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Daniel B Kopans
Unfortunately, a great deal of misinformation has accumulated in the breast cancer screening literature that is based on flawed analyses in an effort to reduce access to screening. Quite remarkably, much of this has come from publications in previously highly respected medical journals. In several papers the intervention (mammography screening) is faulted yet the analyses provided no data on who participated in mammography screening, and which cancers were detected by mammography screening. It is remarkable that a highly respected journal can fault an intervention with no data on the intervention...
February 2017: Gland Surgery
Manas Joglekar, Hector Garcia-Molina, Aditya Parameswaran
We present smart drill-down, an operator for interactively exploring a relational table to discover and summarize "interesting" groups of tuples. Each group of tuples is described by a rule. For instance, the rule (a, b, ⋆, 1000) tells us that there are a thousand tuples with value a in the first column and b in the second column (and any value in the third column). Smart drill-down presents an analyst with a list of rules that together describe interesting aspects of the table. The analyst can tailor the definition of interesting, and can interactively apply smart drill-down on an existing rule to explore that part of the table...
May 2016: Proceedings
Steve W J Kozlowski, Gilad Chen, Eduardo Salas
To launch this Special Issue of the Journal of Applied Psychology celebrating the 1st century of the journal we conducted a review encompassing the background of the founding of the journal; a quantitative assessment of its evolution across the century; and an examination of trends examining article type, article length, authorship patterns, supplemental materials, and research support. The journal was founded in March of 1917 with hopeful optimism about the potential of psychology being applied to practical problems could enhance human happiness, well-being, and effectiveness...
February 16, 2017: Journal of Applied Psychology
Attia Attia, Abdelrahman Ibrahim Abushouk, Hussien Ahmed, Mohamed Gadelkarim, Ahmed Elgebaly, Zeinab Hassan, Mohamed M Abdel-Daim, Ahmed Negida
BACKGROUND: Psoriasis is an inflammatory skin disease that affects 2-3% of the worldwide population. The interleukin-17 cytokine family has been proven to play a central role in the pathogenesis of psoriasis. Brodalumab is a novel biologic agent that targets interleukin-17 molecules and their receptors. We aimed to evaluate the safety and efficacy of brodalumab as a therapeutic agent for moderate-to-severe psoriasis in a meta-analysis framework. METHODS: A computer literature search of PubMed, OVID, Cochrane Central, EMBASE, EBSCO, Scopus, and Web of Science was conducted using relevant keywords...
February 14, 2017: Clinical Drug Investigation
João Ribeiro, Pedro Silva, Ricardo Duarte, Keith Davids, Júlio Garganta
This paper discusses how social network analyses and graph theory can be implemented in team sports performance analyses to evaluate individual (micro) and collective (macro) performance data, and how to use this information for designing practice tasks. Moreover, we briefly outline possible limitations of social network studies and provide suggestions for future research. Instead of cataloguing discrete events or player actions, it has been argued that researchers need to consider the synergistic interpersonal processes emerging between teammates in competitive performance environments...
February 15, 2017: Sports Medicine
Kirnvir K Dhaliwal, Kathryn King-Shier, Braden J Manns, Brenda R Hemmelgarn, James A Stone, David J T Campbell
BACKGROUND: Patients with coronary artery disease experience various barriers which impact their ability to optimally manage their condition. Financial barriers may result in cost related non-adherence to medical therapies and recommendations, impacting patient health outcomes. Patient experiences regarding financial barriers remain poorly understood. Therefore, we used qualitative methods to explore the experience of financial barriers to care among patients with heart disease. METHODS: We conducted a qualitative descriptive study of participants in Alberta, Canada with heart disease (n = 13) who perceived financial barriers to care...
February 14, 2017: BMC Cardiovascular Disorders
Ryan P Borman, Ying Wang, Michael D Nguyen, Mallikarjunarao Ganesana, Scott T Lee, B Jill Venton
Spontaneous adenosine release events have been discovered in the brain that last only a few seconds. The identification of these adenosine events from fast-scan cyclic voltammetry (FSCV) data is difficult due to the random nature of adenosine release. In this study, we develop an algorithm that automatically identifies and characterizes adenosine transient features, including event time, concentration, and duration. Automating the data analysis reduces analysis time from 10 to 18 h to about 40 min per experiment...
February 15, 2017: ACS Chemical Neuroscience
Ann Marie Dale, Lisa Jaegers, Laura Welch, Ellen Barnidge, Nancy Weaver, Bradley A Evanoff
BACKGROUND: Rates of musculoskeletal disorders in construction remain high. Few studies have described barriers and facilitators to the use of available ergonomic solutions. This paper describes these barriers and facilitators and their relationship to the level of adoption. METHODS: Three analysts rated 16 proposed ergonomic solutions from a participatory ergonomics study and assessed the level of adoption, six adoption characteristics, and identified the category of adoption from a theoretical model...
March 2017: American Journal of Industrial Medicine
Lihui Wei, Lixin Qiao, Guangchang Pang, Junbo Xie
At present, developing an efficient assay method for truly reflecting the real feelings of gustatory tissues is of great importance. In this study, a novel biosensor was fabricated to investigate the kinetic characteristics of the receptors in taste bud tissues sensing bitter substances for the first time. Porcine taste bud tissues were used as the sensing elements, and the sandwich-type sensing membrane was fixed onto a glassy carbon electrode for assembling the biosensor. With the developed sensor, the response currents induced by sucrose octaacetate, denatonium benzoate, and quercetin stimulating corresponding receptors were determined...
February 2, 2017: Biosensors & Bioelectronics
Craig Anderson, Louise M Ryan
The field of spatio-temporal modelling has witnessed a recent surge as a result of developments in computational power and increased data collection. These developments allow analysts to model the evolution of health outcomes in both space and time simultaneously. This paper models the trends in ischaemic heart disease (IHD) in New South Wales, Australia over an eight-year period between 2006 and 2013. A number of spatio-temporal models are considered, and we propose a novel method for determining the goodness-of-fit for these models by outlining a spatio-temporal extension of the Moran's I statistic...
February 3, 2017: International Journal of Environmental Research and Public Health
Margaret Hart, Jennifer O'Donnell, Sophie Foxcroft, Eric Gutierrez, Lindsay Elizabeth Reddeman, Gunita Mitera, Padraig Richard Warde
: 238 Background: Peer review (PR) in radiation oncology (RO) has been endorsed as an indicator of treatment quality in North America and internationally. The direct benefits of PR include quality assurance (QA) on individual treatment plans. The indirect benefits for radiation oncology departments or programs (ROPs) have been postulated but not systematically evaluated. We used a rigorous and comprehensive qualitative approach to explore the indirect benefits of PR across a jurisdiction of cancer care, and to identify factors that facilitate PR, barriers to implementation, and strategies for expansion of PR across centers...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Rosita Zakaria, Katrina J Allen, Jennifer J Koplin, Peter Roche, Ronda F Greaves
INTRODUCTION: Through the introduction of advanced analytical techniques and improved throughput, the scope of dried blood spot testing utilising mass spectrometric methods, has broadly expanded. Clinicians and researchers have become very enthusiastic about the potential applications of dried blood spot based mass spectrometric applications. Analysts on the other hand face challenges of sensitivity, reproducibility and overall accuracy of dried blood spot quantification. In this review, we aim to bring together these two facets to discuss the advantages and current challenges of non-newborn screening applications of dried blood spot quantification by mass spectrometry...
December 2016: EJIFCC
Etienne Ruppé, Flaminia Olearo, Daniela Pires, Damien Baud, Gesuele Renzi, Abdessalam Cherkaoui, Daniel Goldenberger, Angela Huttner, Patrice François, Stephan Harbarth, Jacques Schrenzel
OBJECTIVES: Whole-genome sequencing (WGS) is a promising tool for identifying transmission pathways in outbreaks caused by multidrug-resistant bacteria. However, it is uncertain how the data produced by WGS can be best integrated into epidemiological investigations. METHODS: We tested various genomic analyses to identify clonal groups in two distinct outbreaks of KPC-producing Klebsiella pneumoniae that occurred in Switzerland in 2013 and 2015. In blinded fashion, we sequenced 12 strains involved in the 2 outbreaks, respectively, and six that were epidemiologically unrelated...
January 28, 2017: Clinical Microbiology and Infection
Vadivoo Selvaraj, Kangusamy Boopathi, Ramesh Paranjape, Sanjay Mehendale
BACKGROUND AND OBJECTIVES: Respondent-driven sampling (RDS) is widely used to sample hidden populations and RDS data are analyzed using specially designed RDS analysis tool (RDSAT). RDSAT estimates parameters such as proportions. Analysis with RDSAT requires separate weight assignment for individual variables even in a single individual; hence, regression analysis is a problem. RDS-analyst is another advanced software that can perform three methods of estimates, namely, successive sampling method, RDS I and RDS II...
September 2016: Indian Journal of Medical Research
Jessie K Edwards, Alexander P Keil
PURPOSE OF REVIEW: Measurement error threatens public health by producing bias in estimates of the population impact of environmental exposures. Quantitative methods to account for measurement bias can improve public health decision making. RECENT FINDINGS: We summarize traditional and emerging methods to improve inference under a standard perspective, in which the investigator estimates an exposure-response function, and a policy perspective, in which the investigator directly estimates population impact of a proposed intervention...
January 30, 2017: Current Environmental Health Reports
Brigitte Desharnais, Félix Camirand-Lemyre, Pascal Mireault, Cameron D Skinner
Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control (QC) accuracy, with an error up to 154%. Unfortunately, simple tools to perform this selection and tests to validate the resulting model are lacking. We present a stepwise, analyst-independent scheme for selection and validation of calibration models...
January 30, 2017: Journal of Analytical Toxicology
Howard B Levine
No abstract text is available yet for this article.
January 27, 2017: International Journal of Psycho-analysis
David C Magri
Correction for 'Photoinduced electron transfer as a design concept for luminescent redox indicators' by David C. Magri, Analyst, 2015, 140, 7487-7495.
January 27, 2017: Analyst
Rebecca S Just, Lilliana I Moreno, Jill B Smerick, Jodi A Irwin
Though the utility of next-generation sequencing (NGS) technologies for forensic short tandem repeat (STR) typing has been evident for several years, commercially available assays and software solutions developed specifically to meet forensic needs have only recently become available. One of these, the ForenSeq™ DNA Signature Prep Kit (Illumina, Inc.) sequences 27 autosomal STR (aSTR) and 24 Y chromosome STR (Y-STR) loci (concurrent with additional nuclear markers) per multiplexed sample, with automated secondary and tertiary analyses of the data accomplished via the associated ForenSeq™ Universal Analysis Software (UAS)...
January 9, 2017: Forensic Science International. Genetics
Kun Lv, Jian Chen, Hong Wang, Peisheng Zhang, Maolin Yu, Yunfei Long, Pinggui Yi
The design of effective tools for detecting copper ion (Cu(2+)) and sulfide anion (S(2-)) is of great importance due to the abnormal level of Cu(2+) and S(2-) has been associated with an increase in risk of many diseases. Herein, we report on the fabrication of fluorescence resonance energy transfer (FRET) based fluorescent probe PF (PEI-FITC) for detecting Cu(2+) and S(2-) in 100% aqueous media via a facile one-pot method by covalent linking fluorescein isothiocyanate (FITC) with branched-polyethylenimine (b-PEI)...
January 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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