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acute lymphoblastic leukemia testicular

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https://www.readbyqxmd.com/read/27721665/cytopathological-diagnosis-of-an-unusual-cause-of-malignant-hydrocele
#1
Ankur Jain, Alka Khadwal, Gaurav Prakash, Nalini Gupta, Subhash Varma, Pankaj Malhotra
Testicular involvement in a case of acute lymphoblastic leukemia (ALL) is well reported, but occurrence of "isolated" malignant hydrocele is extremely uncommon. We herein report a case of a 22-year-old man who presented to our hematology clinic with fever and easy fatiguability of 2 weeks' duration. Examination revealed pallor, cervical lymphadenopathy, and bilateral scrotal swellings. He was diagnosed as a case of Philadelphia-positive ALL (B-cell type) based on peripheral smear, bone marrow examination, and flow cytometry of the marrow aspirate...
2016: Clinical Medicine Insights. Pathology
https://www.readbyqxmd.com/read/27567613/eq-5d-health-utility-scores-data-from-a-comprehensive-canadian-cancer-centre
#2
Hiten Naik, Doris Howell, Susie Su, Xin Qiu, M Catherine Brown, Ashlee Vennettilli, Margaret Irwin, Vivien Pat, Hannah Solomon, Tian Wang, Henrique Hon, Lawson Eng, Mary Mahler, Henry Thai, Valerie Ho, Wei Xu, Soo Jin Seung, Nicole Mittmann, Geoffrey Liu
BACKGROUND: To improve the precision of health economics analyses in oncology, reference datasets of health utility (HU) scores are needed from cancer survivors across different disease sites. These data are particularly sparse amongst Canadian survivors. METHODS: A survey was completed by 1759 ambulatory cancer survivors at the Princess Margaret Cancer Centre which contained demographic questions and the EuroQol-5D (EQ-5D) instrument. Clinical information was abstracted from electronic records and HU scores were calculated using Canadian health state valuations...
August 27, 2016: Patient
https://www.readbyqxmd.com/read/27547480/alveolar-soft-part-sarcoma-of-urinary-bladder-occurring-as-a-second-primary-malignancy-a-case-report-and-literature-review
#3
Manint Usawachintachit, Piyada Sitthideatphaiboon, Voranuch Thanakit, Sulada Pukiat, Kamol Panumatrassamee, Julin Opanuraks, Apirak Santi-Ngamkun
We report a case of bladder alveolar soft part sarcoma in an 18-year-old Thai male patient who had been treated with testicular radiation and systemic chemotherapy for acute lymphoblastic leukemia with testicular relapse. He presented with recurrent dysuria and gross hematuria. Cystoscopy revealed a 2-centimeter irregular sessile mass at the bladder base adjacent to left ureteral orifice. Transurethral resection of the tumor was performed. The histopathological diagnosis was alveolar soft part sarcoma. Chest and abdominal computed tomography showed no evidence of metastasis...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27408353/aleukemic-leukemia-cutis-presenting-as-a-sole-sign-of-relapsed-paediatric-acute-lymphoblastic-leukemia
#4
Kshitij Joshi, Harsha Panchal, Sonia Parikh, Gaurang Modi, Avinash Talele, Asha Anand, Urmila Uparkar, Nitin Joshi, Itesh Khatawani
The author describes paediatric case of relapsed acute lymphoblastic leukaemia (ALL) presented as aleukemic leukaemia cutis (ALC). A 2 year old child was admitted in tertiary oncology centre. He suffered from pre B cell ALL with absent Philadelphia chromosome. This patient received multiagent induction chemotherapy as per Berlin-Frankfurt-Munster (BFM) protocol for ALL. He achieved remission after 28 days of treatment. Subsequently he presented with multiple skin lesions in the form of multiple small erythematous violaceous macules, papules, plaques and nodules on face, chest and back regions...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27306218/microdissection-testicular-sperm-extraction-in-japanese-patients-with-persistent-azoospermia-after-chemotherapy
#5
Takeshi Shin, Tomohiro Kobayashi, Yukihito Shimomura, Toshiyuki Iwahata, Keisuke Suzuki, Takashi Tanaka, Mai Fukushima, Megumi Kurihara, Akane Miyata, Yoshitomo Kobori, Hiroshi Okada
BACKGROUND: Combinations of surgery, radiation therapy, and chemotherapy can achieve high remission rates in patients with cancer, but these treatments can have damaging effects on spermatogenesis. In particular, cytotoxic chemotherapy may lead to irreversible spermatogenic dysfunction. Microdissection testicular sperm extraction (micro-TESE) is the only method that can address infertility in cancer survivors with persistent postchemotherapy azoospermia. METHODS: We included 66 Japanese patients with postchemotherapy azoospermia who underwent micro-TESE for sperm retrieval in this analysis...
December 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27264050/testicular-prostheses-in-children-is-earlier-better
#6
M Peycelon, G Rossignol, C O Muller, E Carricaburu, P Philippe-Chomette, A Paye-Jaouen, A El Ghoneimi
INTRODUCTION: The absence of a testis occurs for various reasons in children, but testicular prosthesis implantation in children is uncommon. The optimal time for prosthesis placement is still unclear, and its complication rate has been poorly studied in children. OBJECTIVE: The aim of this study was to determine the risk factors of complications in cases of testicular prosthesis implantation in children. STUDY DESIGN: A monocentric, retrospective review was performed of children implanted with a testicular prosthesis between 2008 and 2014...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27171363/sexual-function-in-male-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia
#7
Anu Haavisto, Markus Henriksson, Risto Heikkinen, Leena-Riitta Puukko-Viertomies, Kirsi Jahnukainen
BACKGROUND: Infertility, poor semen quality, and gonadal dysfunction are well recognized long-term sequelae in male survivors of childhood acute lymphoblastic leukemia (ALL). However, few studies have investigated adult sexual functioning in these survivors. METHODS: The authors studied 52 male survivors of childhood ALL at a median age of 28.5 years (range, 25-38 years) ≥ 10 years after diagnosis. In addition, 56 men without a history of cancer were recruited for an age-matched control group...
July 15, 2016: Cancer
https://www.readbyqxmd.com/read/26893061/social-media-and-the-adolescent-and-young-adult-aya-patient-with-cancer
#8
Miguel-Angel Perales, Emily K Drake, Naveen Pemmaraju, William A Wood
Over 70,000 adolescent and young adults (AYA) aged 15 to 39 years are diagnosed with cancer each year in the US. The National Cancer Institute (NCI) has identified AYA cancer patients as a unique population. The most common cancers in this age group include tumors typically seen in pediatric patients such as acute lymphoblastic leukemia (ALL) and brain tumors, as well as cancers more typically seen in adult patients such as breast cancer and melanoma. In addition, some cancers have their highest incidence in AYA patients, such as Hodgkin Lymphoma, testicular cancer, and bone tumors...
February 18, 2016: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/26879921/long-term-outcomes-for-children-with-acute-lymphoblastic-leukemia-all-treated-on-the-cancer-institute-of-new-jersey-all-trial-cinjall
#9
Richard A Drachtman, Margaret Masterson, Angela Shenkerman, Veena Vijayanathan, Peter D Cole
The Cancer Institute of New Jersey Acute Lymphoblastic Leukemia trial (CINJALL) employed a post-induction regimen centered on intensive oral antimetabolite therapy, with no intravenous methotrexate (MTX). Fifty-eight patients enrolled between 2001 and 2005. A high rate of induction death (n = 3) or induction failure (n = 1) was observed. Among those who entered remission, five-year DFS is 80 ± 8.9% for those at standard risk of relapse and 76 ± 7.8% for high-risk patients, with median follow up over six years...
October 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26514976/11-years-later-isolated-testicular-relapse-of-all-after-stem-cell-transplantation-treated-with-surgery-only-a-case-report-and-review-of-the-literature
#10
Rishabh Singh, James T Mills, William C Petersen, Sean T Corbett
Despite advances in therapy for childhood acute lymphoblastic leukemia (ALL), relapses continue to occur and are associated with significant morbidity and mortality. Individuals who relapse after stem cell transplantation (SCT) have an especially poor prognosis and typically require intensive systemic therapy to provide any chance of cure. The majority of relapses occur within 2 years following SCT; relapses later than 4 years post SCT are rare. Here we describe an isolated testicular relapse of ALL 11 years after SCT, treated with local control measures only, and review the literature for other cases of very late ALL relapse following SCT...
January 2016: Urology
https://www.readbyqxmd.com/read/26147907/primary-testicular-ph-positive-b-lymphoblastic-lymphoma-an-unusual-presentation-and-review
#11
REVIEW
Jiling Zhu, Shiying Zhang, Li Zhu, Xinlu Li, Ying Wang, Yaqi Duan, Wei Huang
Primary testicular B-lymphoblastic lymphoma is a rare entity. Primary testicular Ph-positive B lymphoblastic lymphoma was not reported before. We reported a 27-year-old man with primary testicular Ph-positive B lymphoblastic lymphoma, for which fluorescent in-situ hybridization (FISH) for the Philadelphia chromosome was not performed at the initial hospitalization. The patient showed manifestation of Ph-positive acute lymphoblastic leukemia at relapse. In this report, we reviewed the current literature about primary testicular B-lymphoblastic lymphoma, Ph-positive lymphoma and Ph-positive clone evolution...
2015: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/26088403/increased-body-adiposity-and-serum-leptin-concentrations-in-very-long-term-adult-male-survivors-of-childhood-acute-lymphoblastic-leukemia
#12
Kirsi Jahnukainen, Risto Heikkinen, Markus Henriksson, Sture Andersson, Kaisa K Ivaska, Leena-Riitta Puukko-Viertomies, Outi Mäkitie
BACKGROUND: We evaluated the body composition and its association with hypogonadism in adult male long-term acute lymphoblastic leukemia (ALL) survivors. METHODS: The cohort included 49 long-term male ALL survivors and 55 age-matched healthy controls. Fat and lean mass was assessed by dual-energy X-ray absorptiometry; blood biochemistry was obtained for adipokines and testicular endocrine markers. RESULTS: As compared with controls, the ALL survivors (median age 29 years, range 25-38), assessed 10-28 years after ALL diagnosis, had higher percentages of body (p < 0...
2015: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/25523694/re-eliminating-acute-lymphoblastic-leukemia-cells-from-human-testicular-cell-cultures-a-pilot-study
#13
EDITORIAL
Craig Niederberger
No abstract text is available yet for this article.
January 2015: Journal of Urology
https://www.readbyqxmd.com/read/25379043/advancements-in-the-treatment-of-pediatric-acute-leukemia-and-brain-tumor-continuous-efforts-for-100-cure
#14
REVIEW
Hee Young Ju, Che Ry Hong, Hee Young Shin
Treatment outcomes of pediatric cancers have improved greatly with the development of improved treatment protocols, new drugs, and better supportive measures, resulting in overall survival rates greater than 70%. Survival rates are highest in acute lymphoblastic leukemia, reaching more than 90%, owing to risk-based treatment through multicenter clinical trials and protocols developed to prevent central nervous system relapse and testicular relapse in boys. New drugs including clofarabine and nelarabine are currently being evaluated in clinical trials, and other targeted agents are continuously being developed...
October 2014: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/25266309/graft-versus-leukemia-response-without-graft-versus-host-disease-elicited-by-adoptively-transferred-multivirus-specific-t-cells
#15
Jan J Melenhorst, Paul Castillo, Patrick J Hanley, Michael D Keller, Robert A Krance, Judith Margolin, Ann M Leen, Helen E Heslop, A John Barrett, Cliona M Rooney, Catherine M Bollard
A 12-year-old boy with refractory acute lymphoblastic leukemia received a haploidentical transplant from his mother. As prophylaxis for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus, he received ex vivo expanded virus-specific donor T cells 3.5 months after transplant. Four weeks later leukemic blasts bearing the E2A deletion, identified by fluorescent in situ hybridization (FISH), appeared transiently in the blood followed by a FISH-negative hematological remission, which was sustained until a testicular relapse 3...
January 2015: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/25237325/thyroid-nodule-in-an-eighteen-year-old-man-as-the-first-presentation-of-acute-lymphoblastic-leukemia
#16
Majid Valizadeh, Minoush Moghimi, Abdolamir Feizi, Farbod Radmand, Zahra Piri
INTRODUCTION: Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. Patients with ALL commonly present with easy bruising and infections due to medullary involvement. The extra medullary involvements of ALL manifests as hepatosplenomegaly, lymphadenopathy, and testicular enlargement. Among extramedullary manifestations of the ALL, thyroid involvement is rare. Herein, we reported a case of ALL that manifested as a thyroid nodule. CASE PRESENTATION: An 18-year-old young man with a thyroid nodule presented without any other symptom or sign...
July 2014: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24653935/testis-scintigraphy-in-a-patient-with-acute-lymphoblastic-leukemia
#17
Mine Sencan Eren, Murat Koç, Hale Oren, Sermin Ozkal, Hatice Durak
UNLABELLED: Acute lymphoblastic leukemia (ALL) is a pediatric malignancy associated with remissions and relapses. Common relapsing sitesare meninges, testis and ovary. Testicular scintigraphy is a highly specific modality used mainly in the differential diagnosis of testicular torsion and epidydimitis/epidydimo-orchitis. There is only one interesting image on leukemic infiltration with scrotal scintigraphy in the literature. The aim of this case presentation is to report that although the scintigraphic appearance of testicular torsion was observed in a patient with the diagnosis of ALL, testicular ALL infiltration was revealed in pathologic examination...
February 2014: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/24581582/eliminating-acute-lymphoblastic-leukemia-cells-from-human-testicular-cell-cultures-a-pilot-study
#18
Hooman Sadri-Ardekani, Christa H Homburg, Toni M M van Capel, Henk van den Berg, Fulco van der Veen, C Ellen van der Schoot, Ans M M van Pelt, Sjoerd Repping
OBJECTIVE: To study whether acute lymphoblastic leukemia (ALL) cells survive in a human testicular cell culture system. DESIGN: Experimental laboratory study. SETTING: Reproductive biology laboratory, academic medical center. PATIENT(S): Acute lymphoblastic leukemia cells from three patients and testicular cells from three other patients. INTERVENTION(S): Acute lymphoblastic leukemia cells were cultured alone or in combination with testicular cells, at various concentrations, in a system that has recently been developed to propagate human spermatogonial stem cells...
April 2014: Fertility and Sterility
https://www.readbyqxmd.com/read/24331189/therapy-related-myelodysplasia-and-acute-myeloid-leukemia
#19
Smita Bhatia
Therapy-related leukemia (myelodysplasia and acute myeloid leukemia-t-MDS/AML) is a well-known complication of conventional chemoradiotherapy used to treat a variety of primary malignancies including Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), acute lymphoblastic leukemia (ALL), sarcoma, and ovarian and testicular cancers. The median time to development of t-MDS/AML is 3-5 years, with the risk decreasing markedly after the first decade. t-MDS/AML is the major cause of non-relapse mortality after autologous hematopoietic cell transplantation (HCT) for HL or NHL...
December 2013: Seminars in Oncology
https://www.readbyqxmd.com/read/23682320/twenty-years-of-experience-on-stem-cell-transplantation-in-iran
#20
Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Fatemeh Ghaffari, Roshanak Derakhshandeh, Arash Jalali, Mohammad Jahani
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a new window to therapy of many diseases. From March 1991 through April 2011, a total of 3237 HSCT were performed in the Hematology-Oncology and Stem Cell Transplantation Research Center, affiliated to Tehran University of Medical Sciences. Here we report 20 years experience of HSCT. OBJECTIVES: Our strategy and aim include the protraction of cytogenetic and molecular biological diagnostic tests, the expansion of the first Iranian Cord Blood Bank (ICBB) and development of the first Iranian Stem Cell Donor Program (ISCDP), and improvement the researches in new therapeutic fields...
February 2013: Iranian Red Crescent Medical Journal
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