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Bovine Tuberculosis

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https://www.readbyqxmd.com/read/28434972/one-bacillus-to-rule-them-all-investigating-broad-range-host-adaptation-in-mycobacterium-bovis
#1
REVIEW
Adrian R Allen
Recent advances are permitting researchers to undertake largescale comparative genomics studies within and between bacterial species to determine the types of genetic change that underpin the phenotypic spectrum that runs from strict host adaptation to generalist. Within the Mycobacterium tuberculosis complex (MTBC) of bacilli, there is much heterogeneity in host specificity. Globally, Mycobacterium bovis exhibits a broad host range encompassing domesticated bovine and wildlife animals unlike the human adapted specialist M...
April 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28426770/correction-risk-factors-for-bovine-tuberculosis-btb-in-cattle-in-ethiopia
#2
Sintayehu W Dejene, Ignas M A Heitkönig, Herbert H T Prins, Fitsum A Lemma, Daniel A Mekonnen, Zelalem E Alemu, Tessema Z Kelkay, Willem F de Boer
[This corrects the article DOI: 10.1371/journal.pone.0159083.].
2017: PloS One
https://www.readbyqxmd.com/read/28413050/toll-like-receptor-2-gene-polymorphisms-in-chinese-holstein-cattle-and-their-associations-with-bovine-tuberculosis
#3
Zhanqin Zhao, Yun Xue, Zhigang Hu, Feng Zhou, Beibei Ma, Ta Long, Qiao Xue, Huisheng Liu
This study evaluated whether there was an association between polymorphisms within the Toll-like receptor 2 gene (TLR2) of Chinese Holstein cattle and susceptibility to bovine tuberculosis (BTB). In a case-control study including 210 BTB cases and 237 control cattle, we found only two common single-nucleotide polymorphisms (SNPs) within the entire coding region of the TLR2 gene, A631G (rs95214857) and T1707C (rs1388116488). Additionally, the allele and genotype distributions of A631G and T1707C were not different between case and control groups, indicated that these SNPs were not associated with susceptibility to BTB...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28410676/the-immunoregulatory-effects-of-co-infection-with-fasciola-hepatica-from-bovine-tuberculosis-to-johne-s-disease
#4
REVIEW
Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28404571/early-detection-of-circulating-antigen-and-igm-associated-immune-complexes-during-experimental-mycobacterium-bovis-infection-in-cattle
#5
Konstantin P Lyashchenko, Rena Greenwald, Alina Sikar-Gang, Archana A Sridhara, Ashley Johnathan, Paul Lambotte, Javan Esfandiari, Mayara F Maggioli, Tyler C Thacker, Mitchell V Palmer, W Ray Waters
The presence of circulating antigen in cattle experimentally infected with Mycobacterium bovis was demonstrated using dual-path platform (DPP) technology. The antigen-capture immunoassays employed rabbit polyclonal antibody recognizing predominantly M. tuberculosis complex-specific epitopes and were able to detect soluble substances and whole cells of mycobacteria. The antigen found in serum appeared to be mostly bound to IgM, but not to IgG, within the immune complexes formed at early stages of M. bovis infection...
April 12, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28393187/generation-and-characterization-of-induced-pluripotent-stem-cells-from-guinea-pig-fetal-fibroblasts
#6
Yuehong Wu, Ouyang Li, Chengwen He, Yong Li, Min Li, Xiaoming Liu Liu, Yujiong Wang, Yulong He
Induced pluripotent stem cells (iPS) represent an important tool to develop disease‑modeling assays, drug testing assays and cell‑based replacement therapies. The application of iPS in these fields requires the development of suitable animal models. Of the suitable species, guinea pigs are particularly important and offer significant advantages. Successful iPS generation has been accomplished in a number of species; however, it has not been reported in the guinea pig. The present study successfully generated iPS from guinea pigs (giPS) using single polycistronic virus transduction with mouse octamer‑binding transcription factor 4 (Oct4), sex determining region Y‑box 2 (Sox2), Kruppel‑like factor 4 and c‑Myc...
April 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28392519/detection-of-lipomannan-in-cattle-infected-with-bovine-tuberculosis
#7
Dung M Vu, Rama M Sakamuri, W Ray Waters, Basil I Swanson, Harshini Mukundan
Early and rapid detection of bovine tuberculosis (bTB) is critical to controlling the spread of this disease in cattle and other animals. In this study, we demonstrate the development of an immunoassay for the direct detection of the bovine bTB biomarker, lipomannan (LM) in serum using a waveguide-based optical biosensor. We apply an ultra-sensitive detection strategy developed by our team, termed lipoprotein capture, that exploits the pull-down of high-density lipoprotein (HDL) nanodiscs from cattle blood that allows for the recovery and detection of associated LM...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28392087/evaluation-of-the-methodological-quality-of-studies-of-the-performance-of-diagnostic-tests-for-bovine-tuberculosis-using-quadas
#8
Sara H Downs, Simon J More, Anthony V Goodchild, Adam O Whelan, Darrell A Abernethy, Jennifer M Broughan, Angus Cameron, Alasdair J Cook, R Ricardo de la Rua-Domenech, Matthias Greiner, Jane Gunn, Javier Nuñez-Garcia, Shelley Rhodes, Simon Rolfe, Michael Sharp, Paul Upton, Eamon Watson, Michael Welsh, John A Woolliams, Richard S Clifton-Hadley, Jessica E Parry
There has been little assessment of the methodological quality of studies measuring the performance (sensitivity and/or specificity) of diagnostic tests for animal diseases. In a systematic review, 190 studies of tests for bovine tuberculosis (bTB) in cattle (published 1934-2009) were assessed by at least one of 18 reviewers using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies) checklist adapted for animal disease tests. VETQUADAS (VQ) included items measuring clarity in reporting (n=3), internal validity (n=9) and external validity (n=2)...
March 22, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28391623/cost-based-optimization-of-the-stopping-threshold-for-local-disease-surveillance-during-progressive-eradication-of-tuberculosis-from-new-zealand-wildlife
#9
A M Gormley, D P Anderson, G Nugent
Bovine tuberculosis (TB) is managed in New Zealand largely via population reduction of the major wildlife disease reservoir of Mycobacterium bovis, the introduced brushtail possum Trichosurus vulpecula. New Zealand aims to eradicate M. bovis infection from its livestock and wildlife within 40 years, as the culmination of progressive regional eradication programmes. Declarations of regional eradication are decided after extensive possum population control and post-control surveillance; hence, we developed a modelling framework, based on eco-epidemiological simulation data, to provide cost-evaluated options for deciding when to make these declarations...
April 8, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28386030/assessment-of-serological-tests-for-diagnosis-of-bovine-tuberculosis
#10
L McCallan, C Brooks, C Couzens, F Young, J McNair, A W Byrne
No abstract text is available yet for this article.
April 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28385856/updated-reference-genome-sequence-and-annotation-of-mycobacterium-bovis-af2122-97
#11
Kerri M Malone, Damien Farrell, Tod P Stuber, Olga T Schubert, Ruedi Aebersold, Suelee Robbe-Austerman, Stephen V Gordon
We report here an update to the reference genome sequence of the bovine tuberculosis bacillus Mycobacterium bovis AF2122/97, generated using an integrative multiomics approach. The update includes 42 new coding sequences (CDSs), 14 modified annotations, 26 single-nucleotide polymorphism (SNP) corrections, and disclosure that the RD900 locus, previously described as absent from the genome, is in fact present.
April 6, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28382943/badger-macrophages-fail-to-produce-nitric-oxide-a-key-anti-mycobacterial-effector-molecule
#12
Kirstin Bilham, Amy C Boyd, Stephen G Preston, Christina D Buesching, Chris Newman, David W Macdonald, Adrian L Smith
The European badger is recognised as a wildlife reservoir for bovine tuberculosis (bTB); the control of which is complex, costly and controversial. Despite the importance of badgers in bTB and the well-documented role for macrophages as anti-mycobacterial effector cells, badger macrophage (bdMφ) responses remain uncharacterised. Here, we demonstrate that bdMφ fail to produce nitric oxide (NO) or upregulate inducible nitric oxide synthase (iNOS) mRNA following Toll-like receptor (TLR) agonist treatment. BdMφ also failed to make NO after stimulation with recombinant badger interferon gamma (bdIFNγ) or a combination of bdIFNγ and lipopolysaccharide...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372590/proteomic-analysis-of-protein-purified-derivative-of-mycobacterium-bovis
#13
Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda, Franco Roperto
BACKGROUND: Tuberculin skin test based on in vivo intradermal inoculation of purified protein derivative from Mycobacterium bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB). METHODS: Proteomic analysis was performed on different bPPD preparations from M. bovis, strain AN5. Proteins were precipitated from bPPD solutions by TCA precipitation. The proteome of bPPD preparations was investigated by bottom-up proteomics, which consisted in protein digestion and nano-LC-MS/MS analysis...
April 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28365924/spatial-analysis-of-bovine-tuberculosis-in-the-state-of-mexico-mexico
#14
Adrian Zaragoza Bastida, Marivel Herna Ndez Tellez, Lilia Patricia Bustamante Montes, Jaime Nicola S Jaramillo Paniagua, Mari A Eugenia Jaimes Beni Tes, Germa N Eduardo Mendoza Barrera, Ninfa Rami Rez-Dura N
Bovine tuberculosis (bTB) is a chronic infectious disease that affects both domestic animals and wildlife. Veterinary epidemiology studies evaluate bTB using geographic information systems (GIS), which can characterise the spatial and temporal distribution of diseases and identify the geographic areas and animal populations at risk of contracting a disease. The present study used space‑time permutation scan statistic to identify the spatial and temporal distribution of bTB from 2005 to 2010 in the State of Mexico with the goal of creating a similarity model using Mahalanobis Distance to identify areas suitable for bTB occurrence...
March 31, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28348866/integrated-computational-prediction-and-experimental-validation-identifies-promiscuous-t-cell-epitopes-in-the-proteome-of-mycobacterium-bovis
#15
Damien Farrell, Gareth Jones, Christopher Pirson, Kerri Malone, Kevin Rue-Albrecht, Anthony J Chubb, Martin Vordermeier, Stephen V Gordon
The discovery of novel antigens is an essential requirement in devising new diagnostics or vaccines for use in control programmes against human tuberculosis (TB) and bovine tuberculosis (bTB). Identification of potential epitopes recognised by CD4(+) T cells requires prediction of peptide binding to MHC class-II, an obligatory prerequisite for T cell recognition. To comprehensively prioritise potential MHC-II-binding epitopes from Mycobacterium bovis, the agent of bTB and zoonotic TB in humans, we integrated three binding prediction methods with the M...
August 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28347519/meta-analyses-of-the-sensitivity-and-specificity-of-ante-mortem-and-post-mortem-diagnostic-tests-for-bovine-tuberculosis-in-the-uk-and-ireland
#16
Javier Nuñez-Garcia, Sara H Downs, Jessica E Parry, Darrell A Abernethy, Jennifer M Broughan, Angus R Cameron, Alasdair J Cook, Ricardo de la Rua-Domenech, Anthony V Goodchild, Jane Gunn, Simon J More, Shelley Rhodes, Simon Rolfe, Michael Sharp, Paul A Upton, H Martin Vordermeier, Eamon Watson, Michael Welsh, Adam O Whelan, John A Woolliams, Richard S Clifton-Hadley, Matthias Greiner
Bovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accurate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was, through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 different ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic review of the scientific literature (published 1934-2009) diagnostic Se and Sp were estimated using Bayesian logistic regression models adjusting for confounding factors...
March 6, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28335717/genomic-regions-underlying-susceptibility-to-bovine-tuberculosis-in-holstein-friesian-cattle
#17
Kethusegile Raphaka, Oswald Matika, Enrique Sánchez-Molano, Raphael Mrode, Mike Peter Coffey, Valentina Riggio, Elizabeth Janet Glass, John Arthur Woolliams, Stephen Christopher Bishop, Georgios Banos
BACKGROUND: The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle susceptibility to bTB provides an opportunity to select for resistant animals and further understand the genetic mechanisms underlying disease dynamics. METHODS: The present study identified genomic regions associated with susceptibility to bTB using genome-wide association (GWA), regional heritability mapping (RHM) and chromosome association approaches...
March 23, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28333986/building-the-road-to-a-regional-zoonoses-strategy-a-survey-of-zoonoses-programmes-in-the-americas
#18
Melody J Maxwell, Mary H Freire de Carvalho, Armando E Hoet, Marco A N Vigilato, Julio C Pompei, Ottorino Cosivi, Victor J Del Rio Vilas
BACKGROUND: In recent years, global public health security has been threatened by zoonotic disease emergence as exemplified by outbreaks of H5N1 and H1N1 influenza, SARS, and most recently Ebola and Zika. Additionally, endemic zoonoses, such as rabies, burden countries year after year, placing demands on limited finances and personnel. To survey the baseline status of the emerging and endemic zoonoses programmes of the Latin American and the Caribbean (LAC) countries, the Pan American Health Organization (PAHO) conducted a survey of priority emerging and endemic zoonoses, countries´ prioritization criteria and methodologies, and suggestions to strengthen countries capacities and regional approaches to zoonoses control...
2017: PloS One
https://www.readbyqxmd.com/read/28332294/farm-level-risk-factors-associated-with-bovine-tuberculosis-in-the-dairy-sector-in-eritrea
#19
M K Ghebremariam, A L Michel, M Nielen, J C M Vernooij, V P M G Rutten
The aim of our study was to determine the association of selected potential risk factors with the presence of bovine tuberculosis (BTB) in dairy herds in Eritrea. A case-control study was conducted in the three major milk-producing regions of the country by stratified random sampling of 61 case and 65 control herds combined with completion of a standardized pretested questionnaire pertaining 36 relevant risk factors (variables). The variables were divided into two clusters, based on potential association with either "introduction" or "establishment" of BTB on the farms to elucidate association with incident or prevalent cases separately...
March 22, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28331796/an-unexpected-finding-in-a-man-with-multiple-pulmonary-nodules-a-pleural-effusion-and-respiratory-failure
#20
Yik Lam Pang, Quentin Jones
We report the case of a 47-year old Caucasian man with a history of depression and high alcohol intake who presented with a one-month history of weight loss, dry cough and abdominal pain. He had no smoking history of note. The patient was treated for a suspected chest infection, however developed respiratory failure and was intubated. A CT showed multiple pulmonary nodules, left pleural thickening extending to the mediastinum and bilateral pleural effusions-larger on the left, suggestive of disseminated malignancy...
2017: Respiratory Medicine Case Reports
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