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https://www.readbyqxmd.com/read/28532133/neutrophil-lymphocyte-ratio-in-different-stages-of-breast-cancer
#1
Fezzeh Elyasinia, Mohammad Reza Keramati, Farham Ahmadi, Susan Rezaei, Mohammad Ashouri, Reza Parsaei, Maryam Yaghoubi, Fahimeh Elyasinia, Armita Aboutorabi, Ahmad Kaviani
Despite many advances in the treatment of breast cancer, it is still the second most common cause of death in women in the United States. It has been shown that inflammation plays a major role in the treatment of these cancers and inflammatory factors enhance tumor growth, invasion, metastasis, and vascularization. In this study, we would like to analyze peripheral blood neutrophil-lymphocyte ratio (NLR) in breast cancer patients and its correlation with disease staging. This cross-sectional analytic study was conducted in Imam Hospital, affiliated with Tehran University of Medical Sciences; a total of 195 female patients with breast cancer met the inclusion criteria...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532132/distributions-of-high-sensitivity-c-reactive-protein-total-cholesterol-hdl-ratio-and-10-year-cardiovascular-risk-national-population-based-study
#2
Alipasha Meysamie, Saeed Ghodsi, Reza Ghalehtaki, Alireza Esteghamati, Fereshteh Asgari, Mohammad Mehdi Gouya
The present study aimed to evaluate the distributions of High-Sensitivity C-reactive protein, TC-HDL ratio and 10-year risk of cardiovascular diseases among Iranian adult population. We conducted a cross-sectional study on a total of 2125 adults aged 25 to 65. Data of the Third National Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) was used. Anthropometric indices, blood pressure and biochemical measurements had been obtained. Ten-year risk of cardiovascular events was also calculated using different models...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28531889/gender-specific-differences-in-peritoneal-dialysis
#3
Daniel Kitterer, Stephan Segerer, Niko Braun, M Dominik Alscher, Joerg Latus
BACKGROUND/AIMS: Gender-specific differences between patients on renal replacement therapy have so far rarely been investigated. In the present study we aimed to describe gender-specific differences in a large cohort of peritoneal dialysis (PD) patients. METHODS: Clinical information for all patients who started PD at our center has been collected since the start of the PD-program in 1979. We used Cox regression to examine associations between technique failure and gender...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531848/a-systematic-review-and-meta-regression-of-the-prevalence-and-incidence-of-perinatal-depression
#4
REVIEW
C A Woody, A J Ferrari, D J Siskind, H A Whiteford, M G Harris
BACKGROUND: Major Depressive Disorder (MDD) is a leading cause of the disease burden for women of childbearing age, but the burden of MDD attributable to perinatal depression is not yet known. There has been little effort to date to systematically review available literature and produce global estimates of prevalence and incidence of perinatal depression. Enhanced understanding will help to guide resource allocation for screening and treatment. METHODS: A systematic literature review using the databases PsycINFO and PubMED returned 140 usable prevalence estimates from 96 studies...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28531787/clinical-nutrition-in-primary-care-an-evaluation-of-resident-physicians-attitudes-and-self-perceived-proficiency
#5
Sarah L Han, Reto Auer, Jacques Cornuz, Pedro Marques-Vidal
BACKGROUND & AIMS: There is little information regarding the impact of clinical nutrition training among medical residents. We aimed to evaluate the attitudes, self-perceived proficiency and knowledge of Swiss residents regarding clinical nutrition. METHODS: Cross-sectional study conducted between June and September 2014 in two medical education facilities located in Lausanne, Switzerland. Attitudes, self-perceived proficiency and knowledge regarding clinical nutrition were assessed by questionnaire...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531783/prototypical-versus-contemporary-mediterranean-diet
#6
W Rizza, L De Gara, R Antonelli Incalzi, C Pedone
BACKGROUND AND AIMS: To investigate the evolution of the Mediterranean Diet (MD) in a delimited area of Southern Italy, by comparing the diet adopted 60-70 years ago (Prototypical Mediterranean Diet, PMD) with the contemporary one (Contemporary Mediterranean Diet, CMD), and to verify to what extent they fitted the recommendations of the Italian and the USDA dietary guidelines. METHODS: We recruited a total of 106 participants, divided in two groups. PMD group included 52 women aged >80 years, with a good cognitive function and full independence in basic and instrumental activities of daily living...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531781/body-mass-index-kinetics-around-adiposity-rebound-in-anorexia-nervosa-a-case-control-study
#7
Rémi Neveu, Dorine Neveu, Edouard Carrier, Nadia Ourrad, Alain Perroud, Alain Nicolas
BACKGROUND AND OBJECTIVE: Anorexia nervosa (AN) is associated with parameters involved in body mass index (BMI) regulation. Contrary to obesity, BMI kinetics around the adiposity rebound is not documented in AN. This study aimed at investigating which characteristics of BMI kinetics around the adiposity rebound are associated with AN. METHODS: Multicentre case-control study with 101 inpatient women with AN onset after 10 years of age, and 101 healthy women, all free of overweight history and matched for age, level of education and fathers' socio-professional status...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531779/overweight-postmenopausal-women-with-different-plasma-estradiol-concentrations-present-with-a-similar-pattern-of-energy-expenditure-and-substrate-oxidation-rate-before-and-after-a-fatty-meal-challenge
#8
Roberta de Souza Santos, Andressa Feijó da Silva Santos, Deborah J Clegg, Odilon Iannetta, Julio Sérgio Marchini, Vivian Marques Miguel Suen
Menopause-related withdrawal of ovarian estrogens is associated with reduced energy metabolism and overall impairment of substrate oxidation. Estradiol's withdrawal after menopause is associated with a reduction in energy metabolism and impaired substrate oxidation, which contributes to weight gain and visceral fat accumulation. Here we aimed to investigate the association between plasma estradiol concentrations and energy expenditure (EE)/substrate oxidation in a group of overweight postmenopausal women before and after a fatty meal challenge...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531569/factors-associated-with-the-level-of-oral-intake-in-hospitalized-older-adults-with-dysphagia-the-importance-of-mental-activity
#9
Yoshitoshi Kuroda
BACKGROUND AND AIMS: Dysphagia is a highly prevalent condition in hospitalized older adults. One major consequence of dysphagia is reduced oral intake due to difficulty in safe and/or efficient swallowing. The aim of the present study was to explore the factors associated with the level of oral intake in older adults with dysphagia. METHODS: The subjects were enrolled from older patients admitted to an acute hospital presenting with dysphagia, consisting of 36 patients (16 men and 20 women) with a mean age of 88...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531568/macronutrient-and-alcohol-intake-is-associated-with-intermuscular-adipose-tissue-in-a-randomly-selected-group-of-younger-and-older-men-and-women
#10
Kajsa Sjöholm, Lena Gripeteg, Ingrid Larsson
BACKGROUND: Alcohol and macronutrient intake have been found to be related to general and central body fat distribution. Intermuscular adipose tissue (IMAT) is a small ectopic fat depot located within the muscle bundles. IMAT is important for muscle function, mobility and energy homeostasis and also associated with cardiovascular- and diabetes-related risk factors. AIM: To test the hypothesis that macronutrient and alcohol intake is associated with IMAT. METHODS: 50 men and 50 women, randomly selected from the general population formed height- and weight-representative age groups of 50 younger (27-31 years) and 50 older (57-61 years) subjects...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531566/the-high-molecular-weight-multimer-form-of-adiponectin-is-a-useful-marker-of-polycystic-ovary-syndrome-in-bahraini-arab-women
#11
Amina M Al-Awadi, Sameh Sarray, Mona R Arekat, Layal R Saleh, Naeema Mahmood, Wassim Y Almawi
BACKGROUND & AIMS: We tested if decreased total and high molecular weight (HMW)-adiponectin, and altered HMW/total adiponectin ratio (HMWR) constitute reliable markers of polycystic ovary syndrome (PCOS) among Bahraini Arab women. METHODS: Case-control study involving 122 Bahraini Arab women with PCOS and 89 ethnically-matched control women. PCOS was evaluated according to 2003 Rotterdam criteria. Total and HMW-adiponectin were measured by ELISA. RESULTS: Compared to controls, women with PCOS had significantly reduced plasma HMW-adiponectin, and HMWR, more so than total adiponectin...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531379/the-association-between-an-inflammatory-diet-and-global-cognitive-function-and-incident-dementia-in-older-women-the-women-s-health-initiative-memory-study
#12
Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher, Linda G Snetselaar, Oleg Zaslavsky, Stephen R Rapp
INTRODUCTION: The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. METHODS: Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28531316/a-comprehensive-method-to-quantify-adaptations-by-male-and-female-mice-with-hot-flashes-induced-by-the-neurokinin-b-receptor-agonist-senktide
#13
Ashley A Krull, Sarah A Larsen, Donald K Clifton, Genevieve Neal-Perry, Robert A Steiner
Vasomotor symptoms (VMS, or hot flashes) plague millions of reproductive age men and women who have natural or iatrogenic loss of sex steroid production. Many affected individuals are left without treatment options because of contraindications to hormone replacement therapy and the lack of equally effective non-hormonal alternatives. Moreover, development of safer, more effective therapies has been stymied by the lack of an animal model that recapitulates the hot flash phenomenon and enables direct testing of hypotheses regarding the pathophysiology underlying hot flashes...
May 22, 2017: Endocrinology
https://www.readbyqxmd.com/read/28531306/association-of-long-term-opioid-therapy-with-functional-status-adverse-outcomes-and-mortality-among-patients-with-polyneuropathy
#14
E Matthew Hoffman, James C Watson, Jennifer St Sauver, Nathan P Staff, Christopher J Klein
Importance: Polyneuropathy is one of the most common painful conditions managed within general and specialty clinics. Neuropathic pain frequently leads to decisions about using long-term opioid therapy. Understanding the association of long-term opioid use with functional status, adverse outcomes, and mortality among patients with polyneuropathy could influence disease-specific decisions about opioid treatment. Objectives: To quantify the prevalence of long-term opioid use among patients with polyneuropathy and to assess the association of long-term opioid use with functional status, adverse outcomes, and mortality...
May 22, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28531286/is-foetal-hyperexposure-to-androgens-a-cause-of-pcos
#15
Panagiota Filippou, Roy Homburg
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The pathophysiology of this syndrome is still not completely understood but recent evidence suggests that the intra-uterine environment may be a key factor in the pathogenesis of PCOS, in particular, hyperexposure of the foetus to androgens. High concentrations of maternal serum testosterone during pregnancy have been shown to influence behaviour during childhood, the prevalence of autism disorders and anti-Mullerian hormone (AMH) concentrations in adolescence...
May 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#16
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28531261/age-of-acquiring-causal-human-papillomavirus-hpv-infections-leveraging-simulation-models-to-explore-the-natural-history-of-hpv-induced-cervical-cancer
#17
Emily A Burger, Jane J Kim, Stephen Sy, Philip E Castle
Background.: Although new human papillomavirus (HPV) infections can occur at all ages, the age at which women acquire their "causal" HPV infection that develops into cervical cancer is poorly understood and practically unobservable. We aimed to estimate the age distribution at which individuals acquired their causal HPV infection in the absence of HPV vaccination or screening to help guide the optimal use of both. Methods.: Using an empirically calibrated mathematical model that simulates the natural history of cervical cancer, we estimated the cumulative number of causal HPV infections by age, stratified by HPV genotype (HPV16 vs...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28531255/measurement-repeatability-of-central-and-peripheral-blood-pressures-the-aric-study
#18
Fran Yong, Gerardo Heiss, David Couper, Michelle L Meyer, Susan Cheng, Hirofumi Tanaka
BACKGROUND: Central systolic and pulse pressures are markers of risk for small vessel disease in the brain and kidneys. The extent to which these markers are reproducible in the setting of population studies is less well established. We estimated short-term repeatability of central systolic and pulse pressures, and those of their peripheral measures for comparison. METHODS: Participants aged 65 years and over (n = 79, 56% women) were drawn from the 2011-2013 examination of the ARIC cohort...
May 22, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28531244/awareness-prevalence-treatment-and-control-of-hypertension-in-western-nepal
#19
Dinesh Neupane, Archana Shrestha, Shiva Raj Mishra, Joakim Bloch, Bo Christensen, Craig S McLachlan, Arjun Karki, Per Kallestrup
BACKGROUND: Hypertension is a significant contributor to cardiovascular and renal diseases. In low-income settings like Nepal, there are few epidemiological studies assessing hypertension burden. Thus, the purpose was to determine prevalence, awareness, treatment, and control of hypertension in Nepal. METHODS: A cross-sectional survey was conducted in semi-urban area of western Nepal among randomly selected participants, aged between 25 and 65 years. Systolic blood pressure (BP) ≥140 mm Hg and/or diastolic BP of ≥90 mm Hg and/or taking current antihypertensive medicine defined as hypertension...
May 22, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28531243/increased-postural-sway-during-quiet-stance-as-a-risk-factor-for-prospective-falls-in-community-dwelling-elderly-individuals
#20
Jonas Johansson, Anna Nordström, Yngve Gustafson, Göran Westling, Peter Nordström
Objective: fall-related injuries constitute major health risks in older individuals, and these risks are projected to increase in parallel with increasing human longevity. Impaired postural stability is a potential risk factor related to falls, although the evidence is inconclusive, partly due to the lack of prospective studies. This study aimed to investigate how objective measures of postural sway predict incident falls. Design, setting and participants: this prospectively observational study included 1,877 community-dwelling individuals aged 70 years who participated in the Healthy Ageing Initiative between June 2012 and December 2015...
May 22, 2017: Age and Ageing
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