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https://www.readbyqxmd.com/read/27936396/gnpat-p-d519g-is-independently-associated-with-markedly-increased-iron-stores-in-hfe-p-c282y-homozygotes
#1
James C Barton, Wen-Pin Chen, Mary J Emond, Pradyumna D Phatak, V Nathan Subramaniam, Paul C Adams, Lyle C Gurrin, Gregory J Anderson, Grant A Ramm, Lawrie W Powell, Katrina J Allen, John D Phillips, Charles J Parker, Gordon D McLaren, Christine E McLaren
BACKGROUND: GNPAT p.D519G positivity is significantly increased in HFE p.C282Y homozygotes with markedly increased iron stores. We sought to determine associations of p.D519G and iron-related variables with iron stores in p.C282Y homozygotes. METHODS: We defined markedly increased iron stores as serum ferritin >2247pmol/L (>1000μg/L) and either hepatic iron >236μmol/g dry weight or iron >10g by induction phlebotomy (men and women). We defined normal or mildly elevated iron stores as serum ferritin <674...
November 12, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27936361/the-relationship-between-drinking-pattern-social-capital-and-area-deprivation-findings-from-the-health-survey-for-england
#2
Linda Ng Fat, Shaun Scholes, Stephen Jivraj
OBJECTIVE: The purpose of this study was to establish the relationships between heavy episodic and drinking frequency with area-deprivation and social capital in England. METHOD: Using the Health Survey for England 2002-2006, a nationally representative crosssectional survey (N = 54,422), multilevel logistic regression models with individuals nested within primary sampling units were carried out, stratified by sex, on (a) drinkers versus nondrinkers, (b) heavy episodic drinking versus drinking less (on the heaviest drinking day), and (c) fewer than 2 drink-free days versus at least 2 drink-free days...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936279/the-relationship-between-relative-fundamental-frequency-and-a-kinematic-estimate-of-laryngeal-stiffness-in-healthy-adults
#3
Victoria S McKenna, Elizabeth S Heller Murray, Yu-An S Lien, Cara E Stepp
Purpose: This study examined the relationship between the acoustic measure relative fundamental frequency (RFF) and a kinematic estimate of laryngeal stiffness. Method: Twelve healthy adults (mean age = 22.7 years, SD = 4.4; 10 women, 2 men) produced repetitions of /ifi/ while varying their vocal effort during simultaneous acoustic and video nasendoscopic recordings. RFF was determined from the last 10 voicing cycles before the voiceless obstruent (RFF offset) and the first 10 cycles of revoicing (RFF onset)...
December 9, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27936224/change-in-serum-bilirubin-level-as-a-predictor-of-incident-metabolic-syndrome
#4
You-Bin Lee, Seung-Eun Lee, Ji Eun Jun, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Jae Hyeon Kim
AIM: Serum bilirubin level was negatively associated with the prevalence of metabolic syndrome (MetS) in previous cross-sectional studies. However, bilirubin variance preceding the development of MetS has yet to be investigated. We aimed to determine the effect of change in bilirubin concentration on the risk of incident MetS in healthy Korean adults. METHODS: We conducted a retrospective longitudinal study of subjects who had undergone at least four yearly health check-ups between 2006 and 2012...
2016: PloS One
https://www.readbyqxmd.com/read/27936216/genetic-association-analysis-of-common-variants-in-foxo3-related-to-longevity-in-a-chinese-population
#5
Rong Lin, Yunxia Zhang, Dongjing Yan, Xiaoping Liao, Xianshou Wang, Yunxin Fu, Wangwei Cai
Recent studies suggested that forkhead box class O3 (FOXO3) functions as a key regulator for the insulin/insulin-like growth factor-1signaling pathway that influence aging and longevity. This study aimed to comprehensively elucidate the association of common genetic variants in FOXO3 with human longevity in a Chinese population. Eighteen single-nucleotide polymorphisms (SNPs) in FOXO3 were successfully genotyped in 616 unrelated long-lived individuals and 846 younger controls. No nominally significant effects were found...
2016: PloS One
https://www.readbyqxmd.com/read/27936196/resilience-and-associated-factors-among-mainland-chinese-women-newly-diagnosed-with-breast-cancer
#6
Zijing Wu, Ye Liu, Xuelian Li, Xiaohan Li
PURPOSE: Resilience is the individual's ability to bounce back from trauma. It has been studied for some time in the U.S., but few studies in China have addressed this important construct. In mainland China, relatively little is known about the resilience of patients in clinical settings, especially among patients with breast cancer. In this study, we aimed to evaluate the level of resilience and identify predictors of resilience among mainland Chinese women newly diagnosed with breast cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27936187/stroke-as-the-first-manifestation-of-atrial-fibrillation
#7
Jussi Jaakkola, Pirjo Mustonen, Tuomas Kiviniemi, Juha E K Hartikainen, Antti Palomäki, Päivi Hartikainen, Ilpo Nuotio, Antti Ylitalo, K E Juhani Airaksinen
Atrial fibrillation may remain undiagnosed until an ischemic stroke occurs. In this retrospective cohort study we assessed the prevalence of ischemic stroke or transient ischemic attack as the first manifestation of atrial fibrillation in 3,623 patients treated for their first ever stroke or transient ischemic attack during 2003-2012. Two groups were formed: patients with a history of atrial fibrillation and patients with new atrial fibrillation diagnosed during hospitalization for stroke or transient ischemic attack...
2016: PloS One
https://www.readbyqxmd.com/read/27936129/characteristics-of-differently-located-colorectal-cancers-support-proximal-and-distal-classification-a-population-based-study-of-57-847-patients
#8
Jiao Yang, Xiang Lin Du, Shu Ting Li, Bi Yuan Wang, Yin Ying Wu, Zhe Ling Chen, Meng Lv, Yan Wei Shen, Xin Wang, Dan Feng Dong, Dan Li, Fan Wang, En Xiao Li, Min Yi, Jin Yang
BACKGROUND: It has been suggested that colorectal cancer be regarded as several subgroups defined according to tumor location rather than as a single entity. The current study aimed to identify the most useful method for grouping colorectal cancer by tumor location according to both baseline and survival characteristics. METHODS: Cases of pathologically confirmed colorectal adenocarcinoma diagnosed from 2000 to 2012 were identified from the Surveillance, Epidemiology, and End Results database and categorized into three groups: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer (ReC)...
2016: PloS One
https://www.readbyqxmd.com/read/27936110/women-s-perceived-reasons-for-their-excessive-postpartum-weight-retention-a-qualitative-interview-study
#9
Anne Christenson, Eva Johansson, Signy Reynisdottir, Jarl Torgerson, Erik Hemmingsson
INTRODUCTION: Obesity in Sweden has doubled to 14% over the last 20 years. New strategies for treatment and prevention are needed. Excessive gestational weight gain has been found to contribute substantially to obesity, and there is a consistent association between postpartum weight retention and obesity later in life. We aimed to explore what factors women perceive as reasons for having substantial postpartum weight retention, to identify areas for new and improved interventions. METHODS: Qualitative interview study (semi-structured) using an emergent design...
2016: PloS One
https://www.readbyqxmd.com/read/27936092/the-association-between-sexually-transmitted-infections-length-of-service-and-other-demographic-factors-in-the-u-s-military
#10
Robert Deiss, Richard J Bower, Edgie Co, Octavio Mesner, Jose L Sanchez, Jennifer Masel, Anuradha Ganesan, Grace E Macalino, Brian K Agan
BACKGROUND: Numerous studies have found higher rates of sexually transmitted infections (STIs) among military personnel than the general population, but the cumulative risk of acquiring STIs throughout an individual's military career has not been described. METHODS: Using ICD-9 diagnosis codes, we analyzed the medical records of 100,005 individuals from all service branches, divided in equal cohorts (n = 6,667) between 1997 and 2011. As women receive frequent STI screening compared to men, these groups were analyzed separately...
2016: PloS One
https://www.readbyqxmd.com/read/27936024/estimation-of-physical-activity-energy-expenditure-during-free-living-from-wrist-accelerometry-in-uk-adults
#11
Tom White, Kate Westgate, Nicholas J Wareham, Soren Brage
BACKGROUND: Wrist-worn accelerometers are emerging as the most common instrument for measuring physical activity in large-scale epidemiological studies, though little is known about the relationship between wrist acceleration and physical activity energy expenditure (PAEE). METHODS: 1695 UK adults wore two devices simultaneously for six days; a combined sensor and a wrist accelerometer. The combined sensor measured heart rate and trunk acceleration, which was combined with a treadmill test to yield a signal of individually-calibrated PAEE...
2016: PloS One
https://www.readbyqxmd.com/read/27936021/metabolic-syndrome-and-associated-factors-in-adults-of-the-amazon-region
#12
Sérgio Lobato França, Sandra Souza Lima, José Ricardo Dos Santos Vieira
Metabolic syndrome (MS) plays a key role in the origin of cardiovascular diseases. Studies on the MS in Brazil are recent, and its epidemiology in more isolated regions such as the Amazon is still unknown. The study aimed to estimate the prevalence of MS and associated factors in adults of the Brazilian Amazon. This study was conducted in 2012-2013. It is a cross-sectional population-based study, involving 787 adults randomly selected from the urban area of four cities in the state of Pará, in the Brazilian Eastern Amazon...
2016: PloS One
https://www.readbyqxmd.com/read/27935928/myomectomy-revisited-experiences-in-a-teaching-hospital
#13
S Subedi, M Chhetry, S Lamichhane
INTRODUCTION: Uterine myomas are the most common benign tumors of the female reproductive tract with myomectomy being one of the major modalities of the treatment in our set up. The aim of this study was to share the experiences of open myomectomy from a Teaching Hospital. METHODS: A observational study was conducted from a records of myomectomy cases in the department of Obstetrics and Gynaecology at Nobel Medical College teaching Hospital from June 2014- May 2016...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935919/hysteroscopy-in-abnormal-uterine-bleeding-vs-ultrasonography-and-histopathology-report-in-perimenopausal-and-postmenopausal-women
#14
J Sharma, S Tiwari
INTRODUCTION: Abnormal uterine bleeding is one of the most common morbidity landing women to attend medical attention in gynecology outpatient department. This study aims to evaluate the hysteroscopy finding in diagnosis of AUB and its correlation with ultrasonography finding and histopathological reports. METHODS: This was a prospective comparative study in which ultrasonography was performed in fifty patients with abnormal uterine bleeding attending OPD then hysteroscopy was performed...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935908/intestinal-worm-infestation-and-anaemia-in-pregnant-women
#15
K B Raut, K Silwal, K M Pun
INTRODUCTION: Severe Anaemia during pregnancy is an important contributor to maternal mortality, as well as to the low birth weight which is in turn an important risk factor for infant mortality. We aim to determine the prevalence of anaemia in the region amongst pregnant women and identify their problems and to easily provide them with the clinical services. METHODS: A community based cross sectional study done in PHCRC Chapagaun, Lalitpur from July 17,2011 to September 17,2011...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935907/eclampsia-feto-maternal-outcomes-in-a-tertiary-care-centre-in-eastern-nepal
#16
S Ghimire
INTRODUCTION: Eclampsia is a preventable and treatable cause of maternal morbidity and mortality with poor feto-maternal outcome in developing countries. Despite development in the level of health education expertise in human resources and institutional obstetric care in our country, the delay in early recognition of the problem, transportation to proper health facility and getting proper expert care are major hurdles to reduce complications. Therefore, we decided to study feto-maternal outcomes in our setting...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935767/effect-of-physical-activity-and-or-healthy-eating-on-gdm-risk-the-dali-lifestyle-study
#17
David Simmons, Roland Devlieger, André van Assche, Goele Jans, Sander Galjaard, Rosa Corcoy, Juan M Adelantado, Fidelma Dunne, Gernot Desoye, Jürgen Harreiter, Alexandra Kautzky-Willer, Peter Damm, Elisabeth R Mathiesen, Dorte M Jensen, Liselotte Andersen, Annunziata Lapolla, Maria G Dalfrà, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Frank J Snoek, Judith Gm Jelsma, Mireille Nm van Poppel
CONTEXT: Lifestyle approaches for preventing gestational diabetes mellitus (GDM) have produced mixed results. OBJECTIVE: The aim of this study was to compare the effectiveness of three lifestyle interventions (Healthy eating (HE), Physical activity (PA) and both HE and PA (HE+PA)) with usual care (UC) in reducing GDM risk. DESIGN: Multicentre Randomised Controlled Trial 2012-2014: The Dali Lifestyle Study Setting: Antenatal clinics across 11 centres in 9 European countries Patients: Consecutive pregnant women <20 weeks gestation with a BMI≥29 kg/m(2) and without GDM by IADPSG criteria (n=436)...
December 9, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27935524/urinary-potassium-excretion-renal-ammoniagenesis-and-risk-of-graft-failure-and-mortality-in-renal-transplant-recipients
#18
Michele F Eisenga, Lyanne M Kieneker, Sabita S Soedamah-Muthu, Else van den Berg, Petronella E Deetman, Gerjan J Navis, Reinold Ob Gans, Carlo Ajm Gaillard, Stephan Jl Bakker, Michel M Joosten
BACKGROUND: Renal transplant recipients (RTRs) have commonly been urged to limit their potassium intake during renal insufficiency and may adhere to this principle after transplantation. Importantly, in experimental animal models, low dietary potassium intake induces kidney injury through stimulation of ammoniagenesis. In humans, low potassium intake is an established risk factor for high blood pressure. OBJECTIVE: We hypothesized that low 24-h urinary potassium excretion [UKV; urinary potassium concentration × volume], the gold standard for assessment of dietary potassium intake, represents a risk factor for graft failure and mortality in RTRs...
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27935519/the-role-of-obesity-in-the-relation-between-total-water-intake-and-urine-osmolality-in-us-adults-2009-2012
#19
Asher Y Rosinger, Hannah G Lawman, Lara J Akinbami, Cynthia L Ogden
BACKGROUND: Adequate water intake is critical to physiologic and cognitive functioning. Although water requirements increase with body size, it remains unclear whether weight status modifies the relation between water intake and hydration status. OBJECTIVE: We examined how the association between water intake and urine osmolality, which is a hydration biomarker, varied by weight status. DESIGN: NHANES cross-sectional data (2009-2012) were analyzed in 9601 nonpregnant adults aged ≥20 y who did not have kidney failure...
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27935449/multiple-hook-fixation-in-revision-spinal-deformity-surgery-for-patients-with-a-previous-multilevel-fusion-mass-technical-note-and-preliminary-outcomes
#20
Ning Liu, Kirkham B Wood
OBJECTIVE A previous multilevel fusion mass encountered during revision spinal deformity surgery may obscure anatomical landmarks, making instrumentation unworkable or incurring substantial blood loss and operative time. This study introduced a surgical technique of multiple-hook fixation for fixating previous multilevel fusion masses in revision spinal deformity surgeries and then evaluated its outcomes. METHODS Patients with a previous multilevel fusion mass who underwent revision corrective surgery down to the lumbosacral junction were retrospectively studied...
December 9, 2016: Journal of Neurosurgery. Spine
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