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Bovine Tuberculosis

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https://www.readbyqxmd.com/read/29163649/immunopathological-evaluation-of-recombinant-mycobacterial-antigen-hsp65-expressed-in-lactococcus-lactis-as-a-novel-vaccine-candidate
#1
J C Herrera Ramírez, A Ch De la Mora, A De la Mora Valle, G Lopez-Valencia, R M B Hurtado, T B Rentería Evangelista, J L Rodríguez Castillo, A Rodríguez Gardea, S D Gómez Gómez, G E Medina-Basulto
Bovine tuberculosis (TBB) is a zoonotic disease distributed worldwide and is of great importance for public health and the livestock industry. Several experimental vaccines against this disease have been evaluated in recent years, yielding varying results. An example is the Bacillus Calmette-Guérin (BCG) vaccine, which has been used extensively in humans and tested in cattle showing mixed results related to protection (0-80%) against Mycobacterium bovis. In this study, we used the food-grade bacterium Lactococcus lactis as an expression system for production of mycobacterial protein Hsp65...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/29157368/livestock-as-sentinels-for-an-infectious-disease-in-a-sympatric-or-adjacent-living-wildlife-reservoir-host
#2
D P Anderson, A M Gormley, M Bosson, P G Livingstone, G Nugent
A central question to address in managing wildlife diseases is how much effort and resources are required to reduce infection prevalence to below a requisite threshold? This requires surveillance for infection in at least one species involved in the infection cycle, a process that is often expensive and time-consuming but one which could be enhanced using additional sources of readily-obtainable surveillance data. We demonstrate how surveillance data from ruminant livestock monitored for bovine tuberculosis (bTB) in New Zealand can be employed in spatially-explicit modelling to help predict the probability of freedom from Mycobacterium bovis infection in a sympatric wildlife reservoir species, the brushtail possum (Trichosurus vulpecula)...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29155877/immune-response-profiles-of-calves-following-vaccination-with-live-bcg-and-inactivated-mycobacterium-bovis-vaccine-candidates
#3
E M D L van der Heijden, J Chileshe, J C M Vernooij, C Gortazar, R A Juste, I Sevilla, J E Crafford, V P M G Rutten, A L Michel
Conventional control and eradication strategies for bovine tuberculosis (BTB) face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations...
2017: PloS One
https://www.readbyqxmd.com/read/29152194/seasonal-variation-in-daily-patterns-of-social-contacts-in-the-european-badger-meles-meles
#4
Matthew J Silk, Nicola Weber, Lucy C Steward, Richard J Delahay, Darren P Croft, David J Hodgson, Mike Boots, Robbie A McDonald
Social interactions among hosts influence the persistence and spread of infectious pathogens. Daily and seasonal variation in the frequency and type of social interactions will play an important role in disease epidemiology and, alongside other factors, may have an influence on wider disease dynamics by causing seasonal forcing of infection, especially if the seasonal variation experienced by a population is considerable. We explored temporal variation in within-group contacts in a high-density population of European badgers Meles meles naturally infected with Mycobacterium bovis (the causative agent of bovine tuberculosis)...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29145844/development-and-evaluation-of-an-interferon-gamma-assay-for-the-diagnosis-of-tuberculosis-in-red-deer-experimentally-infected-with-mycobacterium-bovis
#5
María Ángeles Risalde, Jobin Thomas, Iker Sevilla, Miriam Serrano, Jose Antonio Ortíz, Joseba Garrido, Mercedes Domínguez, Lucas Domínguez, Christian Gortázar, Jose Francisco Ruíz-Fons
BACKGROUND: Red deer (Cervus elaphus) is regarded as an epidemiologically relevant host for Mycobacterium bovis (M. bovis) and closely related members of the Mycobacterium tuberculosis complex that cause animal tuberculosis (TB). The standard antemortem screening test for the detection of TB in deer is the intradermal tuberculin skin test, but the detection of interferon-gamma (IFNγ) produced by white blood cells exposed to M. bovis antigens can be used as an alternative or supplemental assay in most TB eradication/control programs...
November 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29142508/proteomic-characterisation-of-bovine-and-avian-purified-protein-derivatives-and-identification-of-specific-antigens-for-serodiagnosis-of-bovine-tuberculosis
#6
José Antonio Infantes-Lorenzo, Inmaculada Moreno, María de Los Ángeles Risalde, Álvaro Roy, Margarita Villar, Beatriz Romero, Nieves Ibarrola, José de la Fuente, Eugenia Puentes, Lucía de Juan, Christian Gortázar, Javier Bezos, Lucas Domínguez, Mercedes Domínguez
Background: Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative characteristics, which makes their standardisation difficult. In addition, bPPD can give false-positive tuberculosis results because of sequence homology between Mycobacterium bovis (M. bovis) and M. avium proteins. Thus, the objective of this study was to carry out a proteomic characterisation of bPPD, aPPD and an immunopurified subcomplex from bPPD called P22 in order to identify proteins contributing to cross-reactivity among these three products in tuberculosis diagnosis...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/29116633/mycobacterium-tuberculosis-complex-members-adapted-to-wild-and-domestic-animals
#7
Kerri M Malone, Stephen V Gordon
The Mycobacterium tuberculosis complex (MTBC) is composed of several highly genetically related species that can be broadly classified into those that are human-host adapted and those that possess the ability to propagate and transmit in a variety of wild and domesticated animals. Since the initial description of the bovine tubercle bacillus, now known as Mycobacterium bovis, by Theobald Smith in the late 1800's, isolates originating from a wide range of animal hosts have been identified and characterized as M...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29116026/the-c3heb-fej-mouse-model-recapitulates-the-hallmark-of-bovine-tuberculosis-lung-lesions-following-mycobacterium-bovis-aerogenous-infection
#8
Mélodie Bouté, Florence Carreras, Christelle Rossignol, Emilie Doz, Nathalie Winter, Mathieu Epardaud
Achieving the control of bovine tuberculosis (bTB) would require the discovery of an efficient combined immunodiagnostic and vaccine strategy. Since in vivo experiments on cattle are not ethically and economically acceptable there is a need for a cost-effective animal model capable of reproducing, as closely as possible, the physiopathology of bTB to (i) better characterize the cellular and molecular features of bTB immunopathogenesis and (ii) screen preclinical vaccine candidates. To develop such a model, we focused on the C3HeB/FeJ Kramnik's mouse forming hypoxic, encapsulated granulomas with a caseous necrotic center following Mycobacterium tuberculosis infection...
November 7, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29110869/prevalence-of-zoonotic-tuberculosis-and-associated-risk-factors-in-central-indian-populations
#9
Prachi R Bapat, Renuka S Dodkey, Seema D Shekhawat, Aliabbas A Husain, Amit R Nayak, Anuja P Kawle, Hatim F Daginawala, Lokendra K Singh, Rajpal S Kashyap
In the present study, we aimed to estimate the occurrence of bovine tuberculosis (TB) and examine the determinants of distribution of the disease in three high-risk populations of Central India. A prospective cohort study was conducted in Central India between March 2014 and June 2015. Based on the requisite inclusion criteria, we recruited a total of 301 participants whose blood samples were subjected to polymerase chain reaction-based detection and differentiation of Mycobacterium bovis and Mycobacterium tuberculosis...
December 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29109952/is-tb-testing-associated-with-increased-blood-interferon-gamma-levels
#10
Aideen E Kennedy, Jim O'Mahony, Noel Byrne, John MacSharry, Riona G Sayers
The Republic of Ireland reports a relatively low prevalence of Johne's disease (JD) compared to international counterparts. Postulated reasons for this include a lower average herd size and a grass-based production system. Ireland also engages in high levels of bovine tuberculosis (bTB) testing. As interferon-gamma (IFN-γ) is believed to play a key role in protecting against JD, it is our hypothesis that administration of purified protein derivative (PPD), as part of the bTB test, is associated with a systemic increase in IFN-γ production, which may potentially limit clinical progression of the disease...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29103398/bovine-tuberculosis-in-northern-ireland-quantification-of-the-population-disease-level-effect-from-cattle-leaving-herds-detected-as-a-source-of-infection
#11
L P Doyle, E A Courcier, A W Gordon, M J H O'Hagan, J A Stegeman, F D Menzies
Determination of the proportion of bovine tuberculosis (bTB) breakdowns attributed to a herd purchasing infected animals has not been previously quantified using data from the Animal and Public Health Information System (APHIS) database in Northern Ireland. We used a case-control study design to account for the infection process occurring in the disclosing bTB breakdown herds. Cases (N = 6926) were cattle moving to a future confirmed bTB breakdown where they would disclose as a confirmed bTB reactor or a Lesion at Routine Slaughter (LRS)...
November 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29094040/preliminary-results-indicate-that-inactivated-vaccine-against-paratuberculosis-could-modify-the-course-of-experimental-mycobacterium-bovis-infection-in-calves
#12
Miriam Serrano, Natalia Elguezabal, Iker A Sevilla, María V Geijo, Elena Molina, Ramón A Juste, Joseba M Garrido
Although paratuberculosis (PTB) vaccination has been recognized as an effective tool to control the disease, its use has been limited in countries undergoing bovine tuberculosis (bTB) eradication programs because of its interference with the diagnostic techniques. Due to this restraint, little is known about the effect of vaccinating against PTB on the progression of bTB infection. To assess this topic, an experimental infection was carried out including the following three groups of five calves each: non-vaccinated infected with Mycobacterium bovis (NVI), vaccinated against PTB infected with M...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29076653/tuberculosis-in-southern-brazilian-wild-boars-sus-scrofa-first-epidemiological-findings
#13
A L G Maciel, M R Loiko, T S Bueno, J G Moreira, M Coppola, E R Dalla Costa, K B Schmid, R O Rodrigues, S P Cibulski, A C Bertagnolli, F Q Mayer
Bovine tuberculosis (bTB) is a zoonosis caused mainly by Mycobacterium bovis that affects domestic and wild animals. In Brazil, there are no epidemiological studies on tuberculosis in wild animal populations and their possible role in the disease maintenance in cattle herds; thus, the aim of this study was to evaluate the occurrence of tuberculosis in wild boars in Rio Grande do Sul, southern Brazil. Tissue samples of animals hunted under government consent were submitted to histopathology and M. bovis polymerase chain reaction (PCR) as screening tests; the positive samples were subsequently submitted to bacterial isolation, the gold standard diagnosis...
October 27, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29022287/correction-to-occurrence-and-distribution-of-bovine-tb-pathology-by-age-sex-and-breed-of-cattle-slaughtered-in-gusau-abattoir-zamfara-state-nigeria
#14
Ibrahim Ahmad, Caleb Ayuba Kudi, Alhaji Idris Abdulkadir, S N A Saidu
Unfortunately the Abstract was missing in the original version of this article. The Abstract is published below. Abstract. This study was aimed to record gross lesions suggestive of bovine tuberculosis amongst cattle slaughtered in Gusau abattoir Zamfara State, Nigeria.
October 11, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29021983/an-integrated-framework-for-process-driven-model-construction-in-disease-ecology-and-animal-health
#15
REVIEW
Rebecca Mancy, Patrick M Brock, Rowland R Kao
Process models that focus on explicitly representing biological mechanisms are increasingly important in disease ecology and animal health research. However, the large number of process modelling approaches makes it difficult to decide which is most appropriate for a given disease system and research question. Here, we discuss different motivations for using process models and present an integrated conceptual analysis that can be used to guide the construction of infectious disease process models and comparisons between them...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29017616/quantitative-interferon-gamma-responses-predict-future-disease-progression-in-badgers-naturally-infected-with-mycobacterium-bovis
#16
S N Buzdugan, M A Chambers, R J Delahay, J A Drewe
The diagnosis and control of Mycobacterium bovis infection (bovine tuberculosis: TB) continues to present huge challenges to the British cattle industry. A clearer understanding of the magnitude and duration of immune response to M. bovis infection in the European badger (Meles meles) - a wildlife maintenance host - may assist with the future development of diagnostic tests, and vaccination and disease management strategies. Here, we analyse 5280 diagnostic test results from 550 live wild badgers from a naturally-infected population to investigate whether one diagnostic test (a gamma interferon release [IFNγ] assay, n = 550 tests) could be used to predict future positive results on two other tests for the same disease (a serological test [n = 2342 tests] and mycobacterial culture [n = 2388 tests]) and hence act as an indicator of likely bacterial excretion or disease progression...
October 11, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28978510/identification-of-novel-antigens-recognized-by-serum-antibodies-in-bovine-tuberculosis
#17
Konstantin P Lyashchenko, Adrian Grandison, Karen Keskinen, Alina Sikar-Gang, Paul Lambotte, Javan Esfandiari, Gregory C Ireton, Aarthy Vallur, Steven G Reed, Gareth Jones, H Martin Vordermeier, Judy R Stabel, Tyler C Thacker, Mitchell V Palmer, W Ray Waters
Bovine tuberculosis (TB) caused by Mycobacterium bovis remains an important zoonotic disease posing a serious threat to livestock and wildlife. The current TB tests relying on cell-mediated and humoral immune responses in cattle have performance limitations. To identify new serodiagnostic markers of bovine TB, we screened a panel of 101 recombinant proteins, including 10 polyepitope fusions, by multi-antigen print immunoassay (MAPIA) with well-characterized serum samples serially collected from cattle with experimental or naturally acquired M...
October 4, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28973018/the-importance-of-communication-in-promoting-voluntary-participation-in-an-experimental-trial-a-qualitative-study-based-on-the-assessment-of-the-gamma-interferon-test-for-the-diagnosis-of-bovine-tuberculosis-in-france
#18
Clémence Boireau, Barbara Dufour, Anne Praud
Understanding the factors leading each stakeholder to participate in an experimental trial is a key element for improving trial set-up and for identifying selection bias in statistical analyses. An experimental protocol, validated by the European Commission, was developed in France to assess the ability of the gamma-interferon test in terms of accuracy to replace the second intradermal skin test in cases of suspected bovine tuberculosis. Implemented between 2013 and 2015, this experimental trial was based on voluntary participation...
2017: PloS One
https://www.readbyqxmd.com/read/28944450/dynamic-spatial-models-of-parasite-transmission-in-wildlife-their-structure-applications-and-remaining-challenges
#19
REVIEW
Lauren A White, James D Forester, Meggan E Craft
Individual differences in contact rate can arise from host, group and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livestock and humans. While dynamic disease models can provide a better understanding of the drivers of spatial spread, the effects of landscape heterogeneity have only been modelled in a few well-studied wildlife systems such as rabies and bovine tuberculosis...
September 25, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28944012/assessing-the-effects-of-the-first-2%C3%A2-years-of-industry-led-badger-culling-in-england-on-the-incidence-of-bovine-tuberculosis-in-cattle-in-2013-2015
#20
Lucy A Brunton, Christl A Donnelly, Heather O'Connor, Alison Prosser, Stuart Ashfield, Adam Ashton, Paul Upton, Andrew Mitchell, Anthony V Goodchild, Jessica E Parry, Sara H Downs
Culling badgers to control the transmission of bovine tuberculosis (TB) between this wildlife reservoir and cattle has been widely debated. Industry-led culling began in Somerset and Gloucestershire between August and November 2013 to reduce local badger populations. Industry-led culling is not designed to be a randomized and controlled trial of the impact of culling on cattle incidence. Nevertheless, it is important to monitor the effects of the culling and, taking the study limitations into account, perform a cautious evaluation of the impacts...
September 2017: Ecology and Evolution
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