Songge Xing, Zhaoyong Li, Wenhao Ma, Xiaoping He, Shengqi Shen, Haoran Wei, Shi-Ting Li, Ying Shu, Linchong Sun, Xiuying Zhong, Yuhao Huangfu, Lanhong Su, Junru Feng, Xiaozhang Zhang, Ping Gao, Wei-Dong Jia, Huafeng Zhang
DIS3-like 3'-5' exoribonuclease 2 (DIS3L2) degrades aberrant RNAs, however, its function in tumorigenesis remains largely unexplored. Here, aberrant DIS3L2 expression promoted human hepatocellular carcinoma (HCC) progression via heterogeneous nuclear ribonucleoproteins (hnRNP) U-mediated alternative splicing. DIS3L2 directly interacted with hnRNP U through its cold-shock domains and promoted inclusion of exon 3b during splicing of pre-Rac1 independent of its exonuclease activity, yielding an oncogenic splicing variant, Rac1b, which is known to stimulate cellular transformation and tumorigenesis...
October 1, 2019: Cancer Research