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Aging AND human growth hormone

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https://www.readbyqxmd.com/read/27915352/baseline-characteristics-and-gender-differences-in-prepubertal-children-treated-with-growth-hormone-in-europe-usa-and-japan-25-years-kigs%C3%A2-experience-1987-2012-and-review
#1
Michael B Ranke, Anders Lindberg, Toshiaki Tanaka, Cecilia Camacho-Hübner, David B Dunger, Mitchell E Geffner
BACKGROUND: Information about disease-specific and gender-associated differences over longer time of short children treated with recombinant human growth hormone is missing. METHODS: We analyzed data at growth hormone (GH) start in prepubertal children diagnosed with idiopathic GH deficiency (IGHD), congenital GHD, acquired GHD, idiopathic short stature (ISS), and born small for gestational age (SGA) enrolled (1987-2012) in the Pfizer International Growth Study (KIGS®) from Europe, USA, and Japan...
December 3, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27899970/fish-testing-of-her2-immunohistochemistry-1-invasive-breast-cancer-with-unfavorable-characteristics
#2
Stella Petroni, Lucia Caldarola, Rachele Scamarcio, Francesco Giotta, Agnese Latorre, Anita Mangia, Giovanni Simone
Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features that scored 1+ by immunohistochemistry (IHC). For that purpose, 331 consecutive invasive breast cancers (IBCs) were tested by IHC for HER2 expression between January and December 2013, 102 of which (31%) scored 1+...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895088/hormonal-alterations-in-pcos-and-its-influence-on-bone-metabolism
#3
Abhaya Krishnan, Sridhar Muthusami
According to the World Health Organization (WHO) polycystic ovary syndrome (PCOS) occurs in 4-8% of women worldwide. The prevalence of PCOS in Indian adolescents is 12.2% according to ICMR (Indian Council of Medical Research) report. National Institute of Health documented that it affects approximately 5 million women of reproductive age in the United States . Hormonal imbalance is the characteristic of many women with polycystic ovarian syndrome. The impact of various endocrine changes in PCOS women and their relevance to bone remains to be documented...
November 28, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27869693/putting-the-barker-theory-into-the-future-time-to-act-on-preventing-pediatric-obesity
#4
EDITORIAL
Angelo Pietrobelli, Massimo Agosti, Gianvincenzo Zuccotti, The MeNu Group
Growth and development are key characteristics of childhood and sensitive markers of health and adequate nutrition. The first 1000 days of life-conception through 24 months of age-represent a fundamental period for development and thus the prevention of childhood obesity and its adverse consequences is mandatory. There are many growth drivers during this complex phase of life, such as nutrition, genetic and epigenetic factors, and hormonal regulation. The challenge thus involves maximizing the potential for normal growth without increasing the risk of associated disorders...
November 17, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27865118/dienogest-reduces-proliferation-ngf-expression-and-nerve-fiber-density-in-human-adenomyosis
#5
Arisa Takeuchi, Kaori Koga, Mariko Miyashita, Tomoko Makabe, Fusako Sue, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Tomoyuki Fujii, Yutaka Osuga
OBJECTIVES: To evaluate the in vivo effect of dienogest on proliferation, apoptosis, aromatase expression, vascular density, nerve growth factor (NGF) expression and nerve fiber density in human adenomyosis tissue. STUDY DESIGN: Twelve women who underwent hysterectomy for adenomyosis were enrolled. Six patients received dienogest treatment prior to hysterectomy (dienogest group), and age-matched six patients who had not received any hormonal treatment for ≥3 months before surgery (control group)...
November 8, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27864119/role-of-mir-139-as-a-surrogate-marker-for-tumor-aggression-in-breast-cancer
#6
Hongyan Dai, Dan Gallagher, Sarah Schmitt, Ziyan Y Pessetto, Fang Fan, Andrew K Godwin, Ossama Tawfik
MicroRNAs (miRNAs) are non-protein coding molecules that play a key role in oncogenesis, tumor progression and metastasis in many types of malignancies including breast cancer. In the current study, we studied the expression of miRNA-139-5p (miR-139) in invasive ductal carcinoma (IDC) of the breast and correlated its expression with tumor grade, molecular subtype, hormonal status, human epidermal growth factor receptor 2 (HER2) status, proliferation index, tumor size, lymph node status, patient's age and overall survival in 74 IDC cases...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27807202/estrogens-and-androgens-in-skeletal-physiology-and-pathophysiology
#7
REVIEW
Maria Almeida, Michaël R Laurent, Vanessa Dubois, Frank Claessens, Charles A O'Brien, Roger Bouillon, Dirk Vanderschueren, Stavros C Manolagas
Estrogens and androgens influence the growth and maintenance of the mammalian skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause or loss of both estrogens and androgens in elderly men contribute to the development of osteoporosis, one of the most common and impactful metabolic diseases of old age. In the last 20 years, basic and clinical research advances, genetic insights from humans and rodents, and newer imaging technologies have changed considerably the landscape of our understanding of bone biology as well as the relationship between sex steroids and the physiology and pathophysiology of bone metabolism...
January 2017: Physiological Reviews
https://www.readbyqxmd.com/read/27768810/patterns-of-milk-macronutrients-and-bioactive-molecules-across-lactation-in-a-western-lowland-gorilla-gorilla-gorilla-and-a-sumatran-orangutan-pongo-abelii
#8
Michael L Power, Jay Schulkin, Heather Drought, Lauren A Milligan, Katie L Murtough, Robin M Bernstein
In addition to nutrients, milk contains signaling molecules that influence offspring development. Human milk is similar in nutrient composition to that of apes, but appears to differ in other aspects such as immune function. We examine the longitudinal patterns across lactation of macronutrients, the metabolic hormone adiponectin, the growth factors epidermal growth factor (EGF) and transforming growth factor β2 (TGF-β2), and two receptors for these growth factors (EGF-R and TGF-β2-RIII) in milk samples collected between days 175 and 313 postpartum from a Sumatran orangutan (Pongo abelii) and between days 3 and 1,276 from a western lowland gorilla (Gorilla gorilla), and compare the results with human data from the literature...
October 21, 2016: American Journal of Primatology
https://www.readbyqxmd.com/read/27767099/assessing-her2-testing-quality-in-breast-cancer-variables-that-influence-her2-positivity-rate-from-a-large-multicenter-observational-study-in-germany
#9
Josef Rüschoff, Annette Lebeau, Hans Kreipe, Peter Sinn, Claus Dieter Gerharz, Winfried Koch, Stefanie Morris, Johannes Ammann, Michael Untch
Despite >10 years of routine human epidermal growth factor receptor 2 (HER2) testing in breast cancer, testing quality is still an issue. Guidelines recommend assessing HER2 positivity rates as a quality indicator; however, the extent to which patient- or tumor-related factors influence HER2 positivity is still unknown. The present study analyzed these influences to identify pathology centers with HER2 positivity rates unexplained by patient- or tumor-related factors. This observational, prospective study monitored routine HER2 testing at 57 institutes of pathology in Germany (January 2013-August 2014)...
October 21, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27760283/hormonal-receptor-human-epidermal-growth-factor-and-its-association-with-breast-cancer-tumor-characteristics-in-albania
#10
Edlira Pajenga, Tefta Rexha, Silva Çeliku, Ana Ugrinska, Gazmend Bejtja
AIM: This retrospective study was designed to analyze expression patterns of estrogen receptor (ER), progesterone receptor (PR) and HER2/neu in Albanian patients with breast carcinoma to identify their relationships with tumor size, histological grade (HG), lymph node metastasis and relapse. METHODS: Patients with either biopsy or metastatic relapse were identified. Demographics, tumor characteristics, ER, PR, and HER2/neu status were retrospectively obtained from the medical records of patients treated with breast cancer during 2006-2011...
September 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/27754920/mr-and-mammographic-imaging-features-of-her2-positive-breast-cancers-according-to-hormone-receptor-status-a-retrospective-comparative-study
#11
Sung Eun Song, Min Sun Bae, Jung Min Chang, Nariya Cho, Han Suk Ryu, Woo Kyung Moon
BACKGROUND: Human epidermal growth factor receptor 2-positive (HER2+) breast cancer has two distinct subtypes according to hormone receptor (HR) status. Survival, pattern of recurrence, and treatment response differ between HR-/HER2+ and HR+/HER2+ cancers. PURPOSE: To investigate imaging and clinicopathologic features of HER2+ cancers and their correlation with HR expression. MATERIAL AND METHODS: Between 2011 and 2013, 252 consecutive patients with 252 surgically confirmed HER2+ cancers (125 HR- and 127 HR+) were included...
October 17, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27749734/aging-ovary-and-the-role-for-advanced-glycation-end-products
#12
Magdalena Pertynska-Marczewska, Evanthia Diamanti-Kandarakis
OBJECTIVE: The hypothalamic gonadotropin-releasing hormone pulse generator, the pituitary gonadotropes, the ovaries, and the uterus play a crucial role in female fertility. A decline in reproductive performance represents a complex interplay of actions at all levels of the hypothalamic-pituitary-ovarian axis. Recently, in the field of female reproductive aging attention is drawn to the carbonyl stress theory. Advanced glycation end products (AGEs) contribute directly to protein damage, induce a chain of oxidative stress (OS) reactions, and increase inflammatory reactions...
October 3, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27747785/growth-hormone-concentrations-in-different-body-fluids-before-and-after-moderate-exercise
#13
Liz Gough, Lindy M Castell, Rosalba Gatti, Richard J Godfrey
BACKGROUND: Growth hormone (GH) has many direct and indirect actions and roles including substrate regulation and priming of some cells of the immune system, and the expected aspects of growth and repair. Different concentrations in human body fluids reflect the exercise-induced growth hormone response (EIGR) after exercise. In populations such as elite athletes, the invasive nature of venous sampling is poorly accepted. Thus, this study examines possible viable alternatives such as urine and saliva samples and the GH concentration...
December 2016: Sports Medicine—Open
https://www.readbyqxmd.com/read/27732088/disruption-of-the-gh-receptor-gene-in-adult-mice-increases-maximal-lifespan-in-females
#14
Riia K Junnila, Silvana Duran-Ortiz, Ozan Suer, Elahu G Sustarsic, Darlene E Berryman, Edward O List, John J Kopchick
GH and IGF-1 are important for a variety of physiological processes including growth, development, and aging. Mice with reduced levels of GH and IGF-1 have been shown to live longer than wild-type controls. Our laboratory has previously found that mice with a GH receptor gene knockout (GHRKO) from conception exhibit low rates of cancer, resistance to diet-induced diabetes, and extension of lifespan. The GHRKO mouse as well as other mouse lines with reduced GH action display low IGF-1 levels, smaller body size, increased adiposity, and increased longevity...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27721874/bcl2-as-a-subtype-specific-prognostic-marker-for-breast-cancer
#15
Yong Hwa Eom, Hyung Suk Kim, Ahwon Lee, Byung Joo Song, Byung Joo Chae
PURPOSE: B-cell lymphoma 2 (BCL2) is an antiapoptosis protein and an important clinical breast cancer prognostic marker. As the role of BCL2 is dependent on the estrogen receptor (ER) status, this effect might differ according to molecular subtypes. The aim of this study was to evaluate the relationship between the prognostic outcomes and BCL2 expression among the molecular subtypes. METHODS: We retrieved the data of 1,356 patients who were newly diagnosed with malignant breast cancer between November 2006 and November 2011...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27713155/chicken-ghr-natural-antisense-transcript-regulates-ghr-mrna-in-lmh-cells
#16
Li Zhang, Shudai Lin, Lilong An, Jinge Ma, Fengfang Qiu, Rumin Jia, Qinghua Nie, Dexiang Zhang, Qingbin Luo, Ting Li, Zhang Wang, Xiquan Zhang
Growth hormone receptor (GHR) played key roles in human and animal growth. Both human laron type dwarfism and sex linked dwarf chicken were caused by the mutation of GHR gene. In this study, we identified an endogenously expressed long non-coding natural antisense transcript, GHR-AS, which overlapped with the GHR mRNA (GHR-S) in a tail to tail manner. Spatial and temporal expression analyses indicated that GHR-AS were highly expressed in chicken liver and displayed ascending with the development of chicken from E10 to 3 w of age...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27709449/human-chorionic-gonadotropin-hcg-concentrations-during-the-late-first-trimester-are-associated-with-fetal-growth-in-a-fetal-sex-specific-manner
#17
Mirjana Barjaktarovic, Tim I M Korevaar, Vincent W V Jaddoe, Yolanda B de Rijke, Theo J Visser, Robin P Peeters, Eric A P Steegers
Human chorionic gonadotropin (hCG) is a pregnancy-specific hormone that regulates placental development. hCG concentrations vary widely throughout gestation and differ based on fetal sex. Abnormal hCG concentrations are associated with adverse pregnancy outcomes including fetal growth restriction. We studied the association of hCG concentrations with fetal growth and birth weight. In addition, we investigated effect modification by gestational age of hCG measurement and fetal sex. Total serum hCG (median 14...
October 5, 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27681688/dysregulation-of-calcium-channels-decreases-parasecretion-in-pancreatic-%C3%AE-cells-in-rats-born-small-for-gestational-age
#18
Yan-Yan Jin, Meng-Zao He, Zhen-Yong Wu, Ke Huang, Ying Shen, Li Liang, Jian-Hua Mao
OBJECTIVE: To investigate the role of intrauterine malnourishment in the development and function of pancreatic islet β-cells. METHODS: Whole-cell patch clamping was used to record voltage-gated calcium channel (VGCC)-mediated currents. Insulin secretion was detected by measuring capacitance using a sequence of sine wave stimuli. VGCC currents and insulin secretion were measured in the small for gestational age (SGA) group treated with human recombinant growth hormone (hGH)...
September 29, 2016: Growth Factors
https://www.readbyqxmd.com/read/27672331/polymorphisms-in-the-mthfr-gene-are-associated-with-recurrence-risk-in-lymph-node-positive-breast-cancer-patients
#19
Ali Suner, Hakan Buyukhatipoglu, Gokmen Aktas, Tulay Kus, Mustafa Ulasli, Serdar Oztuzcu, Mehmet Emin Kalender, Alper Sevinc, Seval Kul, Celaletdin Camci
PURPOSE: The aim of this study is to clarify the relationship between recurrence risk of breast cancer and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms. PATIENTS AND METHODS: Breast cancer patients who had undergone surgery in Gaziantep University Oncology Hospital between June 2005 and June 2012 were followed-up and retrospectively enrolled in this study. Blood samples were collected from all patients to assess MTHFR C677T polymorphisms. Stage according to tumor-node-metastasis system, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 status, grade of disease, menopausal status, and administered chemotherapy or hormonal therapy were recorded...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27668645/growth-hormone-deficiency-in-children-and-young-adults
#20
Joanna Oświęcimska, Wojciech Roczniak, Agata Mikołajczak, Agnieszka Szymlak
Growth hormone (GH) is a naturally occurring polypeptide hormone produced by somatotropic cells in the anterior pituitary. The main function of somatotropin is stimulation of linear growth, but it also affects carbohydrate metabolism, increases bone mass and has potent lipolytic, antinatriuretic and antidiuretic effects. Growth hormone deficiency (GHD) may occur both in children and in adults. At the moment there is no gold standard for the diagnosis of GHD, and the diagnosis should take into account clinical, auxological, biochemical and radiological changes and, if necessary, genetic testing...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
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