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https://www.readbyqxmd.com/read/28103644/flow-cytometric-osmotic-fragility-test-increased-assay-sensitivity-for-clinical-application-in-pediatric-hematology
#1
Olga Ciepiela, Anna Adamowicz-Salach, Agata Zgodzińska, Magdalena Łazowska, Iwona Kotuła
BACKGROUND: Osmotic Fragility Test (OFT) is widely considered as a sensitive indicator of red blood cells' sensitivity to the hypotonic solution. It is often used as a screening test for the diagnosis of hereditary spherocytosis (HS). Nowadays, the osmotic fragility test based on flow cytometric analysis (FCM OF) is widely used in laboratory practice. The purpose of this study was to optimize the assay sensitivity and to validate its clinical application in the diagnostic screening of childhood anemias...
January 19, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#2
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28103577/association-of-rab5-overexpression-in-pancreatic-cancer-with-cancer-progression-and-poor-prognosis-via-e-cadherin-suppression
#3
Takamichi Igarashi, Kenichiro Araki, Takehiko Yokobori, Bolag Altan, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Akira Watanabe, Norio Kubo, Tadashi Handa, Yasuo Hosouchi, Masahiko Nishiyama, Tetsunari Oyama, Ken Shirabe, Hiroyuki Kuwano
Pancreatic cancer is a common type of cancer with poor prognosis worldwide. Postoperative survival depends on the existence of metastasis. Elucidation of the mechanism underlying cancer progression is important to improve prognosis. The RAS-associated protein RAB5 activates intracellular membrane trafficking, and RAB5 expression is correlated to progression and epithelial mesenchymal transition in various cancers.The expression of RAB5 and E-cadherin in 111 pancreatic cancer samples was investigated by immunohistochemical staining, and the relationship among RAB5 expression, clinicopathological factors, and E-cadherin expression was assessed...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103572/low-rate-of-positive-margins-and-re-excision-after-partial-mastectomy-in-highly-selected-breast-cancer-patients-a-chinese-single-institution-experience
#4
Siyu Wu, Yanyan Zhu, Zhaozhi Yang, Miao Mo, Hongbo Gao, Wentao Yang, Guangyu Liu
A recent randomized controlled trial firstly demonstrated that cavity shaving significantly decreased the rate of positive margins and re-excision among partial mastectomy (PM) patients. However, it remains unknown whether cavity shaving should be routinely applied to Chinese breast cancer patients undergoing PM. A total of 408 PM patients undergoing 410 PMs among 1796 surgically treated breast cancer patients at Fudan University Shanghai Cancer Centre from January 2015 to June 2015 were included in our study...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103569/an-intelligent-actuator-fault-reconstruction-scheme-for-robotic-manipulators
#5
Bing Xiao, Shen Yin
This paper investigates a difficult problem of reconstructing actuator faults for robotic manipulators. An intelligent approach with fast reconstruction property is developed. This is achieved by using observer technique. This scheme is capable of precisely reconstructing the actual actuator fault. It is shown by Lyapunov stability analysis that the reconstruction error can converge to zero after finite time. A perfect reconstruction performance including precise and fast properties can be provided for actuator fault...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103567/predictive-control-of-networked-multiagent-systems-via-cloud-computing
#6
Guo-Ping Liu
This paper studies the design and analysis of networked multiagent predictive control systems via cloud computing. A cloud predictive control scheme for networked multiagent systems (NMASs) is proposed to achieve consensus and stability simultaneously and to compensate for network delays actively. The design of the cloud predictive controller for NMASs is detailed. The analysis of the cloud predictive control scheme gives the necessary and sufficient conditions of stability and consensus of closed-loop networked multiagent control systems...
January 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103545/a-multimodal-speech-capture-system-for-speech-rehabilitation-and-learning
#7
Nordine Sebkhi, Dhyey Desai, Mohammad Islam, Jun Lu, Kimberly Wilson, Maysam Ghovanloo
Speech-language pathologists (SLPs) are trained to correct articulation of people diagnosed with motor speech disorders by analyzing articulators' motion and assessing speech outcome while patients speak. To assist SLPs in this task, we are presenting the Multimodal Speech Capture System (MSCS) that records and displays kinematics of key speech articulators, the tongue and lips, along with voice, using unobtrusive methods. Collected speech modalities, tongue motion, lips gestures, and voice, are visualized not only in real-time to provide patients with instant feedback but also offline to allow SLPs to perform post-analysis of articulators' motion, particularly the tongue, with its prominent but hardly visible role in articulation...
January 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28103518/adsorption-of-quinolone-tetracycline-and-penicillin-antibiotics-from-aqueous-solution-using-activated-carbons-review
#8
REVIEW
Muthanna J Ahmed
Antibiotics, an important type of pharmaceutical pollutant, have attracted many researchers to the study of their removal from aqueous solutions. Activated carbon (AC) has been widely used as highly effective adsorbent for antibiotics because of its large specific surface area, high porosity, and favorable pore size distribution. In this article, the adsorption performance of AC towards three major types of antibiotics such as tetracyclines, quinolones, and penicillins were reviewed. According to collected data, maximum adsorption capacities of 1340...
January 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28103487/a-turn-on-thiol-functionalized-fluorescent-carbon-quantum-dot-based-chemosensory-system-for-arsenite-detection
#9
Pooja D, Sonia Saini, Anupma Thakur, Baban Kumar, Sachin Tyagi, Manoj K Nayak
Carbon quantum dots (CQDs) have emerged out as promising fluorescent probes for hazardous heavy metals detection in recent past. In this study, water soluble CQDs were synthesized by facile microwave pyrolysis of citric acid & cysteamine, and functionalized with ditheritheritol to impart thiol functionalities at surface for selective detection of toxic arsenite in water. Microscopic analysis reveals that the synthesized CQDs are of uniform size (diameter ∼5nm) and confirmed to have surface SH groups by FT-IR...
January 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28103483/dynamic-interaction-between-reinforcement-learning-and-attention-in-multidimensional-environments
#10
Yuan Chang Leong, Angela Radulescu, Reka Daniel, Vivian DeWoskin, Yael Niv
Little is known about the relationship between attention and learning during decision making. Using eye tracking and multivariate pattern analysis of fMRI data, we measured participants' dimensional attention as they performed a trial-and-error learning task in which only one of three stimulus dimensions was relevant for reward at any given time. Analysis of participants' choices revealed that attention biased both value computation during choice and value update during learning. Value signals in the ventromedial prefrontal cortex and prediction errors in the striatum were similarly biased by attention...
January 18, 2017: Neuron
https://www.readbyqxmd.com/read/28103454/phenotypic-heterogeneity-by-germline-mismatch-repair-gene-defect-in-lynch-syndrome-patients
#11
Jorge Hernâni-Eusébio, Elisabete Barbosa
INTRODUCTION: Lynch syndrome is the most common form of hereditary colorectal cancer, being also responsible for endometrial and other types of cancers. It is associated with germline mutations in DNA mismatch repair genes and microsatellite instability. MLH1 and MSH2 mutations have a "classical" Lynch syndrome phenotype, with MSH2 having a higher association with extracolonic cancer. MSH6 and PMS2 mutations have an atypical phenotype. Clinical expression is heterogeneous, with correlation between mismatch repair mutated gene and phenotypic patterns...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103453/-analysis-of-the-cochrane-review-chromoscopy-versus-conventional-endoscopy-for-the-detection-of-polyps-in-the-colon-and-rectum-cochrane-database-syst-rev-2016-4-cd006439
#12
Diogo Libânio, Luís Filipe Azevedo
Although colonoscopy is considered the most accurate test for the investigation of colorectal polyps, lesions ≤ 10 mm may be missed in approximately 10%. Chromoscopy may increase the detection of colorectal polyps. A systematic review and meta-analysis was performed to investigate the benefit of cromoscopy in colorectal polyps detection. Seven randomized controlled trials were included (incuding 2,727 participants) comparing polyp detection (both neoplastic and non- neoplastic polyps) in patients submitted to conventional colonoscopy or colonoscopy with chromoscopy...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103443/effects-of-childhood-asthma-on-the-development-of-obesity-among-school-aged-children
#13
Zhanghua Chen, Muhammad T Salam, Tanya L Alderete, Rima Habre, Theresa M Bastain, Kiros Berhane, Frank D Gilliland
RATIONALE: Asthma and obesity often occur together in children. It is unknown whether asthma contributes to the childhood obesity epidemic. OBJECTIVES: We aimed to investigate the effects of asthma and asthma medication use on the development of childhood obesity. METHODS: The primary analysis was conducted among 2,171 non-obese children who were 5-8 years of age at study enrollment in the Southern California Children's Health Study (CHS) and were followed for up to 10 years...
January 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28103398/cognitive-behavioral-and-psycho-social-factors-associated-with-successful-and-maintained-quit-smoking-status-among-patients-who-received-smoking-cessation-intervention-with-nurses-counseling
#14
Chie Taniguchi, Hideo Tanaka, Hideo Saka, Isao Oze, Kazunobu Tachibana, Yasuhiro Nozaki, Yukio Suzuki, Hisataka Sakakibara
AIM: To identify cognitive, behavioral and psycho-social factors associated with successful and maintained quit smoking status after patients received smoking cessation intervention with nurses' counseling. BACKGROUND: Although nurses' intervention for smoking cessation is effective for patients, few studies have been conducted to identify cognitive, behavioral and psycho-social factors associated with the success of quitting smoking. DESIGN: Prospective cohort study METHODS: In a multi-institutional study between October 2008 - October 2014, we administered the Japanese smoking cessation therapy, which consists of smoking cessation intervention five times with nurses' counseling over 12 weeks...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28103361/the-relationship-between-body-composition-and-renal-resistive-index-in-new-diagnosed-hypertensive-patients
#15
S Karakan, B Inan, A Aktas, H Yavuz
Objective: Obesity is a major modifiable risk factor for atherosclerosis. Thus, early risk markers are needed to identify obese subjects. The objective of this study was to examine the relationship between body composition and arterial stiffness documented by Doppler-derived renal resistive index (RRI). Materials/Subjects and Methods: We enrolled 120 new-diagnosed hypertensive patients (mean age 45±8 years) who were admitted to our nephrology clinic. Body fat percentage (BFP) was measured by bioelectrical impedance (BIA)...
February 18, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/28103325/assessing-fifty-years-of-general-health-surveillance-of-roe-deer-in-switzerland-a-retrospective-analysis-of-necropsy-reports
#16
Mirjam Pewsner, Francesco Carlo Origgi, Joachim Frey, Marie-Pierre Ryser-Degiorgis
General wildlife health surveillance is a valuable source of information on the causes of mortality, disease susceptibility and pathology of the investigated hosts and it is considered to be an essential component of early warning systems. However, the representativeness of data from such surveillance programs is known to be limited by numerous biases. The roe deer (Capreolus capreolus capreolus) is the most abundant ungulate and a major game species all over Europe. Yet, internationally available literature on roe deer pathology is scarce...
2017: PloS One
https://www.readbyqxmd.com/read/28103312/increased-cardiovascular-events-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients-1-year-prospective-single-centre-study
#17
Piero Ruscitti, Paola Cipriani, Francesco Masedu, Silvio Romano, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Di Benedetto, Saverio Alvaro, Maria Penco, Marco Valenti, Roberto Giacomelli
OBJECTIVES: Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the occurrence of new CVEs and the onset of subclinical atherosclerosis. METHODS: We designed a single centre, bias-adjusted, prospective, observational study to investigate, in a homogeneous subset of RA patients, the occurrence of new onset of CVEs and subclinical atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28103310/epidemiological-and-molecular-characterization-of-a-mexican-population-isolate-with-high-prevalence-of-limb-girdle-muscular-dystrophy-type-2a-due-to-a-novel-calpain-3-mutation
#18
Carlos A Pantoja-Melendez, Antonio Miranda-Duarte, Bladimir Roque-Ramirez, Juan C Zenteno
Limb-Girdle Muscular Dystrophy type 2 (LGMD2) is a group of autosomally recessive inherited disorders defined by weakness and wasting of the shoulder and pelvic girdle muscles. In the past, several population isolates with high incidence of LGMD2 arising from founder mutation effects have been identified. The aim of this work is to describe the results of clinical, epidemiologic, and molecular studies performed in a Mexican village segregating numerous cases of LGMD2. A population census was conducted in the village to identify all LGMD affected patients...
2017: PloS One
https://www.readbyqxmd.com/read/28103308/results-after-cementless-medial-oxford-unicompartmental-knee-replacement-incidence-of-radiolucent-lines
#19
Benjamin Panzram, Ines Bertlich, Tobias Reiner, Tilman Walker, Sébastien Hagmann, Marc-André Weber, Tobias Gotterbarm
PURPOSE: Tibial radiolucent lines (RL) are commonly seen in cemented unicompartmental knee replacement (UKR). In the postoperative course, they can be misinterpreted as signs of loosening, thus leading to unnecessary revision. Since 2004, a cementless OUKR is available. First studies and registry data have shown equally good clinical results of cementless OUKR compared to the cemented version and a significantly reduced incidence of RL in cementless implants. METHODS: This single-centre retrospective cohort study includes the first 30 UKR (27 patients) implanted between 2007 and 2009 with a mean follow-up of 5 years...
2017: PloS One
https://www.readbyqxmd.com/read/28103273/association-between-genetic-polymorphisms-in-interleukin-genes-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#20
Meixiang Zhang, Jiawei Xu, Xiao Bao, Wenbin Niu, Linlin Wang, Linqing Du, Nan Zhang, Yingpu Sun
Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0...
2017: PloS One
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