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Metformin Aging

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https://www.readbyqxmd.com/read/29673333/protocol-for-the-chord-project-community-health-outreach-to-reduce-diabetes-a-cluster-randomized-community-health-worker-trial-to-prevent-diabetes
#1
Nadia Islam, Thomas Gepts, Isaac Lief, Radhika Gore, Natalie Levy, Michael Tanner, Yixin Fang, Scott E Sherman, Mark D Schwartz
BACKGROUND: Type 2 diabetes mellitus (DM) affects 9.4% of US adults and children, while another 33.9% of Americans are at risk of DM. Health care institutions face many barriers to systematically delivering the preventive care needed to decrease DM incidence. Community health workers (CHWs) may, as frontline public health workers bridging clinic and community, help overcome these challenges. This paper presents the protocol for a pragmatic, cluster-randomized trial integrating CHWs into two primary care clinics to support DM prevention for at-risk patients...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29670524/semen-cassiae-extract-improves-glucose-metabolism-by-promoting-glut4-translocation-in-the-skeletal-muscle-of-diabetic-rats
#2
Meiling Zhang, Xin Li, Hangfei Liang, Huqiang Cai, Xueling Hu, Yu Bian, Lei Dong, Lili Ding, Libo Wang, Bo Yu, Yan Zhang, Yao Zhang
Diabetes mellitus is a clinical syndrome characterised by hyperglycaemia; its complications lead to disability and even death. Semen Cassiae is a traditional Chinese medicine, which has anti-hypertensive, anti-hyperlipidaemia, anti-oxidation, and anti-ageing properties. Our study was designed to evaluate the action of total anthraquinones of Semen Cassiae extract (SCE) on the improvement of glucose metabolism in diabetic rats and to elucidate the underlying mechanism. First, we evaluated the effect of SCE on normal rats...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29666753/effect-of-metformin-monotherapy-on-serum-lipid-profile-in-statin-na%C3%A3-ve-individuals-with-newly-diagnosed-type-2-diabetes-mellitus-a-cohort-study
#3
Szu Han Lin, Po Chung Cheng, Shih Te Tu, Shang Ren Hsu, Yun Chung Cheng, Yu Hsiu Liu
Background: Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark United Kingdom Prospective Diabetes Study has shown that metformin therapy reduces cardiovascular events in overweight people with T2DM. This study investigates the effect of metformin monotherapy on serum lipid profile in statin-naïve individuals with newly diagnosed T2DM, and whether the effect, if any, is dosage-related...
2018: PeerJ
https://www.readbyqxmd.com/read/29661588/impact-of-metabolic-diseases-drugs-and-dietary-factors-on-prostate-cancer-risk-recurrence-and-survival-a-systematic-review-by-the-european-association-of-urology-section-of-oncological-urology
#4
REVIEW
Riccardo Campi, Sabine D Brookman-May, Jose Daniel Subiela Henríquez, Bülent Akdoğan, Maurizio Brausi, Tobias Klatte, Johan F Langenhuijsen, Estefania Linares-Espinos, Martin Marszalek, Morgan Roupret, Christian G Stief, Alessandro Volpe, Andrea Minervini, Oscar Rodriguez-Faba
CONTEXT: To date, established risk factors for prostate cancer (PCa) are limited to age, race, family history, and certain genetic polymorphisms. Despite great research efforts, available evidence on potentially modifiable risk factors is conflicting. Moreover, most studies on PCa risk factors did not consider the impact of prostate-specific antigen (PSA) testing on PCa diagnosis. OBJECTIVE: To provide a detailed overview of the latest evidence on the role of metabolic diseases, drugs, and dietary factors for risk of PCa incidence, recurrence, and survival in men exposed to PSA testing...
April 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29659168/metformin-alleviates-human-cellular-aging-by-upregulating-the-endoplasmic-reticulum-glutathione-peroxidase-7
#5
Jingqi Fang, Jiping Yang, Xun Wu, Gangming Zhang, Tao Li, Xi'e Wang, Hong Zhang, Chih-Chen Wang, Guang-Hui Liu, Lei Wang
Metformin, an FDA-approved antidiabetic drug, has been shown to elongate lifespan in animal models. Nevertheless, the effects of metformin on human cells remain unclear. Here, we show that low-dose metformin treatment extends the lifespan of human diploid fibroblasts and mesenchymal stem cells. We report that a low dose of metformin upregulates the endoplasmic reticulum-localized glutathione peroxidase 7 (GPx7). GP×7 expression levels are decreased in senescent human cells, and GPx7 depletion results in premature cellular senescence...
April 16, 2018: Aging Cell
https://www.readbyqxmd.com/read/29652246/metformin-in-non-diabetic-hyperglycaemia-the-glint-feasibility-rct
#6
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar, Stephen Sharp
BACKGROUND: The treatment of people with diabetes with metformin can reduce cardiovascular disease (CVD) and may reduce the risk of cancer. However, it is unknown whether or not metformin can reduce the risk of these outcomes in people with elevated blood glucose levels below the threshold for diabetes [i.e. non-diabetic hyperglycaemia (NDH)]. OBJECTIVE: To assess the feasibility of the Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) and to estimate the key parameters to inform the design of the full trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29645341/effects-on-the-glucagon-response-to-hypoglycaemia-during-dpp-4-inhibition-in-elderly-subjects-with-type-2-diabetes-a-randomized-placebo-controlled-study
#7
Johan Farngren, Margaretha Persson, Bo Ahrén
AIMS: Maintained glucagon response to hypoglycaemia is important as a safeguard against hypoglycaemia during glucose-lowering therapy in type 2 diabetes. During recent years, DPP-4 (dipeptidyl peptidase-4) inhibition has become more commonly used in elderly patients. However, whether DPP-4 inhibition affects the glucagon response to hypoglycaemia in the elderly is not known and was the aim of this study. METHODS: In a single-center, double-blind, randomized, placebo-controlled crossover study, 28 subjects with metformin-treated type 2 diabetes (17 males, 11 females; mean 74 years (range 65-86 years), mean HbA1c 51...
April 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29644957/a-carbohydrate-reduced-high-protein-diet-acutely-decreases-postprandial-and-diurnal-glucose-excursions-in-type-2-diabetes-patients
#8
Amirsalar Samkani, Mads J Skytte, Daniel Kandel, Stine Kjaer, Arne Astrup, Carolyn F Deacon, Jens J Holst, Sten Madsbad, Jens F Rehfeld, Steen B Haugaard, Thure Krarup
The aim of the study was to assess whether a simple substitution of carbohydrate in the conventionally recommended diet with protein and fat would result in a clinically meaningful reduction in postprandial hyperglycaemia in subjects with type 2 diabetes mellitus (T2DM). In all, sixteen subjects with T2DM treated with metformin only, fourteen male, with a median age of 65 (43-70) years, HbA1c of 6·5 % (47 mmol/l) (5·5-8·3 % (37-67 mmol/l)) and a BMI of 30 (sd 4·4) kg/m2 participated in the randomised, cross-over study...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29623622/direct-medical-costs-of-type-2-diabetes-in-france-an-insurance-claims-database-analysis
#9
Bernard Charbonnel, Dominique Simon, Jean Dallongeville, Isabelle Bureau, Sylvie Dejager, Laurie Levy-Bachelot, Julie Gourmelen, Bruno Detournay
OBJECTIVES: Our objects was to estimate the direct healthcare costs of type 2 diabetes mellitus (T2DM) in France in 2013. METHODS: Data were drawn from a random sample of ≈600,000 patients registered in the French national health insurances database, which covers 90% of the French population. An algorithm was used to select patients with T2DM. Direct healthcare costs from a collective perspective were derived from the database and compared with those from a control group to estimate the cost of diabetes and related comorbidities...
August 7, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29620914/effects-of-metformin-on-spatial-and-verbal-memory-in-children-with-asd-and-overweight-associated-with-atypical-antipsychotic-use
#10
Michael G Aman, Jill A Hollway, Jeremy Veenstra-VanderWeele, Benjamin L Handen, Kevin B Sanders, James Chan, Eric Macklin, L Eugene Arnold, Taylor Wong, Cassandra Newsom, Rianne Hastie Adams, Sarah Marler, Naomi Peleg, Evdokia A Anagnostou
OBJECTIVES: Studies in humans and rodents suggest that metformin, a medicine typically used to treat type 2 diabetes, may have beneficial effects on memory. We sought to determine whether metformin improved spatial or verbal memory in children with autism spectrum disorder (ASD) and overweight associated with atypical antipsychotic use. METHODS: We studied the effects of metformin (Riomet® ) concentrate on spatial and verbal memory in 51 youth with ASD, ages 6 through 17 years, who were taking atypical antipsychotic medications, had gained significant weight, and were enrolled in a trial of metformin for weight management...
April 5, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29619987/comorbidities-of-bullous-pemphigoid-in-a-finnish-cohort
#11
Anna Pankakoski, Harri Sintonen, Annamari Ranki, Nicolas Kluger
The incidence of bullous pemphigoid (BP) is increasing in Finland. To investigate the clinical presentation, comorbidities, and medications in a cohort of Finnish patients with confirmed BP managed in a university hospital setting. An observational retrospective study of all consecutive patients diagnosed with BP in 2012-2013 at the Department of dermatology, HUCH. The prevalence of the most common comorbidities was compared to that in a sample population aged over 30 years. Seventy patients were included (mean age: 77 years at diagnosis)...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29618839/metformin-adapts-its-cellular-effects-to-bioenergetic-status-in-a-model-of-metabolic-dysfunction
#12
Christopher Auger, Thibacg Sivayoganathan, Abdikarim Abdullahi, Alexandra Parousis, Bo Wen Pang, Marc G Jeschke
Thermal injury induces a complex immunometabolic response, characterized by hyperglycemia, extensive inflammation and persistent hypermetabolism. It has been suggested that attenuation of the hypermetabolic response is beneficial for patient wellbeing. To that effect, metformin represents an attractive therapeutic agent, as its effects on glycemia, inflammation and bioenergetics can improve outcomes in burn patients. Therefore, we studied metformin and its effects on mitochondrial bioenergetics in a murine model of thermal injury...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614026/prenatal-metformin-therapy-attenuates-hypertension-of-developmental-origin-in-male-adult-offspring-exposed-to-maternal-high-fructose-and-post-weaning-high-fat-diets
#13
You-Lin Tain, Kay L H Wu, Wei-Chia Lee, Steve Leu, Julie Y H Chan
Widespread consumption of a Western diet, comprised of highly refined carbohydrates and fat, may play a role in the epidemic of hypertension. Hypertension can take origin from early life. Metformin is the preferred treatment for type 2 diabetes. We examined whether prenatal metformin therapy can prevent maternal high-fructose plus post-weaning high-fat diets-induced hypertension of developmental origins via regulation of nutrient sensing signals, uric acid, oxidative stress, and the nitric oxide (NO) pathway...
April 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29596951/a-randomized-controlled-trial-to-compare-the-effects-of-sulphonylurea-gliclazide-mr-modified-release-and-the-dpp-4-inhibitor-vildagliptin-on-glycemic-variability-and-control-measured-by-continuous-glucose-monitoring-cgm-in-brazilian-women-with-type-2-diabetes
#14
Andre Gustavo Daher Vianna, Claudio Silva Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Jose Rocha Faria-Neto
AIMS: This study aims to evaluate whether there is a difference between the effects of vildagliptin and gliclazide MR (modified release) on glycemic variability (GV) in women with type 2 diabetes (T2DM) as evaluated by continuous glucose monitoring (CGM). METHODS: An open-label, randomized study was conducted in T2DM women on steady-dose metformin monotherapy which were treated with 50 mg vildagliptin twice daily or 60 to 120 mg of gliclazide MR once daily. CGM and GV indices calculation were performed at baseline and after 24 weeks...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29579736/metformin-reduces-glucose-intolerance-caused-by-rapamycin-treatment-in-genetically-heterogeneous-female-mice
#15
Roxanne Weiss, Elizabeth Fernandez, Yuhong Liu, Randy Strong, Adam B Salmon
The use of rapamycin to extend lifespan and delay age-related disease in mice is well-established despite its potential to impair glucose metabolism which is driven partially due to increased hepatic gluconeogenesis. We tested whether a combination therapeutic approach using rapamycin and metformin could diminish some of the known metabolic defects caused by rapamycin treatment in mice. In genetically heterogeneous HET3 mice, we found that chronic administration of encapsulated rapamycin by diet caused a measurable defect in glucose metabolism in both male and female mice as early as 1 month after treatment...
March 22, 2018: Aging
https://www.readbyqxmd.com/read/29578849/disparities-in-initial-oral-antidiabetic-medication-adherence-among-veterans-with-incident-diabetes
#16
Justin D Gatwood, Marie Chisholm-Burns, Robert Davis, Fridtjof Thomas, Praveen Potukuchi, Adriana Hung, Csaba P Kovesdy
BACKGROUND: Medication nonadherence is a prevalent public health issue, particularly among patients with diabetes mellitus (DM), and negatively affects health outcomes. Because of the prevalence of DM among U.S. veterans, it is crucial to understand how well these patients adhere to oral antidiabetic (OAD) medication and whether certain subgroups are more likely to be nonadherent. OBJECTIVE: To assess initial OAD medication use among veterans with uncomplicated DM and determine factors associated with adherence in the first 2 years of treatment...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29577107/vitamin-d-supplementation-in-patients-with-type-2-diabetes-the-vitamin-d-for-established-type-2-diabetes-ddm2-study
#17
Edith Angellotti, David D'Alessio, Bess Dawson-Hughes, Jason Nelson, Robert M Cohen, Amalia Gastaldelli, Anastassios G Pittas
Context: Observational data support a role for vitamin D in type 2 diabetes, but evidence from trials is inconclusive. Objective: To evaluate the effect of vitamin D supplementation on β -cell function and hemoglobin A1c (HbA1c) in patients with well-controlled type 2 diabetes. Design: Double-blind, randomized, placebo-controlled clinical trial. Setting: Tufts Medical Center, Boston, MA; VA Medical Center, Cincinnati, OH...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29576523/predictors-of-metformin-failure-in-gestational-diabetes-mellitus-gdm
#18
May Oo Khin, Simon Gates, Ponnusamy Saravanan
INTRODUCTION AND OBJECTIVE: The role of metformin in gestational diabetes mellitus (GDM) is also increasing. However, almost half of metformin-treated women required additional insulin. Therefore, identifying the characteristics of these women may help define optimal therapeutic strategy. METHODS: This is a retrospective cohort study done in a District General Hospital, UK. GDM was diagnosed by 75 g OGTT test between 24 and 28 weeks of gestation with fasting levels of ≥6...
January 31, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29573139/effects-of-exenatide-once-weekly-plus-dapagliflozin-exenatide-once-weekly-or-dapagliflozin-added-to-metformin-monotherapy-in-subgroups-of-patients-with-type-2-diabetes-in-the-duration-8-randomized-controlled-trial
#19
Juan P Frías, Elise Hardy, Azazuddin Ahmed, Peter Öhman, Serge Jabbour, Hui Wang, Cristian Guja
This analysis assessed whether responses with exenatide once weekly (QW) plus dapagliflozin (n=231), exenatide QW (n=230), or dapagliflozin (n=233) differed in key patient subpopulations of the DURATION-8 trial. Potential treatment-by-subgroup interactions for changes in glycated haemoglobin (HbA1c) and body weight after 28 weeks were evaluated among subgroups determined by baseline HbA1c, age, sex, body mass index, type 2 diabetes duration, race, ethnicity, and estimated glomerular filtration rate (eGFR). Exenatide QW plus dapagliflozin reduced HbA1c and body weight across all subgroups; least-squares mean (LSM) reductions ranged from -8...
March 23, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29571976/the-effect-of-vitamin-c-and-or-e-supplementations-on-type-2-diabetic-adult-males-under-metformin-treatment-a-single-blinded-randomized-controlled-clinical-trial
#20
Ali Abd El-Aal, Eman A Abd El-Ghffar, Asmaa Abu Ghali, Mohammed R Zughbur, Mahmoud M Sirdah
BACKGROUND AND AIM: Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip. METHODS: Forty T2DM male patients aged 40-60 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90 days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E...
March 16, 2018: Diabetes & Metabolic Syndrome
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