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https://www.readbyqxmd.com/read/28938735/the-age-of-fathers-in-the-usa-is-rising-an-analysis-of-168-867-480-births-from-1972-to-2015
#1
Yash S Khandwala, Chiyuan A Zhang, Ying Lu, Michael L Eisenberg
STUDY QUESTION: How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER: The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. WHAT IS KNOWN ALREADY: While the rise in mean maternal age and its implications for fertility, birth outcomes and public health have been well documented, little is known about paternal characteristics of births within the USA...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938645/sex-specific-association-of-sh2b3-and-smarca4-polymorphisms-with-coronary-artery-disease-susceptibility
#2
Yuqiang Ji, Yanbin Song, Qingwen Wang, Pengcheng Xu, Zhao Zhao, Xia Li, Nan Wang, Tianbo Jin, Chao Chen
To determine whether sex differences affect the association between genetic polymorphisms and coronary artery disease (CAD) in the Chinese Han population, we conducted a study comparing the frequency of SH2B3 and SMARCA4 variants in 456 CAD patients (291 men, 165 women) and 685 age-matched controls (385 men, 300 women). Ten single nucleotide polymorphisms (SNPs) in SH2B3 and SMARCA4 were genotyped using MassARRAY technology. Allelic and genotypic models and haplotype frequencies were compared between groups...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#3
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938457/the-association-of-estrogen-receptor-%C3%AE-gene-variation-with-salt-sensitive-blood-pressure
#4
Worapaka Manosroi, Jia Wei Tan, Chevon M Rariy, Bei Sun, Mark O Goodarzi, Aditi R Saxena, Jonathan S Williams, Luminita H Pojoga, Jessica Lasky-Su, Jinrui Cui, Xiuqing Guo, Kent D Taylor, Yii-Der I Chen, Anny H Xiang, Willa A Hsueh, Leslie J Raffel, Thomas A Buchanan, Jerome I Rotter, Gordon H Williams, Ellen W Seely
Context: Hypertension in young women is uncommon compared to young men and older women. Estrogen appears to protect most women against hypertension with incidence increasing after menopause. Since some premenopausal women develop hypertension, estrogen may play a different role in these women. Genetic variations in the estrogen receptor (ER) are associated with cardiovascular disease. ER-β, encoded by ESR2, is the ER predominantly expressed in vascular smooth muscle. Objective: To determine an association of single nucleotide polymorphisms (SNPs) in ESR2 with salt-sensitivity of blood pressure (SSBP) and estrogen status in women...
September 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938446/vitamin-d-and-testosterone-in-healthy-men-a-randomized-controlled-trial
#5
Elisabeth Lerchbaum, Stefan Pilz, Christian Trummer, Verena Schwetz, Oliver Pachernegg, Annemieke C Heijboer, Barbara Obermayer-Pietsch
Context: Available evidence shows an association of vitamin D with androgen levels in men. However, results from preliminary randomized controlled trials (RCTs) are conflicting. Objective: To evaluate whether vitamin D supplementation increases total testosterone (TT) levels in healthy men. Design: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between December 2012 and January 2017...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938219/age-dependent-effects-of-acute-methylphenidate-on-amygdala-reactivity-in-stimulant-treatment-naive-patients-with-attention-deficit-hyperactivity-disorder
#6
Marco A Bottelier, Anouk Schrantee, Bart Ferguson, Hyke G H Tamminga, Cheima Bouziane, J J Sandra Kooij, Michiel B de Ruiter, Liesbeth Reneman
In the present study, we investigate whether methylphenidate (MPH) affects emotional processing and whether this effect is modulated by age. We measured amygdala reactivity with functional Magnetic Resonance Imaging (fMRI) during processing of angry and fearful facial expressions in male stimulant treatment-naive patients with ADHD (N = 35 boys; N = 46 men) and 23 healthy control subjects (N = 11 boys; N = 12 men). In ADHD patients, we also measured amygdala reactivity 90min after an acute oral challenge with MPH (0...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28938183/age-trends-in-rates-of-substance-use-disorders-across-ages-18-90-differences-by-gender-and-race-ethnicity
#7
Sara A Vasilenko, Rebecca J Evans-Polce, Stephanie T Lanza
BACKGROUND: Although research has documented age differences in substance use, less is known about how prevalence of substance use disorders (SUDs) vary across age and differ by gender and race/ethnicity. METHODS: Time-varying effect models (TVEMs) were estimated on data from the National Epidemiologic Survey of Alcohol and Related Conditions-III (NESARC III; N=36,309), a nationally representative survey of the adult population. The sample was 44% male; 53% White, 21% Black, 19% Hispanic/Latino, 6% other race/ethnicity...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28937936/is-high-t-1-slope-a-significant-risk-factor-for-developing-interlaminar-bony-fusion-after-cervical-laminoplasty-a-retrospective-cohort-study
#8
Takeshi Oichi, Yasushi Oshima, Hiroyuki Oka, Yuki Taniguchi, Hirotaka Chikuda, Yoshitaka Matsubayashi, Katsushi Takeshita, Sakae Tanaka
OBJECTIVE Several investigators have reported the occurrence of interlaminar bony fusion after cervical laminoplasty, which is reportedly associated with reduced postoperative cervical range of motion (ROM). However, to the authors' knowledge, no previous study has investigated the characteristics of patients who were likely to develop interlaminar bony fusion after cervical laminoplasty. Therefore, the objective of this study was to investigate the risk factors for interlaminar bony fusion in patients with cervical spondylotic myelopathy (CSM) following cervical laminoplasty and to investigate the effect of interlaminar bony fusion on surgical outcomes...
September 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28937934/an-evaluation-of-new-york-city-s-2015-birth-certificate-gender-marker-regulation
#9
Erica J Lee, Danielle Gurr, Gretchen Van Wye
PURPOSE: In 1971, the New York City (NYC) Department of Health and Mental Hygiene amended Section 207.05 of the NYC Health Code to allow individuals who had undergone "convertive surgery" (interpreted by the code to mean genital surgery) to amend the gender on their birth certificates. This surgery requirement was removed in 2015. In a survey evaluating the regulation change, we sought to characterize the transgender population newly eligible to obtain a gender-congruent NYC birth certificate by comparing respondents with and without genital surgery...
September 22, 2017: LGBT Health
https://www.readbyqxmd.com/read/28937861/increased-suicides-during-new-year-but-not-during-christmas-in-sweden-analysis-of-cause-of-death-data-2006-2015
#10
Gergö Hadlaczky, Sebastian Hökby
BACKGROUND: Previous studies have investigated the impact of the Christmas and New Year holiday on suicide rates. However, no such data has yet been published on Swedish suicides. AIMS: To examine the occurrence of suicides on these dates in Sweden between 2006 and 2015. METHODS: The suicide count for each date between December 15th and January 15th was obtained from the Swedish cause of death registry. The observations were transformed to Z-scores to enable calculation of p-values...
September 22, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28937851/hpv-vaccine-acceptability-in-high-risk-greek-men
#11
Lea Hoefer, Savas Tsikis, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Antonios Kanelleas, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, John Schneider, Angella Charnot-Katsikas
BACKGROUND: HPV is associated with malignancy in men, yet there is a lack of data on HPV knowledge, vaccine acceptability, and factors affecting vaccine acceptability in Greek men. This study aims to identify determinants of knowledge and willingness to vaccinate against HPV among high-risk Greek men. METHODS: Men (n = 298) between the ages of 18 and 55 were enrolled from the STI and HIV clinics at "Andreas Syggros" Hospital in Athens, Greece from July-October 2015...
September 22, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28937801/clinical-implications-of-hand-position-and-lower-limb-length-measurement-method-on-y-balance-test-scores-and-interpretation
#12
Kim Hébert-Losier
CONTEXT:   The Lower Quarter Y-Balance Test (LQ-YBT) was developed to provide an effective and efficient screen for injury risk in sports. Earlier protocol recommendations for the LQ-YBT involved the athlete placing the hands on the hips and the clinician normalizing scores to lower limb length measured from the anterior-superior iliac spine to the lateral malleolus. The updated LQ-YBT protocol recommends the athlete's hands be free moving and the clinician measure lower limb length to the medial malleolus...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937790/the-doctor-of-philosophy-experience-of-athletic-trainers-facilitators-and-barriers-to-anticipatory-faculty-socialization
#13
Thomas Bowman, Joanne Klossner, Stephanie Mazerolle
CONTEXT:   It is important to understand the process whereby athletic trainers learn about their future roles, particularly when the roles can be complex and demanding. Little is known about the experiences of athletic training doctoral students, including facilitators and barriers to socialization as aspiring faculty members. OBJECTIVE:   To investigate factors influencing the anticipatory socialization of athletic training doctoral students into future faculty roles...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937616/sarcopenia-impairs-prognosis-of-patients-with-hepatocellular-carcinoma-the-role-of-liver-functional-reserve-and-tumor-related-factors-in-loss-of-skeletal-muscle-volume
#14
Kenji Imai, Koji Takai, Satoshi Watanabe, Tatsunori Hanai, Atsushi Suetsugu, Makoto Shiraki, Masahito Shimizu
Sarcopenia impairs survival in patients with hepatocellular carcinoma (HCC). This study aimed to clarify the factors that contribute to decreased skeletal muscle volume in patients with HCC. The third lumbar vertebra skeletal muscle index (L3 SMI) in 351 consecutive patients with HCC was calculated to identify sarcopenia. Sarcopenia was defined as an L3 SMI value ≤ 29.0 cm²/m² for women and ≤ 36.0 cm²/m² for men. The factors affecting L3 SMI were analyzed by multiple linear regression analysis and tree-based models...
September 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28937577/trajectories-of-musculoskeletal-pain-from-adolescence-to-middle-age-the-role-of-early-depressive-symptoms-a-27-year-follow-up-of-the-northern-swedish-cohort
#15
Päivi Leino-Arjas, Kristiina Rajaleid, Gashaw Mekuria, Tapio Nummi, Pekka Virtanen, Anne Hammarström
Depression and musculoskeletal pain are associated, but long-term follow-up studies are rare. We aimed to examine the relationship of early depressive symptoms with developmental patterns of musculoskeletal pain from adolescence to middle age. Adolescents ending compulsory school (age 16) in Luleå, Northern Sweden, in 1981 (n = 1083) were studied and followed up in 1986, 1995, and 2008 (age 43) for musculoskeletal pain. Attrition was very low. Indicators for any and severe pain were based on pain in the neck-shoulders, low back, and the extremities...
September 19, 2017: Pain
https://www.readbyqxmd.com/read/28937455/palliative-surgery-for-spinal-metastases-using-posterior-decompression-and-fixation-combined-with-intraoperative-vertebroplasty
#16
Liang Dong, Mingsheng Tan, Di Wu, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the clinical outcome of palliative surgery using posterior decompression and fixation combined with intraoperative vertebroplasty (PDFIV) for the treatment of spinal metastases, and analyze the indications for PDFIV using a neurological, oncologic, mechanical, and systemic framework. SUMMARY OF BACKGROUND DATA: Palliative surgery is widely used to spinal metastatic patients with poor condition for enough postoperative recovery...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937269/dose-escalation-using-contact-x-ray-brachytherapy-papillon-for-rectal-cancer-does-it-improve-the-chance-of-organ-preservation
#17
Arthur Sun Myint, Fraser McLean Smith, Simon William Gollins, Helen Wong, Christopher Rao, Karen Whitmarsh, Raj Sripadam, Paul Rooney, Michael Jeremy Hershman, Zsolt Fekete, Kate Perkins, D Mark Pritchard
OBJECTIVE: A watch and wait policy for patients with a complete clinical response (cCR) after external beam chemoradiotherapy (EBCRT) for rectal cancer is an attractive option. However, approximately a third of tumours will regrow, which requires surgical salvage for cure. We assessed whether contact x-ray brachytherapy (CXB) can improve organ preservation by avoiding surgery for local regrowth. METHODS: From our institutional database, we identified 200 of 573 patients treated by CXB from 2003 to 2012...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937076/prevalence-and-risk-factors-of-chronic-kidney-disease-in-newly-diagnosed-and-untreated-hypertensive-patients-in-cameroon-a-cross-sectional-study
#18
Félicite Kamdem, Fernando Kemta Lekpa, Marie Solange Doualla, Yvette Ngo Nouga, Olivier Donfack Sontsa, Elvis Temfack, Samuel Kingue
Chronic kidney disease (CKD) has emerged as a worldwide problem and is a major cause for comorbidity in hypertensive patients. In an attempt to enhance awareness and to help in establishing preventive measures and care, it is necessary to describe CKD among newly diagnosed and untreated hypertensive patients. We conducted a cross-sectional study to describe the characteristics of CKD among newly diagnosed, treatment naïve, hypertensive patients in four health-care centers in the city of Douala, Cameroon. Sociodemographic and biological data were collected and serum creatinine was measured by enzymatic - colorimetric methods...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936997/influence-of-age-and-gender-on-the-function-of-postganglionic-sympathetic-sudomotor-axons
#19
Kedar Mal, Hulegar A Abhishekh, Mahavir Prasad Chawla, Trichur R Raju, Talakad N Sathyaprabha
BACKGROUND: The quantitative sudomotor axon reflex test (QSART) is an autonomic function test to evaluate the function of postganglionic sympathetic sudomotor axons. The QSART is used for research and in clinical assessment of various neurological diseases, but few studies have assessed the influence of age, gender and reported a normative range. We assessed the influence of age and gender on QSART parameters. METHODS: We recruited 61 healthy volunteers (41 men and 20 women) after obtaining written informed consent...
May 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28936956/-epidemiology-characteristics-of-crawfish-related-rhabdomyolysis-in-nanjing-2016-a-multicenter-retrospective-investigation
#20
Shaolei Ma, Changsheng Xu, Songqiao Liu, Zongfeng Hu, Wen'ge Liu, Jinsong Zhang, Xufeng Chen, Shinan Nie, Jun Zhang, Dujuan Sha, Jinjin Li, Haibin Ni, Haidong Qin, Ying Gao, Wei Wang, Chengfang Wu, Zhan Yu, Congjian Zhu
OBJECTIVE: To investigate the epidemiology characteristics of crawfish related rhabdomyolysis (RM) in Nanjing, 2016. METHODS: Outpatient and inpatient electronic medical system of 21 hospitals in Nanjing during 2016 were retrospectively searched, and all the patients diagnosed with RM were selected. The patients with none crayfish-related RM was excluded. The epidemiology characteristics were depicted. The geographic information system (GIS) was used to collect, manage and analyze the spatial data, to visualize it, to analyze the spatial distribution features of the disease, and to explore the cause of disease prediction...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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