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Bovine Tuberculosis

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https://www.readbyqxmd.com/read/28926023/the-political-economy-of-bovine-tuberculosis-in-great-britain
#1
R M Bennett
A brief history of bovine tuberculosis (bTB) and its control in Great Britain (GB) is presented. Numerous diverse policies to control the disease in humans, cattle and wildlife have been pursued over the last 100 years and many millions of pounds have been spent. After notable success in reducing the incidence and prevalence of bTB in cattle in GB from the 1950s to the mid-1980s, the geographical spread of the disease and the number of cattle slaughtered have increased continually since that time, with a high point of bTB incidence in 2008...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28903115/erap1-and-pde8a-are-downregulated-in-cattle-protected-against-bovine-tuberculosis
#2
Federico Carlos Blanco, Marcelo Abel Soria, Laura Inés Klepp, Fabiana Bigi
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M...
September 14, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28888636/efficacy-of-oral-bcg-vaccination-in-protecting-free-ranging-cattle-from-natural-infection-by-mycobacterium-bovis
#3
Graham Nugent, Ivor J Yockney, Jackie Whitford, Frank E Aldwell, Bryce M Buddle
Vaccination of cattle against bovine tuberculosis could be a valuable control strategy, particularly in countries faced with intractable ongoing infection from a disease reservoir in wildlife. A field vaccination trial was undertaken in New Zealand. The trial included 1286 effectively free-ranging cattle stocked at low densities in a remote 7600ha area, with 55% of them vaccinated using Mycobacterium bovis BCG (Danish strain 1311). Vaccine was administered orally in all but 34 cases (where it was injected)...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28879829/five-year-surveillance-of-human-tuberculosis-caused-by-mycobacterium-bovis-in-bologna-italy-an-underestimated-problem
#4
G Lombardi, I Botti, M L Pacciarini, M B Boniotti, G Roncarati, P Dal Monte
Human tuberculosis (TB) caused by Mycobacterium bovis surveillance is affected by a lack of data. The aims of the present study were: (i) to estimate the proportion of human TB caused by M. bovis over a period of 5 years in Bologna, Northern Italy, which, like most Western European countries, has been declared bovine TB-free; (ii) to compare the genetic profiles of M. bovis strains identified in humans with those circulating in cattle in the last 15 years in Italy. Among 511 TB patients, the proportion of human TB caused by M...
September 7, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28875176/lactoferricin-peptides-increase-macrophages-capacity-to-kill-mycobacterium-avium
#5
Tânia Silva, Ana C Moreira, Kamran Nazmi, Tânia Moniz, Nuno Vale, Maria Rangel, Paula Gomes, Jan G M Bolscher, Pedro N Rodrigues, Margarida Bastos, Maria Salomé Gomes
Mycobacterial infections cause a significant burden of disease and death worldwide. Their treatment is long, toxic, costly, and increasingly prone to failure due to bacterial resistance to currently available antibiotics. New therapeutic options are thus clearly needed. Antimicrobial peptides represent an important source of new antimicrobial molecules, both for their direct activity and for their immunomodulatory potential. We have previously reported that a short version of the bovine antimicrobial peptide lactoferricin with amino acids 17 to 30 (LFcin17-30), along with its variants obtained by specific amino acid substitutions, killed Mycobacterium avium in broth culture...
July 2017: MSphere
https://www.readbyqxmd.com/read/28841990/high-precision-quantitation-of-a-tuberculosis-vaccine-antigen-with-capillary-gel-electrophoresis-using-an-injection-standard
#6
Agnesa Shala-Lawrence, Samaneh Beheshti, Elena Newman, Mei Tang, Svetlana M Krylova, Michael Leach, Bruce Carpick, Sergey N Krylov
Analysis of proteinogenic vaccine antigens in a quality control environment requires an accurate, precise, and reliable method for protein separation and quantitation. While having multiple advantages over the classical SDS-PAGE, capillary gel electrophoresis (CGE) has not yet become a standard tool in vaccine antigen analysis. Here we report on development of a CGE-based method for quantitative analysis of a tuberculosis vaccine fusion antigen protein, H4, currently in clinical trials. We demonstrate that our method can monitor antigen purity and relative quantity with greater precision and accuracy versus SDS-PAGE...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28841870/molecular-characterization-of-bovine-tuberculosis-strains-in-two-slaughterhouses-in-morocco
#7
Hind Yahyaoui-Azami, Hamid Aboukhassib, Mohammed Bouslikhane, Jaouad Berrada, Soukaina Rami, Miriam Reinhard, Sebastien Gagneux, Julia Feldmann, Sonia Borrell, Jakob Zinsstag
BACKGROUND: Bovine tuberculosis (BTB) is caused by Mycobacterium bovis, which belongs to the Mycobacterium tuberculosis complex. Mycobacterium bovis have been described to be responsible of most cases of bovine tuberculosis. Although M. tuberculosis, M. africanum and non-complex mycobacteria were isolated from cattle. In Morocco, so far, no molecular studies were conducted to characterize the strains responsible of BTB. The present study aims to characterize M. bovis in Morocco. The present study was conducted in slaughterhouses in Rabat and El Jadida...
August 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28830547/relative-abundance-of-mycobacterium-bovis-molecular-types-in-cattle-a-simulation-study-of-potential-epidemiological-drivers
#8
Hannah Trewby, David M Wright, Robin A Skuce, Carl McCormick, Thomas R Mallon, Eleanor L Presho, Rowland R Kao, Daniel T Haydon, Roman Biek
BACKGROUND: The patterns of relative species abundance are commonly studied in ecology and epidemiology to provide insights into underlying dynamical processes. Molecular types (MVLA-types) of Mycobacterium bovis, the causal agent of bovine tuberculosis, are now routinely recorded in culture-confirmed bovine tuberculosis cases in Northern Ireland. In this study, we use ecological approaches and simulation modelling to investigate the distribution of relative abundances of MVLA-types and its potential drivers...
August 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28815647/wildlife-disease-ecology-from-the-individual-to-the-population-insights-from-a-long-term-study-of-a-naturally-infected-european-badger-population
#9
Jenni L McDonald, Andrew Robertson, Matthew J Silk
1. Long-term individual-based datasets on host-pathogen systems are a rare and valuable resource for understanding the infectious disease dynamics in wildlife. A study of European badgers (Meles meles) naturally infected with bovine tuberculosis (bTB) at Woodchester Park in Gloucestershire (UK) has produced a unique dataset, facilitating investigation of a diverse range of epidemiological and ecological questions with implications for disease management. 2. Since the 1970s this badger population has been monitored with a systematic mark-recapture regime yielding a dataset of >15,000 captures of >3000 individuals, providing detailed individual life-history, morphometric, genetic, reproductive and disease data...
August 16, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28810868/nontuberculosis-mycobacteria-are-the-major-causes-of-tuberculosis-like-lesions-in-cattle-slaughtered-at-bahir-dar-abattoir-northwestern-ethiopia
#10
Anwar Nuru, Aboma Zewude, Temesgen Mohammed, Biniam Wondale, Laikemariam Teshome, Muluwork Getahun, Gezahegne Mamo, Girmay Medhin, Rembert Pieper, Gobena Ameni
BACKGROUND: The main cause of bovine tuberculosis (bTB) is believed to be Mycobacterium bovis (M. bovis). Nontuberculosis mycobacteria (NTM) are neglected but opportunistic pathogens and obstacles for bTB diagnosis. This study aimed to isolate and characterize the mycobacteria organisms involved in causing TB-like lesions in cattle in northwestern Ethiopia. RESULTS: A total of 2846 carcasses of cattle were inspected for TB lesions. Ninety six tissues (including lymph nodes such as submandibular, retropharyngeal, tonsilar, mediatinal, bronchial and mesenteric, and organs such as lung, liver and kidney) with suspicious TB lesion(s) were collected and cultured on Lowenstein-Jensen medium...
August 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28802398/a-mycobacterial-growth-inhibition-assay-mgia-for-bovine-tb-vaccine-development
#11
Ilaria Pepponi, Bhagwati Khatri, Rachel Tanner, Bernardo Villarreal-Ramos, Martin Vordermeier, Helen McShane
Human tuberculosis remains a significant cause of mortality and morbidity throughout the world. The global economic impact of bovine TB is considerable. An effective vaccine would be the most cost-effective way to control both epidemics, particularly in emerging economies. TB vaccine research would benefit from the identification of an immune correlate of protection with which vaccines could be gated at both preclinical and clinical levels. In-vitro mycobacterial growth inhibition assays (MGIA) are functional assays that include most aspects of the complex host immune response to mycobacteria, and they may serve as functional immune correlates for vaccine development...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28800642/cost-effectiveness-evaluation-of-bovine-tuberculosis-surveillance-in-wildlife-in-france-sylvatub-system-using-scenario-trees
#12
Julie Rivière, Yann Le Strat, Pascal Hendrikx, Barbara Dufour
Bovine tuberculosis (bTB) is a common disease in cattle and wildlife, with health, zoonotic and economic implications. Infected wild animals, and particularly reservoirs, could hinder eradication of bTB from cattle populations, which could have an important impact on international cattle trade. Therefore, surveillance of bTB in wildlife is of particular importance to better understand the epidemiological role of wild species and to adapt the control measures. In France, a bTB surveillance system for free-ranging wildlife, the Sylvatub system, has been implemented since 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28761195/the-eradication-of-bovine-tuberculosis-in-canada
#13
Hugh G Whitney
No abstract text is available yet for this article.
August 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28739421/whole-genome-sequencing-of-mycobacterium-bovis-to-obtain-molecular-fingerprints-in-human-and-cattle-isolates-from-baja-california-mexico
#14
Sarai Estrella Sandoval-Azuara, Raquel Muñiz-Salazar, Ricardo Perea-Jacobo, Suelee Robbe-Austerman, Alejandro Perera-Ortiz, Gilberto López-Valencia, Doris M Bravo, Alejandro Sanchez-Flores, Daniela Miranda-Guzmán, Carlos Alberto Flores-López, Roberto Zenteno-Cuevas, Rafael Laniado-Laborín, Fabiola Lafarga de la Cruz, Tod P Stuber
OBJECTIVES: To determine genetic diversity by comparing the whole genome sequences of cattle and human Mycobacterium bovis isolates from Baja California. METHODS: A whole genome sequencing strategy was used to obtain the molecular fingerprints of 172 isolates of M. bovis obtained from Baja California, Mexico; 155 isolates were from cattle and 17 isolates were from humans. Spoligotypes were characterized in silico and single nucleotide polymorphism (SNP) differences between the isolates were evaluated...
July 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28723969/matrixlysis-an-improved-sample-preparation-method-for-recovery-of-mycobacteria-from-animal-tissue-material
#15
Christoph Leth, Ashok Varadharajan, Patrick Mester, Marlis Fischaleck, Peter Rossmanith, Friedrich Schmoll, Maria Fink
Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex, is the main causative agent of bovine tuberculosis in alpine regions. Bacterial culture is the gold standard in bovine tuberculosis diagnostic but takes up to twelve weeks. This increases the time and costs for stocks affected with bovine tuberculosis. Hence this study focused on the implementation of a fast and precise mycobacterial detection method and compared it with currently used methods. Matrix lysis is a chemical lysis using high concentrations of urea to solubilize bovine and red deer tissue and was used to detect even smallest amounts or non-visible lesions of mycobacteria...
2017: PloS One
https://www.readbyqxmd.com/read/28713817/generation-of-monoclonal-antibodies-against-ag85a-antigen-of-mycobacterium-tuberculosis-and-application-in-a-competitive-elisa-for-serodiagnosis-of-bovine-tuberculosis
#16
Zhengzhong Xu, Ting Hu, Aihong Xia, Xin Li, Ze Liu, Jingjing Min, Jingjing He, Chuang Meng, Yuelan Yin, Xiang Chen, Xinan Jiao
The Ag85 complex functions as the main secretory protein of Mycobacterium tuberculosis (M. tuberculosis) and BCG. This complex is composed of the proteins, Ag85A, Ag85B, and Ag85C, with Ag85A thought to play the largest role within the complex. However, the lack of commercially available monoclonal antibodies (mAbs) against Ag85A still hinders the biological and applicative research on this protein. In this study, we developed and identified anti-Ag85A mAbs, and five hybridoma cells were established. Using the indirect immunofluorescence test, we found that two anti-Ag85A mAbs did not cross-react with Ag85B and/or Ag85C...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28693300/investigation-of-bovine-tuberculosis-outbreaks-using-the-trace-back-system-and-molecular-typing-in-korean-hanwoo-beef-cattle
#17
Bok Kyung Ku, Bo-Young Jeon, Jae Myung Kim, Young-Boo Jang, Hyeyoung Lee, Jae Young Choi, Suk Chan Jung, Hyang-Mi Nam, Hun Park, Sang-Nae Cho
Bovine tuberculosis is a chronic contagious disease responsible for major agricultural economic losses. Abattoir monitoring and trace-back systems are an appropriate method to control bovine tuberculosis, particularly in beef cattle. In the present study, a trace-back system was applied to bovine tuberculosis outbreaks of Korean native Hanwoo beef cattle. Bovine tuberculosis was detected in three index beef cattle during abattoir monitoring in Jeonbuk Province, Korea, and the original herds were traced back from each index cattle...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28686714/experimental-mycobacterium-bovis-infection-in-three-white-rhinoceroses-ceratotherium-simum-susceptibility-clinical-and-anatomical-pathology
#18
Anita L Michel, Emily P Lane, Lin-Mari de Klerk-Lorist, Markus Hofmeyr, Elisabeth M D L van der Heijden, Louise Botha, Paul van Helden, Michele Miller, Peter Buss
Tuberculosis caused by Mycobacterium bovis is endemic in the African buffalo (Syncerus caffer) population in the Kruger National Park and other conservation areas in South Africa. The disease has been diagnosed in a total of 21 free ranging or semi-free ranging wildlife species in the country with highly variable presentations in terms of clinical signs as well as severity and distribution of tuberculous lesions. Most species are spillover or dead-end hosts without significant role in the epidemiology of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28686691/use-of-fecal-volatile-organic-compound-analysis-to-discriminate-between-non-vaccinated-and-bcg-vaccinated-cattle-prior-to-and-after-mycobacterium-bovis-challenge
#19
Christine K Ellis, Somchai Rice, Devin Maurer, Randal Stahl, W Ray Waters, Mitchell V Palmer, Pauline Nol, Jack C Rhyan, Kurt C VerCauteren, Jacek A Koziel
Bovine tuberculosis is a zoonotic disease of global public health concern. Development of diagnostic tools to improve test accuracy and efficiency in domestic livestock and enable surveillance of wildlife reservoirs would improve disease management and eradication efforts. Use of volatile organic compound analysis in breath and fecal samples is being developed and optimized as a means to detect disease in humans and animals. In this study we demonstrate that VOCs present in fecal samples can be used to discriminate between non-vaccinated and BCG-vaccinated cattle prior to and after Mycobacterium bovis challenge...
2017: PloS One
https://www.readbyqxmd.com/read/28684564/draft-genome-sequences-of-three-mycobacterium-bovis-strains-identified-in-cattle-and-wildlife-in-france
#20
Maxime Branger, Amandine Hauer, Lorraine Michelet, Claudine Karoui, Thierry Cochard, Krystel De Cruz, Sylvie Henault, María Laura Boschiroli, Franck Biet
Mycobacterium bovis is the etiologic agent of bovine tuberculosis, a chronic infectious disease affecting livestock, wild animals, and sometimes humans. We report here three draft genome sequences of Mycobacterium bovis strains of spoligotypes SB0821 and SB0134, isolated from wildlife but circulating in wildlife-livestock multihost systems, and SB0121, circulating exclusively in cattle.
July 6, 2017: Genome Announcements
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