postconcussion symptoms lasting less than 3 months, a positive CT and/or MRI, litigants, and known Test of Memory Malingering (TOMM)-positive cases were excluded, leaving 110 eligible respondents. We found that only 27% of our population eventually recovered, and 67% of those who recovered did so within the first year...
October 26, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27736127/identifying-feigning-in-trauma-exposed-african-immigrants
#7
Rebecca A Weiss, Barry Rosenfeld
As the populations of Western countries become more diverse, the risk of inaccurately generalizing knowledge from majority ethnic groups to minority groups is increasing. However, few of the measures used in forensic assessment are based on normative samples that represent the considerable diversity present in forensic settings. This study examined 4 commonly used measures of feigning: the Dot Counting Test (DCT; Boone, Lu, & Herzberg, 2002); the Miller Forensic Assessment of Symptoms (M-FAST; Miller, 2001); the Test of Memory Malingering (TOMM; Tombaugh, 1996); and a validity scale (atypical responding; ATR) on the Trauma Symptom Inventory-2 (Briere, 2011)...
August 15, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27630711/comparison-of-the-multiattribute-utility-instruments-eq-5d-and-sf-6d-in-a-europe-wide-population-based-cohort-of-patients-with-inflammatory-bowel-disease-10-years-after-diagnosis
#8
Gert Huppertz-Hauss, Eline Aas, Marte Lie Høivik, Ebbe Langholz, Selwyn Odes, Milada Småstuen, Reinhold Stockbrugger, Geir Hoff, Bjørn Moum, Tomm Bernklev
Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27603182/vitamin-d-deficiency-in-inflammatory-bowel-disease-prevalence-and-predictors-in-a-norwegian-outpatient-population
#9
Svein Oskar Frigstad, Marte Høivik, Jørgen Jahnsen, Sandra Rinne Dahl, Milada Cvancarova, Tore Grimstad, Ingrid Prytz Berset, Gert Huppertz-Hauss, Øistein Hovde, Roald Torp, Tomm Bernklev, Bjørn Moum, Lars-Petter Jelsness-Jørgensen
BACKGROUND AND AIM: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD. METHODS: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014...
September 23, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27574298/allergen-induced-il-6-regulates-il-9-il-17a-balance-in-cd4-t-cells-in-allergic-airway-inflammation
#10
Nicole Schütze, Stefanie Trojandt, Stephanie Kuhn, Janina M Tomm, Martin von Bergen, Jan C Simon, Tobias Polte
IL-9-secreting Th9 cells have been considered to play a pivotal role in the pathogenesis of atopic diseases. To what extent IL-9-producing cells are induced or regulated by sensitization with naturally occurring allergens is not yet clear. Naturally occurring allergens are capable of inducing IL-6 production in dendritic cells (DCs). Whether allergen-induced IL-6 supports a Th9 subtype by increasing IL-9 production, as observed in in vitro studies, or rather favors Th17 differentiation is not finally resolved...
October 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27504905/evaluation-of-the-response-bias-scale-and-improbable-failure-scale-in-assessing-feigned-cognitive-impairment
#11
Laura M Grossi, Debbie Green, Shanah Einzig, Brian Belfi
The present study evaluated the Response Bias scale (RBS), a symptom validity test embedded within the Minnesota Multiphasic Personality Inventory (MMPI)-2 Restructured Form (MMPI-2-RF) that assesses for feigned neurocognitive complaints, in a sample of pretrial incompetent to stand trial (IST) criminal defendants. Additionally, we examined the Improbable Failure (IF) scale, a performance validity test embedded within the Structured Interview of Reported Symptoms, Second Edition (SIRS-2), which similarly assesses for feigned cognitive impairment (FCI)...
August 8, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27501116/not-all-performance-validity-tests-are-created-equal-the-role-of-recollection-and-familiarity-in-the-test-of-memory-malingering-and-word-memory-test
#12
Graham M L Eglit, Julie K Lynch, Robert J McCaffrey
INTRODUCTION: The Test of Memory Malingering (TOMM) and the Word Memory Test (WMT) are both performance validity tests (PVTs) that use a two-alternative forced-choice (2AFC) recognition memory format. Several studies have reported that these tests are susceptible to cognitive impairment and that the WMT is more susceptible than the TOMM. The current study explored components of recognition memory (i.e., conscious recollection and familiarity) underlying the TOMM and WMT to identify factors that make them susceptible and resilient to cognitive impairment...
August 8, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27468217/favorable-lifestyle-before-diagnosis-associated-with-lower-risk-of-screen-detected-advanced-colorectal-neoplasia
#13
Markus D Knudsen, Thomas de Lange, Edoardo Botteri, Dung-Hong Nguyen, Helge Evensen, Chloé B Steen, Geir Hoff, Tomm Bernklev, Anette Hjartåker, Paula Berstad
AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia (ACN) in colorectal cancer (CRC) screening. METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero (poorest) to six (best)...
July 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27456971/tomm-trial-1-as-a-performance-validity-indicator-in-a-criminal-forensic-sample
#14
Rachel L Fazio, John H Denning, Robert L Denney
OBJECTIVE: To determine the effectiveness of the Test of Memory Malingering Trial 1 (TOMM1) as a freestanding Performance Validity Test (PVT) as compared to the full TOMM in a criminal forensic sample. METHOD: Participants included 119 evaluees in a Midwestern forensic hospital. Criterion groups were formed based on passing/failing scores on other freestanding PVTs. This resulted in three groups: +MND (Malingered Neurocognitive Dysfunction), who failed two or more freestanding PVTs; possible MND (pMND), who failed one freestanding PVT; and -MND, who failed no other freestanding PVTs...
July 26, 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27446848/validity-reliability-and-responsiveness-of-the-brief-pain-inventory-in-inflammatory-bowel-disease
#15
Lars-Petter Jelsness-Jørgensen, Bjørn Moum, Tore Grimstad, Jørgen Jahnsen, Randi Opheim, Ingrid Prytz Berset, Øistein Hovde, Roald Torp, Svein Oskar Frigstad, Gert Huppertz-Hauss, Tomm Bernklev
Background and Aims. No patient-reported outcome measures targeting pain have yet been validated for use in IBD patients. Consequently, the aim of this study was to test the psychometrical properties of the brief pain inventory (BPI) in an outpatient population with IBD. Methods. Participants were recruited from nine hospitals in the southeastern and western parts of Norway. Clinical and sociodemographic data were collected, and participants completed the BPI, as well as the Short-Form 36 (SF-36). Results. In total, 410 patients were included...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27411749/cognitive-functioning-in-fibromyalgia-the-central-role-of-effort
#16
Tamar Bar-On Kalfon, Gilad Gal, Ran Shorer, Jacob N Ablin
OBJECTIVE: Fibromyalgia syndrome (FM) patients demonstrate deficits in tests of attention, executive functioning and verbal memory. We assessed the role of effort in the cognitive impairment in FM patients, alongside common symptoms of pain, fatigue and depression. METHOD: 50 FM patients underwent a computerized cognitive assessment battery including memory, executive function, attention and information processing speed (NeuroTrax Corp.). Age and education standardized scores were computed...
August 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27237373/comparison-and-optimization-of-methods-for-the-simultaneous-extraction-of-dna-rna-proteins-and-metabolites
#17
Fränze Vorreiter, Silke Richter, Michel Peter, Sven Baumann, Martin von Bergen, Janina M Tomm
The challenge of performing a time-resolved comprehensive analysis of molecular systems has led to the quest to optimize extraction methods. When the size of a biological sample is limited, there is demand for the simultaneous extraction of molecules representing the four areas of "omics": genomics, transcriptomics, proteomics, and metabolomics. Here we optimized a protocol for the simultaneous extraction of DNA, RNA, proteins, and metabolites and compared it with two existing protocols. Our optimization comprised the addition of a methanol/chloroform metabolite purification before the separation of DNA/RNA and proteins...
September 1, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/27206882/blood-glucose-levels-and-cortical-thinning-in-cognitively-normal-middle-aged-adults
#18
Alexandra M V Wennberg, Adam P Spira, Corinne Pettigrew, Anja Soldan, Vadim Zipunnikov, George W Rebok, Allen D Roses, Michael W Lutz, Michael M Miller, Madhav Thambisetty, Marilyn S Albert
Type II diabetes mellitus (DM) increases risk for cognitive decline and is associated with brain atrophy in older demented and non-demented individuals. We investigated (1) the cross-sectional association between fasting blood glucose level and cortical thickness in a sample of largely middle-aged, cognitively normal adults, and (2) whether these associations were modified by genes associated with both lipid processing and dementia. To explore possible modifications by genetic status, we investigated the interaction between blood glucose levels and the apolipoprotein E (APOE) ε4 allele and the translocase of the outer mitochondrial membrane (TOMM) 40 '523 genotype on cortical thickness...
June 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27206016/health-related-quality-of-life-in-patients-with-inflammatory-bowel-disease-20-years-after-diagnosis-results-from-the-ibsen-study
#19
Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Magne Henriksen, Ole Høie, Jørgen Jahnsen, Geir Hoff, Bjørn Moum, Tomm Bernklev
BACKGROUND: Data on the long-term observation of health-related quality of life (HRQoL) in the inflammatory bowel diseases (IBD), Crohn's disease (CD), and ulcerative colitis are scarce. Our aim was to determine HRQoL in a population-based cohort of patients with IBD 20 years after diagnosis and its association with demographic and clinical factors and to compare HRQoL of the cohort with that of the background population. METHODS: Patients with IBD from a large population-based inception cohort (the IBSEN cohort) were invited to a prescheduled 20-year follow-up visit with a structured interview, a clinical examination, and laboratory tests...
July 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27095152/postoperative-fatigue-translation-and-validation-of-a-revised-10-item-short-form-of-the-identity-consequence-fatigue-scale-icfs
#20
Torkjell Nøstdahl, Tomm Bernklev, Johan Raeder, Leiv Sandvik, Olav Fredheim
OBJECTIVE: Postoperative fatigue is a common problem after otherwise uncomplicated surgery. It may defer patients from resuming their daily activities and is often reported to be among their most severe symptoms. There are few validated instruments for assessing postoperative fatigue. Our aim was to translate into Norwegian and explore a Short Form of the Identity-Consequences Fatigue Scale; a fatigue questionnaire specifically developed to assess postoperative fatigue. METHODS: The fatigue scale was translated to Norwegian through a forward-backward process, and subsequently validated in a large, mixed surgical population...
May 2016: Journal of Psychosomatic Research
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