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https://www.readbyqxmd.com/read/27860302/clinical-and-genetic-association-radiological-findings-and-response-to-biological-therapy-in-seven-children-from-qatar-with-non-bacterial-osteomyelitis
#1
Taha Moussa, Venkatraman Bhat, Vishwanatha Kini, Basil M Fathalla
AIM: We aim to report the clinical manifestations, genetic testing results, magnetic resonance imaging (MRI) findings and biologics used in the management of non-bacterial osteomyelitis in our center. METHODS: We conducted a retrospective review of medical records. A previously proposed classification was implemented as follows: chronic recurrent multifocal osteomyelitis (CRMO), chronic non-bacterial osteomyelitis (CNBO) and acute non-bacterial osteomyelitis. RESULTS: Four females and three males with a median age at presentation of 6 years (6 months-14 years) presented with arthralgia (7/7), back pain (4/7), arthritis (4/7) and bone pain (2/7)...
November 9, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27774886/the-clinico-hematological-features-and-management-outcome-in-neonatal-malaria-a-nine-years-analysis-from-north-india
#2
Kriti Mohan
BACKGROUND: Malaria is an important cause of death and illness in children worldwide. Most cases of neonatal malaria are misdiagnosed because of the lack of specific symptoms and a general lack of awareness. Nothing much is known in literature about the haematological changes during malaria infection and outcome of disease in neonates. Neonatal malaria is an underdiagnosed entity. So this hospital based observational study aims to assess diagnostic features of neonatal malaria. METHODS: From August 2004 to August 2013, information of all slide positive for malaria cases aged 0 to 28 days admitted to our pediatric hospital was collected and analysed...
October 20, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27352842/clinico%C3%A2-%C3%A2-laboratory-profile-of-scrub-typhus-an-emerging-rickettsiosis-in-india
#3
Dinesh Kumar Narayanasamy, Arul Kumaran Arunagirinathan, Revathi Krishna Kumar, V D Raghavendran
OBJECTIVE: To study the clinical and laboratory profile of pediatric scrub typhus in rural south India. METHODS: This is a descriptive study of the clinical and laboratory features of 117 children with IgM ELISA proven scrub typhus out of 448 children, who were admitted in the Pediatric ward of a tertiary care hospital, during the study period of November 2014 through March 2015. RESULTS: Fever was present in all 117 children, with mean duration of fever at admission as 9 d...
November 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27273646/the-impact-of-an-intervention-to-improve-malaria-care-in-public-health-centers-on-health-indicators-of-children-in-tororo-uganda-prime-a-cluster-randomized-trial
#4
Sarah G Staedke, Catherine Maiteki-Sebuguzi, Deborah D DiLiberto, Emily L Webb, Levi Mugenyi, Edith Mbabazi, Samuel Gonahasa, Simon P Kigozi, Barbara A Willey, Grant Dorsey, Moses R Kamya, Clare I R Chandler
Optimizing quality of care for malaria and other febrile illnesses is a complex challenge of major public health importance. To evaluate the impact of an intervention aiming to improve malaria case management on the health of community children, a cluster-randomized trial was conducted from 2010-2013 in Tororo, Uganda, where malaria transmission is high. Twenty public health centers were included; 10 were randomized in a 1:1 ratio to intervention or control. Households within 2 km of health centers provided the sampling frame for the evaluation...
August 3, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26758744/combining-long-lasting-insecticidal-nets-and-indoor-residual-spraying-for-malaria-prevention-in-ethiopia-study-protocol-for-a-cluster-randomized-controlled-trial
#5
Wakgari Deressa, Eskindir Loha, Meshesha Balkew, Alemayehu Hailu, Taye Gari, Oljira Kenea, Hans J Overgaard, Teshome Gebremichael, Bjarne Robberstad, Bernt Lindtjørn
BACKGROUND: Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are the main malaria prevention interventions in Ethiopia. There is conflicting evidence that the combined application of both interventions is better than either LLINs or IRS used alone. This trial aims to investigate whether the combination of LLINs (PermaNet 2.0, Vestergaard Frandsen, Lausanne, Switzerland) with IRS using propoxur will enhance the protective benefits and cost-effectiveness of the interventions against malaria and its effect on mosquito behavior, as compared to each intervention alone...
2016: Trials
https://www.readbyqxmd.com/read/26365135/congenital-thrombotic-thrombocytopenic-purpura-upshaw-schulman-syndrome-a-cause-of-neonatal-death-and-review-of-literature
#6
Deepak Sharma, Sweta Shastri, Aakash Pandita, Pradeep Sharma
Thrombotic thrombocytopenic purpura (TTP) is a rare disorder in children characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. The classic Moschcowitz Pentads of TTP include hemolytic anemia, with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decrease renal function and fever. We report a newborn who was diagnosed with congenital TTP. The newborn was admitted at age of 40 h, in our hospital, in view of respiratory distress with impending respiratory failure and red colored urine...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25924279/-tropical-malaria-in-children-in-the-republic-of-tajikistan
#7
N M Khodzhaeva, A M Baranova
The complications of tropical malaria were noted in 25 (9.4%) of 196 pediatric patients followed up. These included cerebral malaria in 8 (3%), severe hemolytic anemia in 15 (5.7%), hemoglobinuric fever in 1 (0.37%), and malarial hepatitis in 1 (0.37%). The occurrence of complications was associated with the late referral of patients to a health care facility and untimely treatment, as well as with preliminary misdiagnoses (acute respiratory viral infection, typhoid-parathyphoid fever, meningitis, acute enteric infection, viral hepatitis, sepsis)...
July 2013: Meditsinskaia Parazitologiia i Parazitarnye Bolezni
https://www.readbyqxmd.com/read/25793475/epidemiological-diagnostic-clinical-and-therapeutic-aspects-of-brucella-bacteremia-in-children-in-southern-israel-a-7-year-retrospective-study-2005-2011
#8
Yariv Fruchtman, Renana Wilkof Segev, Avivit Asher Golan, Yael Dalem, Muhammad Abu Tailakh, Victor Novak, Nehama Peled, Mihai Craiu, Eugene Leibovitz
BACKGROUND: Data on the various aspects of brucellosis in children living in southern Israel are missing. OBJECTIVES: Our aim was to study the epidemiological, microbiological, diagnostic, clinical, therapeutic and outcome features of brucellosis in children <19 years of age in southern Israel during 2005-2011. PATIENTS AND METHODS: The study population included all patients hospitalized with a diagnosis of brucellosis, established according to a clinical presentation compatible with brucellosis+presence of Brucella bacteremia (BB)...
March 2015: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/25346193/intestinal-tuberculosis-in-a-child-living-in-a-country-with-a-low-incidence-of-tuberculosis-a-case-report
#9
Piera Dones, Maria Di Gangi, Maria Concetta Failla, Selene Genova, Caterina Giannitto, Giovanni Corsello, Nicola Principi, Susanna Esposito
BACKGROUND: Relatively common in adults, intestinal tuberculosis is considered rare in children and adolescents. The protean manifestations of intestinal tuberculosis mean that the diagnosis is often delayed (sometimes even for years), thus leading to increased mortality and unnecessary surgery. The main diagnostic dilemma is to differentiate intestinal tuberculosis and Crohn's disease because a misdiagnosis can have dramatic consequences. CASE PRESENTATION: A 13-year-old Caucasian, Italian female adolescent attended the Emergency Department complaining of abdominal pain, a fever of up to 38 °C, night sweats, diarrhea with blood in stool, and a weight loss of about three kilograms over the previous two months...
2014: BMC Research Notes
https://www.readbyqxmd.com/read/25332586/cryosupernatant-and-immunosuppression-as-effective-alternative-therapies-for-ttp-in-three-pediatric-sle-patients
#10
Pragathesh Palaniappan, Arul Premanand Lionel, Indira Agarwal, Sarah Mathai, Leni Mathew, Sanwar Agarwal, Purva Keni, Raju Khubchandani, Sathish Kumar
Thrombotic thrombocytopenic purpura (TTP) and systemic lupus erythematosus (SLE) very rarely present simultaneously and pose a diagnostic and therapeutic dilemma to the physician. Prompt diagnosis and management with plasma exchange and immunosuppression is life-saving. To describe the effectiveness of cryosupernatant and steroids in pediatric SLE with TTP. We describe three children aged 12-14 years with SLE who were diagnosed with TTP based on fever, CNS manifestations, ANA, anti-dsDNA, anti-sm positivity, hypocomplementemia, and microangiopathic anemia with thrombocytopenia...
September 2014: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/25162442/bone-marrow-involvement-is-not-manifest-in-the-early-stages-of-childhood-acute-lymphoblastic-leukaemia
#11
Ninna Brix, Steen Rosthøj
INTRODUCTION: Acute lymphoblastic leukaemia (ALL) in children may have atypical presentations causing diagnostic delay. Guidelines for prompt referral have been published. The utility of the specified criteria is unknown. MATERIAL AND METHODS: Symptoms, signs and laboratory findings at the time of diagnosis were reviewed in a consecutive series of 100 children with ALL in order to determine the frequency of atypical features and to evaluate the Danish referral guideline...
August 2014: Danish Medical Journal
https://www.readbyqxmd.com/read/25161094/fever-in-children-with-sickle-cell-disease-are-all-fevers-equal
#12
Bashar Sami Shihabuddin, Catherine Ann Scarfi
BACKGROUND: Sepsis is the most common cause of mortality in sickle cell disease (SCD). Empiric antibiotic administration after obtaining blood cultures in febrile children with SCD has been a standard practice parameter. OBJECTIVE: Our primary objective was to calculate the rate of bacteremia in febrile pediatric patients with SCD. Our secondary objective was to establish whether vital signs or diagnostics predict bacteremia in these patients. METHODS: We conducted a retrospective chart review of patients with SCD who presented to an urban pediatric emergency department in Newark, NJ between January 1, 2001 and June 30, 2011 with the chief complaint of fever...
October 2014: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25051079/two-case-studies-and-a-review-of-paroxysmal-cold-hemoglobinuria
#13
REVIEW
Stephanie N Slemp, Suzanne M Davisson, Jayanna Slayten, Douglas A Cipkala, Dan A Waxman
Paroxysmal cold hemoglobinuria (PCH) is an acquired hemolytic anemia caused by immunoglobulin G (IgG) antibodies that sensitize red blood cells (RBCs) at cold temperatures by fixing complement to the RBCs causing intravascular hemolysis on rewarming. PCH usually appears in young children as recurrent high fevers, chills, and passage of red-brown urine. The diagnostic test for PCH is the Donath-Landsteiner test, an in vitro assay for biphasic hemolysis. Herein, we present 2 cases of PCH that occurred within 12 months of each other...
2014: Laboratory Medicine
https://www.readbyqxmd.com/read/24712340/symptomatic-malaria-diagnosis-overestimate-malaria-prevalence-but-underestimate-anaemia-burdens-in-children-results-of-a-follow-up-study-in-kenya
#14
Joseph K Choge, Ng'wena G Magak, Willis Akhwale, Julius Koech, Moses M Ngeiywa, Elijah Oyoo-Okoth, Fabian Esamai, Odipo Osano, Christopher Khayeka-Wandabwa, Eliningaya J Kweka
BACKGROUND: The commonly accepted gold standard diagnostic method for detecting malaria is a microscopic reading of Giemsa-stained blood films. However, symptomatic diagnosis remains the basis of therapeutic care for the majority of febrile patients in malaria endemic areas. This study aims to compare the discrepancy in malaria and anaemia burdens between symptomatic diagnosed patients with those diagnosed through the laboratory. METHODS: Data were collected from Western Kenya during a follow-up study of 887 children with suspected cases of malaria visiting the health facilities...
2014: BMC Public Health
https://www.readbyqxmd.com/read/24097641/enteric-fever-a-retrospective-6-year-analysis-of-82-paediatric-cases-in-a-teaching-hospital
#15
T Malla, K K Malla, A Thapalial, C Shaw
Objective: To evaluate the clinical and laboratory properties, to see the response to therapy, incidence of antimicrobial resistance and complications of Enteric Fever in children. Methods: This is a retrospective study of 82 cases of enteric fever admitted in department of pediatrics, Manipal Teaching hospital, Pokhara, Nepal .Study period was six years from (Jan 2000 to Dec 2005). Results: Total of 82 cases of Salmonella infections were admitted .There were 50 (60%) males and 32 (40%) females. Most of the patients were above the age of five...
April 2007: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/23773900/-clinical-and-biological-manifestations-in-primary-parvovirus-b19-infection-in-immunocompetent-adult-a-retrospective-study-of-26-cases
#16
D Parra, Y Mekki, I Durieu, C Broussolle, P Sève
PURPOSE: Parvovirus B19 causes erythema infectiosum in children, transient aplastic anemia in patients with hemoglobinopathies, pur red cell aplasia in immunocompromised persons and hydrops fetalis in pregnancy. The spectrum of clinical and biological manifestations in immunocompetent adult continues to grow up. METHODS: We report on a case series of 26 patients with primary parvovirus B19 infection in immunocompetent adults. This is a retrospective study over the period 2000 to 2010 in two departments of internal medecine...
May 2014: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/23755165/dilemma-in-differentiating-between-acute-osteomyelitis-and-bone-infarction-in-children-with-sickle-cell-disease-the-role-of-ultrasound
#17
Baba P D Inusa, Adeola Oyewo, Felicity Brokke, Gayathriy Santhikumaran, K Haran Jogeesvaran
BACKGROUND: Distinguishing between acute presentations of osteomyelitis (OM) and vaso-occlusive crisis (VOC) bone infarction in children with sickle cell disease (SCD) remains challenging for clinicians, particularly in culture-negative cases. We examined the combined role of ultrasound scan (USS), C - reactive protein and White blood counts (WCC) in aiding early diagnosis in children with SCD presenting acutely with non-specific symptoms such as bone pain, fever or swelling which are common in acute osteomyelitis or VOC...
2013: PloS One
https://www.readbyqxmd.com/read/23165250/rare-extragonadal-teratomas-in-children-complete-tumor-excision-as-a-reliable-and-essential-procedure-for-significant-survival-clinical-experience-and-review-of-the-literature
#18
REVIEW
Guglielmo Paradies, Francesca Zullino, Antonio Orofino, Samuele Leggio
BACKGROUND: Extragonadal teratomas are rare tumors in neonates and infants and can sometimes show unusual, distinctive feature such as an unusual location, a clinical sometimes acute, presentation and a "fetiform" histotype of the lesion. We have extrapolated, from our entire experience of teratomas, 4 unusual cases, mostly operated as emergencies; 2 of them were treated just after birth. Aim of this paper is to report the clinical and pathological findings, to evaluate the surgical approach and the long-term biological behaviour in these cases, in the light of survival and current insights reported in the literature...
January 2014: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/22341665/-study-of-71-cases-of-visceral-leishmaniasis-diagnosed-at-the-mustapha-university-hospital-algiers-from-1998-to-2009
#19
H Zait, Y Ferhani, I Achir, B Hamrioui
OBJECTIVE: The authors retrospectively studied the epidemiological, clinical, diagnostic and therapeutic aspects of 71 cases of visceral leishmaniasis from 1998 to 2009. POPULATION AND METHODS: The diagnosis was made by finding Leishmania amastigotes in bone marrows smears and/or by serology. RESULTS: Most cases occur in winter (35.2%) and in spring (36.6%). The source areas are endemic ones located in the north of Algeria (74.6%) and more rarely arid or semi-arid climate areas (8...
March 2012: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/21865191/point-of-care-measurement-of-blood-lactate-in-children-admitted-with-febrile-illness-to-an-african-district-hospital
#20
George Mtove, Behzad Nadjm, Ilse C E Hendriksen, Ben Amos, Florida Muro, Jim Todd, Hugh Reyburn
BACKGROUND: Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement. We evaluated the use of a point-of-care (POC) diagnostic device for blood lactate measurement to assess the severity of illness in children admitted to a district hospital in Tanzania. METHODS: Children between the ages of 2 months and 13 years with a history of fever were enrolled in the study during a period of 1 year...
September 2011: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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