Thomas R Austin, Howard A Fink, Diana I Jalal, Anna E Törnqvist, Petra Buzkova, Joshua I Barzilay, Tianyuan Lu, Laura Carbone, Maiken E Gabrielsen, Louise Grahnemo, Kristian Hveem, Christian Jonasson, Jorge R Kizer, Arnulf Langhammer, Kenneth J Mukamal, Robert E Gerszten, Maria Nethander, Bruce M Psaty, John A Robbins, Yan V Sun, Anne Heidi Skogholt, Bjørn Olav Åsvold, Rodrigo J Valderrabano, Jie Zheng, J Brent Richards, Eivind Coward, Claes Ohlsson
Hip fractures are associated with significant disability, high cost, and mortality. However, the exact biological mechanisms underlying susceptibility to hip fractures remain incompletely understood. In an exploratory search of the underlying biology as reflected through the circulating proteome, we performed a comprehensive Circulating Proteome Association Study (CPAS) meta-analysis for incident hip fractures. Analyses included 6430 subjects from two prospective cohort studies (Cardiovascular Health Study and Trøndelag Health Study) with circulating proteomics data (aptamer-based 5 K SomaScan version 4...
January 4, 2024: Journal of Bone and Mineral Research