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https://www.readbyqxmd.com/read/29243170/associations-among-physical-symptoms-fear-of-cancer-recurrence-and-emotional-well-being-among-chinese-american-breast-cancer-survivors-a-path-model
#1
Dalnim Cho, Qiao Chu, Qian Lu
PURPOSE: Most existing studies on fear of cancer recurrence (FCR) are exploratory without theoretical underpinnings and have been conducted among non-Hispanic Whites. Based on theoretical models, we hypothesized that more physical symptoms (pain and fatigue) would be associated with higher FCR, which, in turn would be related to lower emotional well-being among Chinese American breast cancer survivors. METHODS: Participants were 77 Chinese American women who were diagnosed with breast cancer of stages 0-III...
December 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29242733/68ga-psma-pet-ct-imaging-of-metastatic-adenoid-cystic-carcinoma
#2
Bart de Keizer, Gerard C Krijger, F Tessa Ververs, Robert J J van Es, Remco de Bree, Stefan Willems
A patient with a history of adenoid cystic carcinoma of the nasal cavity presented himself with bone pain and an elevated PSA level. On suspicion of metastatic prostate cancer a 68Ga-PSMA PET-CT was performed. The PET-CT showed numerous lung and non-sclerotic bone metastasis. Biopsy of a bone metastasis was performed and pathology showed adenoid cystic carcinoma instead of prostate cancer. Immunohistochemical PSMA staining of the primary tumour showed intense PSMA expression in adenoid cystic carcinoma tumour cells...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29241656/adipose-derived-stem-cells-decrease-pain-in-a-rat-model-of-oxaliplatin-induced-neuropathy-role-of-vegf-a-modulation
#3
Lorenzo Di Cesare Mannelli, Barbara Tenci, Laura Micheli, Alessia Vona, Francesca Corti, Matteo Zanardelli, Andrea Lapucci, Ann Maria Clemente, Paola Failli, Carla Ghelardini
Oxaliplatin therapy of colorectal cancer induces a dose-dependent neuropathic syndrome in 50% of patients. Pharmacological treatments may offer limited relief; scientific efforts are needed for new therapeutic approaches. Therefore we evaluated in a preclinical setting the pain relieving properties of mesenchymal stem cells and its secretome. Rat adipose stem cells (rASCs) were administered in a rat model of oxaliplatin-induced neuropathy. A single intravenous injection of rASCs reduced oxaliplatin-dependent mechanical hypersensitivity to noxious and non-noxious stimuli taking effect 1 h after administration, peaking 6 h thereafter and lasting 5 days...
December 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29240048/why-patients-are-afraid-of-opioid-analgesics-study-on-opioid-perception-in-patients-treated-for-chronic-pain
#4
Michał Graczyk, Alina Borkowska, Małgorzata Krajnik
INTRODUCTION    Opiophobia is deemed one of the key barriers in effective pain management.  OBJECTIVES    The study aimed to assess overall perception of opioids in cancer patients suffering from and treated for chronic pain, as well as determine the nature of their most common, related fears.  PATIENTS AND METHODS    The study comprised 100 palliative care patients who suffered from chronic cancer or non-cancer pain. Initially, they had to complete a survey exploring their knowledge on analgesics and potential fear of using opioids...
December 14, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29238222/the-burden-of-selected-cancers-in-the-us-health-behaviors-and-health-care-resource-utilization
#5
Laura Iadeluca, Jack Mardekian, Pratibha Chander, Markay Hopps, Geoffrey T Makinson
Objective: To characterize the disease burden among survivors of those cancers having the highest incidence in the US. Methods: Adult (≥18 years) survivors of the 11 most frequently diagnosed cancers were identified from publically available data sources, including the Surveillance Epidemiology and End Results 9 1973-2012, National Health Interview Survey 2013, and the Medical Expenditure Panel Survey 2011. Chi-square tests and one-way analyses of variance were utilized to assess differences between cancer survivors and non-cancer controls in behavioral characteristics, symptoms and functions, preventative screenings, and health care costs...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29234960/a-new-postoperative-pain-management-intravenous-acetaminophen-acelio%C3%A2-leads-to-enhanced-recovery-after-esophagectomy-a-propensity-score-matched-analysis
#6
Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Shusuke Haruta, Harushi Udagawa
PURPOSES: To investigate the efficacy of postoperative scheduled intravenous acetaminophen to reduce the opioid use and enhance the recovery after esophagectomy. METHODS: A propensity score-matched population was created using the 93 and 69 consecutive patients who underwent esophagectomy for esophageal cancer before and after the introduction of postoperative scheduled intravenous acetaminophen, and the short-term clinical outcomes were compared. RESULTS: Significant defervescence was demonstrated in the Acetaminophen group (A-group) compared with control group (C-group) during the perioperative period (p < 0...
December 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29233995/adeno-associated-virus-serotype-rh10-is-a-useful-gene-transfer-vector-for-sensory-nerves-that-innervate-bone-in-immunodeficient-mice
#7
Sun H Park, Matthew R Eber, Shunsuke Tsuzuki, Mary E Booker, Aaron G Sunil, D Brooke Widner, Renee A Parker, Christopher M Peters, Yusuke Shiozawa
Adeno-associated virus (AAV) is frequently used to manipulate gene expression in the sensory nervous system for the study of pain mechanisms. Although some serotypes of AAV are known to have nerve tropism, whether AAV can distribute to sensory nerves that innervate the bone or skeletal tissue has not been shown. This information is crucial, since bone pain, including cancer-induced bone pain, is an area of high importance in pain biology. In this study, we found that AAVrh10 transduces neurons in the spinal cord and dorsal root ganglia of immunodeficient mice with higher efficacy than AAV2, 5, 6, 8, and 9 when injected intrathecally...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231916/-the-use-of-transdermal-fentanyl-in-the-treatment-of-patients-suffering-from-chronic-non-cancer-pain-case-reports
#8
Tatiana Pietrzyńska, Łukasz Pietrzyński
The use of strong opioids for the treatment of chronic non-cancer pain (CNCP) has gained undisputed acceptance among specialists and should be considered when other pharmacological treatments are not effective or cause serious side effects. However, drugs from the third step of analgesic ladder still raise concerns among doctors and patients in the case of long-term therapy. A CASE REPORT: The authors present reports of three cases of patients with CNCP caused by musculoskeletal disorders and numerous comorbidities...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29230166/the-therapeutic-potential-of-monocyte-macrophage-manipulation-in-the-treatment-of-chemotherapy-induced-painful-neuropathy
#9
REVIEW
Karli Montague, Marzia Malcangio
In cancer treatments a dose-limiting side-effect of chemotherapeutic agents is the development of neuropathic pain, which is poorly managed by clinically available drugs at present. Chemotherapy-induced painful neuropathy (CIPN) is a major cause of premature cessation of treatment and so a greater understanding of the underlying mechanisms and the development of novel, more effective therapies, is greatly needed. In some cases, only a weak correlation between chemotherapy-induced pain and neuronal damage is observed both clinically and preclinically...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29229703/orai1-plays-a-crucial-role-in-central-sensitization-by-modulating-neuronal-excitability
#10
Yannong Dou, Jingsheng Xia, Ruby Gao, Xinghua Gao, Frances M Munoz, Dongyu Wei, Yuzhen Tian, James E Barrett, Seena Ajit, Olimpia Meucci, James W Putney, Yue Dai, Huijuan Hu
Pathological pain is a common and debilitating condition that is often poorly managed. Central sensitization is an important mechanism underlying pathological pain. However, candidate molecules involved in central sensitization remain unclear. Store-operated calcium channels (SOCs) mediate important calcium signals in non-excitable and excitable cells. SOCs have been implicated in a wide variety of human pathophysiological conditions including immunodeficiency, occlusive vascular diseases and cancer. However, the role of SOCs in central nervous system (CNS) disorders has been relatively unexplored...
December 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29229658/effectiveness-of-acupuncture-for-cancer-pain-protocol-for-an-umbrella-review-and-meta-analyses-of-controlled-trials
#11
Yihan He, Yihong Liu, Brian H May, Anthony Lin Zhang, Haibo Zhang, ChuanJian Lu, Lihong Yang, Xinfeng Guo, Charlie Changli Xue
INTRODUCTION: The National Comprehensive Cancer Network guidelines for adult cancer pain indicate that acupuncture and related therapies may be valuable additions to pharmacological interventions for pain management. Of the systematic reviews related to this topic, some concluded that acupuncture was promising for alleviating cancer pain, while others argued that the evidence was insufficient to support its effectiveness. METHODS AND ANALYSIS: This review will consist of three components: (1) synthesis of findings from existing systematic reviews; (2) updated meta-analyses of randomised clinical trials and (3) analyses of results of other types of clinical studies...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229430/self-guided-online-cognitive-behavioral-strategies-for-chemotherapy-induced-peripheral-neuropathy-a-multicenter-pilot-randomized-wait-list-controlled-trial
#12
Robert Knoerl, Ellen M L Smith, Debra L Barton, David A Williams, Janean E Holden, John C Krauss, Beth LaVasseur
The purpose of this pilot, parallel, randomized-controlled trial was to examine the efficacy of a self-guided online cognitive and behaviorally-based pain management intervention (PROSPECT) to reduce "worst" pain for individuals with chronic painful chemotherapy-induced peripheral neuropathy (CIPN). Secondary outcomes included "average" pain, non-painful CIPN symptom severity, impression of change, and pain interference. Sixty patients with chronic painful CIPN were recruited from five outpatient academic and community cancer centers...
December 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29229211/the-use-of-rapid-onset-fentanyl-in-children-and-young-people-for-breakthrough-cancer-pain
#13
Lucy Coombes, Kimberley Burke, Anna-Karenia Anderson
BACKGROUND AND AIMS: No published studies have looked at the dosing and use of rapid onset fentanyl preparations in children. The primary aim of this study was to assess whether there is a correlation between effective dose of rapid onset fentanyl and background oral morphine equivalent analgesia in children less than 18 years old. Secondary objectives included establishing whether there is a correlation between effective dose of rapid onset fentanyl and age and weight. Reported side effects were also reviewed...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29228916/physical-and-psychosomatic-health-outcomes-in-people-bereaved-by-suicide-compared-to-people-bereaved-by-other-modes-of-death-a-systematic-review
#14
Ailbhe Spillane, Celine Larkin, Paul Corcoran, Karen Matvienko-Sikar, Fiona Riordan, Ella Arensman
BACKGROUND: Little research has been conducted into the physical health implications of suicide bereavement compared to other causes of death. There is some evidence that suicide bereaved parents have higher morbidity, particularly in terms of chronic illness. This systematic review aims to examine the physical and psychosomatic morbidities of people bereaved by a family member's suicide and compare them with family members bereaved by other modes of death. METHODS: MEDLINE, EMBASE, CINAHL, and PsycINFO were searched from 1985 to February 2016...
December 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29225684/colon-cancer-presenting-as-pseudo-obstruction-during-pregnancy-a-case-report
#15
Reeva Makhijani, Vicky H Bhagat, Mariam Fayek
The incidence of colorectal cancer in pregnancy is between 0.002 and 0.008%. Diagnosis is often delayed as symptoms of colorectal cancer can mimic as common complaints of pregnancy. We present the case of a 29-year-old with a history of chronic constipation who presented in the second trimester with abdominal pain, inability to tolerate anything orally and no bowel movement in more than three weeks. Non-contrast MRI at presentation failed to show an obstructing mass. Patient was treated conservatively for presumed pseudo-obstruction secondary to worsening constipation from chronic ondansetron use and pregnancy...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29224813/psychometric-validation-of-the-center-for-epidemiological-studies-depression-scale-in-head-and-neck-cancer-patients
#16
K S Chhabria, G D Carnaby
OBJECTIVE: The Center for Epidemiological Studies Depression Scale (CES-D) is a 20-item tool developed to screen for depression in the general population. To psychometrically evaluate and validate the CES-D scale for use in head and neck cancer (HNC) patients. METHODS: The CES-D was applied to 130 subjects at onset of radiation treatment and 3-months following treatment. Analysis was conducted via face and content validity using two expert raters, internal consistency was applied using Cronbach's alpha, test retest reliability comparing baseline to 3-month application, concurrent validity was performed against the FACT-H&N and Pain Disability Index, construct validity was conducted via exploratory factor analysis...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29222840/detection-of-neuropathic-pain-in-end-stage-cancer-patients-diagnostic-accuracy-of-two-questionnaires
#17
Eleftheria Tzamakou, Anastasios Petrou, Louiza Tefa, Vassiliki Siafaka, Eleni Laou, Petros Tzimas, Georgios Pentheroudakis, Georgios Papadopoulos
INTRODUCTION: Neuropathic pain in a frequent consequence of cancer pain. Quite often, in the end stage, it is difficult to discern its presence and delineate its characters in the context of cancer painful complications. The aim of this study was to compare the diagnostic accuracy of the translated to native language DN4 and PainDETECT questionnaires, for the diagnosis of peripheral neuropathic pain in oncology patients. METHODS: End stage cancer patients that presented to the Outpatient Pain Clinic were prospectively followed...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222705/tai-chi-and-qigong-for-cancer-related-symptoms-and-quality-of-life-a-systematic-review-and-meta-analysis
#18
REVIEW
Peter M Wayne, M S Lee, J Novakowski, K Osypiuk, J Ligibel, L E Carlson, R Song
PURPOSE: This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind-body exercises on symptoms and quality of life (QOL) in cancer survivors. METHODS: A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges' g) and publication bias for randomized controlled trials (RCTs)...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29221983/medication-related-osteonecrosis-of-the-jaws-associated-with-targeted-therapy-as-monotherapy-and-in-combination-with-antiresorptives-a-report-of-7-cases-from-the-copenhagen-cohort
#19
Hoda Abel Mahedi Mohamed, Charlotte Emilie Nor Nielsen, Morten Schiodt
OBJECTIVE: The aim of this study was to report cases of medication-related osteonecrosis of the jaws (MRONJ) associated with targeted therapy (TT) with or without concomitant antiresorptive treatment, among the Copenhagen ONJ cohort, which includes all consecutive cases of MRONJ seen in Copenhagen. STUDY DESIGN: We retrospectively studied the treatment of 204 consecutive patients with MRONJ, seen between January 2010 and May 2016, to identify those associated with TT...
November 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29221270/analysis-of-the-clinical-differentiation-of-pulmonary-sclerosing-pneumocytoma-and-lung-cancer
#20
Jun Zhu
Background: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign lung tumor. This study investigated the diagnostic experience of PSP and lung cancer. Methods: This study is a retrospective study. We observed the locations of lung lesions, imaging form and clinical symptoms, and recorded the surgical complications through comparing patients with PSP and lung cancer. Results: From December 2012 to February 2017, 187 PSP cases and 197 lung cancer cases were collected...
September 2017: Journal of Thoracic Disease
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